Allan Mackenzie-Graham, Ph.D.

Assistant Professor In-Residence, Neurology, Neuroscience GPB Home Area Physics & Biology in Medicine GPB Home Area

0000-0001-9966-2335

amg@ucla.edu

710 Westwood Plaza, 4256
Los Angeles, CA 90095
UNITED STATES

Publications

Gray B, Smith AW, MacKenzie-Graham A, Shattuck DW, Tward DJ. Validation of structure tensor analysis for orientation estimation in brain tissue microscopy.. Journal of neuroscience methods, 2025.
Jansen MI, Hrncir H, MacKenzie-Graham A, Waschek JA, Brinkman J, Bradfield LA, Withana M, Musumeci G, D'Agata V, Castorina A. Neuronal PAC1 deletion impairs structural plasticity.. Life sciences, 2025.
Gray B, Smith A, MacKenzie-Graham A, Shattuck DW, Tward D. Validation of Structure Tensor Analysis for Orientation Estimation in Brain Tissue Microscopy.. bioRxiv : the preprint server for biology, 2025.
Kim Y, Hrncir H, Meyer CE, Tabbaa M, Moats RA, Levitt P, Harris NG, MacKenzie-Graham A, Shattuck DW. Mouse Brain Extractor: Brain segmentation of mouse MRI using global positional encoding and SwinUNETR.. bioRxiv : the preprint server for biology, 2024.
Itoh N, Itoh Y, Meyer CE, Suen TT, Cortez-Delgado D, Rivera Lomeli M, Wendin S, Somepalli SS, Golden LC, MacKenzie-Graham A, Voskuhl RR. Estrogen receptor beta in astrocytes modulates cognitive function in mid-age female mice.. Nature communications, 2023.
Meyer CE, Smith AW, Padilla-Requerey AA, Farkhondeh V, Itoh N, Itoh Y, Gao JL, Herbig PD, Nguyen Q, Ngo KH, Oberoi MR, Siddarth P, Voskuhl RR, MacKenzie-Graham A. Neuroprotection in Cerebral Cortex Induced by the Pregnancy Hormone Estriol.. Laboratory investigation; a journal of technical methods and pathology, 2023.
Ago Y, Van C, Condro MC, Hrncir H, Diep AL, Rajbhandari AK, Fanselow MS, Hashimoto H, MacKenzie-Graham AJ, Waschek JA. Overexpression of VIPR2 in mice results in microencephaly with paradoxical increased white matter volume.. Experimental neurology, 2023.
Guma E, Beauchamp A, Liu S, Levitis E, Clasen LS, Torres E, Blumenthal J, Lalonde F, Qiu LR, Hrncir H, MacKenzie-Graham A, Yang X, Arnold AP, Lerch JP, Raznahan A. A Cross-Species Neuroimaging Study of Sex Chromosome Dosage Effects on Human and Mouse Brain Anatomy.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023.
Voskuhl RR, MacKenzie-Graham A. Chronic experimental autoimmune encephalomyelitis is an excellent model to study neuroaxonal degeneration in multiple sclerosis.. Frontiers in molecular neuroscience, 2022.
Voskuhl R, Kuhle J, Siddarth P, Itoh N, Patel K, MacKenzie-Graham A. Decreased neurofilament light chain levels in estriol-treated multiple sclerosis.. Annals of clinical and translational neurology, 2022.
Van C, Condro MC, Ko HH, Hoang AQ, Zhu R, Lov K, Ricaflanca PT, Diep AL, Nguyen NNM, Lipshutz GS, MacKenzie-Graham A, Waschek JA. Targeted deletion of PAC1 receptors in retinal neurons enhances neuron loss and axonopathy in a model of multiple sclerosis and optic neuritis.. Neurobiology of disease, 2021.
Voskuhl RR, Patel K, Paul F, Gold SM, Scheel M, Kuchling J, Cooper G, Asseyer S, Chien C, Brandt AU, Meyer CE, MacKenzie-Graham A. Sex differences in brain atrophy in multiple sclerosis.. Biology of sex differences, 2020.
Hayden EY, Putman J, Nunez S, Shin WS, Oberoi M, Charreton M, Dutta S, Li Z, Komuro Y, Joy MT, Bitan G, MacKenzie-Graham A, Jiang L, Hinman JD. Ischemic axonal injury up-regulates MARK4 in cortical neurons and primes tau phosphorylation and aggregation.. Acta neuropathologica communications, 2019.
Meyer CE, Gao JL, Cheng JY, Oberoi MR, Johnsonbaugh H, Lepore S, Kurth F, Thurston MJ, Itoh N, Patel KR, Voskuhl RR, MacKenzie-Graham A. Axonal damage in spinal cord is associated with gray matter atrophy in sensorimotor cortex in experimental autoimmune encephalomyelitis.. Multiple sclerosis (Houndmills, Basingstoke, England), 2019.
MacKenzie-Graham A, Brook J, Kurth F, Itoh Y, Meyer C, Montag MJ, Wang HJ, Elashoff R, Voskuhl RR. Estriol-mediated neuroprotection in multiple sclerosis localized by voxel-based morphometry.. Brain and behavior, 2018.
Meyer CE, Kurth F, Lepore S, Gao JL, Johnsonbaugh H, Oberoi MR, Sawiak SJ, MacKenzie-Graham A. In vivo magnetic resonance images reveal neuroanatomical sex differences through the application of voxel-based morphometry in C57BL/6 mice.. NeuroImage, 2017.
Reinig MR, Novak SW, Tao X, Bentolila LA, Roberts DG, MacKenzie-Graham A, Godshalk SE, Raven MA, Knowles DW, Kubby J. Enhancing image quality in cleared tissue with adaptive optics.. Journal of biomedical optics, 2016.
Itoh N, Kim R, Peng M, DiFilippo E, Johnsonbaugh H, MacKenzie-Graham A, Voskuhl RR. Bedside to bench to bedside research: Estrogen receptor beta ligand as a candidate neuroprotective treatment for multiple sclerosis.. Journal of neuroimmunology, 2016.
MacKenzie-Graham A, Kurth F, Itoh Y, Wang HJ, Montag MJ, Elashoff R, Voskuhl RR. Disability-Specific Atlases of Gray Matter Loss in Relapsing-Remitting Multiple Sclerosis.. JAMA neurology, 2016.
Roberts DG, Johnsonbaugh HB, Spence RD, MacKenzie-Graham A. Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY.. Journal of visualized experiments : JoVE, 2016.
Voskuhl RR, Wang H, Wu TC, Sicotte NL, Nakamura K, Kurth F, Itoh N, Bardens J, Bernard JT, Corboy JR, Cross AH, Dhib-Jalbut S, Ford CC, Frohman EM, Giesser B, Jacobs D, Kasper LH, Lynch S, Parry G, Racke MK, Reder AT, Rose J, Wingerchuk DM, MacKenzie-Graham AJ, Arnold DL, Tseng CH, Elashoff R. Estriol combined with glatiramer acetate for women with relapsing-remitting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial.. The Lancet. Neurology, 2015.
Spence RD, Kurth F, Itoh N, Mongerson CR, Wailes SH, Peng MS, MacKenzie-Graham AJ. Bringing CLARITY to gray matter atrophy.. NeuroImage, 2014.
Kurth F, MacKenzie-Graham A, Toga AW, Luders E. Shifting brain asymmetry: the link between meditation and structural lateralization.. Social cognitive and affective neuroscience, 2014.
Kurth F, Luders E, Sicotte NL, Gaser C, Giesser BS, Swerdloff RS, Montag MJ, Voskuhl RR, Mackenzie-Graham A. Neuroprotective effects of testosterone treatment in men with multiple sclerosis.. NeuroImage. Clinical, 2014.
Mackenzie-Graham A. In vivo vs. ex vivo Magnetic Resonance Imaging In Mice.. Frontiers in neuroinformatics, 2012.
MacKenzie-Graham AJ, Rinek GA, Avedisian A, Morales LB, Umeda E, Boulat B, Jacobs RE, Toga AW, Voskuhl RR. Estrogen treatment prevents gray matter atrophy in experimental autoimmune encephalomyelitis.. Journal of neuroscience research, 2012.
MacKenzie-Graham A, Rinek GA, Avedisian A, Gold SM, Frew AJ, Aguilar C, Lin DR, Umeda E, Voskuhl RR, Alger JR. Cortical atrophy in experimental autoimmune encephalomyelitis: in vivo imaging.. NeuroImage, 2011.
Dinov ID, Van Horn JD, Lozev KM, Magsipoc R, Petrosyan P, Liu Z, Mackenzie-Graham A, Eggert P, Parker DS, Toga AW. Efficient, Distributed and Interactive Neuroimaging Data Analysis Using the LONI Pipeline.. Frontiers in neuroinformatics, 2009.
MacKenzie-Graham A, Tiwari-Woodruff SK, Sharma G, Aguilar C, Vo KT, Strickland LV, Morales L, Fubara B, Martin M, Jacobs RE, Johnson GA, Toga AW, Voskuhl RR. Purkinje cell loss in experimental autoimmune encephalomyelitis.. NeuroImage, 2009.
Mackenzie-Graham AJ, Van Horn JD, Woods RP, Crawford KL, Toga AW. Provenance in neuroimaging.. NeuroImage, 2008.
MacKenzie-Graham A, Boline J, Toga AW. Brain atlases and neuroanatomic imaging.. Methods in molecular biology (Clifton, N.J.), 2007.
Mackenzie-Graham AJ, Lee EF, Dinov ID, Yuan H, Jacobs RE, Toga AW. Multimodal, multidimensional models of mouse brain.. Epilepsia, 2007.
MacKenzie-Graham A, Tinsley MR, Shah KP, Aguilar C, Strickland LV, Boline J, Martin M, Morales L, Shattuck DW, Jacobs RE, Voskuhl RR, Toga AW. Cerebellar cortical atrophy in experimental autoimmune encephalomyelitis.. NeuroImage, 2006.
Dinov ID, Valentino D, Shin BC, Konstantinidis F, Hu G, MacKenzie-Graham A, Lee EF, Shattuck D, Ma J, Schwartz C, Toga AW. LONI visualization environment.. Journal of digital imaging, 2006.
MacKenzie-Graham A, Lee EF, Dinov ID, Bota M, Shattuck DW, Ruffins S, Yuan H, Konstantinidis F, Pitiot A, Ding Y, Hu G, Jacobs RE, Toga AW. A multimodal, multidimensional atlas of the C57BL/6J mouse brain.. Journal of anatomy, 2004.
MacKenzie-Graham A, Jones ES, Shattuck DW, Dinov ID, Bota M, Toga AW. The informatics of a C57BL/6J mouse brain atlas.. Neuroinformatics, 2003.
Liu H, MacKenzie-Graham AJ, Palaszynski K, Liva S, Voskuhl RR. "Classic" myelin basic proteins are expressed in lymphoid tissue macrophages.. Journal of neuroimmunology, 2001.
Liu H, MacKenzie-Graham AJ, Kim S, Voskuhl RR. Mice resistant to experimental autoimmune encephalomyelitis have increased thymic expression of myelin basic protein and increased MBP specific T cell tolerance.. Journal of neuroimmunology, 2001.
Kahn MA, Dopp JM, Liva S, MacKenzie-Graham AJ, Chang R, Huang A, Nazarian R, Dell'Albani P, Condorelli D, Voskuhl RR, de Vellis J. Temporal kinetics and cellular phenotype of TNF p55/p75 receptors in experimental allergic encephalomyelitis.. Journal of neuroimmunology, 1999.
MacKenzie-Graham AJ, Pribyl TM, Kim S, Porter VR, Campagnoni AT, Voskuhl RR. Myelin protein expression is increased in lymph nodes of mice with relapsing experimental autoimmune encephalomyelitis.. Journal of immunology (Baltimore, Md. : 1950), 1997.
Merrill JE, Murphy SP, Mitrovic B, Mackenzie-Graham A, Dopp JC, Ding M, Griscavage J, Ignarro LJ, Lowenstein CJ. Inducible nitric oxide synthase and nitric oxide production by oligodendrocytes.. Journal of neuroscience research, 1997.
Dopp JM, Mackenzie-Graham A, Otero GC, Merrill JE. Differential expression, cytokine modulation, and specific functions of type-1 and type-2 tumor necrosis factor receptors in rat glia.. Journal of neuroimmunology, 1997.
Voskuhl RR, Pitchekian-Halabi H, MacKenzie-Graham A, McFarland HF, Raine CS. Gender differences in autoimmune demyelination in the mouse: implications for multiple sclerosis.. Annals of neurology, 1996.
Mitrovic B, St Pierre BA, Mackenzie-Graham AJ, Merrill JE. The role of nitric oxide in glial pathology.. Annals of the New York Academy of Sciences, 1994.
Mackenzie-Graham AJ, Mitrovic B, Smoll A, Merrill JE. Differential sensitivity to nitric oxide in immortalized, cloned murine oligodendrocyte cell lines.. Developmental neuroscience, 1994.