Posts classified under: Neurogenetics

Xiangdong William Yang, M.D., Ph.D.

Faculty Member

Professor in Residence
Department of Psychiatry & Biobehavioral Sciences
David Geffen School of Medicine
University of California, Los Angeles

 

Gonda Neuroscience & Genetics Research Center
695 Charles Young Drive,
Los Angeles, CA 90095
Lab: 3309
Office: 3506B

 

Biography

Dr. X. William Yang is a professor in the Department of Psychiatry & Biobehavioral Sciences at David Geffen School of Medicine at UCLA. He is also a member of the Center for Neurobehavioral Genetics at Semel Institute for Neuroscience & Human Behaviors, and a member of the Brain Research Institute at UCLA. He has served as a regular member at the NIH’s Cell Death in Neurodegeneration (CDIN) Study Section, a Scientific Advisory Board member of the Hereditary Disease Foundation, and a faculty member for Faculty 1000 Medicine?s Neurogenetics Section. William grew up in Tianjin, China. He obtained a combined M.S. and B.S. degrees with summa cum laude from Molecular Biophysics & Biochemistry Department at Yale University in 1991. He received Ph.D. in Molecular Genetics and Neuroscience from Rockefeller University in 1998. During his PhD thesis research with Dr. Nathaniel Heintz, William co-invented (together with Nat Heintz and Peter Model) the first recombineering technology to modify large pieces of DNA called Bacterial Artificial Chromosomes (BACs) and to generate BAC transgenic mice. The BAC transgenic technology is now a widely-used tool to generate transgenic animals for analyses of gene expression and gene function, and for modeling human diseases. After obtaining his Ph.D. degree, William went on to complete his M.D. training from Weill Medical College of Cornell University in 2000, and his Medicine Internship at New York-Presbyterian Hospital in 2001. After a brief postdoctoral training with Nat Heintz at Rockefeller University, William joined UCLA as an Assistant Professor in Dept. of Psychiatry in 2002.

S. Lawrence Zipursky, Ph.D.

Faculty Member

Distinguished Professor
Department of Biological Chemistry
David Geffen School of Medicine
University of California, Los Angeles

 

MacDonald Research Laboratories
675 Charles E. Young Dr. South
Los Angeles, CA 90095

Lab: 5619, 5629
Office: 5784

Jessica Rexach, M.D., Ph.D.

Faculty Member

Assistant Professor
Department of Neurology
David Geffen School of Medicine
University of California, Los Angeles

 

UCLA Neurology
P.O. Box 951769, GONDA 2309
Los Angeles, CA 90095-1769

 

Research Interests

New therapeutic targets are needed for neurodegenerative disease including Alzheimer’s and related dementias. The immune system includes many of the most successful therapeutic targets in medicine. My research lab seeks to uncover mechanism by which glia and immune factors influence disease pathology in dementia to inform novel therapeutic strategies. We integrate single cell and tissue transcriptomics, epigenetic profiling, human genetics, and stem cell-based experimental models to identify neuroimmune regulators of dementia. A major focus of our current work is the interplay of glial immune signaling and neuronal dysfunction in dementia, including the role of interferon-mediated immune suppression in disease pathology.

In addition to this basic research, I am an attending at the UCLA Neurogenetics clinic where we apply advanced genomics technologies to the molecular diagnosis of adult-onset genetic diseases, including inherited neurodegenerative disorders.