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HomeUCLA Brain Research Institute (BRI)  > People  > Departments  > School of Nursing
Karen H. Gylys, Ph.D., R.N.

Karen Gylys, R.N., Ph.D.

Biography

Karen Hoppens Gylys is a neuroscientist who joined the faculty of the School of Nursing and the Brain Research Institute in 1998. Dr. Gylys earned a B.S. degree in Nursing and a M.S. degree in Human Development at the University of Texas, Dallas. She received her Ph.D. in Neuroscience, with a major in neuropharmacology, at UCLA in 1993, and did postdoctoral work on molecular mechanisms of opioid tolereance in the NPI. Since joining the faculty of the School of Nursing, she has taught pharmacology and research in the School of Nursing and is actively involved in the BRI. Her laboratory research is focused on understanding the dysfunction and loss of synapses that occurs in Alzheimer’s disease (AD), and she has pioneered the use of flow cytometry for the analysis of synaptosomes.  Her projects use primarily human postmortem AD samples and mouse models of the disease.  Research interests include neuroinflammation and APOE risk for AD, the single biggest genetic risk, which can also be also protective.  Recent projects have isolated brain cell types from human postmortem samples in order to study microglial and astrocyte effects on AD progression.  We also have new projects looking at exosome mechanisms in pathology and signaling between cortical cell types.

Publications

A selected list of publications:

Bilousova Tina, Melnik Mikhail, Miyoshi Emily, Gonzalez Bianca L, Poon Wayne W, Vinters Harry V, Miller Carol A, Corrada Maria M, Kawas Claudia, Hatami Asa, Albay Ricardo, Glabe Charles, Gylys Karen H   Apolipoprotein E/Amyloid-β Complex Accumulates in Alzheimer Disease Cortical Synapses via Apolipoprotein E Receptors and Is Enhanced by APOE4 The American journal of pathology, 2019; 189(8): 1621-1636.
Bilousova Tina, Elias Chris, Miyoshi Emily, Alam Mohammad Parvez, Zhu Chunni, Campagna Jesus, Vadivel Kanagasabai, Jagodzinska Barbara, Gylys Karen Hoppens, John Varghese   Suppression of tau propagation using an inhibitor that targets the DK-switch of nSMase2 Biochemical and biophysical research communications, 2018; 499(4): 751-757.
Gylys Karen Hoppens, Bilousova Tina   Flow Cytometry Analysis and Quantitative Characterization of Tau in Synaptosomes from Alzheimer’s Disease Brains Methods in molecular biology (Clifton, N.J.), 2017; 1523(3): 273-284.
Gonzalez Bianca, Abud Edsel M, Abud Abigail M, Poon Wayne W, Gylys Karen H   Tau Spread, Apolipoprotein E, Inflammation, and More: Rapidly Evolving Basic Science in Alzheimer Disease Neurologic clinics, 2017; 35(2): 175-190.
Abud Edsel M, Ramirez Ricardo N, Martinez Eric S, Healy Luke M, Nguyen Cecilia H H, Newman Sean A, Yeromin Andriy V, Scarfone Vanessa M, Marsh Samuel E, Fimbres Cristhian, Caraway Chad A, Fote Gianna M, Madany Abdullah M, Agrawal Anshu, Kayed Rakez, Gylys Karen H, Cahalan Michael D, Cummings Brian J, Antel Jack P, Mortazavi Ali, Carson Monica J, Poon Wayne W, Blurton-Jones Mathew   iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases Neuron, 2017; 94(2): 278-293.e9.
Prieto G Aleph, Trieu Brian H, Dang Cindy T, Bilousova Tina, Gylys Karen H, Berchtold Nicole C, Lynch Gary, Cotman Carl W   Pharmacological Rescue of Long-Term Potentiation in Alzheimer Diseased Synapses The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017; 37(5): 1197-1212.
Zhang Liang, Trushin Sergey, Christensen Trace A, Bachmeier Benjamin V, Gateno Benjamin, Schroeder Andreas, Yao Jia, Itoh Kie, Sesaki Hiromi, Poon Wayne W, Gylys Karen H, Patterson Emily R, Parisi Joseph E, Diaz Brinton Roberta, Salisbury Jeffrey L, Trushina Eugenia   Altered brain energetics induces mitochondrial fission arrest in Alzheimer’s Disease Scientific reports, 2016; 6(4): 18725.
Bilousova Tina, Miller Carol A, Poon Wayne W, Vinters Harry V, Corrada Maria, Kawas Claudia, Hayden Eric Y, Teplow David B, Glabe Charles, Albay Ricardo, Cole Gregory M, Teng Edmond, Gylys Karen H   Synaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases The American journal of pathology, 2016; 186(1): 185-98.
Wang David B, Kinoshita Yoshito, Kinoshita Chizuru, Uo Takuma, Sopher Bryce L, Cudaback Eiron, Keene C Dirk, Bilousova Tina, Gylys Karen, Case Amanda, Jayadev Suman, Wang Hong-Gang, Garden Gwenn A, Morrison Richard S   Loss of endophilin-B1 exacerbates Alzheimer’s disease pathology Brain : a journal of neurology, 2015; 138(Pt 7): 2005-19.
Sokolow Sophie, Henkins Kristen M, Bilousova Tina, Gonzalez Bianca, Vinters Harry V, Miller Carol A, Cornwell Lindsey, Poon Wayne W, Gylys Karen H   Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer’s disease Journal of neurochemistry, 2015; 133(3): 368-79.
Tai Leon M, Bilousova Tina, Jungbauer Lisa, Roeske Stephen K, Youmans Katherine L, Yu Chunjiang, Poon Wayne W, Cornwell Lindsey B, Miller Carol A, Vinters Harry V, Van Eldik Linda J, Fardo David W, Estus Steve, Bu Guojun, Gylys Karen Hoppens, Ladu Mary Jo   Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples The Journal of biological chemistry, 2013; 288(8): 5914-26.
Sokolow Sophie, Henkins Kristen M, Bilousova Tina, Miller Carol A, Vinters Harry V, Poon Wayne, Cole Gregory M, Gylys Karen Hoppens   AD synapses contain abundant Aβ monomer and multiple soluble oligomers, including a 56-kDa assembly Neurobiology of aging, 2012; 33(8): 1545-55.
Sokolow Sophie, Henkins Kristen M, Williams Iris A, Vinters Harry V, Schmid Ingrid, Cole Gregory M, Gylys Karen H   Isolation of synaptic terminals from Alzheimer’s disease cortex Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2012; 81(3): 248-54.
Arold Stephen, Sullivan Patrick, Bilousova Tina, Teng Edmond, Miller Carol A, Poon Wayne W, Vinters Harry V, Cornwell Lindsey B, Saing Tommy, Cole Gregory M, Gylys Karen Hoppens   Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer’s disease and apoE TR mouse cortex Acta neuropathologica, 2012; 123(1): 39-52.
Ringman John M, Schulman Howard, Becker Chris, Jones Ted, Bai Yuchen, Immermann Fred, Cole Gregory, Sokolow Sophie, Gylys Karen, Geschwind Daniel H, Cummings Jeffrey L, Wan Hong I   Proteomic changes in cerebrospinal fluid of presymptomatic and affected persons carrying familial Alzheimer disease mutations Archives of neurology, 2012; 69(1): 96-104.
Paul M. Macey, Ph.D.

Paul Macey, Ph.D.

Biography

Paul M. Macey is a neuroscientist who has worked at UCLA since 1999. He is an Associate Professor of Nursing, and serves in the School of Nursing Administration as Director of Information Technology and Innovation, and Chief Innovation Officer. Dr. Macey completed a degree in Electrical Engineering at the University of Canterbury, New Zealand, where he focused on bringing engineering approaches to the analysis of breathing signals recorded from infants during sleep. He started at UCLA in a post-doctoral position in the Department of Neurobiology, and continued as and Assistant then Associate Researcher. Dr. Macey then joined the School of Nursing and Brain Research Institute as a faculty member. Dr. Macey teaches in the undergraduate Nursing program, and serves on various faculty committees.

Sophie Sokolow, Ph.D.

Sophie Sokolow, Ph.D.

Biography

 

Dr. Sokolow has a broad background in pharmacology and neurobiology of Alzheimer’s disease (AD), with specific training and expertise in molecular biology, clinical pharmacy and pharmacogenomics with emphasis in analyzing secondary data of drug response in the treatment of cognitive symptoms of AD and mild cognitive impairment (MCI). Her current research project focuses on the discovery of genetic polymorphisms associated with response to AD medications, such as donepezil and other acetylcholinesterase inhibitors. Areas of Scholarly Expertise and Interest: Alzheimer’s disease, genetics, pharmacogenomics, pharmacology and therapeutics, biomarkers, calcium signaling pathways.

Publications

A selected list of publications:

Sokolow Sophie, Li Xiaohui, Chen Lucia, Taylor Kent D, Rotter Jerome I, Rissman Robert A, Aisen Paul S, Apostolova Liana G   Deleterious Effect of Butyrylcholinesterase K-Variant in Donepezil Treatment of Mild Cognitive Impairment Journal of Alzheimer’s disease : JAD, 2017; 56(1): 229-237.
Casamassa Antonella, La Rocca Claudia, Sokolow Sophie, Herchuelz Andre, Matarese Giuseppe, Annunziato Lucio, Boscia Francesca   Ncx3 gene ablation impairs oligodendrocyte precursor response and increases susceptibility to experimental autoimmune encephalomyelitis Glia, 2016; 64(7): 1124-37.
Sokolow Sophie, Henkins Kristen M, Bilousova Tina, Gonzalez Bianca, Vinters Harry V, Miller Carol A, Cornwell Lindsey, Poon Wayne W, Gylys Karen H   Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer’s disease Journal of neurochemistry, 2015; 133(3): 368-79.
Apostolova Liana G, Hwang Kristy S, Avila David, Elashoff David, Kohannim Omid, Teng Edmond, Sokolow Sophie, Jack Clifford R, Jagust William J, Shaw Leslie, Trojanowski John Q, Weiner Michael W, Thompson Paul M, Thompson Paul M   Brain amyloidosis ascertainment from cognitive, imaging, and peripheral blood protein measures Neurology, 2015; 84(7): 729-37.
Hohendanner Felix, Ljubojević Senka, MacQuaide Niall, Sacherer Michael, Sedej Simon, Biesmans Liesbeth, Wakula Paulina, Platzer Dieter, Sokolow Sophie, Herchuelz André, Antoons Gudrun, Sipido Karin, Pieske Burkert, Heinzel Frank R   Intracellular dyssynchrony of diastolic cytosolic [Ca²⁺] decay in ventricular cardiomyocytes in cardiac remodeling and human heart failure Circulation research, 2013; 113(5): 527-38.
Molinaro Pasquale, Cataldi Mauro, Cuomo Ornella, Viggiano Davide, Pignataro Giuseppe, Sirabella Rossana, Secondo Agnese, Boscia Francesca, Pannaccione Anna, Scorziello Antonella, Sokolow Sophie, Herchuelz André, Di Renzo Gianfranco, Annunziato Lucio   Genetically modified mice as a strategy to unravel the role played by the Na(+)/Ca (2+) exchanger in brain ischemia and in spatial learning and memory deficits Advances in experimental medicine and biology, 2013; 961: 213-22.
Henkins Kristen M, Sokolow Sophie, Miller Carol A, Vinters Harry V, Poon Wayne W, Cornwell Lindsey B, Saing Tommy, Gylys Karen Hoppens   Extensive p-tau pathology and SDS-stable p-tau oligomers in Alzheimer’s cortical synapses Brain pathology (Zurich, Switzerland), 2012; 22(6): 826-33.
Pannaccione Anna, Secondo Agnese, Molinaro Pasquale, D’Avanzo Carla, Cantile Maria, Esposito Alba, Boscia Francesca, Scorziello Antonella, Sirabella Rossana, Sokolow Sophie, Herchuelz André, Di Renzo Gianfranco, Annunziato Lucio   A new concept: Aβ1-42 generates a hyperfunctional proteolytic NCX3 fragment that delays caspase-12 activation and neuronal death The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012; 32(31): 10609-17.
Sokolow Sophie, Henkins Kristen M, Bilousova Tina, Miller Carol A, Vinters Harry V, Poon Wayne, Cole Gregory M, Gylys Karen Hoppens   AD synapses contain abundant Aβ monomer and multiple soluble oligomers, including a 56-kDa assembly Neurobiology of aging, 2012; 33(8): 1545-55.
Boscia F, D’Avanzo C, Pannaccione A, Secondo A, Casamassa A, Formisano L, Guida N, Sokolow Sophie, Herchuelz André, Annunziato L   Silencing or knocking out the Na(+)/Ca(2+) exchanger-3 (NCX3) impairs oligodendrocyte differentiation Cell death and differentiation, 2012; 19(4): 562-72.
Sokolow Sophie, Henkins Kristen M, Williams Iris A, Vinters Harry V, Schmid Ingrid, Cole Gregory M, Gylys Karen H   Isolation of synaptic terminals from Alzheimer’s disease cortex Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2012; 81(3): 248-54.
Sokolow Sophie, Luu Sanh H, Nandy Karabi, Miller Carol A, Vinters Harry V, Poon Wayne W, Gylys Karen H   Preferential accumulation of amyloid-beta in presynaptic glutamatergic terminals (VGluT1 and VGluT2) in Alzheimer’s disease cortex Neurobiology of disease, 2012; 45(1): 381-7.
Ringman John M, Schulman Howard, Becker Chris, Jones Ted, Bai Yuchen, Immermann Fred, Cole Gregory, Sokolow Sophie, Gylys Karen, Geschwind Daniel H, Cummings Jeffrey L, Wan Hong I   Proteomic changes in cerebrospinal fluid of presymptomatic and affected persons carrying familial Alzheimer disease mutations Archives of neurology, 2012; 69(1): 96-104.
Nguidjoe Evrard, Sokolow Sophie, Bigabwa Serge, Pachera Nathalie, D’Amico Eva, Allagnat Florent, Vanderwinden Jean-Marie, Sener Abdullah, Manto Mario, Depreter Marianne, Mast Jan, Joanny Geraldine, Montanya Eduard, Rahier Jacques, Cardozo Alessandra K, Eizirik Décio L, Schurmans Stéphane, Herchuelz André   Heterozygous inactivation of the Na/Ca exchanger increases glucose-induced insulin release, β-cell proliferation, and mass Diabetes, 2011; 60(8): 2076-85.
Molinaro Pasquale, Viggiano Davide, Nisticò Robert, Sirabella Rossana, Secondo Agnese, Boscia Francesca, Pannaccione Anna, Scorziello Antonella, Mehdawy Bisan, Sokolow Sophie, Herchuelz André, Di Renzo Gianfranco F, Annunziato Lucio   Na+ -Ca2+ exchanger (NCX3) knock-out mice display an impairment in hippocampal long-term potentiation and spatial learning and memory The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011; 31(20): 7312-21.
Sokolow Sophie, Luu Sanh H, Headley Alison J, Hanson Alecia Y, Kim Taeree, Miller Carol A, Vinters Harry V, Gylys Karen H   High levels of synaptosomal Na(+)-Ca(2+) exchangers (NCX1, NCX2, NCX3) co-localized with amyloid-beta in human cerebral cortex affected by Alzheimer’s disease Cell calcium, 2011; 49(4): 208-16.
Verwey N A, van der Flier W M, Blennow K, Clark C, Sokolow S, De Deyn P P, Galasko D, Hampel H, Hartmann T, Kapaki E, Lannfelt L, Mehta P D, Parnetti L, Petzold A, Pirttila T, Saleh L, Skinningsrud A, Swieten J C V, Verbeek M M, Wiltfang J, Younkin S, Scheltens P, Blankenstein M A   A worldwide multicentre comparison of assays for cerebrospinal fluid biomarkers in Alzheimer’s disease Annals of clinical biochemistry, 2009; 46(Pt 3): 235-40.
Wehling-Henricks Michelle, Sokolow Sophie, Lee Jamie J, Myung Kyu H, Villalta S Armando, Tidball James G   Major basic protein-1 promotes fibrosis of dystrophic muscle and attenuates the cellular immune response in muscular dystrophy Human molecular genetics, 2008; 17(15): 2280-92.
Ringman J M, Younkin S G, Pratico D, Seltzer W, Cole G M, Geschwind D H, Rodriguez-Agudelo Y, Schaffer B, Fein J, Sokolow S, Rosario E R, Gylys K H, Varpetian A, Medina L D, Cummings J L   Biochemical markers in persons with preclinical familial Alzheimer disease Neurology, 2008; 71(2): 85-92.
Fein Jeffrey A, Sokolow Sophie, Miller Carol A, Vinters Harry V, Yang Fusheng, Cole Gregory M, Gylys Karen Hoppens   Co-localization of amyloid beta and tau pathology in Alzheimer’s disease synaptosomes The American journal of pathology, 2008; 172(6): 1683-92.
Jeffs Graham J, Meloni Bruno P, Sokolow Sophie, Herchuelz Andre, Schurmans Stéphane, Knuckey Neville W   NCX3 knockout mice exhibit increased hippocampal CA1 and CA2 neuronal damage compared to wild-type mice following global cerebral ischemia Experimental neurology, 2008; 210(1): 268-73.
Molinaro Pasquale, Cuomo Ornella, Pignataro Giuseppe, Boscia Francesca, Sirabella Rossana, Pannaccione Anna, Secondo Agnese, Scorziello Antonella, Adornetto Annagrazia, Gala Rosaria, Viggiano Davide, Sokolow Sophie, Herchuelz Andre, Schurmans Stèphane, Di Renzo Gianfranco, Annunziato Lucio   Targeted disruption of Na+/Ca2+ exchanger 3 (NCX3) gene leads to a worsening of ischemic brain damage The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008; 28(5): 1179-84.
Sokolow Sophie, Manto Mario, Gailly Philippe, Molgó Jordi, Vandebrouck Clarisse, Vanderwinden Jean-Marie, Herchuelz Andre, Schurmans Stéphane   Impaired neuromuscular transmission and skeletal muscle fiber necrosis in mice lacking Na/Ca exchanger 3 The Journal of clinical investigation, 2004; 113(2): 265-73.