Posts classified under: UCLA Cannabinoid

Kym Faull, Ph.D.


Kym Francis Faull was born, raised and educated at The University of Adelaide, South Australia. He completed a Bachelor of Agricultural Science degree in 1968, an Honours degree in Agricultural Biochemistry (nitrogen metabolism of soil-borne bacteria) in 1969 and a Ph.D. degree in Plant Physiology in 1974 (gibberellin biosynthesis). After a post-doctoral fellowship (74-76) at the University of Wollongong, New South Wales (human metabolic diseases), he joined the research staff at Stanford University School of Medicine Department of Psychiatry and Behavioral Sciences (76-90) where he rose through the ranks of staff and senior staff scientific officers. He joined the faculty at UCLA in 1990 as an Assistant Professor in the Department of Psychiatry & Biobehavioral Sciences and the Neuropsychiatric Institute. With an unusual combination of interests and experience encompassing biochemistry, and in particular brain biochemistry, and with expertise in mass spectrometry, his objective was to develop a multifaceted program in analytical neurochemistry addressing the biochemical substrates of psychiatric diseases. As a consequence of his extensive research collaborations, the scope of Dr. Faull’s responsibilities expanded in 1992 to embrace teaching and research missions across Departments within the Medical School and the College of Letters and Sciences. This change came with his appointment as Director of the newly-created Center for Molecular and Medical Sciences Mass Spectrometry, subsequently re-named The Pasarow Mass Spectrometry Laboratory. Originally located in the then recently completed Molecular Life Sciences Building, the facility has since moved to the Center for Health Sciences, rooms 68-146,, 155 and 162. The mission of this interdepartmental facility was to broadly develop a mass spectrometry research and service facility for the entire campus.


A selected list of publications:

Xudong Fu, Xudong, Randall M. Chin, Laurent Vergnes, Heejun Hwang, Gang Deng, Yanpeng Xing, Melody Y. Pai2, Sichen Li, Lisa Ta1, Farbod Fazlollahi, Chuo Chen, Robert M. Prins, Michael A. Teitell, David A. Nathanson, Albert Lai, Kym F. Faull, Meisheng Jiang, Steven G. Clarke, Timothy F. Cloughesy, Thomas Graeber, Daniel Braas, Heather R. Christofk, Michael E. Jung, Karen Reue, Jing Huang   2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling, Cell Metabolism , 2015; 22: 345-532.
Lesage, Denis, Gabriella Barozzino-Consiglio, Romain Duwald, Catherine Fressigné, Anne Harrison-Marchand, Kym F. Faull, Jacques Maddaluno, and Yves Gimbert   A Lithium Amide Protected Against Protonation in the Gas Phase: Unexpected Effect of LiCl, J. Organic Chemistry, 2015; .
Nigra, Benjamin T., Kym F. Faull and Hans Barnard   Analytical Chemistry in Archaeological Research, Analytical Chemistry (invited review), 2015; 87: 3−18 .
Ma, Daniel, Alexander Yoon, Kym F. Faull, Robert Desharnais, Edith T. Zemanick and Edith Porter   Antimicrobial cholesteryl esters are elevated in bronchial lavage fluid collected from pediatric cystic fibrosis patients and may serve as novel biomarker for disease, PLOS ONE, 2015; .
Rajkovic, Andrei, Sarah Tyler, Annie Kalinoski, Owen E Branson, Jin Seo, Philip R. Gafken, Michael Frietas, Julian Whittelegge, Kym Faull, William Navarre, Andrew Darwin5and Michael Ibba   Cyclic rhamnosylated EF-P establishes antibiotic resistance in Pseudomonas PAK, mBio, 2015; .
Evdokimov, Nicolai, M., Peter M. Clark, Graciela Flores, Timothy Chai, Kym F. Faull, Michael E. Phelps, Owen N. Witte, and Michael E. Jung   Development of 2‑Deoxy-2‑[18F]fluororibose for Positron Emission Tomography Imaging Liver Function in Vivo, Journal of Medicinal Chemistry, 2015; .
Chattopadhyay, Arnab, Victor Grijalva, Greg Hough, Feng Su, Pallavi Mukherjee, Robin Farias-Eisner, G.M. Anantharamahiah, Kym F. Faull, Lin H. Hwang, Mohamad Navab, Alan M. Fogelman, and Srinivasa T. Reddy   Efficacy of Tomato Concentrates in Mouse Models of Dyslipidemia and Cancer, Pharmacology Research & Perspectives, 2015; 3(4): e00154.
Porter, Edith, Daniel C Ma, Sandy Alvarez, and Kym F Faull   Invited manuscript: Antimicrobial Lipids: Emerging Effector Molecules of Innate Host Defense, World Journal of Immunology, 2015; 5: 51-61.
Fazlollahi F, Kongmanas K, Tanphaichitr N, Clair JM, Gopen Q, Faull KF, Suh JD   Lipidomic Profiling of Sinus Mucosa from Patients with Chronic Rhinosinusitis, Clin Transl Sci, 2015; .
Maymon, Maskit, Pilar Martínez-Hidalgo, Stephen S. Tran, Tyler Ice, Karena Craemer, Teni Anbarchian, Tiffany Sung, Lin H. Hwang, Minxia Chou, Nancy A. Fujishige, William Villella, Jerome Ventosa, Johannes Sikorski, Erin R. Sanders, Kym F. Faull, Ann M. Hirsch   Mining the phytomicrobiome to understand how bacterial coinoculations enhance plant growth, Frontiers in Plant Science, 2015; 6(784): .
Kongmanas, Kessiri, Hathairat Kruevaisayawan, Arpornrad Saewu, Clarissa Sugeng, Jason Fernandes, Puneet Souda, Jonathan Angel, Kym F. Faull, R. John Aitken, Julian Whitelegge, Dan Hardy, Trish Berger, Mark Baker, Nongnuj Tanphaichitr   Proteomic Characterization of Pig Sperm Anterior Head Plasma Membrane Vesicles Reveals Roles of Acrosomal Proteins in ZP3 Binding, Journal of Cellular Physiology, 2015; 230: 449–463.
Tanphaichitr, Nongnuj, Kessiri Kongmanas, Hathairat Kruevaisayawan, Arpornrad Saewu, Clarissa Sugeng, Jason Fernandes, Puneet Souda, Jonathan B Angel, Kym F Faull, R John Aitken, Julian Whitelegge, Daniel Hardy, Trish Berger, Mark Baker   Remodeling of the plasma membrane in preparation for sperm–egg recognition: roles of acrosomal proteins, Asian Journal of Andrology, 2015; 17(4): 574–582.
Tanphaichitr N, Kongmanas K, Kruevaisayawan K, Saewu A, Sugeng C, Fernandes J, Souda P, Angel JB, Faull KF, Aitken RJ, Whitelegge J, Hardy D, Berger T and Baker M   Remodelling of the plasma membrane in preparation for sperm-egg recognition: Roles of acrosomal membranes, Asian Journal of Andrology (a special issue for the proceedings of the 12th International Symposium of Spermatology), 2015; .
Sen, Suvajiy, Kawahara, Brian. Divya Gupta, Rebecca Tsai, Sinchita Roy Chowdhuri, Shikha Bose, Marine Khachatryan, Alexander Yoon, Kym Faull, Robin Farias-Eisner, Gautam Chaudhuri   Role of Cystathionine β-Synthase in Human Breast Cancer, Free Radical Biology & Medicine, 2015; .
Jian Feng, Ningyi Shao, Keith E. Szulwach, Vincent Vialou, Jimmy Huynh, Chun Zhong, Thuc Le, Deveroux Ferguson, Michael E. Cahill, Yujing Li, JaWook Koo, Efrain Ribeiro, Benoit Labonte, Benjamin M. Laitman, David Estey, Victoria Stockman, Pamela Kennedy, Thomas Couroussé, Isaac Mensah, Gustavo Turecki, Kym F. Faull, Guo-li Ming, Hongjun Song, Guoping Fan, Patrizia Casaccia, Li Shen, Peng Jin, and Eric J. Nestler   Role of Tet1 and 5-hydroxymethylcytosine in cocaine action, Nature Neuroscience, 2015; .
Clark, Peter M., Graciela Flores, Nikolai M. Evdokimov, Melissa N. McCracken, Timothy Chai, Evan Nair-Gill, Fiona O’Mahony, Simon W. Beaven, Kym F. Faull Michael E. Phelps, Michael E. Jung, Owen N. Witte   A novel positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver, Proc. Natl, Acad. Sci, 2014; .
Randall C., Xudong Fu, Melody Pai, Laurent Vergnes, Simon Diep, Brett Lomenick, Gang Deng, Vijaykumar Meli, Gabriela C. Monsalve, Heejun Hwang, Eileen Hu, Gwanghyun Jung, Stephen A. Whelan, Farbod Fazlollahi, Chitrada Kaweeteerawat, Hilary A. Godwin, Helena R. Chang, Kym F. Faull, Meisheng Jiang, Catherine F. Clarke, Michael Petrascheck, Karen Reue, Michael E. Jung, Alison R. Frand, and Jing Huang   Alpha-ketoglutarate extends lifespan in Caenorhabditis elegans by a novel mechanism mediated by the ATP synthase and TOR, Nature, 2014; .
Nathanson, David A.,Amanda L. Armijo, Michelle Tom, Zheng Li, Wayne R. Austin, Julian Nomme, Dean O. Campbell, Elizabeth Dimitrova, Lisa Ta, Thuc Le, Jason T. Lee, Ryan Darvish, Ari Gordin, Liu Wei, Hsiang-I Liao, Moses Wilks, Colette Martin, Saman Sadeghi, Jennifer M. Murphy, Nidal Boulos, Michael E. Phelps, Kym F. Faull, Harvey R. Herschman, Michael E. Jung, Johannes Czernin, Arnon Lavie, and Caius G. Radu   Co-Targeting of Convergent, Switchable Nucleotide Biosynthetic Pathways Induces Synthetic Lethality in Leukemia, Journal of Experimental Medicine, 2014; 211(3): 473-86.
Sun, D., M. Luo, M. Jeong, B. Rodriguez, Z. Xia, R. Hanna, H. Wang, T. Le, K. Faull, R. Chen, H. Gu, C. Bock, A. Meissner, B. Gottgens, G. Darlington, W. Li, and M.A. Goodell   Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal, Cell Stem Cell, 2014; .
Calkins, Kara L., Lauren A. Sanchez, Chi-Hong Tseng, Kym F. Faull, Alexander J. Yoon, Christopher M. Ryan, Thuc Le, Stephen B. Shew   High-Dose Cysteine Supplementation and Erythrocyte Glutathione Concentrations: a Double-Blinded, Randomized Controlled in Critically Ill Neonates, Journal of Parenteral and Enteral Nutrition, 2014; .
Cole Stephanie J, Yoon Alexander J, Faull Kym F, Diener Andrew C   Host perception of jasmonates promotes infection by Fusarium oxysporum formae speciales that produce isoleucine- and leucine-conjugated jasmonates Molecular plant pathology, 2014; 15(6): 589-600.
Fazlollahi, Farbod, Kessiri Kongmanas, Nongnuj Tanphaichitr, Jeffrey Suh, Kym Faull, Quinton Gopen   Lipidomic Profiling of Mastoid Bone and Tissue from Patients with Chronic Otomastoiditis, International Archives of Otorhinolaryngology, 2014; .
Dawlaty, Meelad, M., Achim Breiling, Thuc Le, M. Inmaculada Barrasa, Günter Raddatz, Qing Gao, Benjamin E. Powell1, Albert W. Cheng, Kym F. Faull, Frank Lyko, and Rudolf Jaenisch   Loss of Tet enzymes compromises normal differentiation of embryonic stem cells, Developmental Cell, 2014; .
Thomer Lena, Becker Samuel, Emolo Carla, Quach Austin, Kim Hwan Keun, Rauch Sabine, Anderson Mark, Leblanc James F, Schneewind Olaf, Faull Kym F, Missiakas Dominique   N-acetylglucosaminylation of serine-aspartate repeat proteins promotes Staphylococcus aureus bloodstream infection The Journal of biological chemistry, 2014; 289(6): 3478-86.
Bullwinkle, Tammy, Noah Reynolds, Medha Raina, Adil Moghal, Eleftheria Matsa, Andrei Rajkovic, Huseyin Kayadibi, Farbod Fazlollahi, Christopher Ryan, Nathaniel Howitz, Kym Faull, Beth Lazazzera and Michael Ibba   Oxidation of cellular amino acid pools leads to context-dependent cytotoxic mistranslation of the genetic code, eLife, 2014; .
Huang, Kevin, Zhourui Wu, Zhenshan Liu, Ganlu Hu, Juehua Yu, Kai H. Chang, Kee-Pyo Kim, Thuc Le, Kym F. Faull, Nagesh Rao, Andrew Gennery, Zhigang Xue, Cun-yu Wang, Matteo Pellegrini, Guoping Fan   Selective demethylation and altered gene expression are associated with ICF Syndrome in human induced pluripotent stem cells and mesenchymal stem cells, Human Molecular Genetics, 2014; .
Dawlaty Meelad M, Breiling Achim, Le Thuc, Raddatz Günter, Barrasa M Inmaculada, Cheng Albert W, Gao Qing, Powell Benjamin E, Li Zhe, Xu Mingjiang, Faull Kym F, Lyko Frank, Jaenisch Rudolf   Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development Developmental cell, 2013; 24(3): 310-23.
Sarafian Theodore A, Ryan Christopher M, Souda Puneet, Masliah Eliezer, Kar Upendra K, Vinters Harry V, Mathern Gary W, Faull Kym F, Whitelegge Julian P, Watson Joseph B   Impairment of mitochondria in adult mouse brain overexpressing predominantly full-length, N-terminally acetylated human α-synuclein PloS one, 2013; 8(5): e63557.
Janzen Deanna M, Paik Daniel Y, Rosales Miguel A, Yep Brian, Cheng Donghui, Witte Owen N, Kayadibi Huseyin, Ryan Christopher M, Jung Michael E, Faull Kym, Memarzadeh Sanaz   Low levels of circulating estrogen sensitize PTEN-null endometrial tumors to PARP inhibition in vivo Molecular cancer therapeutics, 2013; 12(12): 2917-28.
Li Sichen, Chou Arthur P, Chen Weidong, Chen Ruihuan, Deng Yuzhong, Phillips Heidi S, Selfridge Julia, Zurayk Mira, Lou Jerry J, Everson Richard G, Wu Kuan-Chung, Faull Kym F, Cloughesy Timothy, Liau Linda M, Lai Albert   Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation Neuro-oncology, 2013; 15(1): 57-68.
Lam Maggie P Y, Lau Edward, Scruggs Sarah B, Wang Ding, Kim Tae-Young, Liem David A, Zhang Jun, Ryan Christopher M, Faull Kym F, Ping Peipei   Site-specific quantitative analysis of cardiac mitochondrial protein phosphorylation Journal of proteomics, 2013; 81(5): 15-23.
Vincent John J, Huang Yun, Chen Pao-Yang, Feng Suhua, Calvopiña Joseph H, Nee Kevin, Lee Serena A, Le Thuc, Yoon Alexander J, Faull Kym, Fan Guoping, Rao Anjana, Jacobsen Steven E, Pellegrini Matteo, Clark Amander T   Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells Cell stem cell, 2013; 12(4): 470-8.
Rudenko Andrii, Dawlaty Meelad M, Seo Jinsoo, Cheng Albert W, Meng Jia, Le Thuc, Faull Kym F, Jaenisch Rudolf, Tsai Li-Huei   Tet1 is critical for neuronal activity-regulated gene expression and memory extinction Neuron, 2013; 79(6): 1109-22.
Tsirulnikov Kirill, Abuladze Natalia, Vahi Ritu, Hasnain Huma, Phillips Martin, Ryan Christopher M, Atanasov Ivo, Faull Kym F, Kurtz Ira, Pushkin Alexander   Aminoacylase 3 binds to and cleaves the N-terminus of the hepatitis C virus core protein FEBS letters, 2012; 586(21): 3799-804.
Lam Maggie P Y, Scruggs Sarah B, Kim Tae-Young, Zong Chenggong, Lau Edward, Wang Ding, Ryan Christopher M, Faull Kym F, Ping Peipei   An MRM-based workflow for quantifying cardiac mitochondrial protein phosphorylation in murine and human tissue Journal of proteomics, 2012; .
Babiec Walter E, Faull Kym F, Feldman Jack L   Cyclothiazide-induced persistent increase in respiratory-related activity in vitro The Journal of physiology, 2012; 590(Pt 19): 4897-915.
Halgand FJ, Zabrouskov V, Bassilian S, Souda P, Loo JA, Faull KF, Wong DT, Whitelegge JP   Defining intact protein primary structures from saliva: a step toward the human proteome project, Analytical Chemistry, 2012; 84: 4383-95.
Tsirulnikov Kirill, Abuladze Natalia, Bragin Anatol, Faull Kym, Cascio Duilio, Damoiseaux Robert, Schibler Matthew J, Pushkin Alexander   Inhibition of aminoacylase 3 protects rat brain cortex neuronal cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and 4-hydroxy-2-nonenal Toxicology and applied pharmacology, 2012; 263(3): 303-14.
Le Thuc, Kim Kee-Pyo, Fan Guoping, Faull Kym F   A sensitive mass spectrometry method for simultaneous quantification of DNA methylation and hydroxymethylation levels in biological samples Analytical biochemistry, 2011; 412(2): 203-9.
Xu Hongbin, Kongmanas Kessiri, Kadunganattil Suraj, Smith Charles E, Rupar Tony, Goto-Inoue Naoko, Hermo Louis, Faull Kym F, Tanphaichitr Nongnuj   Arylsulfatase A deficiency causes seminolipid accumulation and a lysosomal storage disorder in Sertoli cells Journal of lipid research, 2011; 52(12): 2187-97.
Barnard H., A.N. Dooley, G. Areshian, B. Gasparyan and K.F. Faull   Chemical evidence for wine production around 4000 BCE in the Late Chalcolithic Near Eastern highlands, Journal of Archaeological Science, 2011; 38(5): 977-984.
He Jianbo, Whelan Stephen A, Lu Ming, Shen Dejun, Chung Debra U, Saxton Romaine E, Faull Kym F, Whitelegge Julian P, Chang Helena R   Proteomic-based biosignatures in breast cancer classification and prediction of therapeutic response International journal of proteomics, 2011; 2011(2): 896476.
Meytal Landau, Meytal, Michael R. Sawaya, Kym F. Faull, Arthur Laganowsky, Lin Jiang, Stuart Sievers1, Jie Liu, Jorge Barrio and David Eisenberg   The amyloid pharmacophore, PLoS Biol, 2011; 9: e1001080.
Landau Meytal, Sawaya Michael R, Faull Kym F, Laganowsky Arthur, Jiang Lin, Sievers Stuart A, Liu Jie, Barrio Jorge R, Eisenberg David   Towards a pharmacophore for amyloid PLoS biology, 2011; 9(6): e1001080.
Wolf Mike C, Freiberg Alexander N, Zhang Tinghu, Akyol-Ataman Zeynep, Grock Andrew, Hong Patrick W, Li Jianrong, Watson Natalya F, Fang Angela Q, Aguilar Hector C, Porotto Matteo, Honko Anna N, Damoiseaux Robert, Miller John P, Woodson Sara E, Chantasirivisal Steven, Fontanes Vanessa, Negrete Oscar A, Krogstad Paul, Dasgupta Asim, Moscona Anne, Hensley Lisa E, Whelan Sean P, Faull Kym F, Holbrook Michael R, Jung Michael E, Lee Benhur   A broad-spectrum antiviral targeting entry of enveloped viruses Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(7): 3157-62.
Webb Kristofor J, Zurita-Lopez Cecilia I, Al-Hadid Qais, Laganowsky Arthur, Young Brian D, Lipson Rebecca S, Souda Puneet, Faull Kym F, Whitelegge Julian P, Clarke Steven G   A novel 3-methylhistidine modification of yeast ribosomal protein Rpl3 is dependent upon the YIL110W methyltransferase The Journal of biological chemistry, 2010; 285(48): 37598-606.
Kern Justin, Ryan Christopher, Faull Kym, Schneewind Olaf   Bacillus anthracis surface-layer proteins assemble by binding to the secondary cell wall polysaccharide in a manner that requires csaB and tagO Journal of molecular biology, 2010; 401(5): 757-75.
Leuchter Andrew F, Cook Ian A, Hamilton Steven P, Narr Katherine L, Toga Arthur, Hunter Aimee M, Faull Kym, Whitelegge Julian, Andrews Anne M, Loo Joseph, Way Baldwin, Nelson Stanley F, Horvath Steven, Lebowitz Barry D   Biomarkers to predict antidepressant response Current psychiatry reports, 2010; 12(6): 553-62.
Ryan Christopher M, Souda Puneet, Halgand Frederic, Wong David T, Loo Joseph A, Faull Kym F, Whitelegge Julian P   Confident assignment of intact mass tags to human salivary cystatins using top-down Fourier-transform ion cyclotron resonance mass spectrometry Journal of the American Society for Mass Spectrometry, 2010; 21(6): 908-17.
Duarte Victor M, Han Eugene, Veena Mysore S, Salvado Amanda, Suh Jeffrey D, Liang Li-Jung, Faull Kym F, Srivatsan Eri S, Wang Marilene B   Curcumin enhances the effect of cisplatin in suppression of head and neck squamous cell carcinoma via inhibition of IKKβ protein of the NFκB pathway Molecular cancer therapeutics, 2010; 9(10): 2665-75.
Thangaraj Balakumar, Ryan Christopher M, Souda Puneet, Krause Kirsten, Faull Kym F, Weber Andreas P M, Fromme Petra, Whitelegge Julian P   Data-directed top-down Fourier-transform mass spectrometry of a large integral membrane protein complex: photosystem II from Galdieria sulphuraria Proteomics, 2010; 10(20): 3644-56.
Jansen Michael A, Kiwata Jacqueline, Arceo Jennifer, Faull Kym F, Hanrahan Grady, Porter Edith   Evolving neural network optimization of cholesteryl ester separation by reversed-phase HPLC Analytical and bioanalytical chemistry, 2010; 397(6): 2367-74.
Lu Ming, Whitelegge Julian P, Whelan Stephen A, He Jianbo, Saxton Romaine E, Faull Kym F, Chang Helena R   Hydrophobic Fractionation Enhances Novel Protein Detection by Mass Spectrometry in Triple Negative Breast Cancer Journal of proteomics & bioinformatics, 2010; 3(2): 1-10.
Lu Ming, Whelan Stephen A, He Jianbo, Saxton Romaine E, Faull Kym F, Whitelegge Julian P, Chang Helena R   Hydrophobic Proteome Analysis of Triple Negative and Hormone-Receptor-Positive-Her2-Negative Breast Cancer by Mass Spectrometer Clinical proteomics, 2010; 6(3): 93-103.
Shoemaker Lorelei D, Orozco Nicholas M, Geschwind Daniel H, Whitelegge Julian P, Faull Kym F, Kornblum Harley I   Identification of differentially expressed proteins in murine embryonic and postnatal cortical neural progenitors PloS one, 2010; 5(2): e9121.
Halgand Frédéric, Zabrouskov Vlad, Bassilian Sara, Souda Puneet, Wong David T, Loo Joseph A, Faull Kym F, Whitelegge Julian P   Micro-heterogeneity of human saliva Peptide P-C characterized by high-resolution top-down Fourier-transform mass spectrometry Journal of the American Society for Mass Spectrometry, 2010; 21(5): 868-77.
Keire David A, Whitelegge Julian P, Souda Puneet, Faull Kym F, Bassilian Sara, Reidelberger Roger D, Haver Alvin C, Reeve Joseph R   PYY(1-36) is the major form of PYY in rat distal small intestine: quantification using high-resolution mass spectrometry Regulatory peptides, 2010; 165(2-3): 151-7.
Ryan Christopher M, Souda Puneet, Bassilian Sara, Ujwal Rachna, Zhang Jun, Abramson Jeff, Ping Peipei, Durazo Armando, Bowie James U, Hasan S Saif, Baniulis Danas, Cramer William A, Faull Kym F, Whitelegge Julian P   Post-translational modifications of integral membrane proteins resolved by top-down Fourier transform mass spectrometry with collisionally activated dissociation Molecular & cellular proteomics : MCP, 2010; 9(5): 791-803.
Kongmanas, Kessiri, Hongbin Xu, Arman Yaghoubian, Laura Franchini, Luigi Panza, Fiamma Ronchetti, Kym Faull, Nongnuj Tanphaichitr   Seminolipid quantification by colorimetric assay and ESI-LC-MS/MS-multiple reaction monitoring: compensation of seminolipid expression in Cgt+/- mice Journal of Lipid Research, 2010; 51(12): 3548-58.
Shaw Bryan F, Moustakas Demetri T, Whitelegge Julian P, Faull Kym F   Taking charge of proteins from neurodegeneration to industrial biotechnology Advances in protein chemistry and structural biology, 2010; 79(2): 127-64.
Shaw, Bryan F., Demetri T. Moustakas, Julian P. Whitelegge, and Kym F. Faull   Taking charge of proteins: from neurodegeneration to industrial biotechnology, Advances in Protein Chemistry and Structural Biology, 2010; 79: 128-158.
Tsirulnikov Kirill, Abuladze Natalia, Koag Myong-Chul, Newman Debra, Scholz Karoline, Bondar Galyna, Zhu Quansheng, Avliyakulov Nuraly K, Dekant Wolfgang, Faull Kym, Kurtz Ira, Pushkin Alexander   Transport of N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine, a metabolite of trichloroethylene, by mouse multidrug resistance associated protein 2 (Mrp2) Toxicology and applied pharmacology, 2010; 244(2): 218-25.
Wang Yanju, Lin Wei-Yu, Liu Kan, Lin Rachel J, Selke Matthias, Kolb Hartmuth C, Zhang Nangang, Zhao Xing-Zhong, Phelps Michael E, Shen Clifton K F, Faull Kym F, Tseng Hsian-Rong   An integrated microfluidic device for large-scale in situ click chemistry screening Lab on a chip, 2009; 9(16): 2281-5.
Oliveira Débora L, Nimrichter Leonardo, Miranda Kildare, Frases Susana, Faull Kym F, Casadevall Arturo, Rodrigues Marcio L   Cryptococcus neoformans cryoultramicrotomy and vesicle fractionation reveals an intimate association between membrane lipids and glucuronoxylomannan Fungal genetics and biology : FG & B, 2009; 46(12): 956-63.
Budzik Jonathan M, Poor Catherine B, Faull Kym F, Whitelegge Julian P, He Chuan, Schneewind Olaf   Intramolecular amide bonds stabilize pili on the surface of bacilli Proceedings of the National Academy of Sciences of the United States of America, 2009; 106(47): 19992-7.
Whelan Stephen A, Lu Ming, He Jianbo, Yan Weihong, Saxton Romaine E, Faull Kym F, Whitelegge Julian P, Chang Helena R   Mass spectrometry (LC-MS/MS) site-mapping of N-glycosylated membrane proteins for breast cancer biomarkers Journal of proteome research, 2009; 8(8): 4151-60.
Durazo Armando, Shaw Bryan F, Chattopadhyay Madhuri, Faull Kym F, Nersissian Aram M, Valentine Joan Selverstone, Whitelegge Julian P   Metal-free superoxide dismutase-1 and three different amyotrophic lateral sclerosis variants share a similar partially unfolded beta-barrel at physiological temperature The Journal of biological chemistry, 2009; 284(49): 34382-9.
Bulkacz Jaime, Faull Kym F   Multiple extracellular phospholipase activities from Prevotella intermedia Anaerobe, 2009; 15(3): 91-4.
He Jianbo, Shen Dejun, Chung Debra U, Saxton Romaine E, Whitelegge Julian P, Faull Kym F, Chang Helena R   Tumor proteomic profiling predicts the susceptibility of breast cancer to chemotherapy International journal of oncology, 2009; 35(4): 683-92.
Keire David A, Whitelegge Julian P, Bassilian Sara, Faull Kym F, Wiggins Brian W, Mehdizadeh Omid B, Reidelberger Roger D, Haver Alvin C, Sayegh Ayman I, Reeve Joseph R   A new endogenous form of PYY isolated from canine ileum: Gly-extended PYY(1-36) Regulatory peptides, 2008; 151(1-3): 61-70.
Budzik Jonathan M, Marraffini Luciano A, Souda Puneet, Whitelegge Julian P, Faull Kym F, Schneewind Olaf   Amide bonds assemble pili on the surface of bacilli Proceedings of the National Academy of Sciences of the United States of America, 2008; 105(29): 10215-20.
Franchini Laura, Panza Luigi, Kongmanas Kessiri, Tanphaichitr Nongnuj, Faull Kym F, Ronchetti Fiamma   An efficient and convenient synthesis of deuterium-labelled seminolipid isotopomers and their ESI-MS characterization Chemistry and physics of lipids, 2008; 152(2): 78-85.
Begum Aynun N, Jones Mychica R, Lim Giselle P, Morihara Takashi, Kim Peter, Heath Dennis D, Rock Cheryl L, Pruitt Mila A, Yang Fusheng, Hudspeth Beverly, Hu Shuxin, Faull Kym F, Teter Bruce, Cole Greg M, Frautschy Sally A   Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer’s disease The Journal of pharmacology and experimental therapeutics, 2008; 326(1): 196-208.
Lanigan-Gerdes Sara, Briceno Geraldine, Dooley Alek N, Faull Kym F, Lazazzera Beth A   Identification of residues important for cleavage of the extracellular signaling peptide CSF of Bacillus subtilis from its precursor protein Journal of bacteriology, 2008; 190(20): 6668-75.
Do Thai Q, Moshkani Safiehkhatoon, Castillo Patricia, Anunta Suda, Pogosyan Adelina, Cheung Annie, Marbois Beth, Faull Kym F, Ernst William, Chiang Su Ming, Fujii Gary, Clarke Catherine F, Foster Krishna, Porter Edith   Lipids including cholesteryl linoleate and cholesteryl arachidonate contribute to the inherent antibacterial activity of human nasal fluid Journal of immunology (Baltimore, Md. : 1950), 2008; 181(6): 4177-87.
Wang Dorothy, Veena Mysore S, Stevenson Kerry, Tang Christopher, Ho Baran, Suh Jeffrey D, Duarte Victor M, Faull Kym F, Mehta Kapil, Srivatsan Eri S, Wang Marilene B   Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKT-independent pathway Clinical cancer research : an official journal of the American Association for Cancer Research, 2008; 14(19): 6228-36.
Grintsevich Elena E, Benchaar Sabrina A, Warshaviak Dora, Boontheung Pinmanee, Halgand Frédéric, Whitelegge Julian P, Faull Kym F, Loo Rachel R Ogorzalek, Sept David, Loo Joseph A, Reisler Emil   Mapping the cofilin binding site on yeast G-actin by chemical cross-linking Journal of molecular biology, 2008; 377(2): 395-409.
Anupriwan Araya, Schenk Matthias, Kongmanas Kessiri, Vanichviriyakit Rapeepun, Santos Daniela Costa, Yaghoubian Arman, Liu Fang, Wu Alexander, Berger Trish, Faull Kym F, Saitongdee Porncharn, Sretarugsa Prapee, Tanphaichitr Nongnuj   Presence of arylsulfatase A and sulfogalactosylglycerolipid in mouse ovaries: localization to the corpus luteum Endocrinology, 2008; 149(8): 3942-51.
Fujishige Nancy A, Lum Michelle R, De Hoff Peter L, Whitelegge Julian P, Faull Kym F, Hirsch Ann M   Rhizobium common nod genes are required for biofilm formation Molecular microbiology, 2008; 67(3): 504-15.
Denny Paul, Hagen Fred K, Hardt Markus, Liao Lujian, Yan Weihong, Arellanno Martha, Bassilian Sara, Bedi Gurrinder S, Boontheung Pinmannee, Cociorva Daniel, Delahunty Claire M, Denny Trish, Dunsmore Jason, Faull Kym F, Gilligan Joyce, Gonzalez-Begne Mireya, Halgand Frédéric, Hall Steven C, Han Xuemei, Henson Bradley, Hewel Johannes, Hu Shen, Jeffrey Sherry, Jiang Jiang, Loo Joseph A, Ogorzalek Loo Rachel R, Malamud Daniel, Melvin James E, Miroshnychenko Olga, Navazesh Mahvash, Niles Richard, Park Sung Kyu, Prakobphol Akraporn, Ramachandran Prasanna, Richert Megan, Robinson Sarah, Sondej Melissa, Souda Puneet, Sullivan Mark A, Takashima Jona, Than Shawn, Wang Jianghua, Whitelegge Julian P, Witkowska H Ewa, Wolinsky Lawrence, Xie Yongming, Xu Tao, Yu Weixia, Ytterberg Jimmy, Wong David T, Yates John R, Fisher Susan J   The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions Journal of proteome research, 2008; 7(5): 1994-2006.
Mitrirattanakul Somsak, López-Valdés Héctor E, Liang Jing, Matsuka Yoshizo, Mackie Ken, Faull Kym F, Spigelman Igor   Bidirectional alterations of hippocampal cannabinoid 1 receptors and their endogenous ligands in a rat model of alcohol withdrawal and dependence Alcoholism, clinical and experimental research, 2007; 31(5): 855-67.
Potter Soshanna Zittin, Zhu Haining, Shaw Bryan Francis, Rodriguez Jorge A, Doucette Peter A, Sohn Se Hui, Durazo Armando, Faull Kym F, Gralla Edith Butler, Nersissian Aram M, Valentine Joan Selverstone   Binding of a single zinc ion to one subunit of copper-zinc superoxide dismutase apoprotein substantially influences the structure and stability of the entire homodimeric protein Journal of the American Chemical Society, 2007; 129(15): 4575-83.
He Jianbo, Gornbein Jeffrey, Shen Dejun, Lu Ming, Rovai Leonor E, Shau Hungyi, Katz John, Whitelegge Julian P, Faull Kym F, Chang Helena R   Detection of breast cancer biomarkers in nipple aspirate fluid by SELDI-TOF and their identification by combined liquid chromatography-tandem mass spectrometry International journal of oncology, 2007; 30(1): 145-54.
Waldron Richard T, Whitelegge Julian P, Faull Kym F, Rozengurt Enrique   Identification of a novel phosphorylation site in c-jun directly targeted in vitro by protein kinase D Biochemical and biophysical research communications, 2007; 356(2): 361-7.
Lanigan-Gerdes Sara, Dooley Alek N, Faull Kym F, Lazazzera Beth A   Identification of subtilisin, Epr and Vpr as enzymes that produce CSF, an extracellular signalling peptide of Bacillus subtilis Molecular microbiology, 2007; 65(5): 1321-33.
Whitelegge Julian P, Zabrouskov Vlad, Halgand Frederic, Souda Puneet, Bassilian Sara, Yan Weihong, Wolinsky Larry, Loo Joseph A, Wong David T W, Faull Kym F   Protein-Sequence Polymorphisms and Post-translational Modifications in Proteins from Human Saliva using Top-Down Fourier-transform Ion Cyclotron Resonance Mass Spectrometry International journal of mass spectrometry, 2007; 268(2-3): 190-197.
Lu Ming, Faull Kym F, Whitelegge Julian P, He Jianbo, Shen Dejun, Saxton Romaine E, Chang Helena R   Proteomics and mass spectrometry for cancer biomarker discovery Biomarker insights, 2007; 2(2-3): 347-60.
Kim Danny H, Hee Shane Que, Norris Andrew J, Faull Kym F, Eckhert Curtis D   Boric acid inhibits adenosine diphosphate-ribosyl cyclase non-competitively Journal of chromatography. A, 2006; 1115(1-2): 246-52.
Shaw Bryan Francis, Durazo Armando, Nersissian Aram M, Whitelegge Julian P, Faull Kym F, Valentine Joan Selverstone   Local unfolding in a destabilized, pathogenic variant of superoxide dismutase 1 observed with H/D exchange and mass spectrometry The Journal of biological chemistry, 2006; 281(26): 18167-76.
Mitrirattanakul Somsak, Ramakul Navapoln, Guerrero Andre V, Matsuka Yoshizo, Ono Takeshi, Iwase Hirotate, Mackie Ken, Faull Kym F, Spigelman Igor   Site-specific increases in peripheral cannabinoid receptors and their endogenous ligands in a model of neuropathic pain Pain, 2006; 126(1-3): 102-14.
Norris Andrew J, Whitelegge Julian P, Yaghoubian Arman, Alattia Jean-Rene, Privé Gilbert G, Toyokuni Tatsushi, Sun Hubert, Brooks Mai N, Panza Luigi, Matto Pamela, Compostella Federica, Remmel Natascha, Klingenstein Ralf, Sandhoff Konrad, Fluharty Claire, Fluharty Arvan, Faull Kym F   A novel mass spectrometric assay for the cerebroside sulfate activator protein (saposin B) and arylsulfatase A Journal of lipid research, 2005; 46(10): 2254-64.
Marbois Beth, Gin Peter, Faull Kym F, Poon Wayne W, Lee Peter T, Strahan Jeff, Shepherd Jennifer N, Clarke Catherine F   Coq3 and Coq4 define a polypeptide complex in yeast mitochondria for the biosynthesis of coenzyme Q The Journal of biological chemistry, 2005; 280(21): 20231-8.
Rodriguez Jorge A, Shaw Bryan Francis, Durazo Armando, Sohn Se Hui, Doucette Peter A, Nersissian Aram M, Faull Kym F, Eggers Daryl K, Tiwari Ashutosh, Hayward Lawrence J, Valentine Joan Selverstone   Destabilization of apoprotein is insufficient to explain Cu,Zn-superoxide dismutase-linked ALS pathogenesis Proceedings of the National Academy of Sciences of the United States of America, 2005; 102(30): 10516-21.
Weinglass Adam B, Soskine Misha, Vazquez-Ibar Jose-Luis, Whitelegge Julian P, Faull Kym F, Kaback H Ronald, Schuldiner Shimon   Exploring the role of a unique carboxyl residue in EmrE by mass spectrometry The Journal of biological chemistry, 2005; 280(9): 7487-92.
Kang Mo K, Kim Reuben H, Shin Ki-Hyuk, Zhong Weiguong, Faull Kym F, Park No-Hee   Senescence-associated decline in the intranuclear accumulation of hOGG1-alpha and impaired 8-oxo-dG repair activity in senescing normal human oral keratinocytes in vivo Experimental cell research, 2005; 310(1): 186-95.
Eugene Pekary A, Faull Kym F, Paulson Mark, Lloyd Robert L, Sattin Albert   TRH-like antidepressant peptide, pyroglutamyltyroslyprolineamide, occurs in rat brain Journal of mass spectrometry : JMS, 2005; 40(9): 1232-6.
Katz Jonathan E, Dumlao Darren S, Wasserman Jacob I, Lansdown Michael G, Jung Michael E, Faull Kym F, Clarke Steven   3-Isopropylmalate is the major endogenous substrate of the Saccharomyces cerevisiae trans-aconitate methyltransferase Biochemistry, 2004; 43(20): 5976-86.
Kim Danny H, Faull Kym F, Norris Andrew J, Eckhert Curtis D   Borate-nucleotide complex formation depends on charge and phosphorylation state Journal of mass spectrometry : JMS, 2004; 39(7): 743-51.
Norris Andrew J, Whitelegge Julian P, Strouse M Jane, Faull Kym F, Toyokuni Tatsushi   Inhibition kinetics of carba- and C-fucosyl analogues of GDP-fucose against fucosyltransferase V: implication for the reaction mechanism Bioorganic & medicinal chemistry letters, 2004; 14(3): 571-3.
Weinglass Adam, Whitelegge Julian P, Faull Kym F, Kaback H Ronald   Monitoring conformational rearrangements in the substrate-binding site of a membrane transport protein by mass spectrometry The Journal of biological chemistry, 2004; 279(40): 41858-65.
Whitelegge Julian P, Katz Jonathan E, Pihakari Katianna A, Hale Rebecca, Aguilera Rodrigo, Gómez Stephen M, Faull Kym F, Vavilin Dmitrii, Vermaas Willem   Subtle modification of isotope ratio proteomics; an integrated strategy for expression proteomics Phytochemistry, 2004; 65(11): 1507-15.
Woo Ho-Hyung, Faull Kym F, Hirsch Ann M, Hawes Martha C   Altered life cycle in Arabidopsis plants expressing PsUGT1, a UDP-glucuronosyltransferase-encoding gene from pea Plant physiology, 2003; 133(2): 538-48.
Chen Fayu, Ng Pei-San, Faull Kym F, Lee Rehwa H   Cone photoreceptor betagamma-transducin: posttranslational modification and interaction with phosducin Investigative ophthalmology & visual science, 2003; 44(11): 4622-9.
Ahn Victoria E, Faull Kym F, Whitelegge Julian P, Fluharty Arvan L, Privé Gilbert G   Crystal structure of saposin B reveals a dimeric shell for lipid binding Proceedings of the National Academy of Sciences of the United States of America, 2003; 100(1): 38-43.
Ahn, V. E. Faull, K. F. Whitelegge, J. P. Fluharty, A. L. Prive, G. G.   Crystal structure of saposin B reveals a dimeric shell for lipid binding Proc Natl Acad Sci U S A, 2003; 100(1): 38-43.
Weinglass Adam B, Whitelegge Julian P, Hu Yonglin, Verner Gillian E, Faull Kym F, Kaback H Ronald   Elucidation of substrate binding interactions in a membrane transport protein by mass spectrometry The EMBO journal, 2003; 22(7): 1467-77.
Kim Danny H, Marbois Beth N, Faull Kym F, Eckhert Curtis D   Esterification of borate with NAD+ and NADH as studied by electrospray ionization mass spectrometry and 11B NMR spectroscopy Journal of mass spectrometry : JMS, 2003; 38(6): 632-40.
Ahn Victoria E, Faull Kym F, Whitelegge Julian P, Higginson Jason, Fluharty Arvan L, Privé Gilbert G   Expression, purification, crystallization, and preliminary X-ray analysis of recombinant human saposin B Protein expression and purification, 2003; 27(1): 186-93.
Shau Hungyi, Chandler G Scott, Whitelegge Julian P, Gornbein Jeffrey A, Faull Kym F, Chang Helena R   Proteomic profiling of cancer biomarkers Briefings in functional genomics & proteomics, 2003; 2(2): 147-58.
Whitelegge Julian P, Gómez Stephen M, Faull Kym F   Proteomics of membrane proteins Advances in protein chemistry, 2003; 65(1): 271-307.
Gómez Stephen M, Bil’ Karl Y, Aguilera Rodrigo, Nishio John N, Faull Kym F, Whitelegge Julian P   Transit peptide cleavage sites of integral thylakoid membrane proteins Molecular & cellular proteomics : MCP, 2003; 2(10): 1068-85.
Glasgow Ben J, Abduragimov Adil R, Gassymov Oktay K, Faull Kym F, Yusifov Taleh N, Lehrer Robert I   Characterization of a lipophilin in rabbit tears Advances in experimental medicine and biology, 2002; 506(Pt A): 573-80.
Jonassen Tanya, Marbois Beth N, Faull Kym F, Clarke Catherine F, Larsen Pamela L   Development and fertility in Caenorhabditis elegans clk-1 mutants depend upon transport of dietary coenzyme Q8 to mitochondria The Journal of biological chemistry, 2002; 277(47): 45020-7.
Subbanagounder Ganesamoorthy, Wong Jason W, Lee Hans, Faull Kym F, Miller Elizabeth, Witztum Joseph L, Berliner Judith A   Epoxyisoprostane and epoxycyclopentenone phospholipids regulate monocyte chemotactic protein-1 and interleukin-8 synthesis. Formation of these oxidized phospholipids in response to interleukin-1beta The Journal of biological chemistry, 2002; 277(9): 7271-81.
Gómez Stephen M, Nishio John N, Faull Kym F, Whitelegge Julian P   The chloroplast grana proteome defined by intact mass measurements from liquid chromatography mass spectrometry Molecular & cellular proteomics : MCP, 2002; 1(1): 46-59.
Glasgow Ben J, Abduragimov Adil R, Gassymov Oktay K, Yusifov Taleh N, Ruth Edward C, Faull Kym F   Vitamin E associated with the lipocalin fraction of human tears Advances in experimental medicine and biology, 2002; 506(Pt A): 567-72.

Timothy Fong, M.D.


Dr. Fong is a Professor of Psychiatry, board-certified in Addiction Psychiatry, at the Semel Institute for Neuroscience and Human Behavior at UCLA.    


A selected list of publications:

Fong Timothy W, Reid Rory C, Parhami Iman   Behavioral addictions: where to draw the lines? The Psychiatric clinics of North America, 2012; 35(2): 279-96.
Fink Arlene, Parhami Iman, Rosenthal Richard J, Campos Michael D, Siani Aaron, Fong Timothy W   How Transparent is Behavioral Intervention Research on Pathological Gambling and Other Gambling-Related Disorders? A Systematic Literature Review Addiction (Abingdon, England), 2012; 35(2): .
Parhami Iman, Davtian Margarit, Collard Michael, Lopez Jean, Fong Timothy W   A Preliminary 6-Month Prospective Study Examining Self-reported Religious Preference, Religiosity/Spirituality, and Retention at a Jewish Residential Treatment Center for Substance-Related Disorders The journal of behavioral health services & research, 2012; 35(2): .
Parhami Iman, Siani Aaron, Rosenthal Richard J, Fong Timothy W   Pathological Gambling, Problem Gambling and Sleep Complaints: An Analysis of the National Comorbidity Survey: Replication (NCS-R) Journal of gambling studies / co-sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming, 2012; 35(2): .
Parhami Iman, Hyman Mark, Siani Aaron, Lin Stephanie, Collard Michael, Garcia Johnny, Casaus Laurie, Tsuang John, Fong Timothy W   Screening for addictive disorders within a workers’ compensation clinic: an exploratory study Substance use & misuse, 2012; 47(1): 99-107.
Parhami Iman, Siani Aaron, Rosenthal Richard J, Lin Stephanie, Collard Michael, Fong Timothy W   Sleep and gambling severity in a community sample of gamblers Journal of addictive diseases, 2012; 31(1): 67-79.
Reid Rory C, Carpenter Bruce N, Fong Timothy W   Neuroscience research fails to support claims that excessive pornography consumption causes brain damage Surgical neurology international, 2011; 2(1): 64.
Fong Timothy W, Campos Michael D, Brecht Mary-Lynn, Davis Alice, Marco Adrienne, Pecanha Viviane, Rosenthal Richard J   Problem and pathological gambling in a sample of casino patrons Journal of gambling studies / co-sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming, 2011; 27(1): 35-47.
Xu Jiansong, Azizian Allen, Monterosso John, Domier Catherine P, Brody Arthur L, Fong Timothy W, London Edythe D   Gender effects on mood and cigarette craving during early abstinence and resumption of smoking Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2008; 10(11): 1653-61.
Payer Doris E, Lieberman Matthew D, Monterosso John R, Xu Jiansong, Fong Timothy W, London Edythe D   Differences in cortical activity between methamphetamine-dependent and healthy individuals performing a facial affect matching task Drug and alcohol dependence, 2008; 93(1-2): 93-102.
Fong Timothy W, Tsuang John   Asian-americans, addictions, and barriers to treatment Psychiatry (Edgmont (Pa. : Township)), 2007; 4(11): 51-9.
Fong Timothy W   Understanding and managing compulsive sexual behaviors Psychiatry (Edgmont (Pa. : Township)), 2006; 3(11): 51-8.
Fong Timothy W, De La Garza Richard, Newton Thomas F   A case report of topiramate in the treatment of nonparaphilic sexual addiction Journal of clinical psychopharmacology, 2005; 25(5): 512-4.
Fong Timothy W   Types of psychotherapy for pathological gamblers Psychiatry (Edgmont (Pa. : Township)), 2005; 2(5): 32-9.
Fong Timothy W   The vulnerable faces of pathological gambling Psychiatry (Edgmont (Pa. : Township)), 2005; 2(4): 34-42.
Fong Timothy W   The biopsychosocial consequences of pathological gambling Psychiatry (Edgmont (Pa. : Township)), 2005; 2(3): 22-30.
Tsuang John, Fong Timothy W   Treatment of patients with schizophrenia and substance abuse disorders Current pharmaceutical design, 2004; 10(18): 2249-61.

Edythe London, Ph.D.


Dr. London received her Ph.D. in Pharmacology from the University of Maryland and her postdoctoral training at Johns Hopkins School of Medicine. Before coming to UCLA in 2001, she was the Director of the Brain Imaging Center for the National Institute on Drug Abuse, and held faculty appointments at the University of Maryland and Johns Hopkins Schools of Medicine. Dr. London is a Professor-in-Residence in the Departments of Psychiatry and Biobehavioral Sciences and Molecular and Medical Pharmacology. Her work focuses on the use of neuroimaging to study neural circuitry underlying self-control and behaviors related to addiction.


A selected list of publications:

Lee, B, Groman, S, London, E D, Jentsch, J D   Dopamine D2/D3 receptors play a specific role in the reversal of a learned visual discrimination in monkeys, Neuropsychopharmacology, 2007; 32(10): 2125-2134.
Wong, D F, Kuwabara, H, Schretlen, D J, Bonson, K R, Nandi, A, Brasic, J R, Kimes, A S, Maris, M A, Kumar, A, Contoreggi, C, Links, J, Ernst, M, Rousset, O, Zukin, S, Grace, A A, Lee, J S, Rohde, C, Jasinski, D R, Gjedde, A, London, E D   Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving, Neuropsychopharmacology, 2006; 31(12): 2716-2727.
London, E D, Berman, S M, Voytek, B, Simon, S L, Mandelkern, M A, Monterosso, J, Thompson, P M, Brody, A L, Geaga, J A, Hong, M S, Hayashi, K M, Rawson, R A, Ling, W   Cerebral metabolic dysfunction and impaired vigilance in recently abstinent methamphetamine abusers, Biological Psychiatry, 2005; 58(10): 770-778.
Rotheram-Fuller, E, Shoptaw, S, Berman, S M, London, E D   Impaired performance in a test of decision-making by opiate-dependent tobacco smokers, Drug and Alcohol Dependence, 2004; 73(1): 79-86.
London, E D, Simon, S L, Berman, S M, Mandelkern, M A, Lichtman, A M, Bramen, J, … Ling, W   Mood disturbances and regional cerebral metabolic abnormalities in recently abstinent methamphetamine abusers, Archives of General Psychiatry, 2004; 61(1): 73-84.
Thompson, P M, Hayashi, K M, Simon, S L, Geaga, J A, Hong, M S, Sui, Y, Lee, J Y, Toga, A W, Ling, W, London, E D   Structural abnormalities in the brains of human subjects who use methamphetamine, Journal of Neuroscience, 2004; 24(26): 6028-6036.
Ernst, M, Bolla, K, Mouratidis, M, Contoreggi, C, Matochik, J A, Kurian, V, … London, E D   Decision-making in a risk-taking task: a PET study, Neuropsychopharmacology, 2002; 26(5): 682-691.
Bonson, K R, Grant, S J, Contoreggi C S, Links, J M, Metcalfe J, Weyl, H L, … London, E D   Neural systems and cue-induced cocaine craving, Neuropsychopharmacology, 2002; 26(3): 376-386.
Ernst, M, Heishman, S J, Spurgeon, L, & London, E D   Smoking history and nicotine effects on cognitive performance, Neuropsychopharmacology, 2001; 25(3): 313-319.
Faulkner, P, Ghahremani, D G, Tyndale, R F, Cox, C M, Kazanjian, A S, Paterson, N, Lotfipour, S, Hellemann, G S, Petersen, N, Vigil, C, London, E D   Reduced-Nicotine Cigarettes in Young Smokers: Impact of Nicotine Metabolism on Nicotine Dose Effects Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017; 42(8): 1610-1618.
Okita, K, Mandelkern, M A, London, E D   Cigarette Use and Striatal Dopamine D2/3 Receptors: Possible Role in the Link between Smoking and Nicotine Dependence The international journal of neuropsychopharmacology, 2016; 19(11): 15-22.
Okita, K, Petersen, N, Robertson, C L, Dean, A C, Mandelkern, M A, London, E D   Sex Differences in Midbrain Dopamine D2-Type Receptor Availability and Association with Nicotine Dependence Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016; 41(12): 2913-2919.
Robertson, C L, Ishibashi, K, Chudzynski, J, Mooney, L J, Rawson, R A, Dolezal, B A, Cooper, C B, Brown, A K, Mandelkern, M A, London, E D   Effect of Exercise Training on Striatal Dopamine D2/D3 Receptors in Methamphetamine Users during Behavioral Treatment Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016; 41(6): 1629-36.
Morales, A M, Kohno, M, Robertson, C L, Dean, A C, Mandelkern, M A, London, E D   Gray-matter volume, midbrain dopamine D2/D3 receptors and drug craving in methamphetamine users Molecular psychiatry, 2015; 20(6): 764-71.
Robertson, C L, Ishibashi, K, Mandelkern, M A, Brown, A K, Ghahremani, D G, Sabb, F, Bilder, R, Cannon, T, Borg, J, London, E D   Striatal D1- and D2-type dopamine receptors are linked to motor response inhibition in human subjects The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015; 35(15): 5990-7.
Kohno, M, Ghahremani, D G, Morales, A M, Robertson, C L, Ishibashi, K, Morgan, A T, Mandelkern, M A, London, E D   Risk-taking behavior: dopamine D2/D3 receptors, feedback, and frontolimbic activity Cerebral cortex (New York, N.Y. : 1991), 2015; 25(1): 236-45.
O’Neill, J, Tobias, M C, Hudkins, M, London, E D   Glutamatergic neurometabolites during early abstinence from chronic methamphetamine abuse The international journal of neuropsychopharmacology, 2014; 18(3): 236-45.
Kohno, M, Morales, A M, Ghahremani, D G, Hellemann, G, London, E D   Risky decision making, prefrontal cortex, and mesocorticolimbic functional connectivity in methamphetamine dependence JAMA psychiatry, 2014; 71(7): 812-20.
O’Neill, J, Tobias, M C, Hudkins, M, Oh, E Y, Hellemann, G S, Nurmi, E L, London, E D   Thalamic glutamate decreases with cigarette smoking Psychopharmacology, 2014; 231(13): 2717-24.
Groman, S M, Morales, A M, Lee, B, London, E D, Jentsch, J D   Methamphetamine-induced increases in putamen gray matter associate with inhibitory control Psychopharmacology, 2013; 229(3): 527-38.
Brown, A K, Mandelkern, M A, Farahi, J, Robertson, C, Ghahremani, D G, Sumerel, B, Moallem, N, London, E D   Sex differences in striatal dopamine D2/D3 receptor availability in smokers and non-smokers The international journal of neuropsychopharmacology, 2012; 15(7): 989-94.
Zorick, T, Lee, B, Mandelkern, M A, Fong, T, Robertson, C, Ghahremani, D G, Brown, A K, Sumerel, B, London, E D   Low striatal dopamine receptor availability linked to caloric intake during abstinence from chronic methamphetamine abuse Molecular psychiatry, 2012; 17(6): 569-71.
Ghahremani, D G, Lee, B, Robertson, C L, Tabibnia, G, Morgan, A T, De Shetler, N, Brown, A K, Monterosso, J R, Aron, A R, Mandelkern, M A, Poldrack, R A, London, E D   Striatal dopamine D₂/D₃ receptors mediate response inhibition and related activity in frontostriatal neural circuitry in humans The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012; 32(21): 7316-24.
Ishibashi, K, Berman, S M, Paz-Filho, G, Lee, B, Robertson, C, Mandelkern, M A, Wong, M L, Licinio, J, London, E D   Dopamine D2/D3 receptor availability in genetically leptin-deficient patients after long-term leptin replacement Molecular psychiatry, 2012; 17(4): 352-3.
Groman, S M, Lee, B, Seu, E, James, A S, Feiler, K, Mandelkern, M A, London, E D, Jentsch, J D   Dysregulation of D₂-mediated dopamine transmission in monkeys after chronic escalating methamphetamine exposure The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012; 32(17): 5843-52.
Payer, D E, Nurmi, E L, Wilson, S A, McCracken, J T, London, E D   Effects of methamphetamine abuse and serotonin transporter gene variants on aggression and emotion-processing neurocircuitry Translational psychiatry, 2012; 2(4): e80.
Dean, A C, Sevak, R J, Monterosso, J R, Hellemann, G, Sugar, C A, London, E D   Acute modafinil effects on attention and inhibitory control in methamphetamine-dependent humans Journal of studies on alcohol and drugs, 2011; 72(6): 943-53.
Zorick, T, Sugar, C A, Hellemann, G, Shoptaw, S, London, E D   Poor response to sertraline in methamphetamine dependence is associated with sustained craving for methamphetamine Drug and alcohol dependence, 2011; 118(2-3): 500-3.
Ghahremani, D G, Tabibnia, G, Monterosso, J, Hellemann, G, Poldrack, R A, London, E D   Effect of modafinil on learning and task-related brain activity in methamphetamine-dependent and healthy individuals Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011; 36(5): 950-9.
Zorick, T, Mandelkern, M A, Lee, B, Wong, M-L, Miotto, K, Shabazian, J, London, E D   Elevated plasma prolactin in abstinent methamphetamine-dependent subjects The American journal of drug and alcohol abuse, 2011; 37(1): 62-7.
Zorick, T, Sevak, R J, Miotto, K, Shoptaw, S, Swanson, A-N, Clement, C, De La Garza, R, Newton, T F, London, E D   Pilot safety evaluation of varenicline for the treatment of methamphetamine dependence Journal of experimental pharmacology, 2010; 2(10): 13-8.
Zorick, T, Nestor, L, Miotto, K, Sugar, C, Hellemann, G, Scanlon, G, Rawson, R, London, E D   Withdrawal symptoms in abstinent methamphetamine-dependent subjects Addiction (Abingdon, England), 2010; 105(10): 1809-18.
Azizian, A, Nestor, L J, Payer, D, Monterosso, J R, Brody, A L, London, E D   Smoking reduces conflict-related anterior cingulate activity in abstinent cigarette smokers performing a Stroop task Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010; 35(3): 775-82.
London, E D, Berman, S M, Mohammadian, P, Ritchie, T, Mandelkern, M A, Susselman, M K W, Schlagenhauf, F, Noble, E P   Effect of the TaqIA polymorphism on ethanol response in the brain Psychiatry research, 2009; 174(3): 163-70.
Lee, B, London, E D, Poldrack, R A, Farahi, J, Nacca, A, Monterosso, J R, Mumford, J A, Bokarius, A V, Dahlbom, M, Mukherjee, J, Bilder, R M, Brody, A L, Mandelkern, M A   Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009; 29(47): 14734-40.
Brody, A L, Mandelkern, M A, Olmstead, R E, Allen-Martinez, Z, Scheibal, D, Abrams, A L, Costello, M R, Farahi, J, Saxena, S, Monterosso, J, London, E D   Ventral striatal dopamine release in response to smoking a regular vs a denicotinized cigarette Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009; 34(2): 282-9.
Xu, J, Azizian, A, Monterosso, J, Domier, C P, Brody, A L, Fong, T W, London, E D   Gender effects on mood and cigarette craving during early abstinence and resumption of smoking Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2008; 10(11): 1653-61.
Berman, S M, Voytek, B, Mandelkern, M A, Hassid, B D, Isaacson, A, Monterosso, J, Miotto, K, Ling, W, London, E D   Changes in cerebral glucose metabolism during early abstinence from chronic methamphetamine abuse Molecular psychiatry, 2008; 13(9): 897-908.
Baicy, K, London, E D, Monterosso, J, Wong, M-L, Delibasi, T, Sharma, A, Licinio, J   Leptin replacement alters brain response to food cues in genetically leptin-deficient adults Proceedings of the National Academy of Sciences of the United States of America, 2007; 104(46): 18276-9.
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Gina Poe, Ph.D.


Gina Poe has been working since 1995 on the mechanisms through which sleep serves memory consolidation and restructuring. Dr. Poe is a southern California native who graduated from Stanford University then worked for two post-baccalaureate years at the VA researching Air Force Test Pilots’ brainwave signatures under high-G maneuvers. She then earned her PhD in Basic Sleep in the Neuroscience Interdepartmental Program at UCLA under the guidance of Ronald Harper then moved to the University of Arizona for her postdoctoral studies with Carol Barnes and Bruce McNaughtons looking at graceful degradation of hippocampal function in aged rats as well as hippocampal coding in a 3-D maze navigated in the 1998 space shuttle mission. She brought these multiunit teachings to answer a burning question of whether REM sleep were for remembering or forgetting and found that activity of neurons during REM sleep is consistent both with the consolidation of novel memories and the elimination of already consolidated memories from the hippocampus, readying the associative memory network for new learning the next day. Moving first to Washington State University then to the University of Michigan before joining UCLA in 2016, Poe has over 80 undergraduates, 6 graduate students, and 6 postdoctoral scholars, and has served in university faculty governance as well as leading 5 different programs designed to diversify the neuroscience workforce and increase representation of people of the global majority in the STEM fields. At UCLA she continues research and teaching and Directs the COMPASS-Life Sciences and BRI-SURE programs and co-Directs the MARC-U*STAR program. Nationally she is course director of the Marine Biological Lab’s SPINES course and co-Directs the Society for Neuroscience’s NSP program which earned the nation’s highest mentoring honor in 2018. These programs have served over 600 PhD level trainees over the years.

Research Interests

The Poe lab investigates the mechanisms by which sleep traits serve learning and memory consolidation. Memories are encoded by the pattern of synaptic connections between neurons. We employ tetrode recording and optogenetic techniques in learning animals to see how neural patterns underlying learning are reactivated during sleep, and how activity during sleep influences the neural memory code. Both strengthening and weakening of synapses is important to the process of sculpting a network when we make new memories and integrate them into old schema. Results from our studies suggest that while synaptic strengthening can be efficiently accomplished during the waking learning process, the synaptic weakening part of memory integration requires conditions unique to sleep. The absence of noradrenaline during sleep spindles and REM sleep as well as the low levels of serotonin during REM sleep allow the brain to integrate new memories and to refresh and renew old synapses so that we are ready to build new associations the next waking period. Memory difficulties involved in post-traumatic stress disorder, Schizophrenia, Alzheimer’s disease and even autism involve abnormalities in the sleep-dependent memory consolidation process that my lab studies. Keywords: Sleep, learning and memory, PTSD, memory consolidation, reconsolidation, REM sleep, sleep spindles, Norepinephrine, LTP, depotentiation, reversal learning, optogenetics, electrophysiology, tetrode recordings, hippocampus, prefrontal cortex.


B.A., Human Biology, Stanford University 1987
Ph.D., Neuroscience, University of California, Los Angeles 1995

Selected Publications

Cabrera Y, Holloway J, Poe GR (2020) ‘Sleep Changes Across the Female Hormonal Cycle Affecting Memory: Implications for Resilient Adaptation to Traumatic Experiences.’ J Womens Health (Larchmt), 29 (3): 446-451. PMID: 32186966

Swift KM, Keus K, Echeverria CG, Cabrera Y, Jimenez J, Holloway J, Clawson BC, Poe GR () ‘Sex differences within sleep in gonadally-intact rats.’ Sleep, 2019.PMID: 31784755

Swift KM, Gross BA, Frazer MA, Bauer DS, Clark KJD, Vazey EM, Aston-Jones G, Li Y, Pickering AE, Sara SJ, Poe GR (2018) ‘Abnormal Locus Coeruleus Sleep Activity Alters Sleep Signatures of Memory Consolidation and Impairs Place Cell Stability and Spatial Memory.’ Curr Biol, 28 (22): 3599-3609.e4. PMID: 30393040

Zaborszky L, Gombkoto P, Varsanyi P, Poe GR, Role L, Ananth M, Rajebhosale P, Talmage D, Hasselmo M, Dannenberg H, Minces V, Chiba A, “Specific basal forebrain-cortical cholinergic circuits coordinate cognitive operations”, J Neurosci, 38 (44): 9446-9458 (2018).

Lewis P, Knoblich G, Poe GR, “Recasting reality: how memory replay in sleep boosts creative problem solving”, Trends Cogni Sci, 22 (6): 491-503 (2018).

Bjorness TE, Booth V, Poe GR (2018) ‘Hippocampal theta power pressure builds over non-REM sleep and dissipates within REM sleep episodes.’ Arch Ital Biol, 156 (3): 112-126. PMID: 30324607

Poe GR (2017) ‘Sleep Is for Forgetting.’ J Neurosci, 37 (3): 464-473. PMID: 28100731

Javanbakht, A and Poe, GR, “Behavioral neuroscience of circuits involved in arousal regulation”, The Neurobiology of PTSD, Ressler, K and Liberzon, I(Eds.), 130-147 (2016).

Emrick JJ, Gross BA, Riley BT, Poe GR (2016) ‘Different Simultaneous Sleep States in the Hippocampus and Neocortex.’ Sleep, 39 (12): 2201-2209. PMID: 27748240

Vanderheyden WM, George SA, Urpa L, Kehoe M, Liberzon I, Poe GR (2015) ‘Sleep alterations following exposure to stress predict fear-associated memory impairments in a rodent model of PTSD.’ Exp Brain Res, 233 (8): 2335-46. PMID: 26019008.

Watts A, Gritton HJ, Sweigart J, Poe GR (2012) ‘Antidepressant suppression of non-REM sleep spindles and REM sleep impairs hippocampus-dependent learning while augmenting striatum-dependent learning.’ J Neurosci, 32 (39): 13411-20. PMID: 23015432

Booth V, Poe GR (2006) ‘Input source and strength influences overall firing phase of model hippocampal CA1 pyramidal cells during theta: relevance to REM sleep reactivation and memory consolidation.’ Hippocampus, 16 (2): 161-73. PMID: 16411243