Itzhak Fried, M.D., Ph.D.

Director, Epilepsy Surgery Professor, Neurosurgery Psychiatry and Biobehavioral Sciences Jane and Terry Semel Institute for Neuroscience and Human Behavior Member, Brain Research Institute Neuroscience GPB Home Area

0000-0002-5962-2678

ifried@mednet.ucla.edu

(310) 825-8409

UCLA Med-Neuro
BOX 957039, 18-225 NPI
Los Angeles, CA 90095
UNITED STATES

Website

Publications

Falach R, Geva-Sagiv M, Eliashiv D, Goldstein L, Budin O, Gurevitch G, Morris G, Strauss I, Globerson A, Fahoum F, Fried I, Nir Y. Annotated interictal discharges in intracranial EEG sleep data and related machine learning detection scheme.. Scientific data, 2024.
Lakretz Y, Friedmann N, King JR, Mankin E, Rangel A, Tankus A, Dehaene S, Fried I. Modality-Specific and Amodal Language Processing by Single Neurons.. bioRxiv : the preprint server for biology, 2024.
Weiss SA, Sperling MR, Engel J, Liu A, Fried I, Wu C, Doyle W, Mikell C, Mofakham S, Salamon N, Sim MS, Bragin A, Staba R. Simulated resections and responsive neurostimulator placement can optimize postoperative seizure outcomes when guided by fast ripple networks.. Brain communications, 2024.
Tacikowski P, Kalender G, Ciliberti D, Fried I. Human hippocampal and entorhinal neurons encode the temporal structure of experience.. Nature, 2024.
Bergman L, Shofty B, Agur A, Sibony SU, Treiber JM, Curry DJ, Fried I, Weiner HL, Roth J. Hippocampal resection during hemispherotomy: is it needed?. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2024.
Weiss SA, Sperling MR, Engel J, Liu A, Fried I, Wu C, Doyle W, Mikell C, Mofakham S, Salamon N, Sim MS, Bragin A, Staba R. Simulated resections and RNS placement can optimize post-operative seizure outcomes when guided by fast ripple networks.. medRxiv : the preprint server for health sciences, 2024.
Schmidig FJ, Geva-Sagiv M, Falach R, Yakim S, Gat Y, Sharon O, Fried I, Nir Y. A visual paired associate learning (vPAL) paradigm to study memory consolidation during sleep.. Journal of sleep research, 2024.
Schonhaut DR, Rao AM, Ramayya AG, Solomon EA, Herweg NA, Fried I, Kahana MJ. MTL neurons phase-lock to human hippocampal theta.. eLife, 2024.
Weiss SA, Fried I, Engel J, Bragin A, Wang S, Sperling MR, Wong RKS, Nir Y, Staba RJ. Pathological neurons generate ripples at the UP-DOWN transition disrupting information transfer.. Epilepsia, 2023.
Schonhaut DR, Aghajan ZM, Kahana MJ, Fried I. A neural code for time and space in the human brain.. Cell reports, 2023.
M Aghajan Z, Kreiman G, Fried I. Minute-scale periodicity of neuronal firing in the human entorhinal cortex.. Cell reports, 2023.
Shamas M, Yeh HJ, Fried I, Engel J, Staba RJ. High-rate leading spikes in propagating spike sequences predict seizure outcome in surgical patients with temporal lobe epilepsy.. Brain communications, 2023.
Maoz SLL, Stangl M, Topalovic U, Batista D, Hiller S, Aghajan ZM, Knowlton B, Stern J, Langevin JP, Fried I, Eliashiv D, Suthana N. Dynamic neural representations of memory and space during human ambulatory navigation.. Nature communications, 2023.
Levy M, Zurawel M, d'Hardemare V, Moran A, Andelman F, Manor Y, Cohen J, Meshulam M, Balash Y, Gurevich T, Fried I, Bergman H. Subthalamic nucleus physiology is correlated with deep brain stimulation motor and non-motor outcomes.. Brain communications, 2023.
Weiss SA, Fried I, Engel J, Sperling MR, Wong RKS, Nir Y, Staba RJ. Fast ripples reflect increased excitability that primes epileptiform spikes.. Brain communications, 2023.
Andelman-Gur MM, Fried I. Consciousness: a neurosurgical perspective.. Acta neurochirurgica, 2023.
Weiss SA, Fried I, Engel J, Bragin A, Wang S, Sperling MR, Wong RKS, Nir Y, Staba RJ. Pathological neurons generate ripples at the UP-DOWN transition disrupting information transfer.. medRxiv : the preprint server for health sciences, 2023.
Poker G, Oren N, Bezalel V, Abecasis D, Hendler T, Fried I, Wagner AD, Shapira-Lichter I. Neural evidence for advantaged representation of first items in memory.. NeuroImage, 2023.
Geva-Sagiv M, Mankin EA, Eliashiv D, Epstein S, Cherry N, Kalender G, Tchemodanov N, Nir Y, Fried I. Augmenting hippocampal-prefrontal neuronal synchrony during sleep enhances memory consolidation in humans.. Nature neuroscience, 2023.
Nagahama Y, Dewar S, Behnke E, Eliashiv D, Stern JM, Kalender G, Fields TA, Wilson C, Staba R, Engel J, Fried I. Outcome of stereo-electroencephalography with single-unit recording in drug-refractory epilepsy.. Journal of neurosurgery, 2023.
Weiss SA, Fried I, Engel J, Sperling MR, Wong RKS, Nir Y, Staba RJ. Fast ripples reflect increased excitability that primes epileptiform spikes.. medRxiv : the preprint server for health sciences, 2023.
Roth J, Fried I, Constantini S, Kramer U, Strauss I, Uliel-Sibony S. [EPILEPSY SURGERY IN CHILDREN: A SUMMARY OF A DECADE AT THE SOURASKY TEL AVIV MEDICAL CENTER].. Harefuah, 2023.
Weiss SA, Eliashiv D, Stern J, Rubinstein D, Fried I, Wu C, Sharan A, Engel J, Staba R, Sperling MR. Stimulation better targets fast-ripple generating networks in super responders to the responsive neurostimulator system.. Epilepsia, 2023.
Yamin HG, Gurevitch G, Gazit T, Shpigelman L, Fried I, Nir Y, Benjamini Y, Hendler T. Decoding human spontaneous spiking activity in medial temporal lobe from scalp EEG.. iScience, 2023.
Topalovic U, Barclay S, Ling C, Alzuhair A, Yu W, Hokhikyan V, Chandrakumar H, Rozgic D, Jiang W, Basir-Kazeruni S, Maoz SL, Inman CS, Stangl M, Gill J, Bari A, Fallah A, Eliashiv D, Pouratian N, Fried I, Suthana N, Markovic D. A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans.. Nature neuroscience, 2023.
Zhang Y, Aghajan ZM, Ison M, Lu Q, Tang H, Kalender G, Monsoor T, Zheng J, Kreiman G, Roychowdhury V, Fried I. Decoding of human identity by computer vision and neuronal vision.. Scientific reports, 2023.
Weiss SA, Fried I, Wu C, Sharan A, Rubinstein D, Engel J, Sperling MR, Staba RJ. Graph theoretical measures of fast ripple networks improve the accuracy of post-operative seizure outcome prediction.. Scientific reports, 2023.
Shamas M, Yeh HJ, Fried I, Engel J, Staba R. Interictal Gamma Event Connectivity Differentiates the Seizure Network and Outcome in Patients after Temporal Lobe Epilepsy Surgery.. eNeuro, 2022.
Weiss SA, Sheybani L, Seenarine N, Fried I, Wu C, Sharan A, Engel J, Sperling MR, Nir Y, Staba RJ. Delta oscillation coupled propagating fast ripples precede epileptiform discharges in patients with focal epilepsy.. Neurobiology of disease, 2022.
Miron G, Strauss I, Fried I, Fahoum F. Anterior thalamic deep brain stimulation in epilepsy patients refractory to vagus nerve stimulation: A single center observational study.. Epilepsy & behavior reports, 2022.
Hayat H, Marmelshtein A, Krom AJ, Sela Y, Tankus A, Strauss I, Fahoum F, Fried I, Nir Y. Author Correction: Reduced neural feedback signaling despite robust neuron and gamma auditory responses during human sleep.. Nature neuroscience, 2022.
Ho VM, Dewar S, Salamon N, Fried I, Eliashiv D. Strategic targeting of the temporal lobe with orthogonal placement of responsive neurostimulation leads.. Epilepsia, 2022.
Hayat H, Marmelshtein A, Krom AJ, Sela Y, Tankus A, Strauss I, Fahoum F, Fried I, Nir Y. Reduced neural feedback signaling despite robust neuron and gamma auditory responses during human sleep.. Nature neuroscience, 2022.
Weinstein M, Sepkuty J, Getter N, Hyman E, Lorberboim M, Luckman J, Zer-Zion M, Fried I, Levy M. [DIAGNOSIS AND TREATMENT OF A GIRL SUFFERING FROM DRUG RESISTANT EPILEPSY WITH AN INNOVATIVE MINIMALLY INVASIVE APPROACH].. Harefuah, 2022.
Weiss SA, Pastore T, Orosz I, Rubinstein D, Gorniak R, Waldman Z, Fried I, Wu C, Sharan A, Slezak D, Worrell G, Engel J, Sperling MR, Staba RJ. Graph theoretical measures of fast ripples support the epileptic network hypothesis.. Brain communications, 2022.
Feinsinger A, Pouratian N, Ebadi H, Adolphs R, Andersen R, Beauchamp MS, Chang EF, Crone NE, Collinger JL, Fried I, Mamelak A, Richardson M, Rutishauser U, Sheth SA, Suthana N, Tandon N, Yoshor D, NIH Research Opportunities in Humans Consortium. Ethical commitments, principles, and practices guiding intracranial neuroscientific research in humans.. Neuron, 2022.
Fried I. Neurons as will and representation.. Nature reviews. Neuroscience, 2021.
Dewar SR, Pieters HC, Fried I. Surgical Decision-Making for Temporal Lobe Epilepsy: Patient Experiences of the Informed Consent Process.. Frontiers in neurology, 2021.
Fried I, Fahoum F, Frew A, Andelman F, Andelman-Gur MM, Salamon N. Laser ablation of human guilt.. Brain stimulation, 2021.
Tankus A, Lustig Y, Fried I, Strauss I. Impaired Timing of Speech-Related Neurons in the Subthalamic Nucleus of Parkinson Disease Patients Suffering Speech Disorders.. Neurosurgery, 2021.
Stern JM, Spivak NM, Becerra SA, Kuhn TP, Korb AS, Kronemyer D, Khanlou N, Reyes SD, Monti MM, Schnakers C, Walshaw P, Keselman I, Cohen MS, Yong W, Fried I, Jordan SE, Schafer ME, Engel J, Bystritsky A. Safety of focused ultrasound neuromodulation in humans with temporal lobe epilepsy.. Brain stimulation, 2021.
Qasim SE, Fried I, Jacobs J. Phase precession in the human hippocampus and entorhinal cortex.. Cell, 2021.
Sheth J, Tankus A, Tran M, Pouratian N, Fried I, Speier W. Generalizing neural signal-to-text brain-computer interfaces.. Biomedical physics & engineering express, 2021.
Fried I. Neurosurgery as a window to the human mind: free will and the sense of self.. Acta neurochirurgica, 2021.
Stangl M, Topalovic U, Inman CS, Hiller S, Villaroman D, Aghajan ZM, Christov-Moore L, Hasulak NR, Rao VR, Halpern CH, Eliashiv D, Fried I, Suthana N. Boundary-anchored neural mechanisms of location-encoding for self and others.. Nature, 2020.
Mankin EA, Aghajan ZM, Schuette P, Tran ME, Tchemodanov N, Titiz A, Kalender G, Eliashiv D, Stern J, Weiss SA, Kirsch D, Knowlton B, Fried I, Suthana N. Stimulation of the right entorhinal white matter enhances visual memory encoding in humans.. Brain stimulation, 2020.
Lakretz Y, Ossmy O, Friedmann N, Mukamel R, Fried I. Single-cell activity in human STG during perception of phonemes is organized according to manner of articulation.. NeuroImage, 2020.
Topalovic U, Aghajan ZM, Villaroman D, Hiller S, Christov-Moore L, Wishard TJ, Stangl M, Hasulak NR, Inman CS, Fields TA, Rao VR, Eliashiv D, Fried I, Suthana N. Wireless Programmable Recording and Stimulation of Deep Brain Activity in Freely Moving Humans.. Neuron, 2020.
Andelman-Gur MM, Gazit T, Strauss I, Fried I, Fahoum F. Stimulating the inferior fronto-occipital fasciculus elicits complex visual hallucinations.. Brain stimulation, 2020.
Gazit T, Gonen T, Gurevitch G, Cohen N, Strauss I, Zeevi Y, Yamin H, Fahoum F, Hendler T, Fried I. Author Correction: The role of mPFC and MTL neurons in human choice under goal-conflict.. Nature communications, 2020.
Gazit T, Gonen T, Gurevitch G, Cohen N, Strauss I, Zeevi Y, Yamin H, Fahoum F, Hendler T, Fried I. The role of mPFC and MTL neurons in human choice under goal-conflict.. Nature communications, 2020.
Berger A, Cohen N, Fahoum F, Medvedovsky M, Meller A, Ekstein D, Benifla M, Aizenstein O, Fried I, Gazit T, Strauss I. Preoperative localization of seizure onset zones by magnetic source imaging, EEG-correlated functional MRI, and their combination.. Journal of neurosurgery, 2020.
Krom AJ, Marmelshtein A, Gelbard-Sagiv H, Tankus A, Hayat H, Hayat D, Matot I, Strauss I, Fahoum F, Soehle M, Boström J, Mormann F, Fried I, Nir Y. Anesthesia-induced loss of consciousness disrupts auditory responses beyond primary cortex.. Proceedings of the National Academy of Sciences of the United States of America, 2020.
Knorr C, Greuter L, Constantini S, Fried I, Kremer U, Datta AN, Guzman R, Soleman J. Subgroup analysis of seizure and cognitive outcome after vagal nerve stimulator implantation in children.. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2020.
Mankin EA, Fried I. Modulation of Human Memory by Deep Brain Stimulation of the Entorhinal-Hippocampal Circuitry.. Neuron, 2020.
Weiss SA, Song I, Leng M, Pastore T, Slezak D, Waldman Z, Orosz I, Gorniak R, Donmez M, Sharan A, Wu C, Fried I, Sperling MR, Bragin A, Engel J, Nir Y, Staba R. Ripples Have Distinct Spectral Properties and Phase-Amplitude Coupling With Slow Waves, but Indistinct Unit Firing, in Human Epileptogenic Hippocampus.. Frontiers in neurology, 2020.
Andelman-Gur MM, Gazit T, Fahoum F, Andelman F, Fried I. Negative and positive volitional responses induced by stimulating the superior frontal gyrus: A case study.. Brain stimulation, 2019.
Andelman-Gur MM, Gazit T, Andelman F, Kipervasser S, Kramer U, Neufeld MY, Fried I, Fahoum F. Spatial distribution and hemispheric asymmetry of electrically evoked experiential phenomena in the human brain.. Journal of neurosurgery, 2019.
Tankus A, Fried I. Degradation of Neuronal Encoding of Speech in the Subthalamic Nucleus in Parkinson's Disease.. Neurosurgery, 2019.
Pryluk R, Kfir Y, Gelbard-Sagiv H, Fried I, Paz R. A Tradeoff in the Neural Code across Regions and Species.. Cell, 2019.
Cohen N, Tsizin E, Fried I, Fahoum F, Hendler T, Gazit T, Medvedovsky M. Conductive gel bridge sensor for motion tracking in simultaneous EEG-fMRI recordings.. Epilepsy research, 2018.
Elahian B, Lado NE, Mankin E, Vangala S, Misra A, Moxon K, Fried I, Sharan A, Yeasin M, Staba R, Bragin A, Avoli M, Sperling MR, Engel J, Weiss SA. Low-voltage fast seizures in humans begin with increased interneuron firing.. Annals of neurology, 2018.
Soleman J, Stein M, Knorr C, Datta AN, Constantini S, Fried I, Guzman R, Kramer U. Improved quality of life and cognition after early vagal nerve stimulator implantation in children.. Epilepsy & behavior : E&B, 2018.
Tankus A, Mirelman A, Giladi N, Fried I, Hausdorff JM. Pace of movement: the role of single neurons in the subthalamic nucleus.. Journal of neurosurgery, 2018.
Watrous AJ, Miller J, Qasim SE, Fried I, Jacobs J. Phase-tuned neuronal firing encodes human contextual representations for navigational goals.. eLife, 2018.
Gelbard-Sagiv H, Mudrik L, Hill MR, Koch C, Fried I. Human single neuron activity precedes emergence of conscious perception.. Nature communications, 2018.
Shapira-Lichter I, Strauss I, Oren N, Gazit T, Sammartino F, Giacobbe P, Kennedy S, Hutchison WD, Fried I, Hendler T, Lozano AM. Conflict monitoring mechanism at the single-neuron level in the human ventral anterior cingulate cortex.. NeuroImage, 2018.
M Aghajan Z, Schuette P, Fields TA, Tran ME, Siddiqui SM, Hasulak NR, Tcheng TK, Eliashiv D, Mankin EA, Stern J, Fried I, Suthana N. Theta Oscillations in the Human Medial Temporal Lobe during Real-World Ambulatory Movement.. Current biology : CB, 2017.
Fried I, Haggard P, He BJ, Schurger A. Volition and Action in the Human Brain: Processes, Pathologies, and Reasons.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017.
Nir Y, Andrillon T, Marmelshtein A, Suthana N, Cirelli C, Tononi G, Fried I. Selective neuronal lapses precede human cognitive lapses following sleep deprivation.. Nature medicine, 2017.
Shimamoto S, Waldman ZJ, Orosz I, Song I, Bragin A, Fried I, Engel J, Staba R, Sharan A, Wu C, Sperling MR, Weiss SA. Utilization of independent component analysis for accurate pathological ripple detection in intracranial EEG recordings recorded extra- and intra-operatively.. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2017.
Titiz AS, Hill MRH, Mankin EA, M Aghajan Z, Eliashiv D, Tchemodanov N, Maoz U, Stern J, Tran ME, Schuette P, Behnke E, Suthana NA, Fried I. Theta-burst microstimulation in the human entorhinal area improves memory specificity.. eLife, 2017.
Reed CM, Dewar S, Fried I, Engel J, Eliashiv D. Failed epilepsy surgery deserves a second chance.. Clinical neurology and neurosurgery, 2017.
Waldman ZJ, Shimamoto S, Song I, Orosz I, Bragin A, Fried I, Engel J, Staba R, Sperling MR, Weiss SA. A method for the topographical identification and quantification of high frequency oscillations in intracranial electroencephalography recordings.. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2017.
Song I, Orosz I, Chervoneva I, Waldman ZJ, Fried I, Wu C, Sharan A, Salamon N, Gorniak R, Dewar S, Bragin A, Engel J, Sperling MR, Staba R, Weiss SA. Bimodal coupling of ripples and slower oscillations during sleep in patients with focal epilepsy.. Epilepsia, 2017.
Roth J, Nagar S, Constantini S, Fried I. [HEMISPHEROTOMY FOR TREATMENT OF REFRACTORY EPILEPSY IN CHILDREN].. Harefuah, 2017.
Kornblith S, Quian Quiroga R, Koch C, Fried I, Mormann F. Persistent Single-Neuron Activity during Working Memory in the Human Medial Temporal Lobe.. Current biology : CB, 2017.
Tankus A, Strauss I, Gurevich T, Mirelman A, Giladi N, Fried I, Hausdorff JM. Subthalamic Neurons Encode Both Single- and Multi-Limb Movements in Parkinson's Disease Patients.. Scientific reports, 2017.
Mormann F, Kornblith S, Cerf M, Ison MJ, Kraskov A, Tran M, Knieling S, Quian Quiroga R, Koch C, Fried I. Scene-selective coding by single neurons in the human parahippocampal cortex.. Proceedings of the National Academy of Sciences of the United States of America, 2017.
De Falco E, Ison MJ, Fried I, Quian Quiroga R. Long-term coding of personal and universal associations underlying the memory web in the human brain.. Nature communications, 2016.
Weiss SA, Orosz I, Salamon N, Moy S, Wei L, Van't Klooster MA, Knight RT, Harper RM, Bragin A, Fried I, Engel J, Staba RJ. Ripples on spikes show increased phase-amplitude coupling in mesial temporal lobe epilepsy seizure-onset zones.. Epilepsia, 2016.
Fried I. Brain Stimulation in Alzheimer's Disease.. Journal of Alzheimer's disease : JAD, 2016.
Hill MR, Boorman ED, Fried I. Observational learning computations in neurons of the human anterior cingulate cortex.. Nature communications, 2016.
Viskontas IV, Knowlton BJ, Fried I. Responses of neurons in the medial temporal lobe during encoding and recognition of face-scene pairs.. Neuropsychologia, 2016.
Klovatch-Podlipsky I, Gazit T, Fahoum F, Tsirelson B, Kipervasser S, Kremer U, Ben-Zeev B, Goldberg-Stern H, Eisenstein O, Harpaz Y, Levy O, Kirschner A, Neufeld MY, Fried I, Hendler T, Medvedovsky M. Dual array EEG-fMRI: An approach for motion artifact suppression in EEG recorded simultaneously with fMRI.. NeuroImage, 2016.
Volovitz I, Shapira N, Ezer H, Gafni A, Lustgarten M, Alter T, Ben-Horin I, Barzilai O, Shahar T, Kanner A, Fried I, Veshchev I, Grossman R, Ram Z. A non-aggressive, highly efficient, enzymatic method for dissociation of human brain-tumors and brain-tissues to viable single-cells.. BMC neuroscience, 2016.
Lopour BA, Staba RJ, Stern JM, Fried I, Ringach DL. Characterization of long-range functional connectivity in epileptic networks by neuronal spike-triggered local field potentials.. Journal of neural engineering, 2016.
Gazit T, Andelman F, Glikmann-Johnston Y, Gonen T, Solski A, Shapira-Lichter I, Ovadia M, Kipervasser S, Neufeld MY, Fried I, Hendler T, Perry D. Probabilistic machine learning for the evaluation of presurgical language dominance.. Journal of neurosurgery, 2016.
Weiss SA, Alvarado-Rojas C, Bragin A, Behnke E, Fields T, Fried I, Engel J, Staba R. Ictal onset patterns of local field potentials, high frequency oscillations, and unit activity in human mesial temporal lobe epilepsy.. Epilepsia, 2015.
Dewar S, Eliashiv D, Walshaw PD, Engel J, Fried I, Moseley BD. Safety, efficacy, and life satisfaction following epilepsy surgery in patients aged 60 years and older.. Journal of neurosurgery, 2015.
Andrillon T, Nir Y, Cirelli C, Tononi G, Fried I. Single-neuron activity and eye movements during human REM sleep and awake vision.. Nature communications, 2015.
Suthana NA, Parikshak NN, Ekstrom AD, Ison MJ, Knowlton BJ, Bookheimer SY, Fried I. Specific responses of human hippocampal neurons are associated with better memory.. Proceedings of the National Academy of Sciences of the United States of America, 2015.
Fried I. Brain stimulation and memory.. Brain : a journal of neurology, 2015.
Ison MJ, Quian Quiroga R, Fried I. Rapid Encoding of New Memories by Individual Neurons in the Human Brain.. Neuron, 2015.
Ossmy O, Fried I, Mukamel R. Decoding speech perception from single cell activity in humans.. NeuroImage, 2015.
Memarian N, Madsen SK, Macey PM, Fried I, Engel J, Thompson PM, Staba RJ. Ictal depth EEG and MRI structural evidence for two different epileptogenic networks in mesial temporal lobe epilepsy.. PloS one, 2015.
Miller JF, Fried I, Suthana N, Jacobs J. Repeating spatial activations in human entorhinal cortex.. Current biology : CB, 2015.
Perez O, Mukamel R, Tankus A, Rosenblatt JD, Yeshurun Y, Fried I. Preconscious prediction of a driver's decision using intracranial recordings.. Journal of cognitive neuroscience, 2015.
Hill MR, Fried I, Koch C. Quantification and classification of neuronal responses in kernel-smoothed peristimulus time histograms.. Journal of neurophysiology, 2014.
Quian Quiroga R, Kraskov A, Mormann F, Fried I, Koch C. Single-cell responses to face adaptation in the human medial temporal lobe.. Neuron, 2014.
Singer N, Podlipsky I, Esposito F, Okon-Singer H, Andelman F, Kipervasser S, Neufeld MY, Goebel R, Fried I, Hendler T. Distinct iEEG activity patterns in temporal-limbic and prefrontal sites induced by emotional intentionality.. Cortex; a journal devoted to the study of the nervous system and behavior, 2014.
Rey HG, Fried I, Quian Quiroga R. Timing of single-neuron and local field potential responses in the human medial temporal lobe.. Current biology : CB, 2014.
Roth J, Fried I, Constantini S. [Neurosurgical aspects in the treatment of children with tuberous sclerosis complex].. Harefuah, 2014.
Bari A, Niu T, Langevin JP, Fried I. Limbic neuromodulation: implications for addiction, posttraumatic stress disorder, and memory.. Neurosurgery clinics of North America, 2013.
Ramot M, Fisch L, Davidesco I, Harel M, Kipervasser S, Andelman F, Neufeld MY, Kramer U, Fried I, Malach R. Emergence of sensory patterns during sleep highlights differential dynamics of REM and non-REM sleep stages.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013.
Lopour BA, Tavassoli A, Fried I, Ringach DL. Coding of information in the phase of local field potentials within human medial temporal lobe.. Neuron, 2013.
Jacobs J, Weidemann CT, Miller JF, Solway A, Burke JF, Wei XX, Suthana N, Sperling MR, Sharan AD, Fried I, Kahana MJ. Direct recordings of grid-like neuronal activity in human spatial navigation.. Nature neuroscience, 2013.
Suthana N, Fried I. Deep brain stimulation for enhancement of learning and memory.. NeuroImage, 2013.
Tankus A, Fried I, Shoham S. Cognitive-motor brain-machine interfaces.. Journal of physiology, Paris, 2013.
Speier W, Fried I, Pouratian N. Improved P300 speller performance using electrocorticography, spectral features, and natural language processing.. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2013.
Meshulam M, Ramot M, Harel M, Kipervasser S, Andelman F, Neufeld MY, Kramer U, Fried I, Malach R. Selectivity of audiovisual ECoG responses revealed under naturalistic stimuli in the human cortex.. Journal of neurophysiology, 2013.
Quiroga RQ, Fried I, Koch C. Brain cells for grandmother.. Scientific American, 2013.
Davidesco I, Harel M, Ramot M, Kramer U, Kipervasser S, Andelman F, Neufeld MY, Goelman G, Fried I, Malach R. Spatial and object-based attention modulates broadband high-frequency responses across the human visual cortical hierarchy.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013.
Blouin AM, Fried I, Wilson CL, Staba RJ, Behnke EJ, Lam HA, Maidment NT, Karlsson KÆ, Lapierre JL, Siegel JM. Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction.. Nature communications, 2013.
Esposito F, Singer N, Podlipsky I, Fried I, Hendler T, Goebel R. Cortex-based inter-subject analysis of iEEG and fMRI data sets: application to sustained task-related BOLD and gamma responses.. NeuroImage, 2012.
Tankus A, Fried I, Shoham S. Sparse decoding of multiple spike trains for brain-machine interfaces.. Journal of neural engineering, 2012.
Ramot M, Fisch L, Harel M, Kipervasser S, Andelman F, Neufeld MY, Kramer U, Fried I, Malach R. A widely distributed spectral signature of task-negative electrocorticography responses revealed during a visuomotor task in the human cortex.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012.
Horowitz G, Amit M, Fried I, Neufeld MY, Sharf L, Kramer U, Fliss DM. Vagal nerve stimulation for refractory epilepsy: the surgical procedure and complications in 100 implantations by a single medical center.. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2012.
Suthana N, Fried I. Percepts to recollections: insights from single neuron recordings in the human brain.. Trends in cognitive sciences, 2012.
Medvedovsky M, Taulu S, Gaily E, Metsähonkala EL, Mäkelä JP, Ekstein D, Kipervasser S, Neufeld MY, Kramer U, Blomstedt G, Fried I, Karppinen A, Veshchev I, Roivainen R, Ben-Zeev B, Goldberg-Stern H, Wilenius J, Paetau R. Sensitivity and specificity of seizure-onset zone estimation by ictal magnetoencephalography.. Epilepsia, 2012.
Rosenberg-Katz K, Jamshy S, Singer N, Podlipsky I, Kipervasser S, Andelman F, Neufeld MY, Intrator N, Fried I, Hendler T. Enhanced functional synchronization of medial and lateral PFC underlies internally-guided action planning.. Frontiers in human neuroscience, 2012.
Howard MW, Viskontas IV, Shankar KH, Fried I. Ensembles of human MTL neurons "jump back in time" in response to a repeated stimulus.. Hippocampus, 2012.
Engel J, McDermott MP, Wiebe S, Langfitt JT, Stern JM, Dewar S, Sperling MR, Gardiner I, Erba G, Fried I, Jacobs M, Vinters HV, Mintzer S, Kieburtz K, Early Randomized Surgical Epilepsy Trial (ERSET) Study Group. Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial.. JAMA, 2012.
Suthana N, Haneef Z, Stern J, Mukamel R, Behnke E, Knowlton B, Fried I. Memory enhancement and deep-brain stimulation of the entorhinal area.. The New England journal of medicine, 2012.
Tankus A, Fried I, Shoham S. Structured neuronal encoding and decoding of human speech features.. Nature communications, 2012.
Andrillon T, Nir Y, Staba RJ, Ferrarelli F, Cirelli C, Tononi G, Fried I. Sleep spindles in humans: insights from intracranial EEG and unit recordings.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011.
Staba RJ, Ekstrom AD, Suthana NA, Burggren A, Fried I, Engel J, Bookheimer SY. Gray matter loss correlates with mesial temporal lobe neuronal hyperexcitability inside the human seizure-onset zone.. Epilepsia, 2011.
Tankus A, Fried I. Visuomotor coordination and motor representation by human temporal lobe neurons.. Journal of cognitive neuroscience, 2011.
Hindi-Ling H, Kipervasser S, Neufeld MY, Andelman F, Nagar S, Chistik V, Veshchev I, Fried I, Kramer U. Epilepsy surgery in children compared to adults.. Pediatric neurosurgery, 2011.
Mukamel R, Fried I. Human intracranial recordings and cognitive neuroscience.. Annual review of psychology, 2011.
Mormann F, Dubois J, Kornblith S, Milosavljevic M, Cerf M, Ison M, Tsuchiya N, Kraskov A, Quiroga RQ, Adolphs R, Fried I, Koch C. A category-specific response to animals in the right human amygdala.. Nature neuroscience, 2011.
Ison MJ, Mormann F, Cerf M, Koch C, Fried I, Quiroga RQ. Selectivity of pyramidal cells and interneurons in the human medial temporal lobe.. Journal of neurophysiology, 2011.
Uliel-Sibony S, Kramer U, Fried I, Fattal-Valevski A, Constantini S. Pediatric temporal low-grade glial tumors: epilepsy outcome following resection in 48 children.. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2011.
Nir Y, Staba RJ, Andrillon T, Vyazovskiy VV, Cirelli C, Fried I, Tononi G. Regional slow waves and spindles in human sleep.. Neuron, 2011.
Fried I, Mukamel R, Kreiman G. Internally generated preactivation of single neurons in human medial frontal cortex predicts volition.. Neuron, 2011.
Watrous AJ, Fried I, Ekstrom AD. Behavioral correlates of human hippocampal delta and theta oscillations during navigation.. Journal of neurophysiology, 2011.
Cerf M, Thiruvengadam N, Mormann F, Kraskov A, Quiroga RQ, Koch C, Fried I. On-line, voluntary control of human temporal lobe neurons.. Nature, 2010.
Mukamel R, Nir Y, Harel M, Arieli A, Malach R, Fried I. Invariance of firing rate and field potential dynamics to stimulus modulation rate in human auditory cortex.. Human brain mapping, 2010.
Rosenberg K, Nossek E, Liebling R, Fried I, Shapira-Lichter I, Hendler T, Ram Z. Prediction of neurological deficits and recovery after surgery in the supplementary motor area: a prospective study in 26 patients.. Journal of neurosurgery, 2010.
Privman E, Fisch L, Neufeld MY, Kramer U, Kipervasser S, Andelman F, Yeshurun Y, Fried I, Malach R. Antagonistic relationship between gamma power and visual evoked potentials revealed in human visual cortex.. Cerebral cortex (New York, N.Y. : 1991), 2010.
Le Van Quyen M, Staba R, Bragin A, Dickson C, Valderrama M, Fried I, Engel J. Large-scale microelectrode recordings of high-frequency gamma oscillations in human cortex during sleep.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010.
Jacobs J, Korolev IO, Caplan JB, Ekstrom AD, Litt B, Baltuch G, Fried I, Schulze-Bonhage A, Madsen JR, Kahana MJ. Right-lateralized brain oscillations in human spatial navigation.. Journal of cognitive neuroscience, 2010.
Mukamel R, Ekstrom AD, Kaplan J, Iacoboni M, Fried I. Single-neuron responses in humans during execution and observation of actions.. Current biology : CB, 2010.
Jacobs J, Kahana MJ, Ekstrom AD, Mollison MV, Fried I. A sense of direction in human entorhinal cortex.. Proceedings of the National Academy of Sciences of the United States of America, 2010.
Paz R, Gelbard-Sagiv H, Mukamel R, Harel M, Malach R, Fried I. A neural substrate in the human hippocampus for linking successive events.. Proceedings of the National Academy of Sciences of the United States of America, 2010.
Engel J, Akhtari M, Bragin A, Fried I, Ogren JA, Staba RJ, Salamon N, Thompson PM. New approaches to structural and functional imaging in focal epilepsy.. Epilepsia, 2010.
Upchurch K, Stern JM, Salamon N, Dewar S, Engel J, Vinters HV, Fried I. Epileptogenic temporal cavernous malformations: operative strategies and postoperative seizure outcomes.. Seizure, 2009.
Viskontas IV, Quiroga RQ, Fried I. Human medial temporal lobe neurons respond preferentially to personally relevant images.. Proceedings of the National Academy of Sciences of the United States of America, 2009.
Ogren JA, Wilson CL, Bragin A, Lin JJ, Salamon N, Dutton RA, Luders E, Fields TA, Fried I, Toga AW, Thompson PM, Engel J, Staba RJ. Three-dimensional surface maps link local atrophy and fast ripples in human epileptic hippocampus.. Annals of neurology, 2009.
Fisch L, Privman E, Ramot M, Harel M, Nir Y, Kipervasser S, Andelman F, Neufeld MY, Kramer U, Fried I, Malach R. Neural "ignition": enhanced activation linked to perceptual awareness in human ventral stream visual cortex.. Neuron, 2009.
Manning JR, Jacobs J, Fried I, Kahana MJ. Broadband shifts in local field potential power spectra are correlated with single-neuron spiking in humans.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009.
Pedreira C, Mormann F, Kraskov A, Cerf M, Fried I, Koch C, Quiroga RQ. Responses of human medial temporal lobe neurons are modulated by stimulus repetition.. Journal of neurophysiology, 2009.
Tankus A, Yeshurun Y, Fried I. An automatic measure for classifying clusters of suspected spikes into single cells versus multiunits.. Journal of neural engineering, 2009.
Quian Quiroga R, Kraskov A, Koch C, Fried I. Explicit encoding of multimodal percepts by single neurons in the human brain.. Current biology : CB, 2009.
Tankus A, Yeshurun Y, Flash T, Fried I. Encoding of speed and direction of movement in the human supplementary motor area.. Journal of neurosurgery, 2009.
Stern Y, Neufeld MY, Kipervasser S, Zilberstein A, Fried I, Teicher M, Adi-Japha E. Source localization of temporal lobe epilepsy using PCA-LORETA analysis on ictal EEG recordings.. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, 2009.
Ekstrom A, Suthana N, Millett D, Fried I, Bookheimer S. Correlation between BOLD fMRI and theta-band local field potentials in the human hippocampal area.. Journal of neurophysiology, 2009.
Milstein J, Mormann F, Fried I, Koch C. Neuronal shot noise and Brownian 1/f2 behavior in the local field potential.. PloS one, 2009.
Lerner JT, Salamon N, Hauptman JS, Velasco TR, Hemb M, Wu JY, Sankar R, Donald Shields W, Engel J, Fried I, Cepeda C, Andre VM, Levine MS, Miyata H, Yong WH, Vinters HV, Mathern GW. Assessment and surgical outcomes for mild type I and severe type II cortical dysplasia: a critical review and the UCLA experience.. Epilepsia, 2009.
Gelbard-Sagiv H, Mukamel R, Harel M, Malach R, Fried I. Internally generated reactivation of single neurons in human hippocampus during free recall.. Science (New York, N.Y.), 2008.
Mormann F, Kornblith S, Quiroga RQ, Kraskov A, Cerf M, Fried I, Koch C. Latency and selectivity of single neurons indicate hierarchical processing in the human medial temporal lobe.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008.
Nir Y, Mukamel R, Dinstein I, Privman E, Harel M, Fisch L, Gelbard-Sagiv H, Kipervasser S, Andelman F, Neufeld MY, Kramer U, Arieli A, Fried I, Malach R. Interhemispheric correlations of slow spontaneous neuronal fluctuations revealed in human sensory cortex.. Nature neuroscience, 2008.
Ekstrom A, Suthana N, Behnke E, Salamon N, Bookheimer S, Fried I. High-resolution depth electrode localization and imaging in patients with pharmacologically intractable epilepsy.. Journal of neurosurgery, 2008.
Rosenberg K, Liebling R, Avidan G, Perry D, Siman-Tov T, Andelman F, Ram Z, Fried I, Hendler T. Language related reorganization in adult brain with slow growing glioma: fMRI prospective case-study.. Neurocase, 2008.
Nir Y, Fisch L, Mukamel R, Gelbard-Sagiv H, Arieli A, Fried I, Malach R. Coupling between neuronal firing rate, gamma LFP, and BOLD fMRI is related to interneuronal correlations.. Current biology : CB, 2007.
Staba RJ, Frighetto L, Behnke EJ, Mathern GW, Fields T, Bragin A, Ogren J, Fried I, Wilson CL, Engel J. Increased fast ripple to ripple ratios correlate with reduced hippocampal volumes and neuron loss in temporal lobe epilepsy patients.. Epilepsia, 2007.
Kipervasser S, Nagar S, Chistik V, Kramer U, Fried I, Neufeld MY. The prognostic significance of interictal epileptiform activity in postoperative EEGs of patients with mesial temporal lobe epilepsy.. Clinical EEG and neuroscience, 2007.
Privman E, Nir Y, Kramer U, Kipervasser S, Andelman F, Neufeld MY, Mukamel R, Yeshurun Y, Fried I, Malach R. Enhanced category tuning revealed by intracranial electroencephalograms in high-order human visual areas.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007.
Jacobs J, Kahana MJ, Ekstrom AD, Fried I. Brain oscillations control timing of single-neuron activity in humans.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007.
Kraskov A, Quiroga RQ, Reddy L, Fried I, Koch C. Local field potentials and spikes in the human medial temporal lobe are selective to image category.. Journal of cognitive neuroscience, 2007.
Viskontas IV, Ekstrom AD, Wilson CL, Fried I. Characterizing interneuron and pyramidal cells in the human medial temporal lobe in vivo using extracellular recordings.. Hippocampus, 2007.
Ekstrom A, Viskontas I, Kahana M, Jacobs J, Upchurch K, Bookheimer S, Fried I. Contrasting roles of neural firing rate and local field potentials in human memory.. Hippocampus, 2007.
Reddy L, Quiroga RQ, Wilken P, Koch C, Fried I. A single-neuron correlate of change detection and change blindness in the human medial temporal lobe.. Current biology : CB, 2006.
Waydo S, Kraskov A, Quian Quiroga R, Fried I, Koch C. Sparse representation in the human medial temporal lobe.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006.
Viskontas IV, Knowlton BJ, Steinmetz PN, Fried I. Differences in mnemonic processing by neurons in the human hippocampus and parahippocampal regions.. Journal of cognitive neuroscience, 2006.
Andelman F, Kipervasser S, Reider-Groswasser II, Fried I, Neufeld MY. Hippocampal memory function as reflected by the intracarotid sodium methohexital Wada test.. Epilepsy & behavior : E&B, 2006.
Zeitzer JM, Morales-Villagran A, Maidment NT, Behnke EJ, Ackerson LC, Lopez-Rodriguez F, Fried I, Engel J, Wilson CL. Extracellular adenosine in the human brain during sleep and sleep deprivation: an in vivo microdialysis study.. Sleep, 2006.
Schrader LM, Stern JM, Wilson CL, Fields TA, Salamon N, Nuwer MR, Vespa PM, Fried I. Low frequency electrical stimulation through subdural electrodes in a case of refractory status epilepticus.. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2006.
Andelman F, Kipervasser S, Neufeld MY, Kramer U, Fried I. Predictive value of Wada memory scores on postoperative learning and memory abilities in patients with intractable epilepsy.. Journal of neurosurgery, 2006.
Mukamel R, Gelbard H, Arieli A, Hasson U, Fried I, Malach R. Coupling between neuronal firing, field potentials, and FMRI in human auditory cortex.. Science (New York, N.Y.), 2005.
Bragin A, Wilson CL, Fields T, Fried I, Engel J. Analysis of seizure onset on the basis of wideband EEG recordings.. Epilepsia, 2005.
Ekstrom AD, Caplan JB, Ho E, Shattuck K, Fried I, Kahana MJ. Human hippocampal theta activity during virtual navigation.. Hippocampus, 2005.
Engel AK, Moll CK, Fried I, Ojemann GA. Invasive recordings from the human brain: clinical insights and beyond.. Nature reviews. Neuroscience, 2005.
Crick F, Koch C, Kreiman G, Fried I. Consciousness and neurosurgery.. Neurosurgery, 2004.
Frazee J, Fried I, Kawamoto H, Lazareff J, Nieto J, Patel S, Urata M, van de Wiele B. The separation of Guatemalan craniopagus twins.. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2004.
Staba RJ, Wilson CL, Bragin A, Jhung D, Fried I, Engel J. High-frequency oscillations recorded in human medial temporal lobe during sleep.. Annals of neurology, 2004.
Andelman F, Zuckerman-Feldhay E, Hoffien D, Fried I, Neufeld MY. Lateralization of deficit in self-awareness of memory in patients with intractable epilepsy.. Epilepsia, 2004.
Mintzer S, Cendes F, Soss J, Andermann F, Engel J, Dubeau F, Olivier A, Fried I. Unilateral hippocampal sclerosis with contralateral temporal scalp ictal onset.. Epilepsia, 2004.
Kipervasser S, Andelman F, Kramer U, Nagar S, Fried I, Neufeld MY. Effects of topiramate on memory performance on the intracarotid amobarbital (Wada) test.. Epilepsy & behavior : E&B, 2004.
Amador N, Fried I. Single-neuron activity in the human supplementary motor area underlying preparation for action.. Journal of neurosurgery, 2004.
Andelman F, Neufeld MY, Fried I. Contribution of neuropsychology to epilepsy surgery.. The Israel journal of psychiatry and related sciences, 2004.
Hendler T, Pianka P, Sigal M, Kafri M, Ben-Bashat D, Constantini S, Graif M, Fried I, Assaf Y. Delineating gray and white matter involvement in brain lesions: three-dimensional alignment of functional magnetic resonance and diffusion-tensor imaging.. Journal of neurosurgery, 2003.
Ekstrom AD, Kahana MJ, Caplan JB, Fields TA, Isham EA, Newman EL, Fried I. Cellular networks underlying human spatial navigation.. Nature, 2003.
Cornford EM, Shamsa K, Zeitzer JM, Enriquez CM, Wilson CL, Behnke EJ, Fried I, Engel J. Regional analyses of CNS microdialysate glucose and lactate in seizure patients.. Epilepsia, 2002.
Bragin A, Wilson CL, Staba RJ, Reddick M, Fried I, Engel J. Interictal high-frequency oscillations (80-500 Hz) in the human epileptic brain: entorhinal cortex.. Annals of neurology, 2002.
Staba RJ, Wilson CL, Bragin A, Fried I, Engel J. Quantitative analysis of high-frequency oscillations (80-500 Hz) recorded in human epileptic hippocampus and entorhinal cortex.. Journal of neurophysiology, 2002.
Staba RJ, Wilson CL, Bragin A, Fried I, Engel J. Sleep states differentiate single neuron activity recorded from human epileptic hippocampus, entorhinal cortex, and subiculum.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002.
Fried I, Cameron KA, Yashar S, Fong R, Morrow JW. Inhibitory and excitatory responses of single neurons in the human medial temporal lobe during recognition of faces and objects.. Cerebral cortex (New York, N.Y. : 1991), 2002.
Kreiman G, Fried I, Koch C. Single-neuron correlates of subjective vision in the human medial temporal lobe.. Proceedings of the National Academy of Sciences of the United States of America, 2002.
Kahn I, Yeshurun Y, Rotshtein P, Fried I, Ben-Bashat D, Hendler T. The role of the amygdala in signaling prospective outcome of choice.. Neuron, 2002.
Staba RJ, Wilson CL, Fried I, Engel J. Single neuron burst firing in the human hippocampus during sleep.. Hippocampus, 2002.
Fried I, Wilson CL, Maidment NT, Engel J, Behnke E, Fields TA, MacDonald KA, Morrow JW, Ackerson L. Cerebral microdialysis combined with single-neuron and electroencephalographic recording in neurosurgical patients. Technical note.. Journal of neurosurgery, 1999.