Posts classified under: D

Joseph DiStefano III, Ph.D.

Biography

Professor DiStefano was born in New York in 1938, graduated from Stuyvesant High School in 1956, received the BEE in Electrical Engineering from CCNY in 1961, and MS and PhD degrees from UCLA in 1964 & 1966, in the fields of Control Systems (MS) and Biocybernetics, Computer Methodology and Applied Mathematics (PhD), with minor field studies in Physiology. He joined the UCLA Engineering faculty in 1966, Medicine faculty in 1970, Computer Science faculty in 1982 and Cybernetics Inderdepartmental Program (IDP), as Chair, in 1981. He received a Distinguished Teaching Award in Engineering in 1971, was a Senior Fulbright-Hays Scholar in Italy in 1979, was awarded the UCLA Distinguished Teaching Award in 2003 and the Lockeed-Martin Award for Teaching Excellence in 2004. Currently, he Chairs the Cybernetics IDP, the Computational Systems Biology graduate program in Computer Science, Co-Chairs the Biocybernetics Subfield in the Biomedical Engineering IDP and is the Director of the Biocybernetics Research Laboratory. His research areas include systems biology, biocybernetics, PK/PD, multicompartmental and other dynamic systems modeling and optimization methodology, expert systems applications in life sciences research, endocrine system physiology and control, optimal experiment design, thyroid hormone regulation & metabolism in mammals and fishes, and disease (cancer, HCV, diabetes) process dynamics and optimal therapies.

Publications

A selected list of publications:

Meshkat Nicolette, Anderson Chris, DiStefano Joseph J   Alternative to Ritt’s pseudodivision for finding the input-output equations of multi-output models Mathematical biosciences, 2012; 239(1): 117-23.
Ben-Shachar Rotem, Eisenberg Marisa, Huang Stephen A, DiStefano Joseph J   Simulation of post-thyroidectomy treatment alternatives for triiodothyronine or thyroxine replacement in pediatric thyroid cancer patients Thyroid : official journal of the American Thyroid Association, 2012; 22(6): 595-603.
Ben-Shachar Rotem, Eisenberg Marisa, Huang Stephen, Distefano Joseph J   Simulation of Post-thyroidectomy Treatment Alternatives for T3 or T4 Replacement in Pediatric Thyroid Cancer Patients Thyroid : official journal of the American Thyroid Association, 2011; 22(6): .
Meshkat Nicolette, Anderson Chris, Distefano Joseph J   Finding identifiable parameter combinations in nonlinear ODE models and the rational reparameterization of their input-output equations Mathematical biosciences, 2011; 233(1): 19-31.
Nichols John W, Breen Miyuki, Denver Robert J, Distefano Joseph J, Edwards Jeremy S, Hoke Robert A, Volz David C, Zhang Xiaowei   Predicting chemical impacts on vertebrate endocrine systems Environmental toxicology and chemistry / SETAC, 2011; 30(1): 39-51.
Eisenberg Marisa C, Santini Ferruccio, Marsili Alessandro, Pinchera Aldo, DiStefano Joseph J   TSH regulation dynamics in central and extreme primary hypothyroidism Thyroid : official journal of the American Thyroid Association, 2010; 20(11): 1215-28.
Meshkat Nicolette, Eisenberg Marisa, Distefano Joseph J   An algorithm for finding globally identifiable parameter combinations of nonlinear ODE models using Gröbner Bases Mathematical biosciences, 2009; 222(2): 61-72.
Eisenberg Marisa, Distefano Joseph J   TSH-based protocol, tablet instability, and absorption effects on L-T4 bioequivalence Thyroid : official journal of the American Thyroid Association, 2009; 19(2): 103-10.
Eisenberg Marisa, Samuels Mary, DiStefano Joseph J   Extensions, validation, and clinical applications of a feedback control system simulator of the hypothalamo-pituitary-thyroid axis Thyroid : official journal of the American Thyroid Association, 2008; 18(10): 1071-85.
Eisenberg Marisa, Samuels Mary, DiStefano Joseph J   L-T4 bioequivalence and hormone replacement studies via feedback control simulations Thyroid : official journal of the American Thyroid Association, 2006; 16(12): 1279-92.
Russell Solomon, Distefano Joseph J   W3MAMCAT: a world wide web based tool for mammillary and catenary compartmental modeling and expert system distinguishability Computer methods and programs in biomedicine, 2006; 83(1): 34-42.
Ferl Gregory Z, Kenanova Vania, Wu Anna M, DiStefano Joseph J   A two-tiered physiologically based model for dually labeled single-chain Fv-Fc antibody fragments Molecular cancer therapeutics, 2006; 5(6): 1550-8.
Hori Sharon S, Kurland Irwin J, DiStefano Joseph J   Role of endosomal trafficking dynamics on the regulation of hepatic insulin receptor activity: models for Fao cells Annals of biomedical engineering, 2006; 34(5): 879-92.
Ferl Gregory Z, Wu Anna M, DiStefano Joseph J   A predictive model of therapeutic monoclonal antibody dynamics and regulation by the neonatal Fc receptor (FcRn) Annals of biomedical engineering, 2005; 33(11): 1640-52.
Harless Charles, Distefano Joseph J   Automated expert multiexponential biomodeling interactively over the Internet Computer methods and programs in biomedicine, 2005; 79(2): 169-78.
Bulis Kirk D, DiStefano Joseph J   W3MCSim: an online and reconfigurable Monte Carlo simulator for interactive probabilistic/statistical modeling Computer methods and programs in biomedicine, 2005; 77(1): 71-9.
Tee Daniel, DiStefano Joseph   Simulation of tumor-induced angiogenesis and its response to anti-angiogenic drug treatment: mode of drug delivery and clearance rate dependencies Journal of cancer research and clinical oncology, 2004; 130(1): 15-24.
Nguyen Thuvan T, Mol Koen A, DiStefano Joseph J   Thyroid hormone production rates in rat liver and intestine in vivo: a novel graph theory and experimental solution American journal of physiology. Endocrinology and metabolism, 2003; 285(1): E171-81.

Mirella Dapretto, Ph.D.

Biography

Dr. Dapretto is presently appointed as Professor in the Department of Psychiatry and Biobehavioral Sciences at UCLA. She received a Ph.D. in Developmental Psychology from the UCLA Psychology Department, with a minor in Behavioral Neuroscience. She then acquired expertise in neuroimaging methods as a postdoctoral fellow at the UCLA Ahmanson-Lovelace Brain Mapping Center and joined the faculty of the UCLA Semel Institute for Neuroscience and Human Behavior in 1999. Capitalizing on her dual training as a developmental psychologist andn neuroscientist, Dr. Dapretto’’s research combines neuroimaging, behavioral, and genetic data to better characterize typical and atypical brain function from infancy to adulthood. Her work has been published in prestigious scientific journals such as Neuron, Nature Neuroscience, JAMA Psychiatry, Psychological Science, and Child Development .

Supported by numerous awards by private foundations as well as the National Institute of Health (NIH), over the past 20 years, Dr. Dapretto has conducted cutting-edge research elucidating the neural correlates of core deficits in autism spectrum disorder (ASD). Since 2007, as part of the NIH-funded Autism Center of Excellence (ACE) at UCLA, Dr. Dapretto has led the imaging projects in youth with ASD. These include an ongoing multimodal study in infants at high risk for ASD aimed at identifying y biomarkers of ASD in the first year of life to ultimately inform the earliest possible interventions. Her current research on autism is also supported by a multisite NIH-funded ACE Network examining gender differences during the transition from adolescence to young adulthood in a large balanced sample of boys and  girls with ASD, as well asby another NIH-funded study seeking to parse the incredible heterogeneity observed across individuals with an ASD diagnosis in order to guide more personalized and efficacious treatments.

In addition to her research on autism, Dr. Dapretto has long been interested in neurotypical development. Some of her early work focused on characterizing the neural basis of language processing, including some pioneering studies that examined developmental changes in the neural networks subserving language learning  from childhood through adulthood. Dr. Dapretto has also conducted many studies on the neural correlates of key issues in adolescence (e.g., social exclusion, self concept development, social media influence). Currently, Dr. Dapretto is involved in the NIH-funded Adolescent Brain Cognitive Development(ABCD) study, a large-scale multisite consortium on neurodevelopmental and behavioral predictors and consequences of substance abuse from late childhood through adolescence. Dr. Dapretto is also site PI on another NIH-funded multisite project – the Lifespan Human Connectome: Development (HCP-D) – a study that aims to characterize the development of functional brain networks and brain-behavior relationships from childhood to young adulthood, with particular emphasis on adolescence as a key developmental transition.

Dr. Dapretto is a dedicated mentor and educator who feels passionate about raising the next generation of neuroscientists. In 2018, Dr. Dapretto received the departmental Research Mentor Award in recognition of her outstanding mentoring record and dedication to her trainees who ahve been consistently successful in securing prestigious pre- and post-doctoral fellowships as well as numerous dissertation awards. Dr. Dapretto has been affiliated with the Neuroscience Interdepartmental Ph.D. Program for almost 20 years, serving on its Admission, Advising, and Curriculum Committees. For over a decade, Dr. Dapretto also played a key role in the UCLA Center for Culture, Brain, and Development, an educational program focused on interdisciplinary training across traditional separate disciplines (i.e., anthropology, neuroscience and psychology). Dr. Dapretto has also been a participating faculty member in the NIH-funded training programs in Advanced Neuroimaging and Neurobehavioral Genetics. Currently, together with Drs. Fuligni and Galvan, she directs another NIH-funded training program designed to train graduate students on brain and behavioral development during adolescence.

At UCLA, Dr. Dapretto is affiliated with the Brian Research Institute (BRI), the Center for Autism Research and Treatment (CART), the Center for Cognitive Neuroscience (CCN), the UC Consortium on the Developmental Science of Adolescence, and the Intellectual and Developmental Disabilities Research Center (IDDRC) for Translational Research in Neurodevelopment. Lastly, Dr. Dapretto is a member of the International Society for Autism Research, the Organization for Human Brain Mapping, the Society for Neuroscience, and the Flux Society.

View a up-to-date publication list: https://www.ncbi.nlm.nih.gov/myncbi/mirella.dapretto.1/bibliography/public/

Andrew Dean, Ph.D.

Publications

A selected list of publications:

Dean Andy C, Kohno Milky, Morales Angelica M, Ghahremani Dara G, London Edythe D   Denial in methamphetamine users: Associations with cognition and functional connectivity in brain Drug and alcohol dependence, 2015; 151: 84-91.
Ballard Michael E, Mandelkern Mark A, Monterosso John R, Hsu Eustace, Robertson Chelsea L, Ishibashi Kenji, Dean Andy C, London Edythe D   Low Dopamine D2/D3 Receptor Availability is Associated with Steep Discounting of Delayed Rewards in Methamphetamine Dependence The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), 2015; 18(7): pyu119.
Ballard Michael E, Dean Andy C, Mandelkern Mark A, London Edythe D   Striatal Dopamine D2/D3 Receptor Availability Is Associated with Executive Function in Healthy Controls but Not Methamphetamine Users PloS one, 2015; 10(12): e0143510.
Dean Andy C, Kohno Milky, Hellemann Gerhard, London Edythe D   Childhood maltreatment and amygdala connectivity in methamphetamine dependence: a pilot study Brain and behavior, 2014; 4(6): 867-76.
Sayegh Philip, Arentoft Alyssa, Thaler Nicholas S, Dean Andy C, Thames April D   Quality of education predicts performance on the Wide Range Achievement Test-4th Edition Word Reading subtest Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, 2014; 29(8): 731-6.
Dean Andy C, Groman Stephanie M, Morales Angelica M, London Edythe D   An evaluation of the evidence that methamphetamine abuse causes cognitive decline in humans Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013; 38(2): 259-74.
Dean Andy C, Altstein Lily L, Berman Mitchell E, Constans Joseph I, Sugar Catherine A, McCloskey Michael S   Secondary Psychopathy, but not Primary Psychopathy, is Associated with Risky Decision-Making in Noninstitutionalized Young Adults Personality and individual differences, 2013; 54(2): 272-277.
Dean Andy C, Hellemann Gerhard, Sugar Catherine A, London Edythe D   Educational attainment is not a good proxy for cognitive function in methamphetamine dependence Drug and alcohol dependence, 2012; 123(1-3): 249-54.
Payer Doris E, Dean Andy C, Boileau Isabelle   What matters in measuring methamphetamine-related cognitive impairments: ‘abnormality detection’ versus ‘everyday import’? Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012; 37(5): 1081-2.
Dean Andy C, Sevak Rajkumar J, Monterosso John R, Hellemann Gerhard, Sugar Catherine A, London Edythe D   Acute modafinil effects on attention and inhibitory control in methamphetamine-dependent humans Journal of studies on alcohol and drugs, 2011; 72(6): 943-53.
Dean Andy C, Sugar Catherine A, Hellemann Gerhard, London Edythe D   Is all risk bad? Young adult cigarette smokers fail to take adaptive risk in a laboratory decision-making test Psychopharmacology, 2011; 215(4): 801-11.
Simon Sara L, Dean Andy C, Cordova Xochitl, Monterosso John R, London Edythe D   Methamphetamine dependence and neuropsychological functioning: evaluating change during early abstinence Journal of studies on alcohol and drugs, 2010; 71(3): 335-44.
Tobias Marc C, O’Neill Joseph, Hudkins Matthew, Bartzokis George, Dean Andrew C, London Edythe D   White-matter abnormalities in brain during early abstinence from methamphetamine abuse Psychopharmacology, 2010; 209(1): 13-24.
Dean Andy C, London Edythe D, Sugar Catherine A, Kitchen Christina M R, Swanson Aimee-Noelle, Heinzerling Keith G, Kalechstein Ari D, Shoptaw Steven   Predicting adherence to treatment for methamphetamine dependence from neuropsychological and drug use variables Drug and alcohol dependence, 2009; 105(1-2): 48-55.
Dean Andy C, Victor Tara L, Boone Kyle B, Philpott Linda M, Hess Ryan A   Dementia and effort test performance The Clinical neuropsychologist, 2009; 23(1): 133-52.
Dean Andy C, Boone Kyle B, Kim Michelle S, Curiel Ashley R, Martin David J, Victor Tara L, Zeller Michelle A, Lang Yoshado K   Examination of the impact of ethnicity on the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) Fake Bad Scale The Clinical neuropsychologist, 2008; 22(6): 1054-60.
Dean Andy C, Victor Tara L, Boone Kyle B, Arnold Ginger   The relationship of IQ to effort test performance The Clinical neuropsychologist, 2008; 22(4): 705-22.
Arnold Ginger, Boone Kyle Brauer, Lu Po, Dean Andy, Wen Johnny, Nitch Steve, McPherson Susan   Sensitivity and specificity of finger tapping test scores for the detection of suspect effort The Clinical neuropsychologist, 2005; 19(1): 105-20.

Antonio Delgado-Escueta, M.D.

Publications

A selected list of publications:

Escueta A V, Bacsal F E, Treiman D M   Complex partial seizures on closed-circuit television and EEG: a study of 691 attacks in 79 patients Annals of neurology, 1982; 11(3): 292-300.
Escueta A V, Kunze U, Waddell G, Boxley J, Nadel A   Lapse of consciousness and automatisms in temporal lobe epilepsy: a videotape analysis Neurology, 1977; 27(2): 144-55.
Nadel A, Waddell G, Volow M, Escueta A V   Unconsciousness, automatisms, and myoclonic jerks with diffuse rhythmic 9-Hz discharges Epilepsia, 1975; 16(3): 511-20.
Escueta A V, Davidson D, Hartwig G, Reilly E   The freezing lesion. III. The effects of diphenylhydantoin on potassium transport within nerve terminals from the primary foci Brain research, 1975; 86(1): 85-96.
Escueta A V, Davidson D, Hartwig G, Reilly E   The freezing lesion. II. Potassium transport within nerve terminals isolated from epileptogenic foci Brain research, 1974; 78(2): 223-7.
Wilson W A, Escueta A V   Common synaptic effects of pentylenetetrazol and penicillin Brain research, 1974; 72(1): 168-71.
Escueta A V, Boxley J, Stubbs N, Waddell G, Wilson W A   Prolonged twilight state and automatisms: a case report Neurology, 1974; 24(4): 331-9.
David R J, Wilson W A, Escueta A V   Voltage clamp analysis of pentylenetetrazol effects on Aplysia neurons Brain research, 1974; 67(3): 549-54.
Escueta A V, Appel S H   The effects of electroshock seizures on potassium transport within synaptosomes from rat brain Journal of neurochemistry, 1972; 19(7): 1625-38.
Escueta A V, Appel S H   Brain synapses. An in vitro model for the study of seizures Archives of internal medicine, 1972; 129(2): 333-44.
Escueta A V, Appel S H   Diphenylhydantoin and potassium transport in isolated nerve terminals The Journal of clinical investigation, 1971; 50(9): 1977-84.
Appel S H, Festoff B W, Autilio L, Escueta A V   Biochemical approaches to the study of synaptic function Biological psychiatry, 1970; 2(3): 219-33.
Appel S H, Escueta A V, Smith S, Parrott B   Carbohydrate metabolism of synapses Neurology, 1970; 20(4): 392.
Appel S H, Autilio L, Festoff B W, Escueta A V   Biochemical studies of synapses in vitro. 3. Ionic activation of protein synthesis The Journal of biological chemistry, 1969; 244(12): 3166-72.
Escueta A V, Appel S H   Biochemical studies of synapses in vitro. II. Potassium transport Biochemistry, 1969; 8(2): 725-33.
Appel S H, Autilio L, Escueta A   Synapse function in vitro Neurology, 1968; 18(3): 292-3.
Ludwig G D, Chaykin L B, Escueta A V   Cerebral gigantism with intermittent fractional hypopituitarism and normal sella turcica Annals of internal medicine, 1967; 67(1): 123-31.
Goldensohn E, Escueta A, Runk L   Unit membrane shifts and firing patterns during spreading depression Electroencephalography and clinical neurophysiology, 1967; 23(1): 84.