Andrew Charles, M.D.

Director, UCLA Goldberg Migraine Program Professor, Meyer and Renee Luskin Chair in Migraine and Headache Studies, Neurology Hatos Center for Neuropharmacology Member, Brain Research Institute

(310) 206-7226

635 Charles Young Drive
Los Angeles, CA 90095
UNITED STATES

Publications

Jensen RH, Tassorelli C, Tepper SJ, Charles A, Goadsby PJ, Snoer AH, Sperling B, Krog Josiassen M, Borgen Linander C, Ettrup A, Boneva N. Efficacy and Safety of Eptinezumab in Episodic Cluster Headache: A Randomized Clinical Trial.. JAMA neurology, 2025.
Tassorelli C, Jensen RH, Goadsby PJ, Charles AC, Tepper SJ, Snoer AH, Josiassen MK, Linander CB, Ettrup A, Sperling B, Boneva N. Long-term safety, tolerability, and efficacy of eptinezumab in chronic cluster headache (CHRONICLE): an open-label safety trial.. The Lancet. Neurology, 2025.
Charles AC, Goadsby PJ. The cortical spreading depression/migraine aura hypothesis - Finally some definitive evidence.. Headache, 2025.
Schwedt TJ, Pradhan AA, Oshinsky ML, Brin MF, Rosen H, Lalvani N, Charles A, Ashina M, Do TP, Burstein R, Gelfand AA, Dodick DW, Pozo-Rosich P, Lipton RB, Ailani J, Szperka CL, Charleston L, Digre KB, Russo AF, Buse DC, Powers SW, Tassorelli C, Goadsby PJ, Headache Research Priorities Working Group Members. The headache research priorities: Research goals from the American Headache Society and an international multistakeholder expert group.. Headache, 2024.
Charles AC, Digre KB, Goadsby PJ, Robbins MS, Hershey A, American Headache Society. Calcitonin gene-related peptide-targeting therapies are a first-line option for the prevention of migraine: An American Headache Society position statement update.. Headache, 2024.
Charles A. The role of caffeine in headache disorders.. Current opinion in neurology, 2024.
Podraza K, Bangera N, Feliz A, Charles A. Reduction in retinal microvascular perfusion during migraine attacks.. Headache, 2023.
Aframian K, Yousef Yengej D, Nwaobi S, Raman S, Faas GC, Charles A. Effects of chronic caffeine on patterns of brain blood flow and behavior throughout the sleep-wake cycle in freely behaving mice.. PNAS nexus, 2023.
Charles A. Aura is a symptom of a migraine attack, not its cause.. Headache, 2023.
Lassegard JC, Dubin BJ, Compton P, Charles AC, Macey PM. Pain Following Endoscopic Foreheadplasty Surgery in Women.. Aesthetic surgery journal, 2022.
Yousef Yengej D, Nwaobi SE, Ferando I, Kechechyan G, Charles A, Faas GC. Different characteristics of cortical spreading depression in the sleep and wake states.. Headache, 2022.
Heimbuch IS, Fan TK, Wu AD, Faas GC, Charles AC, Iacoboni M. Ultrasound stimulation of the motor cortex during tonic muscle contraction.. PloS one, 2022.
Ferrari MD, Goadsby PJ, Burstein R, Kurth T, Ayata C, Charles A, Ashina M, van den Maagdenberg AMJM, Dodick DW. Migraine.. Nature reviews. Disease primers, 2022.
Charles A, Nwaobi SE, Goadsby P. Inflammation in migraine…or not…: A critical evaluation of the evidence.. Headache, 2021.
Yousef Yengej DN, Ferando I, Kechechyan G, Nwaobi SE, Raman S, Charles A, Faas GC. Continuous long-term recording and triggering of brain neurovascular activity and behaviour in freely moving rodents.. The Journal of physiology, 2021.
Charles A. Memantine for migraine-Big promise but little evidence.. Headache, 2021.
Kamins J, Richards R, Barney BJ, Locandro C, Pacchia CF, Charles AC, Cook LJ, Gioia G, Giza CC, Blume HK. Evaluation of Posttraumatic Headache Phenotype and Recovery Time After Youth Concussion.. JAMA network open, 2021.
Mojadidi MK, Kumar P, Mahmoud AN, Elgendy IY, Shapiro H, West B, Charles AC, Mattle HP, Sorensen S, Meier B, Silberstein SD, Tobis JM. Pooled Analysis of PFO Occluder Device Trials in Patients With PFO and Migraine.. Journal of the American College of Cardiology, 2021.
Charles A, Pozo-Rosich P. Targeting calcitonin gene-related peptide: a new era in migraine therapy.. Lancet (London, England), 2019.
Hansen JM, Charles A. Differences in treatment response between migraine with aura and migraine without aura: lessons from clinical practice and RCTs.. The journal of headache and pain, 2019.
Ellingson BM, Hesterman C, Johnston M, Dudeck NR, Charles AC, Villablanca JP. Advanced Imaging in the Evaluation of Migraine Headaches.. Neuroimaging clinics of North America, 2019.
Charles A. A new opportunity after migraine treatment failure?. Lancet (London, England), 2018.
Charles A. The Migraine Aura.. Continuum (Minneapolis, Minn.), 2018.
Kamins J, Charles A. Posttraumatic Headache: Basic Mechanisms and Therapeutic Targets.. Headache, 2018.
Close LN, Eftekhari S, Wang M, Charles AC, Russo AF. Cortical spreading depression as a site of origin for migraine: Role of CGRP.. Cephalalgia : an international journal of headache, 2018.
West BH, Noureddin N, Mamzhi Y, Low CG, Coluzzi AC, Shih EJ, Gevorgyan Fleming R, Saver JL, Liebeskind DS, Charles A, Tobis JM. Frequency of Patent Foramen Ovale and Migraine in Patients With Cryptogenic Stroke.. Stroke, 2018.
Hoffmann J, Charles A. Glutamate and Its Receptors as Therapeutic Targets for Migraine.. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2018.
Starling AJ, Tepper SJ, Marmura MJ, Shamim EA, Robbins MS, Hindiyeh N, Charles AC, Goadsby PJ, Lipton RB, Silberstein SD, Gelfand AA, Chiacchierini RP, Dodick DW. A multicenter, prospective, single arm, open label, observational study of sTMS for migraine prevention (ESPOUSE Study).. Cephalalgia : an international journal of headache, 2018.
Charles A. The pathophysiology of migraine: implications for clinical management.. The Lancet. Neurology, 2017.
Tobis JM, Charles A, Silberstein SD, Sorensen S, Maini B, Horwitz PA, Gurley JC. Percutaneous Closure of Patent Foramen Ovale in Patients With Migraine: The PREMIUM Trial.. Journal of the American College of Cardiology, 2017.
Charles A. Migraine.. The New England journal of medicine, 2017.
Chang MY, Phasukkijwatana N, Garrity S, Pineles SL, Rahimi M, Sarraf D, Johnston M, Charles A, Arnold AC. Foveal and Peripapillary Vascular Decrement in Migraine With Aura Demonstrated by Optical Coherence Tomography Angiography.. Investigative ophthalmology & visual science, 2017.
Charles A. Migraine.. The New England journal of medicine, 2017.
Sharav Y, Katsarava Z, Charles A. Facial presentations of primary headache disorders.. Cephalalgia : an international journal of headache, 2017.
Matynia A, Nguyen E, Sun X, Blixt FW, Parikh S, Kessler J, Pérez de Sevilla Müller L, Habib S, Kim P, Wang ZZ, Rodriguez A, Charles A, Nusinowitz S, Edvinsson L, Barnes S, Brecha NC, Gorin MB. Peripheral Sensory Neurons Expressing Melanopsin Respond to Light.. Frontiers in neural circuits, 2016.
Tipton AF, Tarash I, McGuire B, Charles A, Pradhan AA. The effects of acute and preventive migraine therapies in a mouse model of chronic migraine.. Cephalalgia : an international journal of headache, 2016.
Charles A, Pradhan AA. Delta-opioid receptors as targets for migraine therapy.. Current opinion in neurology, 2016.
Charles A. Comment: Outcomes of migraine therapy with IV dihydroergotamine.. Neurology, 2016.
Houben T, Loonen IC, Baca SM, Schenke M, Meijer JH, Ferrari MD, Terwindt GM, Voskuyl RA, Charles A, van den Maagdenberg AM, Tolner EA. Optogenetic induction of cortical spreading depression in anesthetized and freely behaving mice.. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2016.
Diener HC, Charles A, Goadsby PJ, Holle D. New therapeutic approaches for the prevention and treatment of migraine.. The Lancet. Neurology, 2015.
Charles A, Hansen JM. Migraine aura: new ideas about cause, classification, and clinical significance.. Current opinion in neurology, 2015.
Hansen JM, Goadsby PJ, Charles AC. Variability of clinical features in attacks of migraine with aura.. Cephalalgia : an international journal of headache, 2015.
Hansen JM, Goadsby PJ, Charles A. Reduced efficacy of sumatriptan in migraine with aura vs without aura.. Neurology, 2015.
Charles A. Sounding out migraine-related interactions between the brainstem and cortex.. Cephalalgia : an international journal of headache, 2015.
Tepe N, Filiz A, Dilekoz E, Akcali D, Sara Y, Charles A, Bolay H. The thalamic reticular nucleus is activated by cortical spreading depression in freely moving rats: prevention by acute valproate administration.. The European journal of neuroscience, 2014.
López-Valdés HE, Clarkson AN, Ao Y, Charles AC, Carmichael ST, Sofroniew MV, Brennan KC. Memantine enhances recovery from stroke.. Stroke, 2014.
Pradhan AA, Smith ML, Zyuzin J, Charles A. δ-Opioid receptor agonists inhibit migraine-related hyperalgesia, aversive state and cortical spreading depression in mice.. British journal of pharmacology, 2014.
Hansen JM, Baca SM, Vanvalkenburgh P, Charles A. Distinctive anatomical and physiological features of migraine aura revealed by 18 years of recording.. Brain : a journal of neurology, 2013.
Pradhan AA, Smith ML, McGuire B, Tarash I, Evans CJ, Charles A. Characterization of a novel model of chronic migraine.. Pain, 2013.
Charles AC, Baca SM. Cortical spreading depression and migraine.. Nature reviews. Neurology, 2013.
Johnston MM, Jordan SE, Charles AC. Pain referral patterns of the C1 to C3 nerves: implications for headache disorders.. Annals of neurology, 2013.
Charles A. Migraine: a brain state.. Current opinion in neurology, 2013.
Brennan KC, Bates EA, Shapiro RE, Zyuzin J, Hallows WC, Huang Y, Lee HY, Jones CR, Fu YH, Charles AC, Ptácek LJ. Casein kinase iδ mutations in familial migraine and advanced sleep phase.. Science translational medicine, 2013.
Charles A. Vasodilation out of the picture as a cause of migraine headache.. The Lancet. Neurology, 2013.
Clarkson AN, López-Valdés HE, Overman JJ, Charles AC, Brennan KC, Thomas Carmichael S. Multimodal examination of structural and functional remapping in the mouse photothrombotic stroke model.. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2013.
Charles A. The evolution of a migraine attack - a review of recent evidence.. Headache, 2012.
Hansen JM, Lipton RB, Dodick DW, Silberstein SD, Saper JR, Aurora SK, Goadsby PJ, Charles A. Migraine headache is present in the aura phase: a prospective study.. Neurology, 2012.
Romero-Reyes M, Akerman S, Nguyen E, Vijjeswarapu A, Hom B, Dong HW, Charles AC. Spontaneous behavioral responses in the orofacial region: a model of trigeminal pain in mouse.. Headache, 2012.
Charles A. Migraine is not primarily a vascular disorder.. Cephalalgia : an international journal of headache, 2012.
Charles A. Defining and refining 5-HT receptor targets for migraine.. The Lancet. Neurology, 2012.
Charles A. [Novel migraine mechanisms as targets for therapy].. Rinsho shinkeigaku = Clinical neurology, 2012.
Rodríguez JA, Luria-Pérez R, López-Valdés HE, Casero D, Daniels TR, Patel S, Avila D, Leuchter R, So S, Ortiz-Sánchez E, Bonavida B, Martínez-Maza O, Charles AC, Pellegrini M, Helguera G, Penichet ML. Lethal iron deprivation induced by non-neutralizing antibodies targeting transferrin receptor 1 in malignant B cells.. Leukemia & lymphoma, 2011.
Charles A. Headache: new genes, new mechanisms, and new therapies.. The Lancet. Neurology, 2011.
López-Valdés HE, Beltran-Parrazal L, Brennan KC, Charles AC. Bradykinin increases resensitization of purinergic receptor signaling in glioma cells.. Cancer cell international, 2010.
Brennan KC, Charles A. An update on the blood vessel in migraine.. Current opinion in neurology, 2010.
Charles A. Does cortical spreading depression initiate a migraine attack? Maybe not . . .. Headache, 2010.
Chang JC, Shook LL, Biag J, Nguyen EN, Toga AW, Charles AC, Brennan KC. Biphasic direct current shift, haemoglobin desaturation and neurovascular uncoupling in cortical spreading depression.. Brain : a journal of neurology, 2010.
Charles A. Stimulating studies of visual cortical function in migraine.. Cephalalgia : an international journal of headache, 2010.
Charles A, Brennan KC. The neurobiology of migraine.. Handbook of clinical neurology, 2010.
Charles A, Brennan K. Cortical spreading depression-new insights and persistent questions.. Cephalalgia : an international journal of headache, 2009.
Ohara PT, Vit JP, Bhargava A, Romero M, Sundberg C, Charles AC, Jasmin L. Gliopathic pain: when satellite glial cells go bad.. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2009.
Brennan KC, Charles A. Sleep and headache.. Seminars in neurology, 2009.
Charles A. Advances in the basic and clinical science of migraine.. Annals of neurology, 2009.
Karumbayaram S, Kelly TK, Paucar AA, Roe AJ, Umbach JA, Charles A, Goldman SA, Kornblum HI, Wiedau-Pazos M. Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS.. Disease models & mechanisms, 2009.
Cutrer FM, Charles A. The neurogenic basis of migraine.. Headache, 2008.
Charles A, Brennan KC. A touch of increased pain: cutaneous allodynia in migraine.. Annals of neurology, 2008.
Charles A, Flippen C, Romero Reyes M, Brennan KC. Memantine for prevention of migraine: a retrospective study of 60 cases.. The journal of headache and pain, 2007.
Charles A, Brennan KC. Sumatriptan-naproxen combination for acute migraine.. Nature clinical practice. Neurology, 2007.
Rodríguez JA, Helguera G, Daniels TR, Neacato II, López-Valdés HE, Charles AC, Penichet ML. Binding specificity and internalization properties of an antibody-avidin fusion protein targeting the human transferrin receptor.. Journal of controlled release : official journal of the Controlled Release Society, 2007.
Brennan KC, Romero Reyes M, López Valdés HE, Arnold AP, Charles AC. Reduced threshold for cortical spreading depression in female mice.. Annals of neurology, 2007.
Brennan KC, Beltrán-Parrazal L, López-Valdés HE, Theriot J, Toga AW, Charles AC. Distinct vascular conduction with cortical spreading depression.. Journal of neurophysiology, 2007.
Ghiani CA, Beltran-Parrazal L, Sforza DM, Malvar JS, Seksenyan A, Cole R, Smith DJ, Charles A, Ferchmin PA, de Vellis J. Genetic program of neuronal differentiation and growth induced by specific activation of NMDA receptors.. Neurochemical research, 2006.
Beltran-Parrazal L, López-Valdés HE, Brennan KC, Díaz-Muñoz M, de Vellis J, Charles AC. Mitochondrial transport in processes of cortical neurons is independent of intracellular calcium.. American journal of physiology. Cell physiology, 2006.
Tiwari-Woodruff S, Beltran-Parrazal L, Charles A, Keck T, Vu T, Bronstein J. K+ channel KV3.1 associates with OSP/claudin-11 and regulates oligodendrocyte development.. American journal of physiology. Cell physiology, 2006.
Ghiani CA, Lelievre V, Beltran-Parrazal L, Sforza DM, Malvar J, Smith DJ, Charles AC, Ferchmin PA, de Vellis J. Gene expression is differentially regulated by neurotransmitters in embryonic neuronal cortical culture.. Journal of neurochemistry, 2006.
Lai A, Le DN, Paznekas WA, Gifford WD, Jabs EW, Charles AC. Oculodentodigital dysplasia connexin43 mutations result in non-functional connexin hemichannels and gap junctions in C6 glioma cells.. Journal of cell science, 2006.
Charles A. Teaching resources. Glial intercellular waves.. Science's STKE : signal transduction knowledge environment, 2005.
Charles A. Reaching out beyond the synapse: glial intercellular waves coordinate metabolism.. Science's STKE : signal transduction knowledge environment, 2005.
Charles AC, Hales TG. From inhibition to excitation: functional effects of interaction between opioid receptors.. Life sciences, 2004.
Bryant JA, Finn RS, Slamon DJ, Cloughesy TF, Charles AC. EGF activates intracellular and intercellular calcium signaling by distinct pathways in tumor cells.. Cancer biology & therapy, 2004.
Zhang Y, Zhang YF, Bryant J, Charles A, Boado RJ, Pardridge WM. Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer.. Clinical cancer research : an official journal of the American Association for Cancer Research, 2004.
Beltran-Parrazal L, Charles A. Riluzole inhibits spontaneous Ca2+ signaling in neuroendocrine cells by activation of K+ channels and inhibition of Na+ channels.. British journal of pharmacology, 2003.
Stout C, Charles A. Modulation of intercellular calcium signaling in astrocytes by extracellular calcium and magnesium.. Glia, 2003.
Yoshida H, Beltran-Parrazal L, Butler P, Conti M, Charles AC, Weiner RI. Lowering cyclic adenosine-3',5'-monophosphate (cAMP) levels by expression of a cAMP-specific phosphodiesterase decreases intrinsic pulsatile gonadotropin-releasing hormone secretion from GT1 cells.. Molecular endocrinology (Baltimore, Md.), 2003.
Charles AC, Mostovskaya N, Asas K, Evans CJ, Dankovich ML, Hales TG. Coexpression of delta-opioid receptors with micro receptors in GH3 cells changes the functional response to micro agonists from inhibitory to excitatory.. Molecular pharmacology, 2003.
Stout CE, Costantin JL, Naus CC, Charles AC. Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels.. The Journal of biological chemistry, 2002.
Charles A, Weiner R, Costantin J. cAMP modulates the excitability of immortalized H=hypothalamic (GT1) neurons via a cyclic nucleotide gated channel.. Molecular endocrinology (Baltimore, Md.), 2001.
Costantin JL, Charles AC. Modulation of Ca(2+) signaling by K(+) channels in a hypothalamic neuronal cell line (GT1-1).. Journal of neurophysiology, 2001.
Costantin JL, Charles AC. Spontaneous action potentials initiate rhythmic intercellular calcium waves in immortalized hypothalamic (GT1-1) neurons.. Journal of neurophysiology, 1999.
Charles AC, Piros ET, Evans CJ, Hales TG. L-type Ca2+ channels and K+ channels specifically modulate the frequency and amplitude of spontaneous Ca2+ oscillations and have distinct roles in prolactin release in GH3 cells.. The Journal of biological chemistry, 1999.
Charles A. Intercellular calcium waves in glia.. Glia, 1998.
Bronstein JM, Hales TG, Tyndale RF, Charles AC. A conditionally immortalized glial cell line that expresses mature myelin proteins and functional GABA(A) receptors.. Journal of neurochemistry, 1998.
Harris-White ME, Zanotti SA, Frautschy SA, Charles AC. Spiral intercellular calcium waves in hippocampal slice cultures.. Journal of neurophysiology, 1998.
Zanotti S, Charles A. Extracellular calcium sensing by glial cells: low extracellular calcium induces intracellular calcium release and intercellular signaling.. Journal of neurochemistry, 1997.
Charles AC, Kodali SK, Tyndale RF. Intercellular calcium waves in neurons.. Molecular and cellular neurosciences, 1996.
Sneyd J, Wetton BT, Charles AC, Sanderson MJ. Intercellular calcium waves mediated by diffusion of inositol trisphosphate: a two-dimensional model.. The American journal of physiology, 1995.
Charles AC, Hales TG. Mechanisms of spontaneous calcium oscillations and action potentials in immortalized hypothalamic (GT1-7) neurons.. Journal of neurophysiology, 1995.
Hales TG, Sanderson MJ, Charles AC. GABA has excitatory actions on GnRH-secreting immortalized hypothalamic (GT1-7) neurons.. Neuroendocrinology, 1994.
Sneyd J, Charles AC, Sanderson MJ. A model for the propagation of intercellular calcium waves.. The American journal of physiology, 1994.
Charles AC. Glia-neuron intercellular calcium signaling.. Developmental neuroscience, 1994.
Sanderson MJ, Charles AC, Boitano S, Dirksen ER. Mechanisms and function of intercellular calcium signaling.. Molecular and cellular endocrinology, 1994.
Mitrovic B, Martin FC, Charles AC, Ignarro LJ, Anton PA, Shanahan F, Merrill JE. Neurotransmitters and cytokines in CNS pathology.. Progress in brain research, 1994.
Zhong LT, Sarafian T, Kane DJ, Charles AC, Mah SP, Edwards RH, Bredesen DE. bcl-2 inhibits death of central neural cells induced by multiple agents.. Proceedings of the National Academy of Sciences of the United States of America, 1993.
Charles AC, Dirksen ER, Merrill JE, Sanderson MJ. Mechanisms of intercellular calcium signaling in glial cells studied with dantrolene and thapsigargin.. Glia, 1993.
Martin FC, Charles AC, Sanderson MJ, Merrill JE. Substance P stimulates IL-1 production by astrocytes via intracellular calcium.. Brain research, 1992.
Charles AC, Naus CC, Zhu D, Kidder GM, Dirksen ER, Sanderson MJ. Intercellular calcium signaling via gap junctions in glioma cells.. The Journal of cell biology, 1992.
Charles AC, Merrill JE, Dirksen ER, Sanderson MJ. Intercellular signaling in glial cells: calcium waves and oscillations in response to mechanical stimulation and glutamate.. Neuron, 1991.
Mazziotta JC, Itabashi H, Orfuss C, Charles A, Collins R. A 49-year-old man with aseptic meningitis and multiple cranial neuropathies.. The Western journal of medicine, 1991.
Sanderson MJ, Charles AC, Dirksen ER. Mechanical stimulation and intercellular communication increases intracellular Ca2+ in epithelial cells.. Cell regulation, 1990.