Diane M Papazian
Professor, Physiology, University of California Los Angeles
papazian@mednet.ucla.edu
3108255766
Laboratory
CHS
Los Angeles, CA 90095
UNITED STATES
Office
CHS
Los Angeles, CA 90095
UNITED STATES
Biography
Professor Papazian received her B.S. in Chemistry from the University of Michigan in 1977. She received her Ph.D. in Biological Chemistry from Harvard University in 1983. She was a postdoctoral fellow in Dr. Lily Jan’s laboratory at the University of California at San Francisco from 1983-1989. She joined the UCLA faculty in 1989 and now holds the rank of Professor in the Department of Physiology
Publications
- Hsieh JY, Ulrich BN, Issa FA, Lin MA, Brown B, Papazian DM. Infant and adult SCA13 mutations differentially affect Purkinje cell excitability, maturation, and viability in vivo.. eLife, 2020.
- Lin MA, Cannon SC, Papazian DM. Kv4.2 autism and epilepsy mutation enhances inactivation of closed channels but impairs access to inactivated state after opening.. Proceedings of the National Academy of Sciences of the United States of America, 2018.
- Hsieh JY, Papazian DM. In Vivo Analysis of Potassium Channelopathies: Loose Patch Recording of Purkinje Cell Firing in Living, Awake Zebrafish.. Methods in molecular biology (Clifton, N.J.), 2018.
- Hsieh JY, Ulrich B, Issa FA, Wan J, Papazian DM. Rapid development of Purkinje cell excitability, functional cerebellar circuit, and afferent sensory input to cerebellum in zebrafish.. Frontiers in neural circuits, 2014.
- Issa FA, Mock AF, Sagasti A, Papazian DM. Spinocerebellar ataxia type 13 mutation that is associated with disease onset in infancy disrupts axonal pathfinding during neuronal development.. Disease models & mechanisms, 2012.
- Minassian NA, Lin MC, Papazian DM. Altered Kv3.3 channel gating in early-onset spinocerebellar ataxia type 13.. The Journal of physiology, 2012.
- Lin MC, Hsieh JY, Mock AF, Papazian DM. R1 in the Shaker S4 occupies the gating charge transfer center in the resting state.. The Journal of general physiology, 2011.
- Issa FA, Mazzochi C, Mock AF, Papazian DM. Spinocerebellar ataxia type 13 mutant potassium channel alters neuronal excitability and causes locomotor deficits in zebrafish.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011.
- Issa FA, O'Brien G, Kettunen P, Sagasti A, Glanzman DL, Papazian DM. Neural circuit activity in freely behaving zebrafish (Danio rerio).. The Journal of experimental biology, 2011.
- Mock AF, Richardson JL, Hsieh JY, Rinetti G, Papazian DM. Functional effects of spinocerebellar ataxia type 13 mutations are conserved in zebrafish Kv3.3 channels.. BMC neuroscience, 2010.
- Lin MC, Abramson J, Papazian DM. Transfer of ion binding site from ether-a-go-go to Shaker: Mg2+ binds to resting state to modulate channel opening.. The Journal of general physiology, 2010.
- Koag MC, Papazian DM. Voltage-dependent conformational changes of KVAP S4 segment in bacterial membrane environment.. Channels (Austin, Tex.), 2009.
- Papazian DM. S0, where is it?. The Journal of general physiology, 2008.
- Lin MC, Papazian DM. Differences between ion binding to eag and HERG voltage sensors contribute to differential regulation of activation and deactivation gating.. Channels (Austin, Tex.), 2008.
- Richardson J, Blunck R, Ge P, Selvin PR, Bezanilla F, Papazian DM, Correa AM. Distance measurements reveal a common topology of prokaryotic voltage-gated ion channels in the lipid bilayer.. Proceedings of the National Academy of Sciences of the United States of America, 2006.
- Waters MF, Minassian NA, Stevanin G, Figueroa KP, Bannister JP, Nolte D, Mock AF, Evidente VG, Fee DB, Müller U, Dürr A, Brice A, Papazian DM, Pulst SM. Mutations in voltage-gated potassium channel KCNC3 cause degenerative and developmental central nervous system phenotypes.. Nature genetics, 2006.
- Bannister JP, Chanda B, Bezanilla F, Papazian DM. Optical detection of rate-determining ion-modulated conformational changes of the ether-à-go-go K+ channel voltage sensor.. Proceedings of the National Academy of Sciences of the United States of America, 2005.
- Silverman WR, Bannister JP, Papazian DM. Binding site in eag voltage sensor accommodates a variety of ions and is accessible in closed channel.. Biophysical journal, 2004.
- Myers MP, Khanna R, Lee EJ, Papazian DM. Voltage sensor mutations differentially target misfolded K+ channel subunits to proteasomal and non-proteasomal disposal pathways.. FEBS letters, 2004.
- Papazian DM. BK channels: the spring between sensor and gate.. Neuron, 2004.
- Khanna R, Lee EJ, Papazian DM. Transient calnexin interaction confers long-term stability on folded K+ channel protein in the ER.. Journal of cell science, 2004.
- Lainé M, Papazian DM, Roux B. Critical assessment of a proposed model of Shaker.. FEBS letters, 2004.
- Lainé M, Lin MC, Bannister JP, Silverman WR, Mock AF, Roux B, Papazian DM. Atomic proximity between S4 segment and pore domain in Shaker potassium channels.. Neuron, 2003.
- Silverman WR, Roux B, Papazian DM. Structural basis of two-stage voltage-dependent activation in K+ channels.. Proceedings of the National Academy of Sciences of the United States of America, 2003.
- Papazian DM, Silverman WR, Lin MC, Tiwari-Woodruff SK, Tang CY. Structural organization of the voltage sensor in voltage-dependent potassium channels.. Novartis Foundation symposium, 2002.
- Papazian DM. Potassium channels: some assembly required.. Neuron, 1999.