Posts classified under: TNT Internal Advisory Board

Dr. Nader Pouratian

Professor of Neurosurgery, Bioengineering, Neuroscience, and Radiation Oncology Bioegineering, cofounder of TNT

Wentai Liu, Ph.D.

Publications

A selected list of publications:

M. Chae, Z. Yang, W. Liu   A 128-Channel 6mW Wireless Neural Recording IC with On-the-fly Spike Sorting and UWB transmitter, IEEE Trans. on Neural Engineering and Rehabilitation Engineering, ; 14(9): 2009.
Xu, X. Wu, K. Islam, X. Huang, M. Je, W. Liu, and Z. Yang   A New System Architecture for Future Long-Term High-Density Neural Recording, IEEE Trans. On Biomedical Engineering, 2012; .
W. Liu, et al.   An experimental platform for retinal prosthesis – system perspective and performance evaluation, IEEE Trans. on Biomedical Circuits and Systems, 2012; .
G. Wang, P. Wang, Y. Tang, and W. Liu   Analysis of dual band power and data telemetry for biomedical implants, IEEE Trans. on Biomedical Circuits and Systems, 2012; .
Z. Yang, M. Keshtkaran, Y. Zhou, J. Xu, V. Pikov, C. Guan, and W. Liu   Threshold Estimation for In-Vivo Neural Spike Detection, Journal of Neural Engineering, 2012; .
Z. Yang, E. Keefer, Q. Zhao, L. Hoang, and W. Liu   1/f Neural Noise Reduction and Spike Feature Extraction using a Subset of Informative Samples, Annals of Biomedical Engineering, 2011; 39(4): 1264-1277.
K. Huang, Y. Zhou, X. Wu, W. Liu, and Zhi Yang   Design and Optimization of Inductive Power Link for Biomedical Applications, Intech, 2011; .
K. Chen, Z. Yang, L. Hoang, J. Weiland, M. Humayun and W. Liu   An Integrated 256-channel Epiretinal Prosthesis, IEEE J. of Solid State Circuits, 2010; 45(9): .
Z. Yang, Q. Zhao, E. Keefer and W. Liu   Noise Characterization, Modeling, and Reduction for In Vivo Neural Recording, Advances in Neural Information Processing Systems , 2010; 2160-2168.
E. Basham, Z. Yang, and W. Liu   Circuit and Coil Design for In Vitro Magnetic Neural Stimulation Systems, IEEE Transactions on Biomedical Circuits and Systems (TBCAS), 2009; 3: 321-331.
Z. Yang, Q. Zhao and W. Liu   Improving Spike Separation Using Waveform Derivative, Journal of Neural Engineering, 2009; 6(4): .
A. Rosen, W. Liu, and M. Tohgi   MTT Special Issue on RF and Microwave Techniques for Wireless Implants and Biomedical Applications: Guest Editorial, IEEE Trans. on Microwave Theory and Techniques, 2009; 57(9): .
Z. Yang, Q. Zhao and W. Liu   Neural Signal Classification Using a Simplified Feature Set with Energy Based Non-parametric Clustering, Neurocomputing, 2009; 73: 412-422.
Z. Yang, Q. Zhao and W. Liu   Spike Feature Extraction Using Informative Samples, Spotlight presentation, Advances in Neural Information Processing Systems (NIPS21), 2009; 1865-1872.
M. Zhou and W. Liu   A Non-Coherent DPSK Data Receiver with Interference Cancellation for Dual-Band Transcutaneous Telemetries, IEEE Journal of Solid-State Circuits, 2008; .
M. Chae, and W. Liu,   Design Optimization for Integrated Neural Recording Systems, IEEE Journal of Solid-State Circuits, 2008; .
W. Liu, M. Humayun, and M. Liker   Implantable Biomimetic Microelectronics Systems, IEEE Proceedings, 2008; 96(7): 1073-1075.
W. Liu, M. Humayun, and M. Liker   Special Issue on Implantable Biomimetic Microelectronics Systems: Guest Editorial, Proceeding of IEEE, 2008; 96(7): .
K. Cockerham, W. Liu, L. Crow, M. Sivaprakasam, A. Olmos, M. Oehleberg, O. Pantchenko and S. Aro,   The Application of Nano-Technology and Engineering in Medicine: A New Paradigm for Facial Muscle Reanimation, Expert Review of Medical Devices, 2008; .
K. Cockerham, W. Liu, L. Crow, M. Sivaprakasam, A. Olmos, M. Oehleberg, O. Pantchenko and S. Aro,   The Application of Nano-Technology and Engineering in Medicine: A New Paradigm for Facial Muscle Reanimation, Expert Review of Medical Devices, 2008; .
M. R. Yuce and W. Liu   Design and performance of a wideband sub-sampling front-ends for multi-standard software radios, International Journal of Electronics and Communications Elsevier, 2007; .
Z.Yang, W. Liu and E. Basham   Optimization of Coils for Biomedical Applications,”, IEEE Transactions on Magnetics, 2007; 43: 3851-3860.
M. R. Yuce, W. Liu, J. Damiano, B. Bharat, P. D. Franzon and N. S. Dogan   SOI CMOS implementation of a multirate PSK receiver for space communications, IEEE Transactions on Circuits and Systems I, 2007; .
R. Bashirullah, W. Liu, and R. Cavin   A 16Gb/s Adaptive Bandwidth Bus Based on Hybrid Current/Voltage Mode Signaling Repeaters, IEEE Journal of Solid-State Circuits, 2006; 41: 461-473.
W. Liu and M. Sivaprakasam   IC Technology Challenges for Implantable Devices, Future Fab International, 2006; 20: 17-19.
M. Sivaprakasam, W. Liu, M. S. Humayun, and J. D. Weiland   A Variable Range Bi-Phasic Current Stimulus Driver Circuitry for an Implantable Retinal Prosthetic Device, IEEE Journal of Solid-State Circuit, 2005; 40: 763 – 771.
M. Yuce, W. Liu   A low power multirate DPSK receiver for space applications, IEEE Transactions on Vehicular Technology, 2005; 54(2074-2084): .
G. A. Kendir, W. Liu, G. Wang, M. Sivaprakasam, R. Bashirullah, M. S. Humayun, and J. D. Weiland   An Optimal Design Methodology for Inductive Power Link with Class-E Amplifier, IEEE Transactions on Circuits and Systems – I, 2005; 52: 857 – 866.
M. Sivaprakasam, W. Liu, G. Wang, J. D. Weiland, and M. S. Humayun   Architecture Tradeoffs in High Density Microstimulators for Retinal Prosthesis, IEEE Transactions on Circuits and Systems – I, Special Issue on Biomedical Circuits and Systems, 2005; 52: 2629-2641.
M. Sivaprakasam, W. Liu, G. Wang, J. D. Weiland, and M. S. Humayun   Architecture Tradeoffs in High Density Microstimulators for Retinal Prosthesis, IEEE Transactions on Circuits and Systems – I, Special Issue on Biomedical Circuits and Systems, 2005; 52: 2629-2641.
G. Wang, W. Liu, M. Sivaprakasam, and G. A. Kendir   Design and Analysis of an Adaptive Transcutaneous Power Telemetry for Biomedical Implants, IEEE Transactions on Circuits and Systems – I, 2005; 52: 857-866.
W. Liu, M. Sivaprakasam, G. Wang, M. Zhou, J. Granacki, J. LaCoss, J. Wills   Microelectronics Design for Implantable Wireless Biomimetic Microelectronic Systems, IEEE Engineering in Medicine and Biology Magazine, 2005; 24: 66 – 74.
J. D. Weiland, W. Liu and M. Humayun   Retinal Prosthesis, Annual Review of Biomedical Engineering, 2005; 7: .
R. Bashirullah, W. Liu, R. Cavin, and D. Edwards   “A Hybrid Current/Voltage Mode On-Chip Signaling Scheme With Adaptive Bandwidth Capability, IEEE Transactions on Very Large Scale Integration (VLSI) Systems, 2004; 12: 876-880.
S. DeMarco, W. Liu, P. R. Singh, G. Lazzi, M. Humayun, J. Weiland   An Arbitrary Waveform Stimulus Circuit for Visual Prostheses using a Low Area Multibias DAC, IEEE Journal of Solid State Circuits, 2003; .
S. C. Demarco, G. Lazzi, W. Liu, J. D. Weiland, and M. S. Humayun   Computed SAR and Thermal Elevation in a 0.25-mm 2-D Model of the Human Eye and Head in Response to an Implanted Retinal Stimulator – Part I: Models and Methods, IEEE Transactions on Antennas and Propagation, 2003; 51: 2274-2285.
S. C. Demarco, G. Lazzi, W. Liu, J. D. Weiland, and M. S. Humayun,   Computed SAR and Thermal Elevation in a 0.25-mm 2-D Model of the Human Eye and Head in Response to an Implanted Retinal Stimulator – Part II: Models and Methods, IEEE Transactions on Antennas and Propagation, 2003; 51: 2286-2295.
R. Bashirullah, W. Liu, and R. Cavin III   Current-Mode Signaling in Deep Submicron Global Interconnects, IEEE Transactions on Very Large Scale Integration (VLSI) Systems, 2003; 11: 406-417.
W. Liu, M. Sivaprakasam, P. R. Singh, R. Bashirullah, and G. Wang   Electronic Visual Prostheses, Artificial Organs, 2003; 27: 986-995.
R. Bashirullah, W. Liu   Raised Cosine Approximation Signaling for Reduced Noise Cross-talk, IEEE Electronic Letters, 2002; 38(21): 1256-1258.
E. Margalit, M. Maia, J. Weiland, R. Greenberg, G. Fujii , G. Torres, D. Piyathaisere, T. O’Hearn, W. Liu, G. Lazzi, G. Dagnelie, D. Scribner, E. de Juan Jr, M. Humayun   Retinal Prosthesis for the Blind, Survey of Opthalmology, 2002; 47(4): 335-356.

Gina Poe, Ph.D.

Biography

Gina Poe has been working since 1995 on the mechanisms through which sleep serves memory consolidation and restructuring. Dr. Poe is a southern California native who graduated from Stanford University then worked for two post-baccalaureate years at the VA researching Air Force Test Pilots’ brainwave signatures under high-G maneuvers. She then earned her PhD in Basic Sleep in the Neuroscience Interdepartmental Program at UCLA under the guidance of Ronald Harper then moved to the University of Arizona for her postdoctoral studies with Carol Barnes and Bruce McNaughtons looking at graceful degradation of hippocampal function in aged rats as well as hippocampal coding in a 3-D maze navigated in the 1998 space shuttle mission. She brought these multiunit teachings to answer a burning question of whether REM sleep were for remembering or forgetting and found that activity of neurons during REM sleep is consistent both with the consolidation of novel memories and the elimination of already consolidated memories from the hippocampus, readying the associative memory network for new learning the next day. Moving first to Washington State University then to the University of Michigan before joining UCLA in 2016, Poe has over 80 undergraduates, 6 graduate students, and 6 postdoctoral scholars, and has served in university faculty governance as well as leading 5 different programs designed to diversify the neuroscience workforce and increase representation of people of the global majority in the STEM fields. At UCLA she continues research and teaching and Directs the COMPASS-Life Sciences and BRI-SURE programs and co-Directs the MARC-U*STAR program. Nationally she is course director of the Marine Biological Lab’s SPINES course and co-Directs the Society for Neuroscience’s NSP program which earned the nation’s highest mentoring honor in 2018. These programs have served over 600 PhD level trainees over the years.

Research Interests

The Poe lab investigates the mechanisms by which sleep traits serve learning and memory consolidation. Memories are encoded by the pattern of synaptic connections between neurons. We employ tetrode recording and optogenetic techniques in learning animals to see how neural patterns underlying learning are reactivated during sleep, and how activity during sleep influences the neural memory code. Both strengthening and weakening of synapses is important to the process of sculpting a network when we make new memories and integrate them into old schema. Results from our studies suggest that while synaptic strengthening can be efficiently accomplished during the waking learning process, the synaptic weakening part of memory integration requires conditions unique to sleep. The absence of noradrenaline during sleep spindles and REM sleep as well as the low levels of serotonin during REM sleep allow the brain to integrate new memories and to refresh and renew old synapses so that we are ready to build new associations the next waking period. Memory difficulties involved in post-traumatic stress disorder, Schizophrenia, Alzheimer’s disease and even autism involve abnormalities in the sleep-dependent memory consolidation process that my lab studies. Keywords: Sleep, learning and memory, PTSD, memory consolidation, reconsolidation, REM sleep, sleep spindles, Norepinephrine, LTP, depotentiation, reversal learning, optogenetics, electrophysiology, tetrode recordings, hippocampus, prefrontal cortex.

Education

B.A., Human Biology, Stanford University 1987
Ph.D., Neuroscience, University of California, Los Angeles 1995

Selected Publications

Cabrera Y, Holloway J, Poe GR (2020) ‘Sleep Changes Across the Female Hormonal Cycle Affecting Memory: Implications for Resilient Adaptation to Traumatic Experiences.’ J Womens Health (Larchmt), 29 (3): 446-451. PMID: 32186966

Swift KM, Keus K, Echeverria CG, Cabrera Y, Jimenez J, Holloway J, Clawson BC, Poe GR () ‘Sex differences within sleep in gonadally-intact rats.’ Sleep, 2019.PMID: 31784755

Swift KM, Gross BA, Frazer MA, Bauer DS, Clark KJD, Vazey EM, Aston-Jones G, Li Y, Pickering AE, Sara SJ, Poe GR (2018) ‘Abnormal Locus Coeruleus Sleep Activity Alters Sleep Signatures of Memory Consolidation and Impairs Place Cell Stability and Spatial Memory.’ Curr Biol, 28 (22): 3599-3609.e4. PMID: 30393040

Zaborszky L, Gombkoto P, Varsanyi P, Poe GR, Role L, Ananth M, Rajebhosale P, Talmage D, Hasselmo M, Dannenberg H, Minces V, Chiba A, “Specific basal forebrain-cortical cholinergic circuits coordinate cognitive operations”, J Neurosci, 38 (44): 9446-9458 (2018).

Lewis P, Knoblich G, Poe GR, “Recasting reality: how memory replay in sleep boosts creative problem solving”, Trends Cogni Sci, 22 (6): 491-503 (2018).

Bjorness TE, Booth V, Poe GR (2018) ‘Hippocampal theta power pressure builds over non-REM sleep and dissipates within REM sleep episodes.’ Arch Ital Biol, 156 (3): 112-126. PMID: 30324607

Poe GR (2017) ‘Sleep Is for Forgetting.’ J Neurosci, 37 (3): 464-473. PMID: 28100731

Javanbakht, A and Poe, GR, “Behavioral neuroscience of circuits involved in arousal regulation”, The Neurobiology of PTSD, Ressler, K and Liberzon, I(Eds.), 130-147 (2016).

Emrick JJ, Gross BA, Riley BT, Poe GR (2016) ‘Different Simultaneous Sleep States in the Hippocampus and Neocortex.’ Sleep, 39 (12): 2201-2209. PMID: 27748240

Vanderheyden WM, George SA, Urpa L, Kehoe M, Liberzon I, Poe GR (2015) ‘Sleep alterations following exposure to stress predict fear-associated memory impairments in a rodent model of PTSD.’ Exp Brain Res, 233 (8): 2335-46. PMID: 26019008.

Watts A, Gritton HJ, Sweigart J, Poe GR (2012) ‘Antidepressant suppression of non-REM sleep spindles and REM sleep impairs hippocampus-dependent learning while augmenting striatum-dependent learning.’ J Neurosci, 32 (39): 13411-20. PMID: 23015432

Booth V, Poe GR (2006) ‘Input source and strength influences overall firing phase of model hippocampal CA1 pyramidal cells during theta: relevance to REM sleep reactivation and memory consolidation.’ Hippocampus, 16 (2): 161-73. PMID: 16411243