Bruce Kagan, M.D., Ph.D.

bkagan@mednet.ucla.edu

Website

Publications

Fogelson DL, Kagan BL. Bipolar spectrum disorder masquerading as treatment resistant unipolar depression.. CNS spectrums, 2020.
Karno MP, Rawson R, Rogers B, Spear S, Grella C, Mooney LJ, Saitz R, Kagan B, Glasner S. Effect of screening, brief intervention and referral to treatment for unhealthy alcohol and other drug use in mental health treatment settings: a randomized controlled trial.. Addiction (Abingdon, England), 2020.
Karkisaval AG, Rostagno A, Azimov R, Ban DK, Ghiso J, Kagan BL, Lal R. Ion channel formation by N-terminally truncated Aβ (4-42): relevance for the pathogenesis of Alzheimer's disease.. Nanomedicine : nanotechnology, biology, and medicine, 2020.
Glasner S, Kay-Lambkin F, Budney AJ, Gitlin M, Kagan B, Chokron-Garneau H, Ang A, Venegas A. Preliminary Outcomes of a Computerized CBT/MET Intervention for Depressed Cannabis Users in Psychiatry Care.. Cannabis (Albuquerque, N.M.), 2018.
Lee J, Kim YH, T Arce F, Gillman AL, Jang H, Kagan BL, Nussinov R, Yang J, Lal R. Amyloid β Ion Channels in a Membrane Comprising Brain Total Lipid Extracts.. ACS chemical neuroscience, 2017.
Jang H, Arce FT, Lee J, Gillman AL, Ramachandran S, Kagan BL, Lal R, Nussinov R. Computational Methods for Structural and Functional Studies of Alzheimer's Amyloid Ion Channels.. Methods in molecular biology (Clifton, N.J.), 2016.
Patel N, Ramachandran S, Azimov R, Kagan BL, Lal R. Ion Channel Formation by Tau Protein: Implications for Alzheimer's Disease and Tauopathies.. Biochemistry, 2015.
Jang H, Arce FT, Ramachandran S, Kagan BL, Lal R, Nussinov R. Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs.. Chemical Society reviews, 2014.
Lee J, Gillman AL, Jang H, Ramachandran S, Kagan BL, Nussinov R, Teran Arce F. Role of the fast kinetics of pyroglutamate-modified amyloid-β oligomers in membrane binding and membrane permeability.. Biochemistry, 2014.
Gillman AL, Jang H, Lee J, Ramachandran S, Kagan BL, Nussinov R, Teran Arce F. Activity and architecture of pyroglutamate-modified amyloid-β (AβpE3-42) pores.. The journal of physical chemistry. B, 2014.
Jang H, Arce FT, Ramachandran S, Kagan BL, Lal R, Nussinov R. Familial Alzheimer's disease Osaka mutant (ΔE22) β-barrels suggest an explanation for the different Aβ1-40/42 preferred conformational states observed by experiment.. The journal of physical chemistry. B, 2013.
Jang H, Connelly L, Arce FT, Ramachandran S, Lal R, Kagan BL, Nussinov R. Alzheimer's disease: which type of amyloid-preventing drug agents to employ?. Physical chemistry chemical physics : PCCP, 2013.
Jang H, Connelly L, Arce FT, Ramachandran S, Kagan BL, Lal R, Nussinov R. Mechanisms for the Insertion of Toxic, Fibril-like β-Amyloid Oligomers into the Membrane.. Journal of chemical theory and computation, 2012.
Connelly L, Jang H, Arce FT, Ramachandran S, Kagan BL, Nussinov R, Lal R. Effects of point substitutions on the structure of toxic Alzheimer's β-amyloid channels: atomic force microscopy and molecular dynamics simulations.. Biochemistry, 2012.
Capone R, Jang H, Kotler SA, Connelly L, Teran Arce F, Ramachandran S, Kagan BL, Nussinov R, Lal R. All-d-Enantiomer of β-Amyloid Peptide Forms Ion Channels in Lipid Bilayers.. Journal of chemical theory and computation, 2012.
Connelly L, Jang H, Arce FT, Capone R, Kotler SA, Ramachandran S, Kagan BL, Nussinov R, Lal R. Atomic force microscopy and MD simulations reveal pore-like structures of all-D-enantiomer of Alzheimer's β-amyloid peptide: relevance to the ion channel mechanism of AD pathology.. The journal of physical chemistry. B, 2012.
Capone R, Jang H, Kotler SA, Kagan BL, Nussinov R, Lal R. Probing structural features of Alzheimer's amyloid-β pores in bilayers using site-specific amino acid substitutions.. Biochemistry, 2012.
Kagan BL. Membrane pores in the pathogenesis of neurodegenerative disease.. Progress in molecular biology and translational science, 2012.
Kagan BL, Jang H, Capone R, Teran Arce F, Ramachandran S, Lal R, Nussinov R. Antimicrobial properties of amyloid peptides.. Molecular pharmaceutics, 2011.
Kagan BL. Antimicrobial amyloids?. Biophysical journal, 2011.
Jang H, Arce FT, Ramachandran S, Capone R, Azimova R, Kagan BL, Nussinov R, Lal R. Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome.. Proceedings of the National Academy of Sciences of the United States of America, 2010.
Kagan BL, Thundimadathil J. Amyloid peptide pores and the beta sheet conformation.. Advances in experimental medicine and biology, 2010.
Epand RF, Zhang YL, Mirzabekov T, Kagan B, Silberstein A, Hubbell WL, Epand RM, Chakraborti S, Dimitrov DS, Anderson WF, Rozenberg-Adler Y. Membrane activity of an amphiphilic alpha-helical membrane-proximal cytoplasmic domain of the MoMuLV envelope glycoprotein.. Experimental and molecular pathology, 2007.
Fagan T, Kagan B, Corbin D, Hwang W, Glabe C, Nault L, Lal R, Teplow D, Albensi B, Sokolov Y. Alzheimer Research Forum Live Discussion: Now you see them, now you don't: The amyloid channel hypothesis.. Journal of Alzheimer's disease : JAD, 2006.
Quist A, Doudevski I, Lin H, Azimova R, Ng D, Frangione B, Kagan B, Ghiso J, Lal R. Amyloid ion channels: a common structural link for protein-misfolding disease.. Proceedings of the National Academy of Sciences of the United States of America, 2005.
Kagan BL. Amyloidosis and protein folding.. Science (New York, N.Y.), 2005.
Kagan BL, Azimov R, Azimova R. Amyloid peptide channels.. The Journal of membrane biology, 2004.
Lin MC, Kagan BL. Electrophysiologic properties of channels induced by Abeta25-35 in planar lipid bilayers.. Peptides, 2002.
Kagan BL, Hirakura Y, Azimov R, Azimova R, Lin MC. The channel hypothesis of Alzheimer's disease: current status.. Peptides, 2002.
Hirakura Y, Carreras I, Sipe JD, Kagan BL. Channel formation by serum amyloid A: a potential mechanism for amyloid pathogenesis and host defense.. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 2002.
Kagan BL, Hirakura Y, Azimov R, Azimova R. The channel hypothesis of Huntington's disease.. Brain research bulletin, 2001.