Faculty Member
Professor
Department of Oral Biology
School of Dentistry
University of California, Los Angeles
Center for Health Sciences
10833 Le Conte Avenue,
Los Angeles, CA 90095
Publications
A selected list of publications:
Shen Yi, Lindemeyer A Kerstin, Spigelman Igor, Sieghart Werner, Olsen Richard W, Liang Jing Plasticity of GABAA receptors after ethanol pre-exposure in cultured hippocampal neurons Molecular pharmacology, 2011; 79(3): 432-42.
Ruangsri Supanigar, Lin Audrey, Mulpuri Yatendra, Lee Kyung, Spigelman Igor, Nishimura Ichiro RELATIONSHIP OF AXONAL VOLTAGE-GATED SODIUM CHANNEL 1.8 (NaV1.8) mRNA ACCUMULATION TO SCIATIC NERVE INJURY-INDUCED PAINFUL NEUROPATHY IN RATS The Journal of biological chemistry, 2011; .
Suryanarayanan Asha, Liang Jing, Meyer Edward M, Lindemeyer A Kerstin, Chandra Dev, Homanics Gregg E, Sieghart Werner, Olsen Richard W, Spigelman Igor Subunit Compensation and Plasticity of Synaptic GABA(A) Receptors Induced by Ethanol in ?4 Subunit Knockout Mice Frontiers in neuroscience, 2011; 5(3): 110.
Díaz-Cintra Sofia, Xue Baogang, Spigelman Igor, Van K, Wong Alan M, Obenaus Andre, Ribak Charles E Dentate granule cells form hilar basal dendrites in a rat model of hypoxia-ischemia Brain research, 2009; 1285: 182-7.
Thakor Devang Kashyap, Lin Audrey, Matsuka Yoshizo, Meyer Edward M, Ruangsri Supanigar, Nishimura Ichiro, Spigelman Igor Increased peripheral nerve excitability and local NaV1.8 mRNA up-regulation in painful neuropathy Molecular pain, 2009; 5(1): 14.
Ribak Charles E, Shapiro Lee A, Perez Zachary D, Spigelman Igor Microglia-associated granule cell death in the normal adult dentate gyrus Brain structure & function, 2009; .
Liang Jing, Spigelman Igor, Olsen Richard W Tolerance to sedative/hypnotic actions of GABAergic drugs correlates with tolerance to potentiation of extrasynaptic tonic currents of alcohol-dependent rats Journal of neurophysiology, 2009; 102(1): 224-33.
Matsuka Yoshizo, Ono Takeshi, Iwase Hirotate, Mitrirattanakul Somsak, Omoto Kevin S, Cho Ting, Lam Yan Yan N, Snyder Bradley, Spigelman Igor Altered ATP release and metabolism in dorsal root ganglia of neuropathic rats Molecular pain, 2008; 4(1): 66.
Jain Naveen K, Ishikawa Tomo-o, Spigelman Igor, Herschman Harvey R COX-2 expression and function in the hyperalgesic response to paw inflammation in mice Prostaglandins, leukotrienes, and essential fatty acids, 2008; 79(6): 183-90.
Liang Jing, Suryanarayanan Asha, Chandra Dev, Homanics Gregg E, Olsen Richard W, Spigelman Igor Functional consequences of GABAA receptor alpha 4 subunit deletion on synaptic and extrasynaptic currents in mouse dentate granule cells Alcoholism, clinical and experimental research, 2008; 32(1): 19-26.
Chandra Dev, Werner David F, Liang Jing, Suryanarayanan Asha, Harrison Neil L, Spigelman Igor, Olsen Richard W, Homanics Gregg E Normal acute behavioral responses to moderate/high dose ethanol in GABAA receptor alpha 4 subunit knockout mice Alcoholism, clinical and experimental research, 2008; 32(1): 10-8.
Mitrirattanakul Somsak, López-Valdés Héctor E, Liang Jing, Matsuka Yoshizo, Mackie Ken, Faull Kym F, Spigelman Igor Bidirectional alterations of hippocampal cannabinoid 1 receptors and their endogenous ligands in a rat model of alcohol withdrawal and dependence Alcoholism, clinical and experimental research, 2007; 31(5): 855-67.
Liang Jing, Suryanarayanan Asha, Abriam Alana, Snyder Bradley, Olsen Richard W, Spigelman Igor Mechanisms of reversible GABAA receptor plasticity after ethanol intoxication The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007; 27(45): 12367-77.
Thakor Devang, Spigelman Igor, Tabata Yasuhiko, Nishimura Ichiro Subcutaneous peripheral injection of cationized gelatin/DNA polyplexes as a platform for non-viral gene transfer to sensory neurons Molecular therapy : the journal of the American Society of Gene Therapy, 2007; 15(12): 2124-31.
Liang, J., Zhang, N., Cagetti, E. Houser, C.R., Olsen, R.W. and Spigelman, I. Chronic intermittent ethanol treatment-induced switch of ethanol actions from extrasynaptic to synaptic hippocampal GABAA receptors, Journal of Neuroscience, 2006; 26: 1749-1758.
Liang Jing, Zhang Nianhui, Cagetti Elisabetta, Houser Carolyn R, Olsen Richard W, Spigelman Igor Chronic intermittent ethanol-induced switch of ethanol actions from extrasynaptic to synaptic hippocampal GABAA receptors The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006; 26(6): 1749-58.
Chandra, D., Jia, F., Liang, J., Peng, Z., Suryanarayanan, A., Werner, D.F., Spigelman, I., Houser, C.R., Olsen, R.W., Harrison, N.L. and Homanics, G.E. GABA(A) receptor alpha4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol, Proceedings of the National Academy of Sciences USA, 2006; 103: 15230-15235.
Spigelman, I. Physiologic mechanisms of inhibition and status epilepticus, In: Status Epilepticus, Mechanisms and Management, C.G. Wasterlain and D.M. Treiman editors, MIT Press, Cambridge,, 2006; Chapter 21: 281-293.
Mitrirattanakul Somsak, Ramakul Navapoln, Guerrero Andre V, Matsuka Yoshizo, Ono Takeshi, Iwase Hirotate, Mackie Ken, Faull Kym F, Spigelman Igor Site-specific increases in peripheral cannabinoid receptors and their endogenous ligands in a model of neuropathic pain Pain, 2006; 126(1-3): 102-14.
Olsen, R.W., Liang, J., Cagetti, E., and Spigelman, I. Plasticity of GABAA receptors in brains of rats treated with chronic intermittent ethanol , Neurochemical Research, 2005; 30: 1579-1588.
Matsuka Y. and Spigelman, I. Hyperosmolar solutions selectively block action potentials in rat myelinated sensory fibers: implications for diabetic neuropathy, Journal of Neurophysiology, 2004; 91: 48-56.
Matsuka, Y Neubert, JK Maidment, NT Spigelman, I Concurrent release of ATP and substance P within guinea pig trigeminal ganglia in vivo Brain research. , 2001; 915(2): 248-55.
Spigelman, I., Gold, M.S., Light A.R. Electrophysiological Methods in Pain Research, Methods in Pain Research, 2001; Chapter 8: 147-168.
Spigelman, I., Neubert, J.K., Matsuka, Y., Maidment, N.T. Extracellular Sampling, Methods in Pain Research, 2001; Chapter 7: 133-146.
Neubert, JK Maidment, NT Matsuka, Y Adelson, DW Kruger, L Spigelman, I Inflammation-induced changes in primary afferent-evoked release of substance P within trigeminal ganglia in vivo Brain research. , 2000; 871(2): 181-91.
Spigelman, I Yan, XX Obenaus, A Lee, EY Wasterlain, CG Ribak, CE Dentate granule cells form novel basal dendrites in a rat model of temporal lobe epilepsy Neuroscience. , 1998; 86(1): 109-20.
Spigelman, I Obenaus, A Mazarati, A Wasterlain, CG Intravenously administered cell-permeant calcium buffer decreases evoked synaptic potentials in rat dentate gyrus in vivo Brain research. , 1998; 810(1-2): 269-73.
Spigelman, I Tymianski, M Wallace, CM Carlen, PL Velumian, AA Modulation of hippocampal synaptic transmission by low concentrations of cell-permeant Ca2+ chelators: effects of Ca2+ affinity, chelator structure and binding kinetics Neuroscience. , 1996; 75(2): 559-72.
Faculty Member
Associate Professor
Department of Nursing
School of Nursing
University of California, Los Angeles
5-238 Factor Building
700 Tiverton Dr,
Los Angeles, CA 90095
BOX 956919
Biography
Dr. Sokolow has a broad background in pharmacology and neurobiology of Alzheimer’s disease (AD), with specific training and expertise in molecular biology, clinical pharmacy and pharmacogenomics with emphasis in analyzing secondary data of drug response in the treatment of cognitive symptoms of AD and mild cognitive impairment (MCI). Her current research project focuses on the discovery of genetic polymorphisms associated with response to AD medications, such as donepezil and other acetylcholinesterase inhibitors. Areas of Scholarly Expertise and Interest: Alzheimer’s disease, genetics, pharmacogenomics, pharmacology and therapeutics, biomarkers, calcium signaling pathways.
Publications
A selected list of publications:
Sokolow Sophie, Li Xiaohui, Chen Lucia, Taylor Kent D, Rotter Jerome I, Rissman Robert A, Aisen Paul S, Apostolova Liana G Deleterious Effect of Butyrylcholinesterase K-Variant in Donepezil Treatment of Mild Cognitive Impairment Journal of Alzheimer’s disease : JAD, 2017; 56(1): 229-237.
Casamassa Antonella, La Rocca Claudia, Sokolow Sophie, Herchuelz Andre, Matarese Giuseppe, Annunziato Lucio, Boscia Francesca Ncx3 gene ablation impairs oligodendrocyte precursor response and increases susceptibility to experimental autoimmune encephalomyelitis Glia, 2016; 64(7): 1124-37.
Sokolow Sophie, Henkins Kristen M, Bilousova Tina, Gonzalez Bianca, Vinters Harry V, Miller Carol A, Cornwell Lindsey, Poon Wayne W, Gylys Karen H Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer’s disease Journal of neurochemistry, 2015; 133(3): 368-79.
Apostolova Liana G, Hwang Kristy S, Avila David, Elashoff David, Kohannim Omid, Teng Edmond, Sokolow Sophie, Jack Clifford R, Jagust William J, Shaw Leslie, Trojanowski John Q, Weiner Michael W, Thompson Paul M, Thompson Paul M Brain amyloidosis ascertainment from cognitive, imaging, and peripheral blood protein measures Neurology, 2015; 84(7): 729-37.
Hohendanner Felix, Ljubojević Senka, MacQuaide Niall, Sacherer Michael, Sedej Simon, Biesmans Liesbeth, Wakula Paulina, Platzer Dieter, Sokolow Sophie, Herchuelz André, Antoons Gudrun, Sipido Karin, Pieske Burkert, Heinzel Frank R Intracellular dyssynchrony of diastolic cytosolic [Ca²⁺] decay in ventricular cardiomyocytes in cardiac remodeling and human heart failure Circulation research, 2013; 113(5): 527-38.
Molinaro Pasquale, Cataldi Mauro, Cuomo Ornella, Viggiano Davide, Pignataro Giuseppe, Sirabella Rossana, Secondo Agnese, Boscia Francesca, Pannaccione Anna, Scorziello Antonella, Sokolow Sophie, Herchuelz André, Di Renzo Gianfranco, Annunziato Lucio Genetically modified mice as a strategy to unravel the role played by the Na(+)/Ca (2+) exchanger in brain ischemia and in spatial learning and memory deficits Advances in experimental medicine and biology, 2013; 961: 213-22.
Henkins Kristen M, Sokolow Sophie, Miller Carol A, Vinters Harry V, Poon Wayne W, Cornwell Lindsey B, Saing Tommy, Gylys Karen Hoppens Extensive p-tau pathology and SDS-stable p-tau oligomers in Alzheimer’s cortical synapses Brain pathology (Zurich, Switzerland), 2012; 22(6): 826-33.
Pannaccione Anna, Secondo Agnese, Molinaro Pasquale, D’Avanzo Carla, Cantile Maria, Esposito Alba, Boscia Francesca, Scorziello Antonella, Sirabella Rossana, Sokolow Sophie, Herchuelz André, Di Renzo Gianfranco, Annunziato Lucio A new concept: Aβ1-42 generates a hyperfunctional proteolytic NCX3 fragment that delays caspase-12 activation and neuronal death The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012; 32(31): 10609-17.
Sokolow Sophie, Henkins Kristen M, Bilousova Tina, Miller Carol A, Vinters Harry V, Poon Wayne, Cole Gregory M, Gylys Karen Hoppens AD synapses contain abundant Aβ monomer and multiple soluble oligomers, including a 56-kDa assembly Neurobiology of aging, 2012; 33(8): 1545-55.
Boscia F, D’Avanzo C, Pannaccione A, Secondo A, Casamassa A, Formisano L, Guida N, Sokolow Sophie, Herchuelz André, Annunziato L Silencing or knocking out the Na(+)/Ca(2+) exchanger-3 (NCX3) impairs oligodendrocyte differentiation Cell death and differentiation, 2012; 19(4): 562-72.
Sokolow Sophie, Henkins Kristen M, Williams Iris A, Vinters Harry V, Schmid Ingrid, Cole Gregory M, Gylys Karen H Isolation of synaptic terminals from Alzheimer’s disease cortex Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2012; 81(3): 248-54.
Sokolow Sophie, Luu Sanh H, Nandy Karabi, Miller Carol A, Vinters Harry V, Poon Wayne W, Gylys Karen H Preferential accumulation of amyloid-beta in presynaptic glutamatergic terminals (VGluT1 and VGluT2) in Alzheimer’s disease cortex Neurobiology of disease, 2012; 45(1): 381-7.
Ringman John M, Schulman Howard, Becker Chris, Jones Ted, Bai Yuchen, Immermann Fred, Cole Gregory, Sokolow Sophie, Gylys Karen, Geschwind Daniel H, Cummings Jeffrey L, Wan Hong I Proteomic changes in cerebrospinal fluid of presymptomatic and affected persons carrying familial Alzheimer disease mutations Archives of neurology, 2012; 69(1): 96-104.
Nguidjoe Evrard, Sokolow Sophie, Bigabwa Serge, Pachera Nathalie, D’Amico Eva, Allagnat Florent, Vanderwinden Jean-Marie, Sener Abdullah, Manto Mario, Depreter Marianne, Mast Jan, Joanny Geraldine, Montanya Eduard, Rahier Jacques, Cardozo Alessandra K, Eizirik Décio L, Schurmans Stéphane, Herchuelz André Heterozygous inactivation of the Na/Ca exchanger increases glucose-induced insulin release, β-cell proliferation, and mass Diabetes, 2011; 60(8): 2076-85.
Molinaro Pasquale, Viggiano Davide, Nisticò Robert, Sirabella Rossana, Secondo Agnese, Boscia Francesca, Pannaccione Anna, Scorziello Antonella, Mehdawy Bisan, Sokolow Sophie, Herchuelz André, Di Renzo Gianfranco F, Annunziato Lucio Na+ -Ca2+ exchanger (NCX3) knock-out mice display an impairment in hippocampal long-term potentiation and spatial learning and memory The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011; 31(20): 7312-21.
Sokolow Sophie, Luu Sanh H, Headley Alison J, Hanson Alecia Y, Kim Taeree, Miller Carol A, Vinters Harry V, Gylys Karen H High levels of synaptosomal Na(+)-Ca(2+) exchangers (NCX1, NCX2, NCX3) co-localized with amyloid-beta in human cerebral cortex affected by Alzheimer’s disease Cell calcium, 2011; 49(4): 208-16.
Verwey N A, van der Flier W M, Blennow K, Clark C, Sokolow S, De Deyn P P, Galasko D, Hampel H, Hartmann T, Kapaki E, Lannfelt L, Mehta P D, Parnetti L, Petzold A, Pirttila T, Saleh L, Skinningsrud A, Swieten J C V, Verbeek M M, Wiltfang J, Younkin S, Scheltens P, Blankenstein M A A worldwide multicentre comparison of assays for cerebrospinal fluid biomarkers in Alzheimer’s disease Annals of clinical biochemistry, 2009; 46(Pt 3): 235-40.
Wehling-Henricks Michelle, Sokolow Sophie, Lee Jamie J, Myung Kyu H, Villalta S Armando, Tidball James G Major basic protein-1 promotes fibrosis of dystrophic muscle and attenuates the cellular immune response in muscular dystrophy Human molecular genetics, 2008; 17(15): 2280-92.
Ringman J M, Younkin S G, Pratico D, Seltzer W, Cole G M, Geschwind D H, Rodriguez-Agudelo Y, Schaffer B, Fein J, Sokolow S, Rosario E R, Gylys K H, Varpetian A, Medina L D, Cummings J L Biochemical markers in persons with preclinical familial Alzheimer disease Neurology, 2008; 71(2): 85-92.
Fein Jeffrey A, Sokolow Sophie, Miller Carol A, Vinters Harry V, Yang Fusheng, Cole Gregory M, Gylys Karen Hoppens Co-localization of amyloid beta and tau pathology in Alzheimer’s disease synaptosomes The American journal of pathology, 2008; 172(6): 1683-92.
Jeffs Graham J, Meloni Bruno P, Sokolow Sophie, Herchuelz Andre, Schurmans Stéphane, Knuckey Neville W NCX3 knockout mice exhibit increased hippocampal CA1 and CA2 neuronal damage compared to wild-type mice following global cerebral ischemia Experimental neurology, 2008; 210(1): 268-73.
Molinaro Pasquale, Cuomo Ornella, Pignataro Giuseppe, Boscia Francesca, Sirabella Rossana, Pannaccione Anna, Secondo Agnese, Scorziello Antonella, Adornetto Annagrazia, Gala Rosaria, Viggiano Davide, Sokolow Sophie, Herchuelz Andre, Schurmans Stèphane, Di Renzo Gianfranco, Annunziato Lucio Targeted disruption of Na+/Ca2+ exchanger 3 (NCX3) gene leads to a worsening of ischemic brain damage The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008; 28(5): 1179-84.
Sokolow Sophie, Manto Mario, Gailly Philippe, Molgó Jordi, Vandebrouck Clarisse, Vanderwinden Jean-Marie, Herchuelz Andre, Schurmans Stéphane Impaired neuromuscular transmission and skeletal muscle fiber necrosis in mice lacking Na/Ca exchanger 3 The Journal of clinical investigation, 2004; 113(2): 265-73.
Faculty Member
Professor
Department of Neurobiology
David Geffen School of Medicine
University of California, Los Angeles
501 Neuroscience Research Building
Los Angeles, CA 90095
Research Interests
Our work is directed at achieving a better understanding of the cell biology of the response to injury in the adult central nervous system. We are particularly interested in the roles played by specific cell types (e.g. astroglia) and specific molecules (e.g. growth factors and cytokines) in mediating neuroprotection, regulating inflammation and determining the capacity for regeneration. Our studies are based largely on systems-level analysis in transgenic mouse models. Specific techniques employed include microsurgery, tissue culture, grafting (also from precursor cells and genetically modified cells), immunohistochemistry, tract-tracing, quantitative morphometry, and various molecular biological techniques associated with generating, maintaining, and evaluating transgenic mice.