P – UCLA Brain Research Institute (BRI)

Biography

Gina Poe has been working since 1995 on the mechanisms through which sleep serves memory consolidation and restructuring. Dr. Poe is a southern California native who graduated from Stanford University then worked for two post-baccalaureate years at the VA researching Air Force Test Pilots’ brainwave signatures under high-G maneuvers. She then earned her PhD in Basic Sleep in the Neuroscience Interdepartmental Program at UCLA under the guidance of Ronald Harper then moved to the University of Arizona for her postdoctoral studies with Carol Barnes and Bruce McNaughtons looking at graceful degradation of hippocampal function in aged rats as well as hippocampal coding in a 3-D maze navigated in the 1998 space shuttle mission. She brought these multiunit teachings to answer a burning question of whether REM sleep were for remembering or forgetting and found that activity of neurons during REM sleep is consistent both with the consolidation of novel memories and the elimination of already consolidated memories from the hippocampus, readying the associative memory network for new learning the next day. Moving first to Washington State University then to the University of Michigan before joining UCLA in 2016, Poe has over 80 undergraduates, 9 graduate students, and 8 postdoctoral scholars, and has served in university faculty governance as well as led 5 different programs designed to diversify the neuroscience workforce and increase representation of people of the global majority in the STEM fields. At UCLA she continues research and teaching and Directs the COMPASS-Life Sciences and BRI-SURE programs and co-Directs the MARC-U*STAR program. Nationally she has served as course director of the Marine Biological Lab’s SPINES course and co-Directs the Society for Neuroscience’s NSP program which earned the nation’s highest mentoring honor in 2018. These programs have over 1000 PhD level alumni.

Research Interests

The Poe lab investigates the mechanisms by which sleep traits serve learning and memory consolidation. Memories are encoded by the pattern of synaptic connections between neurons. We employ tetrode recording and optogenetic techniques in learning animals to see how neural patterns underlying learning are reactivated during sleep, and how activity during sleep influences the neural memory code. Both strengthening and weakening of synapses is important to the process of sculpting a network when we make new memories and integrate them into old schema. Results from our studies suggest that while synaptic strengthening can be efficiently accomplished during the waking learning process, the synaptic weakening part of memory integration requires conditions unique to sleep. The absence of noradrenaline during sleep spindles and REM sleep as well as the low levels of serotonin during REM sleep allow the brain to integrate new memories and to refresh and renew old synapses so that we are ready to build new associations the next waking period. Memory difficulties involved in post-traumatic stress disorder, Schizophrenia, Alzheimer’s disease and even autism involve abnormalities in the sleep-dependent memory consolidation process that my lab studies. Keywords: Sleep, learning and memory, PTSD, memory consolidation, reconsolidation, REM sleep, sleep spindles, Norepinephrine, LTP, depotentiation, reversal learning, optogenetics, electrophysiology, tetrode recordings, hippocampus, prefrontal cortex.

Education

B.A., Human Biology, Stanford University 1987
Ph.D., Neuroscience, University of California, Los Angeles 1995

Selected Publications

Cao J, Herman AB, West GB, Poe G, Savage VM. Unraveling why we sleep: Quantitative analysis reveals abrupt transition from neural reorganization to repair in early development. Sci Adv 6(38):eaba0398 (11 pages), 2020. doi: 10.1126/sciadv.aba0398.

Guthrie R, Ciliberti D, Mankin E, Poe GR. Recurrent hippocampo-neocortical sleep-state divergence in humans. PNAS 119(44): e2123427119, PM36279474, 2022.

Frazer M, Cabrera Y, Guthrie R, Poe GR. Shining a light on the mechanisms of sleep for memory consolidation. Current Sleep Medicine Rep, 7:221-231, 2021. https://doi.org/10.1007/s40675-021-00204-3.

Cabrera Y, Holloway J, Poe GR (2020) ‘Sleep Changes Across the Female Hormonal Cycle Affecting Memory: Implications for Resilient Adaptation to Traumatic Experiences.’ J Womens Health (Larchmt), 29 (3): 446-451. PMID: 32186966

Swift KM, Keus K, Echeverria CG, Cabrera Y, Jimenez J, Holloway J, Clawson BC, Poe GR () ‘Sex differences within sleep in gonadally-intact rats.’ Sleep, 2019.PMID: 31784755

Swift KM, Gross BA, Frazer MA, Bauer DS, Clark KJD, Vazey EM, Aston-Jones G, Li Y, Pickering AE, Sara SJ, Poe GR (2018) ‘Abnormal Locus Coeruleus Sleep Activity Alters Sleep Signatures of Memory Consolidation and Impairs Place Cell Stability and Spatial Memory.’ Curr Biol, 28 (22): 3599-3609.e4. PMID: 30393040

Zaborszky L, Gombkoto P, Varsanyi P, Poe GR, Role L, Ananth M, Rajebhosale P, Talmage D, Hasselmo M, Dannenberg H, Minces V, Chiba A, “Specific basal forebrain-cortical cholinergic circuits coordinate cognitive operations”, J Neurosci, 38 (44): 9446-9458 (2018).

Lewis P, Knoblich G, Poe GR, “Recasting reality: how memory replay in sleep boosts creative problem solving”, Trends Cogni Sci, 22 (6): 491-503 (2018).

Bjorness TE, Booth V, Poe GR (2018) ‘Hippocampal theta power pressure builds over non-REM sleep and dissipates within REM sleep episodes.’ Arch Ital Biol, 156 (3): 112-126. PMID: 30324607

Poe GR (2017) ‘Sleep Is for Forgetting.’ J Neurosci, 37 (3): 464-473. PMID: 28100731

Javanbakht, A and Poe, GR, “Behavioral neuroscience of circuits involved in arousal regulation”, The Neurobiology of PTSD, Ressler, K and Liberzon, I(Eds.), 130-147 (2016).

Emrick JJ, Gross BA, Riley BT, Poe GR (2016) ‘Different Simultaneous Sleep States in the Hippocampus and Neocortex.’ Sleep, 39 (12): 2201-2209. PMID: 27748240

Vanderheyden WM, George SA, Urpa L, Kehoe M, Liberzon I, Poe GR (2015) ‘Sleep alterations following exposure to stress predict fear-associated memory impairments in a rodent model of PTSD.’ Exp Brain Res, 233 (8): 2335-46. PMID: 26019008.

Watts A, Gritton HJ, Sweigart J, Poe GR (2012) ‘Antidepressant suppression of non-REM sleep spindles and REM sleep impairs hippocampus-dependent learning while augmenting striatum-dependent learning.’ J Neurosci, 32 (39): 13411-20. PMID: 23015432

Booth V, Poe GR (2006) ‘Input source and strength influences overall firing phase of model hippocampal CA1 pyramidal cells during theta: relevance to REM sleep reactivation and memory consolidation.’ Hippocampus, 16 (2): 161-73. PMID: 16411243

Publications

A selected list of publications:

Khankan, R.R., I.B. Wanner, and P.E. Phelps Olfactory ensheathing cell-neurite alignment enhances neurite outgrowth in scar-like cultures, Experimental Neurology, 2015; 269: 93-101.

Abadesco, A., M. Cilluffo, G.M. Yvone, E.M. Carpenter, B.W. Howell, and P.E. Phelps Novel Disabled-1-expressing neurons identified in adult brain and spinal cord, European Journal of Neuroscience , 2014; 39: 579-592.

Awe, J.P., P.C. Lee, C. Ramathal, A. Vega-Crespo, J. Durruthy-Durruthy, A. Cooper, S. Karumbayaram, W. Lowry, A. Clark, J. Zack, V. Sebastiano, D. Kohn, A. Pyle, M. Martin, G.S. Lipshutz, P.E. Phelps, R. Reijo Pera and J.A. Byrne Generation and characterization of transgene-free human induced pluripotent stem cells and conversion to putative clinical-grade status, Stem Cell Research & Therapy, 2013; 4: 87.

Wang, X., A.H. Babayan, A.I. Basbaum and P.E. Phelps Loss of the Reelin-signaling pathway differentially disrupts heat, mechanical and chemical nociceptive processing. , Neuroscience, 2012; 226: 441-450.

Moore K.D, Chen R., Cilluffo M., Golden J.A., Phelps P.E. Lis1 reduction causes tangential migratory errors in mouse spinal cord The Journal of Comparative Neurology, 2012; 520: 1198-211.

Takeoka, A., D.L. Jindrich, C. Muñoz-Quiles, H. Zhong, R. van den Brand, D.L. Pham, M.D. Ziegler, A. Ramón-Cueto, R.R. Roy, V.R. Edgerton, and P.E. Phelps Axon regeneration can facilitate or suppress hindlimb function after OEG transplantation, Journal of Neuroscience, 2011; 31: 4298-4310.
Download

Ziegler MD, Hsu D, Takeoka A, Zhong H, Ramón-Cueto A, Phelps PE, Roy RR, and Edgerton VR Further evidence of Olfactory Ensheathing Glia facilitating axonal regeneration after a complete spinal cord transection, Experimental Neurology, 2011; 229: 109-119.

Shields*, S.D., K.D. Moore*, P.E. Phelps, and A.I. Basbaum Olfactory ensheathing glia express Aquaporin 1, Journal of Comparative Neurology , 2010; 518: 4329-4341.
Download

Akopians Alin L, Babayan Alex H, Beffert Uwe, Herz Joachim, Basbaum Allan I, Phelps Patricia E Contribution of the Reelin signaling pathways to nociceptive processing European Journal of Neuroscience, 2008; 27: 523-37.
Download

Villeda, SA, Akopians, AL, Babayan, AH, Basbaum, AI, and Phelps, PE Absence of reelin results in altered nociception and aberrant neuronal positioning in the dorsal spinal cord, Neuroscience, 2006; 139: 1385-1396.
Download

Posts classified under: P

Chao Peng, Ph.D.

Nicole Petersen, Ph.D.

Gina Poe, Ph.D.