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David E. Krantz, M.D., Ph.D.

David Krantz, M.D., Ph.D.

Biography

David Krantz is Professor in Residence in the Department of Psychiatry and Biobehavioral Sciences at the David Geffen School of Medicine at UCLA. An undergraduate at Brown University, he completed an MD/PhD in the Medical Scientist Training Program at UCLA in 1991, where he performed his dissertation on Drosophila eye development with Larry Zipursky. After a residency in psychiatry at UCLA, he was awarded a Howard Hughes Postdoctoral Fellowship for Physicians to investigate the regulation of vesicular neurotransmitter transporters in Robert Edwards’ laboratory at UCSF. He returned to UCLA in 2000, and is currently using Drosophila to study how changes in the function of neurotransmitter transporters may influence synaptic transmission and behavior.

Publications

A selected list of publications:

Hunter Aimee M, Nghiem Thien X, Cook Ian A, Krantz David E, Minzenberg Michael J, Leuchter Andrew F   Change in Quantitative EEG Theta Cordance as a Potential Predictor of Repetitive Transcranial Magnetic Stimulation Clinical Outcome in Major Depressive Disorder Clinical EEG and neuroscience, 2018; 49(5): 306-315.
Aguilar Jenny I, Dunn Matthew, Mingote Susana, Karam Caline S, Farino Zachary J, Sonders Mark S, Choi Se Joon, Grygoruk Anna, Zhang Yuchao, Cela Carolina, Choi Ben Jiwon, Flores Jorge, Freyberg Robin J, McCabe Brian D, Mosharov Eugene V, Krantz David E, Javitch Jonathan A, Sulzer David, Sames Dalibor, Rayport Stephen, Freyberg Zachary   Neuronal Depolarization Drives Increased Dopamine Synaptic Vesicle Loading via VGLUT Neuron, 2017; 95(5): 1074-1088.e7.
Kobayashi Brian, Cook Ian A, Hunter Aimee M, Minzenberg Michael J, Krantz David E, Leuchter Andrew F   Can neurophysiologic measures serve as biomarkers for the efficacy of repetitive transcranial magnetic stimulation treatment of major depressive disorder? International review of psychiatry (Abingdon, England), 2017; 29(2): 98-114.
Freyberg Zachary, Sonders Mark S, Aguilar Jenny I, Hiranita Takato, Karam Caline S, Flores Jorge, Pizzo Andrea B, Zhang Yuchao, Farino Zachary J, Chen Audrey, Martin Ciara A, Kopajtic Theresa A, Fei Hao, Hu Gang, Lin Yi-Ying, Mosharov Eugene V, McCabe Brian D, Freyberg Robin, Wimalasena Kandatege, Hsin Ling-Wei, Sames Dalibor, Krantz David E, Katz Jonathan L, Sulzer David, Javitch Jonathan A   Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain Nature communications, 2016; 7(2): 10652.
Martin Ciara A, Myers Katherine M, Chen Audrey, Martin Nathan T, Barajas Angel, Schweizer Felix E, Krantz David E   Ziram, a pesticide associated with increased risk for Parkinson’s disease, differentially affects the presynaptic function of aminergic and glutamatergic nerve terminals at the Drosophila neuromuscular junction Experimental neurology, 2016; 275 Pt 1(2): 232-41.
Majdi Soodabeh, Berglund E Carina, Dunevall Johan, Oleinick Alexander I, Amatore Christian, Krantz David E, Ewing Andrew G   Electrochemical Measurements of Optogenetically Stimulated Quantal Amine Release from Single Nerve Cell Varicosities in Drosophila Larvae Angewandte Chemie (International ed. in English), 2015; 54(46): 13609-12.
Leuchter Andrew F, Hunter Aimee M, Krantz David E, Cook Ian A   Rhythms and blues: modulation of oscillatory synchrony and the mechanism of action of antidepressant treatments Annals of the New York Academy of Sciences, 2015; 1344(7): 78-91.
Wasserman Sara M, Aptekar Jacob W, Lu Patrick, Nguyen Jade, Wang Austin L, Keles Mehmet F, Grygoruk Anna, Krantz David E, Larsen Camilla, Frye Mark A   Olfactory neuromodulation of motion vision circuitry in Drosophila Current biology : CB, 2015; 25(4): 467-72.
Leuchter Andrew F, Hunter Aimee M, Krantz David E, Cook Ian A   Intermediate phenotypes and biomarkers of treatment outcome in major depressive disorder Dialogues in clinical neuroscience, 2014; 16(4): 525-37.
Martin Ciara A, Barajas Angel, Lawless George, Lawal Hakeem O, Assani Khadij, Lumintang Yosephine P, Nunez Vanessa, Krantz David E   Synergistic effects on dopamine cell death in a Drosophila model of chronic toxin exposure Neurotoxicology, 2014; 44(9): 344-51.
Martin Ciara A, Krantz David E   Drosophila melanogaster as a genetic model system to study neurotransmitter transporters Neurochemistry international, 2014; 73(3): 71-88.
Grygoruk Anna, Chen Audrey, Martin Ciara A, Lawal Hakeem O, Fei Hao, Gutierrez Gabriel, Biedermann Traci, Najibi Rod, Hadi Richard, Chouhan Amit K, Murphy Niall P, Schweizer Felix E, Macleod Gregory T, Maidment Nigel T, Krantz David E   The redistribution of Drosophila vesicular monoamine transporter mutants from synaptic vesicles to large dense-core vesicles impairs amine-dependent behaviors The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014; 34(20): 6924-37.
Wu Ting-Han, Lu Yu-Ning, Chuang Chia-Lung, Wu Chia-Lin, Chiang Ann-Shyn, Krantz David E, Chang Hui-Yun   Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau Acta neuropathologica, 2013; 125(5): 711-25.
Lawal Hakeem O, Krantz David E   SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine Molecular aspects of medicine, 2013; 34(2-3): 360-72.
Chen Audrey, Ng Fanny, Lebestky Tim, Grygoruk Anna, Djapri Christine, Lawal Hakeem O, Zaveri Harshul A, Mehanzel Filmon, Najibi Rod, Seidman Gabriel, Murphy Niall P, Kelly Rachel L, Ackerson Larry C, Maidment Nigel T, Jackson F Rob, Krantz David E   Dispensable, redundant, complementary, and cooperative roles of dopamine, octopamine, and serotonin in Drosophila melanogaster Genetics, 2013; 193(1): 159-76.
Brooks Elizabeth S, Greer Christina L, Romero-Calderón Rafael, Serway Christine N, Grygoruk Anna, Haimovitz Jasmine M, Nguyen Bac T, Najibi Rod, Tabone Christopher J, de Belle J Steven, Krantz David E   A putative vesicular transporter expressed in Drosophila mushroom bodies that mediates sexual behavior may define a neurotransmitter system Neuron, 2011; 72(2): 316-29.
Grygoruk Anna, Fei Hao, Daniels Richard W, Miller Bradley R, Chen Audrey, DiAntonio Aaron, Krantz David E   Vesicular neurotransmitter transporter trafficking in vivo: moving from cells to flies Fly, 2011; 4(4): 302-5.
Lawal Hakeem O, Chang Hui-Yun, Terrell Ashley N, Brooks Elizabeth S, Pulido Dianne, Simon Anne F, Krantz David E   The Drosophila vesicular monoamine transporter reduces pesticide-induced loss of dopaminergic neurons Neurobiology of disease, 2010; 40(1): 102-12.
Fei Hao, Chow Dawnis M, Chen Audrey, Romero-Calderón Rafael, Ong Wei S, Ackerson Larry C, Maidment Nigel T, Simpson Julie H, Frye Mark A, Krantz David E   Mutation of the Drosophila vesicular GABA transporter disrupts visual figure detection The Journal of experimental biology, 2010; 213(Pt 10): 1717-30.
Bahadorani Sepehr, Cho Jaehyoung, Lo Thomas, Contreras Heidy, Lawal Hakeem O, Krantz David E, Bradley Timothy J, Walker David W   Neuronal expression of a single-subunit yeast NADH-ubiquinone oxidoreductase (Ndi1) extends Drosophila lifespan Aging cell, 2010; 9(2): 191-202.
Grygoruk Anna, Fei Hao, Daniels Richard W, Miller Bradley R, Diantonio Aaron, Krantz David E   A tyrosine-based motif localizes a Drosophila vesicular transporter to synaptic vesicles in vivo The Journal of biological chemistry, 2010; 285(10): 6867-78.
Cheli Verónica T, Daniels Richard W, Godoy Ruth, Hoyle Diego J, Kandachar Vasundhara, Starcevic Marta, Martinez-Agosto Julian A, Poole Stephen, DiAntonio Aaron, Lloyd Vett K, Chang Henry C, Krantz David E, Dell’Angelica Esteban C   Genetic modifiers of abnormal organelle biogenesis in a Drosophila model of BLOC-1 deficiency Human molecular genetics, 2010; 19(5): 861-78.
Mosharov Eugene V, Larsen Kristin E, Kanter Ellen, Phillips Kester A, Wilson Krystal, Schmitz Yvonne, Krantz David E, Kobayashi Kazuto, Edwards Robert H, Sulzer David   Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons Neuron, 2009; 62(2): 218-29.
Simon, Daniels, Romero-Calderòn, Grygoruk, Chang, Najibi, Shamouelian, Salazar, Solomon, Ackerson, Maidment, Diantonio, Krantz   Drosophila Vesicular Monoamine Transporter Mutants can adapt to Reduced or Eliminated Vesicular Stores of Dopamine and Serotonin Genetics, 2008; .
Romero-Calderón Rafael, Uhlenbrock Guido, Borycz Jolanta, Simon Anne F, Grygoruk Anna, Yee Susan K, Shyer Amy, Ackerson Larry C, Maidment Nigel T, Meinertzhagen Ian A, Hovemann Bernhard T, Krantz David E   A glial variant of the vesicular monoamine transporter is required to store histamine in the Drosophila visual system PLoS genetics, 2008; 4(11): e1000245.
Fei Hao, Grygoruk Anna, Brooks Elizabeth S, Chen Audrey, Krantz David E   Trafficking of vesicular neurotransmitter transporters Traffic (Copenhagen, Denmark), 2008; 9(9): 1425-36.
Fei Hao, Karnezis Tara, Reimer Richard J, Krantz David E   Membrane topology of the Drosophila vesicular glutamate transporter Journal of neurochemistry, 2007; 101(6): 1662-71.
Simon Anne F, Krantz David E   Road rage and fruit flies Nature genetics, 2007; 39(5): 581-2.
Romero-Calderón Rafael, Shome Ratula M, Simon Anne F, Daniels Richard W, DiAntonio Aaron, Krantz David E   A screen for neurotransmitter transporters expressed in the visual system of Drosophila melanogaster identifies three novel genes Developmental neurobiology, 2007; 67(5): 550-69.
Falcón-Pérez Juan M, Romero-Calderón Rafael, Brooks Elizabeth S, Krantz David E, Dell’Angelica Esteban C   The Drosophila pigmentation gene pink (p) encodes a homologue of human Hermansky-Pudlak syndrome 5 (HPS5) Traffic (Copenhagen, Denmark), 2007; 8(2): 154-68.
Sang Tzu-Kang, Chang Hui-Yun, Lawless George M, Ratnaparkhi Anuradha, Mee Lisa, Ackerson Larry C, Maidment Nigel T, Krantz David E, Jackson George R   A Drosophila model of mutant human parkin-induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007; 27(5): 981-92.
Simon Anne F, Liang Debbie T, Krantz David E   Differential decline in behavioral performance of Drosophila melanogaster with age Mechanisms of ageing and development, 2006; 127(7): 647-51.
Romero-Calderón Rafael, Krantz David E   Transport of polyamines in Drosophila S2 cells: kinetics, pharmacology and dependence on the plasma membrane proton gradient The Biochemical journal, 2006; 393(Pt 2): 583-9.
Krantz David E   Vesicular monogamy? Neuron, 2006; 49(1): 1-2.
Greer Christina L, Grygoruk Anna, Patton David E, Ley Brett, Romero-Calderon Rafael, Chang Hui-Yun, Houshyar Roozbeh, Bainton Roland J, Diantonio Aaron, Krantz David E   A splice variant of the Drosophila vesicular monoamine transporter contains a conserved trafficking domain and functions in the storage of dopamine, serotonin, and octopamine Journal of neurobiology, 2005; 64(3): 239-58.
Daniels Richard W, Collins Catherine A, Gelfand Maria V, Dant Jaime, Brooks Elizabeth S, Krantz David E, DiAntonio Aaron   Increased expression of the Drosophila vesicular glutamate transporter leads to excess glutamate release and a compensatory decrease in quantal content The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004; 24(46): 10466-74.
Rajesh Kumar, Ph.D.

Rajesh Kumar, Ph.D.

Biography

Dr. Kumar has a doctoral degree in Radiology from Sanjay Gandhi Postgraduate Institute of Medical Sciences, UP, India in 2002. He received Postdoctoral training in Neurobiology at the Department of Neurobiology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, California from December 2002 to June 2006. Dr. Kumar has been an Assistant Researcher from July 2006 to September 14, 2013 the Department of Neurobiology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, California. Dr. Kumar joined in the Department of Anesthesiology with secondary appointment in the Department of Radiological Sciences, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, California in September 15, 2013. He has expertise in various magnetic resonance imaging (MRI) and spectroscopy procedures. Dr. Kumar’s research is based on the evaluation of the neural tissue integrity, resulting from breathing or cardiovascular effects, in brain areas of patients with obstructive sleep apnea (OSA) and heart failure (HF) using MR procedures. It helps understand the brain processes that affect autonomic, memory and mood regulations in patients with these conditions.Dr. Kumar is funded by National Institutes of Health (NIH) since August 2012. His current NIH R01 studies involve determination of the pathological stage and nature of white matter damage, using diffusion tensor imaging, including fiber tractography, diffusional kurtosis imaging, and magnetization transfer imaging procedures, in recently-diagnosed, treatment naïve OSA subjects, and examination of how damaged brain autonomic regulatory areas (hypothalamus, insula cortex, and cerebellum) respond to an autonomic challenge, using diffusion tensor imaging and functional MRI procedures, and the laterality of functional responses to that challenge in HF subjects. Dr. Kumar has published over 80 peer-reviewed research manuscripts, 5 book chapters, and over 140 abstracts presented in national and international scientific meetings.

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