Posts classified under: H

Weizhe Hong, Ph.D.


The Hong Lab employs a multidisciplinary approach to identify the molecular and neural circuit mechanisms underlying normal social behaviors as well as their dysregulations in neuropsychiatric disorders. Social behaviors are essential for the survival and reproduction of animals. The control of social behavior is of particular importance in social species such as humans. Abnormalities in social behaviors are associated with several neuropsychiatric disorders, such as autism spectrum disorders and schizophrenia.  Despite its importance, many fundamental questions regarding social behavior and its disorders still remain unanswered. We aim to understand how social behavior is regulated at the molecular and circuit level and how social behavior and social experience lead to molecular and circuit level changes in the brain.

We study these questions across molecular, circuit, and behavioral levels, by linking genes to circuits to behaviors. To do that, we take a multi-disciplinary approach and utilize a variety of experimental and computational technologies, including but not limited to optogenetics/chemogenetics, in vivo/vitro calcium imaging and electrophysiology, various genetic and molecular biology techniques, systems approaches such as next-generation sequencing and bioinformatics, and engineering and computational approaches such as machine learning and computer vision.

Wayne Hubbell, Ph.D.


During his graduate and postdoctoral work with Harden McConnell at Stanford University, Wayne Hubbell used spin label technology to first describe the fluidity and fluidity gradient in biological membranes, landmark discoveries of broad impact in cell and membrane biology.

In 1970, he joined the faculty of the Department of Chemistry at UC Berkeley where his laboratory designed new surfactants, pioneered the molecular characterization of reconstituted membrane proteins, and developed a series of unique spin label probes to study membrane electrostatics.

In 1983, Prof. Hubbell moved his laboratory to UCLA where he became the first Jules Stein Professor of Ophthalmology and Professor of Chemistry and Biochemistry. Soon after arriving, he combined unrelated technical advancements in molecular biology and EPR spectroscopy and pioneered the powerful new technology of site-directed spin labeling (SDSL) for the determination of structure and conformational dynamics in both soluble and membrane proteins.

For his development and application of SDSL, Prof. Hubbell has received numerous honors and awards including the Gold Medal of the International EPR/ESR Society, the International Zavoisky Award from the Physical Technical Institute of the Russian Academy of Sciences, the Bruker Prize from the Royal Society of Chemistry-ESR Group, and the Elisabeth Roberts Cole from the Biophysical Society (US). He is a member of the National Academy of Sciences, American Academy of Arts and Sciences, elected to the first class of fellows of the Biophysical Society and recipient of an honorary doctorate from the University of Pécs, Hungary.

Elaine Hsiao, Ph.D.


A selected list of publications:

Hsiao Elaine Y   Gastrointestinal issues in autism spectrum disorder Harvard review of psychiatry, 2015; 22(2): 104-11.
Yano Jessica M, Yu Kristie, Donaldson Gregory P, Shastri Gauri G, Ann Phoebe, Ma Liang, Nagler Cathryn R, Ismagilov Rustem F, Mazmanian Sarkis K, Hsiao Elaine Y   Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis Cell, 2015; 161(2): 264-76.
Hsiao Elaine Y, McBride Sara W, Hsien Sophia, Sharon Gil, Hyde Embriette R, McCue Tyler, Codelli Julian A, Chow Janet, Reisman Sarah E, Petrosino Joseph F, Patterson Paul H, Mazmanian Sarkis K   Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders Cell, 2013; 155(7): 1451-63.
Hsiao Elaine Y   Immune dysregulation in autism spectrum disorder International review of neurobiology, 2013; 113(7): 269-302.
Garay Paula A, Hsiao Elaine Y, Patterson Paul H, McAllister A K   Maternal immune activation causes age- and region-specific changes in brain cytokines in offspring throughout development Brain, behavior, and immunity, 2013; 31(7): 54-68.
Hsiao Elaine Y, Patterson Paul H   Placental regulation of maternal-fetal interactions and brain development Developmental neurobiology, 2012; 72(10): 1317-26.
Hsiao Elaine Y, McBride Sara W, Chow Janet, Mazmanian Sarkis K, Patterson Paul H   Modeling an autism risk factor in mice leads to permanent immune dysregulation Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(31): 12776-81.
Malkova Natalia V, Yu Collin Z, Hsiao Elaine Y, Moore Marlyn J, Patterson Paul H   Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism Brain, behavior, and immunity, 2012; 26(4): 607-16.
Hsiao Elaine Y, Patterson Paul H   Activation of the maternal immune system induces endocrine changes in the placenta via IL-6 Brain, behavior, and immunity, 2011; 25(4): 604-15.
Ito Hiroshi T, Smith Stephen E P, Hsiao Elaine, Patterson Paul H   Maternal immune activation alters nonspatial information processing in the hippocampus of the adult offspring Brain, behavior, and immunity, 2010; 24(6): 930-41.