Posts classified under: ICLM

Austin Coley, Ph.D.

Biography

The Coley laboratory investigates neural populations and dynamics associated with depressive-like behaviors. We apply integrative approaches such as in vivo 2-photon calcium imaging to measure neural activity and population dynamics, and ex vivo electrophysiology to record synaptic properties. We utilize optogenetics techniques to selectively activate neural circuits and assess the response within specific neurons. We also use computer-based tracking systems to monitor behavioral tasks and apply machine learning methods to uncover the relationship between neural activity and behavior. Additionally, we use computational models to further understand neuronal population function in higher-order processing regions.

Publications

Coley, A.A. +, Batra, K., Delahanty, J.M., Keyes, L.R., Pamintuan, R., Ramot, A., Hagemann, J., Lee, C.R., Liu, V., Adivikolanu, H., Cressy, J., Jia, C., Massa, F., LeDuke., D., Gabir, M., Durubeh, B., Linderhof, L., Patel, R., Wichmann, R., Li, H., Fischer, K.B., Pereira, T, Tye, K.M. (2024) BioRxiv. doi.org/10.1101/2024.12.18.629202

Li, H*, Namburi, P*, Olson, J.M.*, Borio, M, Lemieux, M.E., Beyeler, A, Calhoon, G.G., Hitora-Imamura, N, Coley, A.A., Libster, A, Bal, A, Jin, X, Wang, H, Jia, C, Choudhury, S.R., Shi, X, Felix-Ortiz, A.C., De la Fuente, V, Barth, V.P., King, H.O., Izadmehr, E.M., Revanna, J.S., Batra K., Fischer, K.B., Keyes, L.R., Padilla-Coreano, N, Siciliano, C.A., McCullough, K.M., Wichmann, R, Ressler, K.J., Fiete, I.R., Zhang, F, Li, Y, Tye, K.M (2022). Neurotensin orchestrates valence assignment in the amygdala. Nature. doi: 10.1038/s41586-022-04964-y

Coley, A.A.*, Padilla-Coreano, N*, Patel, R*, Tye, K.M (2021). Valence processing in the PFC: reconciling circuit-level and systems-level views. International Review of Neurobiology. doi.org/10.1016/bs.irn.2020.12.002

McEachern, E.P.*, Coley, A.A.*, Yang, S.S., Gao W.J. (2020). “PSD-95 alters GABAergic inhibition in the medial prefrontal cortex.” Neuropharmacology. doi.org/10.1016/j.neuropharm.2020.108277

Coley, A. A. and W.-J. Gao (2019). “PSD-95 deficiency disrupts PFC-associated function and behavior during neurodevelopment.” Scientific Reports 9(1): 9486. doi: 10.1038/s41598-019-45971-w; PMCID: PMC6602948

Hill, S.A.*, Blaeser A.*, Coley, A.A., Xie Y., Shepard K.A., Harwell C., Gao W.J., Garcia A.D.R (2019). Sonic hedgehog signaling in astrocytes mediates cell-type-specific synaptic organization. eLife 8: e45545. doi: 10.7554/eLife.45545; PMCID: PMC6629371

Coley, A. A. and W.-J. Gao (2018). “PSD-95: A synaptic protein implicated in schizophrenia or autism?” Progress in Neuro-Psychopharmacology and Biological Psychiatry 82: 187-194. doi: 10.1016/j.pnpbp.2017.11.016; PMCID: PMC5801047

Yang, S.S., Li Y.C., Coley, A.A., Chamberlain L.A., Yu P., Gao W.J. (2018). Cell-type specific development of the hyperpolarization-activated current, Ih, in prefrontal cortical neurons. Frontiers in Synaptic Neuroscience 10(7): doi:10.3389/fnsyn.2018.00007; PMCID: PMC5958189

Monaco, S.A.*, Coley, A.A.*, Gao W.J (2016). The Convergence of Glutamate and GABA Dysregulation in Schizophrenia. Schizophrenia Treatment: The New Facets. Ed. Yu-Chih Shen. Book Chapter: 1. PMCID not applicable.

Coley, A.A, Ruffin, V.A, Moss, F., Hopfer, U., Boron, W.F. (2013). Immunocytochemical identification of electroneutral Na+-coupled HCO3– transporters in freshly dissociated mouse medullary raphé neurons. Neuroscience. 246:451-67. doi: 10.1016/j.neuroscience.2013.02.064

Keith Vossel

Keith Vossel’s laboratory studies mechanisms and novel treatments for seizures and associated memory loss in Alzheimer’s disease. Investigations include cell and molecular, neural network, and behavior relationships in mouse models of Alzheimer’s disease and related dementias, and bridges bench discoveries with human clinical trials.

Recent Publications

  • Johnson, EL, Krauss GL, Kucharska-Newton A, Albert MS, Brandt J, Walker KA, Yasar S, Knopman DS, Vossel K, Gottesman RF. Dementia in late-onset epilepsy: the Atherosclerosis Risk in Communities study. Neurology 2020. In Press.
  • Peters ST, Fahrenkopf A, Choquette JM, Vermilyea S, Lee MK, Vossel K. Ablating tau reduces hyperexcitability and moderates electroencephalographic slowing in transgenic mice expressing A53T human α-synuclein. Frontiers in Neurology 2020, 11:563. doi: 10.3389/fneur.2020.00563.
  • Ranasinghe KG, Cha J, Hinkley LB, Beagle AJ, Jagust W, Miller BL, Rankin KP, Rabinovici GD, Vossel KA, Nagarajan SS. Neurophysiological signatures in Alzheimer’s disease are distinctly associated with tau, amyloid-beta accumulation, and cognitive decline. Science Translational Medicine 2020. doi: 10.1126/scitranslmed.aaz4069.
  • Vossel KA, Tartaglia MC, Nygaard HB, Zeman AZ, Miller BL. Epileptic activity in Alzheimer’s disease: causes and clinical relevance. The Lancet Neurology 2017, 16:311-322.
  • Beagle AJ, Darwish SM, Ranasinghe KG, La AL, Karageorgiou E, Vossel KA. Relative incidence of seizures and myoclonus in Alzheimer’s disease, dementia with Lewy bodies, and frontotemporal dementia. Journal of Alzheimer’s Disease 2017, 60:211-223. doi: 10.3233/JAD-170031.
  • Vossel KA, Ranasinghe KG, Beagle AJ, Mizuiri D, Honma SM, Dowling AF, Darwish SM, Barnes DE, Mantle M, Roberson ED, Miller BL, Garcia PA, Kirsch HE, Mucke L, Nagarajan SS. Incidence and impact of subclinical epileptiform activity in Alzheimer’s disease. Annals of Neurology 2016, 80:858-870. doi: 10.1002/ana.24794.
  • Vossel KA, Xu JC, Fomenko V, Miyamoto T, Suberbielle E, Knox JA, Ho K, Yu G, Mucke L. Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β. The Journal of Cell Biology 2015, 209:419-433. doi: 10.1083/jcb.201407065.
  • Ranasinghe KG, Hinkley LB, Beagle AJ, Mizuiri D, Dowling AF, Honma SM, Finucane MM, Scherling C, Miller BL, Nagarajan SS, Vossel KA. Regional functional connectivity predicts distinct cognitive impairments in Alzheimer’s disease spectrum. NeuroImage Clinical 2014, 5:385–395. doi: 10.1016/j.nicl.2014.07.006.
  • Vossel KA, Beagle AJ, Rabinovici GD, Shu H, Lee SE, Naasan G, Hegde M, Cornes SB, Henry ML, Nelson AB, Seeley WW, Geschwind MD, Gorno-Tempini ML, Shih T, Kirsch HE, Garcia PA, Miller BL, Mucke L. Seizures and epileptiform activity in the early stages of Alzheimer disease. JAMA Neurology 2013, 70:1158-66. doi: 10.1001/jamaneurol.2013.136.
  • Vossel KA, Zhang K, Brodbeck J, Daub AC, Sharma P, Finkbeiner S, Cui B, Mucke L. Tau reduction prevents Aβ-induced defects in axonal transport. Science 2010, 330:198. doi: 10.1126/science.1194653.

Daniel Aharoni

Dr. Daniel Aharoni has a background in equipment design, test and measurement systems, data analysis, and product development. His work focuses on bridging the gap between specialized tool design and the intricacies of modern neuroscience. By applying design methodologies from engineering and physics, the Aharoni laboratory develops specialized neuroscience research devices to addresses open questions in the field. This group leads the development of the UCLA Miniscope project and builds other tools with an emphasis on i) neural recording techniques for freely behaving animals and ii) open-source dissemination of novel technology. Through innovation and optimization, this work aims to extend the reach of neuroscience and train the next generation of research driven tool developers.

Recent Publications:

  • Skocek*, O.; Nobauer*, T.; Weilguny, L.; Traub, F. M.; Xia, C. N.; Molodtsov, M. I.; Grama, A.; Yamagata, M.; Aharoni, D.; Cox, D. D.; Golshani, P.; Vaziri, A.; “High-speed volumetric imaging of neuronal activity in freely moving rodent”, Nature Methods, Forthcoming, 2018
  • Cai*, D. J.; Aharoni*, D.; Shuman*, T.; Shobe*, J.; Biane, J.; Song, W.; Wei, B.; Veshkini, M.; La-Vu, M.; Lou, J.; Flores, S. E.; Kim, I.; Sano, Y.; Zhou, M.; Baumgaertel, K.; Lavi, A.; Kamata, M.; Tuszynski, M.; Mayford, M.; Golshani, P.; Silva, A. J.; “A shared neural ensemble links distinct contextual memories encoded close in time”, Nature, Volume 534, Issue 7605, May 2016
  • Shtrhman, M.; Aharoni, D.; Hardy, N. F.; Buonomano, D. V.; Arisaka, K.; Otis, T. S.; “Multifocal Fluorescence Microscope for Fast Optical Recordings of Neuronal Action Potentials”, Biophysical Journal, Volume 108, Issue 3, February 2015
  • Cushman*, J. D.; Aharoni*, D.; Willers, B.; Ravassard, P.; Kees, A.; Vuong, B.; Arisaka, K.; Mehta, M. R.; “Multisensory control of multimodal behavior”, PLoS ONE, Volume 8, Issue 11, June 2013