Biography
Sleep, Motor control Our primary interest is in understanding the evolution, function and disorders of REM sleep. We are analyzing the brainstem-forebrain interactions responsible for the control of muscle tone in waking and across the sleep cycle. This is of importance in understanding REM sleep behavior disorder, cataplexy and sleep apnea. We are studying the phylogeny of sleep by investigating the physiology and neurochemistry of sleep in reptiles, marine mammals and other species. We are particularly interested in the role of monoamines in the control of arousal and movement. A major focus of the laboratory is on narcolepsy, its anatomy, pathophysiology and treatment. We have identified the cause of human narcolepsy, a loss of hypocretin cells. We are investigating ways of identifying, controlling and reversing the symptoms of narcolepsy in narcoleptic animals and in humans.
Publications
A selected list of publications:
See: http://www.npi.ucla.edu/sleepresearch , , ; .
Siegel Jerome M
Why we sleep Scientific American, 2003; 289(5): 92-7.
Cohen Seth A, Kasmin Franklin E, Siegel Jerome H
Re: ERCP during pregnancy The American journal of gastroenterology, 2003; 98(7): 1658-9; author reply 1659.
Siegel, J.M. A tribute to Nathaniel Kleitman, Arch. Ital. Biol. , 2001; 139: 3-10.
Eiland, M.M., Lyamin, O.I. and Siegel, J.M. State related discharge of neruons in the brainstem of freely moving box turtles, Terapene Carolina major, Arch. Ital. Biol, 2001; 139: 23-36.
Siegel, J. M. Brainstem mechanisms generating REM sleep, Principles and Practice of Sleep Medicine, 2000; Third Edition: 112-133.
Siegel, J. M. Brainstem mechanisms generating REM sleep, Principles and Practice of Sleep Medicine, 2000; Third Edition: 112-133.
Siegel, J.M. Narcolepsy, Scientific American, 2000; 282: 76-81.
Siegel, J.M. Phylogenetic data bearing on the REM sleep-learning connection, The Behavioral and Brain Sciences, 2000; 23: 1007.
Lyamin, O.I., Manger,P.R. Mukhametov, L.M., Siegel, J.M.and Shpak, O.V. Rest and activity states in a gray whale, J. Sleep Res, 2000; 9: 261-267.
Rechtschaffen, A. and Siegel, J.M. Sleep and Dreaming, Principles of Neuroscience, 2000; Fourth Edition: 936-947.
Siegel, J.M. Narcolepsy: A key role for hypocretins (orexins), Cell, 1999; 98: 409-412.
Lai. Y.Y., Shalita, T., Hajnik, T., Wu, J.-P., Kuo, J.-S., Chia, L.-G., and Siegel, J.M. Neurotoxic Nmethyl-D-Aspartate lesion of the ventral midbrain and mesopontine junction alters sleep-wake organization, Neuroscience, 1999; 90: 469-483.
Siegel, JM Manger, PR Nienhuis, R Fahringer, HM Shalita, T Pettigrew, JD
Sleep in the platypus Neuroscience. , 1999; 91(1): 391-400.
Siegel, J.M. Sleep, Encarta Encyclopedia, 1999; 2000: 0000.
Siegel, J.M. Sleep, Encarta Encyclopedia, 1999; 2000: 0000.
Siegel, J.M. The evolution of REM sleep, In Handbook of Behavioral State Control, 1999; first edition: pp 87-100.
Siegel, JM Nienhuis, R Gulyani, S Ouyang, S Wu, MF Mignot, E Switzer, RC McMurry, G Cornford, M
Neuronal degeneration in canine narcolepsy The Journal of neuroscience : the official journal of the Society for Neuroscience. , 1999; 19(1): 248-57.
Kohyama, J., Lai, Y.Y. and Siegel, J.M. Conduction velocity of the reticulospinal system mediating muscle tone suppression, J. Neurophysiol, 1998; 80: 1839-1851.
Lai, Y.Y. and Siegel, J.M. Muscle atonia and REM sleep, Rapid eye movement sleep, 1998; first edition: 69-90.
Nitz, D. and Siegel, J.M. GABA release in the locus coeruleus as a function of sleep/wake state, Neuroscience, 1997; 78: 795-801.
Siegel, J.M. Sleep in monotremes; implications for the evolution of REM sleep, Sleep and sleep disorders: from molecule to behavior, 1997; First edition: 113-128.
Siegel, J.M. and Harper, R.H. Sleep, Human Physiology, 1996; 1: 1183-1197.
Siegel, J.M. and Harper, R.H. Sleep, Human Physiology, 1996; 1: 1183-1197.
Nishino, S., Tafti, M., Reid, M., Shelton, J., Siegel, J.M., Dement, W.C., and Mignot, E. Muscle atonia is triggered by cholinergic stimulation of the basal forebrain: Implications for the pathophysiology of narcolepsy, J. Neuroscience , 1995; 15: 4806-4814.
Siegel, J. M. Brainstem mechanisms generating REM sleep, Principles and Practice of Sleep Medicine, 1994; Third Edition: 125-144.
Siegel, J.M., and Lai, Y.Y. Brainstem systems mediating the control of muscle tone, Environment and Physiology, 1994; First Edition: 62-78.
Carskadon, M.A., Rechtschaffen, A., Richardson, G., Roth, T., Siegel, J.M.v (Editor), Encyclopedia of Sleep and Dreaming, 1993; 703 pages.
Kodama, T., and Siegel, J.M. Brainstem acetylcholine release and REM sleep, Sleep Wakefulness, 1993; First edition: 51-56.
Wu, M.F, Jenden, D.J., Fairchild, D.M. and Siegel, J.M. Cholinergic mechanisms in startle and prepulse inhibition:Effect of the false cholinergic precursor N-aminodeanol, Behavioral Neurosci, 1993; 107: 306-316.
Siegel, J.M. Function of REM sleep, Encyclopedia of Sleep and Dreaming, 1993; First Edition: 507-510.
Siegel, J.M. Medulla, Encyclopedia of Sleep and Dreaming, 1993; 358-359.
Siegel, J.M. Pons, Encyclopedia of Sleep and Dreaming, 1993; First edition: 461-462.
Siegel, J.M. REM sleep Mechanisms, Encyclopedia of Sleep and Dreaming, 1993; First Edition: 510-513.
Mignot, E Nishino, S Sharp, LH Arrigoni, J Siegel, JM Reid, MS Edgar, DM Ciaranello, RD Dement, WC
Heterozygosity at the canarc-1 locus can confer susceptibility for narcolepsy: induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems The Journal of neuroscience : the official journal of the Society for Neuroscience. , 1993; 13(3): 1057-64.
Kodama, T., Lai, Y.Y. and Siegel, J.M. Enhancement of acetylcholine release during REM sleep in the caudo-medial medulla measured by in vivo microdialysis, Brain Res. , 1992; 580: 348-350.
McGinty, D. J. and Siegel, J. M. Neuronal unit recording in unrestrained animals: Role in structure-function analysis of sleep-waking mechanisms, Progress in Physiological Psychology , 1992; 15: 85-140.
Siegel, J.M. Brain Mechanisms of Sleep and Wakefulness, Basics of Sleep Behavior, 1991; .
Lai, Y.Y. and Siegel, J.M. Ponto-medullary glutamate receptors mediating locomotion and muscle tone suppression, J. Neurosci, 1991; 11: 2931-2937.
Shouse, M. N., King, A., Langer, J., Wellesley, K., Vreeken, T., King, K., Siegel, J., Szymusiak, R. Basic mechanisms underlying seizure prone and seizure resistant sleep states, Kindling, 1990; 4: 313-327.
Siegel, J. M. Mechanisms of sleep control, J. Clin Neurophysiol, 1990; 7: 49-65.
Siegel, J. M. Brainstem mechanisms generating REM sleep, Principles and Practice of Sleep Medicine, 1989; 104-121.
Siegel, J. M. Brainstem mechanisms generating REM sleep, Principles and Practice of Sleep Medicine, 1989; 104-121.
Wu, M.F., Mallick, B.N. and Siegel J.M. Lateral geniculate spikes, muscle atonia and startle response elicited by auditory stimuli as a function of stimulus parameters and arousal state, Brain Res, 1989; 499: 7-17.
Lai, Y. Y., Siegel, J. M. and Wilson, W. J. Effect of blood pressure manipulations on medial medulla-induced muscle atonia, Am. J. Physiol, 1987; 252: H1249-H1257.
Siegel, J. M., Tomaszewski, K. S. and Nienhuis, R. Behavioral states in the chronic medullary and mid-pontine cat, Electroenceph. clin Neurophysiol, 1986; 63: 274-288.
Siegel, J. M. and McGinty, D. J. Location of the systems generating REM sleep: lateral vs. medial pons. Commentary, Behav. Brain Sci, 1986; 9: 420-421.
Siegel, J. M. Pontomedullary interactions in the generation of REM sleep, Brain Mechanisms of Sleep, 1985; 157-174.
Siegel, J. M. A behavioral approach to the analysis of reticular formation unit activity, Behavioral Approaches to Brain Research, 1983; 94-116.
Siegel, J. M. Brainstem mechanisms in REM sleep control, Sleep Functions and Mechanisms in Animals and Man: An Evolutionary Perspective, 1983; 217-231.
Siegel, J. M. Reticular activity and arousal. Commentary, Behav. Brain Sci, 1983; 6: 741-743.
McGinty, D. J. and Siegel, J. M. Sleep states, Handbook of Behavioral Neurobiology: Motivation, 1983; 105-181.
Siegel, J. M. Behavioral functions of the reticular formation, Brain Res. Rev, 1979; 1: 69-105.
Siegel, J. M. Reticular formation activity and REM sleep, The Functions of Sleep, 1979; 37-71.
Siegel, J. M. and McGinty, D. J. Pontine reticular formation neurons and motor activity, Science, 1978; 199: 207-208.
McGinty, D. J. and Siegel, J. M. Neuronal activity patterns during rapid-eye- movement sleep:relation to waking patterns, Neurobiology of Sleep and Memory , 1977; 135-158.
Siegel, J. M. and McGinty, D. J. Brainstem neurons without spontaneous unit discharge, Science, 1976; 193: 240-242.