Posts classified under: Neuroendocrinology

Niranjala Tillakaratne, Ph.D

Publications

A selected list of publications:

Duru Paul, Tillakaratne Niranjala, Kim Jung, Zhong Hui, Stauber Stacey, Pham Tran, Xiao Mei Si, Edgerton V. Reggie, Roy Roland.   Spinal neuronal activation during locomotor-like activity enabled by epidural stimulation and 5-hydroxytryptamine agonists in spinal rats, J Neurosci Res, 2015; 93(8): 1229-1239.
Tillakaratne Niranjala J K, Duru Paul, Fujino Hidemi, Zhong Hui, Xiao Mei Si, Edgerton V Reggie, Roy Roland R   Identification of interneurons activated at different inclines during treadmill locomotion in adult rats Journal of neuroscience research, 2014; 92(12): 1714-22.
Shah Prithvi K, Garcia-Alias Guillermo, Choe Jaehoon, Gad Parag, Gerasimenko Yury, Tillakaratne Niranjala, Zhong Hui, Roy Roland R, Edgerton V Reggie   Use of quadrupedal step training to re-engage spinal interneuronal networks and improve locomotor function after spinal cord injury Brain : a journal of neurology, 2013; 136(Pt 11): 3362-77.
Joseph M Selvan, Ying Zhe, Zhuang Yumei, Zhong Hui, Wu Aiguo, Bhatia Harsharan S, Cruz Rusvelda, Tillakaratne Niranjala J K, Roy Roland R, Edgerton V Reggie, Gomez-Pinilla Fernando   Effects of diet and/or exercise in enhancing spinal cord sensorimotor learning PloS one, 2012; 7(7): e41288.
Joseph M Selvan, Bilousova Tina, Zdunowski Sharon, Wu Zhongqi-Phyllis, Middleton Blake, Boudzinskaia Maia, Wong Bonnie, Ali Noore, Zhong Hui, Yong Jing, Washburn Lorraine, Escande-Beillard Nathalie, Dang Hoa, Edgerton V Reggie, Tillakaratne Niranjala J K, Kaufman Daniel L   Transgenic mice with enhanced neuronal major histocompatibility complex class I expression recover locomotor function better after spinal cord injury Journal of neuroscience research, 2011; 89(3): 365-72.
Tillakaratne NJ, Guu JJ, de Leon RD, Bigbee AJ, London NJ, Zhong H, Ziegler M,Joynes R, Roy RR, Edgerton VR.   Functional recovery of stepping in rats after a complete neonatal spinal cord transection is not due to regrowth across the lesion site , Neuroscience, 2010; 166: 23-33.
Khristy W, Ali NJ, Bravo AB, de Leon R, Roy RR, Zhong H, London NJ, Edgerton VR, Tillakaratne NJ   Changes in GABA(A) receptor subunit gamma 2 in extensor and flexor motoneurons and astrocytes after spinal cord transection and motor training, Brain Res, 2009; 1273: 9-17.
Otoshi CK, Walwyn WM, Tillakaratne NJ, Zhong H, Roy RR, Edgerton VR   Distribution and localization of 5-HT(1A) receptors in the rat lumbar spinal cord after transection and deafferentation, J Neurotrauma, 2009; 26: 575-84.
Jindrich DL, Joseph MS, Otoshi CK, Wei RY, Zhong H, Roy RR, Tillakaratne NJ,Edgerton VR   Spinal learning in the adult mouse using the Horridge paradigm, J Neurosci Methods, , 2009; 182(2): 250-4.
Edgerton VR, Courtine G, Gerasimenko YP, Lavrov I, Ichiyama RM, Fong AJ, Cai LL, Otoshi CK, Tillakaratne NJ, Burdick JW, Roy RR   Training locomotor networks, Brain Res Rev, 2008; 57: 241-54 (Review).
Bigbee AJ, Crown ED, Ferguson AR, Roy RR, Tillakaratne NJ, Grau JW, Edgerton VR   Two chronic motor training paradigms differentially influence acute, Behav Brain Res, 2007; 180: 95-101.
Ahn, SN Guu, JJ Tobin, AJ Edgerton, VR Tillakaratne, NJ   Use of c-fos to identify activity-dependent spinal neurons after stepping in intact adult rats Spinal Cord, 2006; 44: 547-59.
Zanjani H, Lemaigre-Dubreuil Y, Tillakaratne NJK, Blokhin A, McMahon RP, Tobin AJ and Vogel MW.   Cerebellar Purkinje cell loss in aging Hu-Bcl2 transgenic mice, J Comp Neurol, 2004; 475: 481-92.
Edgerton VR, Tillakaratne NJK, Bigbee AJ, de Leon RD, and Roy RR   Locomotor recovery potential after spinal cord injury, Neuro-behavioral determinants of interlimb coordination, edited by Swinnen S. & P Duysens J, 2004; .
Edgerton, VR Tillakaratne, NJ Bigbee, AJ de Leon, RD Roy, RR   Plasticity of the spinal neural circuitry after injury Annual review of neuroscience. , 2004; 27: 145-67.
Hoang, TX Nieto, JH Tillakaratne, NJ Havton, LA   Autonomic and motor neuron death is progressive and parallel in a lumbosacral ventral root avulsion model of cauda equina injury The Journal of comparative neurology. , 2003; 467(4): 477-86.
Mackie, M Hughes, DI Maxwell, DJ Tillakaratne, NJ Todd, AJ   Distribution and colocalisation of glutamate decarboxylase isoforms in the rat spinal cord Neuroscience. , 2003; 119(2): 461-72.
Tillakaratne, NJ de Leon, RD Hoang, TX Roy, RR Edgerton, VR Tobin, AJ   Use-dependent modulation of inhibitory capacity in the feline lumbar spinal cord The Journal of neuroscience, 2002; 22(8): 3130-43.
Edgerton, VR Leon, RD Harkema, SJ Hodgson, JA London, N Reinkensmeyer, DJ Roy, RR Talmadge, RJ Tillakaratne, NJ Timoszyk, W Tobin, A   Retraining the injured spinal cord The Journal of physiology. , 2001; 533(Pt 1): 15-22.
Tillakaratne, NJ Mouria, M Ziv, NB Roy, RR Edgerton, VR Tobin, AJ   Increased expression of glutamate decarboxylase (GAD(67)) in feline lumbar spinal cord after complete thoracic spinal cord transection Journal of neuroscience research. , 2000; 60(2): 219-30.
Banerjee, PK Tillakaratne, NJ Brailowsky, S Olsen, RW Tobin, AJ Snead, OC   Alterations in GABAA receptor alpha 1 and alpha 4 subunit mRNA levels in thalamic relay nuclei following absence-like seizures in rats Experimental neurology. , 1998; 154(1): 213-23.
Banerjee PK, Olsen RW, Tillakaratne NJK, Brailowsky S, Tobin AJ, and Snead OC, 3rd.   Absence seizures decrease steroid modulation of t-[35S]butylbicyclophosphorothionate binding in thalamic relay nuclei, J Pharmacol Exp Ther, 1998; 287: 766-772.
Edgerton VR, Roy RR, de Leon RD, Tillakaratne NJK, and Hodgson JA.   Does motor learning occur in spinal cord?, The neuroscientist, 1997; 3: 287-294.
Edgerton, VR de Leon, RD Tillakaratne, N Recktenwald, MR Hodgson, JA Roy, RR   Use-dependent plasticity in spinal stepping and standing Advances in neurology. , 1997; 72: 233-47.
Mahmoudi M, Kang M H, Tillakaratne N, Tobin A J, Olsen R W   Chronic intermittent ethanol treatment in rats increases GABA(A) receptor alpha4-subunit expression: possible relevance to alcohol dependence Journal of neurochemistry, 1997; 68(6): 2485-92.
Tillakaratne N J, Medina-Kauwe L, Gibson K M   gamma-Aminobutyric acid (GABA) metabolism in mammalian neural and nonneural tissues Comparative biochemistry and physiology. Part A, Physiology, 1995; 112(2): 247-63.
Segovia J, Lawless G M, Tillakaratne N J, Brenner M, Tobin A J   Cyclic AMP decreases the expression of a neuronal marker (GAD67) and increases the expression of an astroglial marker (GFAP) in C6 cells Journal of neurochemistry, 1994; 63(4): 1218-25.
Hendrickson A E, Tillakaratne N J, Mehra R D, Esclapez M, Erickson A, Vician L, Tobin A J   Differential localization of two glutamic acid decarboxylases (GAD65 and GAD67) in adult monkey visual cortex The Journal of comparative neurology, 1994; 343(4): 566-81.
Medina-Kauwe L K, Tillakaratne N J, Wu J Y, Tobin A J   A rat brain cDNA encodes enzymatically active GABA transaminase and provides a molecular probe for GABA-catabolizing cells Journal of neurochemistry, 1994; 62(4): 1267-75.
Esclapez M, Tillakaratne N J, Kaufman D L, Tobin A J, Houser C R   Comparative localization of two forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the forms The Journal of neuroscience : the official journal of the Society for Neuroscience, 1994; 14(3 Pt 2): 1834-55.
Esclapez M, Tillakaratne N J, Tobin A J, Houser C R   Comparative localization of mRNAs encoding two forms of glutamic acid decarboxylase with nonradioactive in situ hybridization methods The Journal of comparative neurology, 1993; 331(3): 339-62.
Greif K F, Tillakaratne N J, Erlander M G, Feldblum S, Tobin A J   Transient increase in expression of a glutamate decarboxylase (GAD) mRNA during the postnatal development of the rat striatum Developmental biology, 1992; 153(1): 158-64.
Kasckow J W, Tillakaratne N J, Kim H, Strecker G J, Tobin A J, Olsen R W   Expression of GABAA receptor polypeptides in clonal rat cell lines Brain research, 1992; 581(1): 143-7.
Bu D F, Erlander M G, Hitz B C, Tillakaratne N J, Kaufman D L, Wagner-McPherson C B, Evans G A, Tobin A J   Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene Proceedings of the National Academy of Sciences of the United States of America, 1992; 89(6): 2115-9.
Tillakaratne N J, Erlander M G, Collard M W, Greif K F, Tobin A J   Glutamate decarboxylases in nonneural cells of rat testis and oviduct: differential expression of GAD65 and GAD67 Journal of neurochemistry, 1992; 58(2): 618-27.
Erlander M G, Tillakaratne N J, Feldblum S, Patel N, Tobin A J   Two genes encode distinct glutamate decarboxylases Neuron, 1991; 7(1): 91-100.
Khrestchatisky M, MacLennan A J, Tillakaratne N J, Chiang M Y, Tobin A J   Sequence and regional distribution of the mRNA encoding the alpha 2 polypeptide of rat gamma-aminobutyric acidA receptors Journal of neurochemistry, 1991; 56(5): 1717-22.
MacLennan A J, Brecha N, Khrestchatisky M, Sternini C, Tillakaratne N J, Chiang M Y, Anderson K, Lai M, Tobin A J   Independent cellular and ontogenetic expression of mRNAs encoding three alpha polypeptides of the rat GABAA receptor Neuroscience, 1991; 43(2-3): 369-80.
Greif K F, Erlander M G, Tillakaratne N J, Tobin A J   Postnatal expression of glutamate decarboxylases in developing rat cerebellum Neurochemical research, 1991; 16(3): 235-42.
Tobin A J, Khrestchatisky M, MacLennan A J, Chiang M Y, Tillakaratne N J, Xu W T, Jackson M B, Brecha N, Sternini C, Olsen R W   Structural, developmental and functional heterogeneity of rat GABAA receptors Advances in experimental medicine and biology, 1991; 287(3): 365-74.
John Maclennan A, Frantz G D, Weatherwax R C, Tillakaratne N J, Tobin A J   Expression of mRNAs that encode D2 dopamine receptor subtypes: Anatomical, developmental, and pharmacological studies Molecular and cellular neurosciences, 1990; 1(2): 151-60.
Segovia J, Tillakaratne N J, Whelan K, Tobin A J, Gale K   Parallel increases in striatal glutamic acid decarboxylase activity and mRNA levels in rats with lesions of the nigrostriatal pathway Brain research, 1990; 529(1-2): 345-8.
Kim Y S, Thomas J W, Tillakaratne N J, Montpied P, Suzdak P D, Banner C, Ginns E, Tobin A J, Paul S M   Glutamic acid decarboxylase mRNA in rat brain: regional distribution and effects of intrastriatal kainic acid Brain research, 1987; 427(1): 77-82.

Hong Yang, M.D., Ph.D.

Biography

Hong Yang is a physiologist who has served on the UCLA School of Medicine since she joined the Department of Medicine in 1987. She became a full Researcher in 2002 and is a member of Brain Research Institute, Center for Ulcer Research and Education: Digestive Diseases Research Center and Center for Neurovisceral Sciences & Women’s Health. Dr. Yang earned her M.D and Ph.D. in Physiology at Beijing Medical University in China. She was a postdoctoral fellow, an Assistant Researcher and Associate Researcher at the Department of Medicine, UCLA where she worked on Brain-Gut Interactions. Dr. Yang’s research focuses on the medullary mechanism of autonomic disorders in metabolic diseases. She is the principal investigator of NIH and Department of Veterans Affairs funded grants for investigating the medullary mechanism of hypothyroidism-induced autonomic disorders. She is also a reviewer for multiple scientific journals including Am J Physiol (E,G,R), Metabolism and J Physiol, as well as an ad hoc grant reviewer for American Diabetes Association, the Department of Veterans Affairs and NIH/HIDDK.

Publications

A selected list of publications:

Tache Y and Yang H   Central actions of peptides in the vagally mediated regulation of gastric function, In: Encyclopedia of Hormones and Related Cell Regulators. , 2003; in press.
Yuan, PQ Yang, H   Neuronal activation of brain vagal-regulatory pathways and upper gut enteric plexuses by insulin hypoglycemia American journal of physiology. Endocrinology and metabolism. , 2002; 283(3): E436-48.
Yang H, Tache Y, Ohning G and Go VLW   Activation of raphe pallidus neurons increases insulin through medullary TRH-vagal pathways, Pancreas, 2002; 25: 301-307.
Yang H   Hypothyroidism and autonomic changes: role of medullary TRH, In Brain-Gut Peptides in the New Millenium: A Tribute to John Walsh by His Collaborators. Tache Y ed, 2002; 243-253.
Yuan P Q, Tache Y, Miampamba M and Yang H   Acute cold exposure induces vagal mediated Fos expression in gastric myenteric cells in conscious rats, Am J Physiol, 2001; 281: G560-G568.
Yang H, Yuan PQ, Wang L and Tache Y   Activation of the parapyramidal region in the ventral medulla stimulates gastric acid secretion through vagal pathways in rats, Neuroscience , 2000; 95: 773-779.
Yuan P Q and Yang H   Location of thyroid hormone receptor b2 in medullary TRH synthesizing neurons, Brain Res, 2000; 868: 22-30.
Yang H, Kawakubo K, Wong H, Ohning G and Tache Y   Peripheral PYY inhibits intracisternal TRH-induced gastric acid secretion by acting in the brain, Am J Physiol, 2000; 279: G575-G581.
Yuan, PQ Yang, H   Hypothyroidism induces Fos-like immunoreactivity in ventral medullary neurons that synthesize TRH The American journal of physiology. , 1999; 277(5 Pt 1): E927-36.
Yang H, Yuan PQ, Wu V and Tache Y   Feedback regulation of thyrotropin-releasing hormone gene expression by thyroid hormone in the caudal raphe nuclei in rats, Endocrinology, 1999; 140: 43-49.
Yang H, Kawakubo K and Tache Y   Intracisternal PYY increases gastric mucosal resistance : role of cholinergic CGRP and NO pathways, Am J Physiol, 1999; 277: G555-G562.
Yang H, Kawakubo K and Tache Y   Kainic acid into the parapyramidal region protects gastric injury by ethanol, Eur J Pharmacol, 1999; 372: R1-R3.
Yang H, Li WP, Reeve J R. Jr. and Tache Y   PYY preferring receptor in the dorsal vagal complex mediates PYY stimulation of gastric acid secretion in rats, Br J Pharmacol, 1998; 123: 1549-1554.
Yang H and Tache Y   Inhibitory effect of substance P in the dorsal motor nucleus of the vagus on TRH-induced gastric acid secretion, Am J Physiol, 1997; 272: G987-G993.
Yang H and Tache Y   Caudal medullary raphe nuclei and vagal regulation of gastric function, In: Gastrointestinal Tract and Endocrine System , Singer MV, Ziegler R and Rohr G ed, 1995; 39-49.
21. Yang H, Zhang XJ, Tache Y, Yoneda M and Wang CC   Central serotonin influences the devolopment of cold-restraint stress-induced gastric ulceration: role of autonomic and endocrine mechanisms, In: Gastrointestinal Tract and Endocrine System, Singer MV, Ziegler R and Rohr G ed, 1995; 77-82.
Yang H and Tache Y   Peptide YY in brainstem nuclei stimulates gastric acid secretion through vagal pathways in rats, Am J Physiol, 1995; 268: G943-G948.
Tache Y, Yang H, Yoneda M and Bonaz B   Role of medullary TRH in vagally mediated formation of gastric lesions. In: Neuroendocrinology of Gastrointestinal Ulceration:, Hans Selye Symposia on Neuroendocrinology and Stress. Szabo S, Tache Y and Glavin G ed, 1995; 161-173.
Yang H and Tache Y   Prepro-TRH-(160-169) potentiates gastric acid secretion stimulated by TRH microinjected into the dorsal motor nucleus of the vagus, Neurosci Lett. , 1994; 79: 43-46.
Tache Y and Yang H   Role of medullary TRH in the vagal regulation of gastric function, In: Innervation of the Gut: pathophysiological Implications. Tache Y, Wingate DL and Burks TF. ed, 1994; 67-80.
Yang H, Ohning G and Tache Y   TRH in the dorsal vagal complex mediates the acid response to excitation of raphe pallidus neurons in rats, Am J Physiol, 1993; 265: G880-G886.
Yang H, Stephens R and Tache Y   TRH analog microinjected into specific medullary nuclei stimulates gastric serotonin secretion in rats, Am J Physiology, 1992; 262: G216-G222.
Tache Y and Yang H   Brain regulation of gastric acid secretion by peptides: sites and mechanisms of action. In: Neurobiology of Stress Ulcers, Ann.N.Y.Acad.Sci, 1990; 597: 88-145.
Yang H, Ishikawa T and Tache Y   Microinjection of TRH analogs into the raphe pallidus stimulates gastric acid secretion in the rat, Brain Res., , 1990; 531: 280-285.
Yang H, Wong H, Wu V, Walsh JH, Tache Y   Somatostatin monoclonal antibody immunoneutralization increases gastrin and gastric acid secretion in urethane-anesthetized rats, Gastroenterology, 1990; 99: 659-665.
Yang H, Walsh JH, Tache Y   Effect of gastrin monoclonal antibody 28.2 on acid response to chemical vagal stimulation in rats, Life Sci, 1989; 45: 2413-2418.
Yang H, Cuttitta F, Raybould H, Tache Y   Intrathecal injection of bombesin inhibits gastric acid secretion in the rat, Gastroenterology , 1989; 96: 1403-1409.
Yang H, Zhang XJ and Wang CC   Effect of central 5-HT on the changes of lysosome and barrier mucus of gastric mucosa during stress in rats. (in Chinese), Chinese J. Appl. Physiol, 1988; 4(1): 1-5.
Yang H, Zhang XJ   Effect of intracerebroventricular injection of 5-HT on the activity of ATPase and the contents of ATP, ADP in the gastric mucosa after stress, Acta Physiologica Sinica, 1988; 40(1): 84-90.
An SZ, Yang H   Central 5-HT participates in the enhancement of plasma corticosterone level induced by 2-deoxy-glucose, J.Beijing Medical University , 1987; 19: 326.
Yang H, Sun J and Zhang XJ   Effects of cortisol and thyroxine on the enhancement of central 5-HT on stress-induced gastric ulceration, Chinese J. Physiol. Sci, 1987; 3(3): 290-296.
Yang H, Zhang XJ   Effects of intracerebroventricular injection of neuropeptide Y, bombesin and TRH on the metabolic rate of rat brain 5-hydroxytryptamine during stress-induced gastric ulceration, J. Beijing Medical University, 1987; 19: 87-89.
Yang H, Qiu C-F, Zhang S-X, An S-Z and Zhang XJ   Role of central 5-HT in the activation of hypothalamic-pituitary-adrenal and hypothalamic-pituitary-thyroid axes during stress ulceration, Chinese J. Physiol. Sci, 1987; 3(3): 280-289.
Yang H, Zhang XJ   The role of central 5-hydroxytryptamine in 2-deoxyglucose-induced hyperglycemia, J. Beijing Medical University, 1986; 18: 1-5.
Yang, H Zhang, XJ   [The role of brain 5-hydroxytryptamine in the genesis of stress-induced gastric ulcer in rats] Sheng li xue bao [Acta physiologica Sinica]. , 1985; 37(5): 416-24.
Yang H, Zhang XJ, Wang CC   The enhancing effect of intracerebroventricular injection of bovine pancreatic polypeptide and neuropeptide Y on stress-induced gastric ulceration in rats, Chinese J. Physiological Sciences, 1985; 1: 96-101.
Yang H, Wu XR, Zhang XJ   Effect of intracerebroventricular injection of 5-hydroxytryptamine on plasma glucose concentration in rabbits, J. Beijing Medical College, 1984; 16: 187-189.
Yang H, Zhang XJ   The hyperglycemic effect of morphine after brain injection in rabbits, J. Beijing Medical College, 1984; 16: 11-15.
Yang H, Zhang XJ   The role of brain endogenous opioids in stress-induced hyperglycemia, Acta Physiologica Sinica, 1984; 36: 117-121.
Yang H   Effect of morphine and endophins on feeding behavior, Progress in Physiological Science, 1983; 14: 370-371.