Diane Papazian, Ph.D.

Diane Papazian, Ph.D.

Publications

• Bavan S, Goodkin HP, Papazian DM. Altered closed state inactivation gating in Kv4.2 channels results in developmental and epileptic encephalopathies in human patients.. Human mutation, 2022.
• Hsieh JY, Ulrich BN, Issa FA, Lin MA, Brown B, Papazian DM. Infant and adult SCA13 mutations differentially affect Purkinje cell excitability, maturation, and viability in vivo.. eLife, 2020.
• Lin MA, Cannon SC, Papazian DM. Kv4.2 autism and epilepsy mutation enhances inactivation of closed channels but impairs access to inactivated state after opening.. Proceedings of the National Academy of Sciences of the United States of America, 2018.
• Hsieh JY, Papazian DM. In Vivo Analysis of Potassium Channelopathies: Loose Patch Recording of Purkinje Cell Firing in Living, Awake Zebrafish.. Methods in molecular biology (Clifton, N.J.), 2018.
• Duarri A, Lin MC, Fokkens MR, Meijer M, Smeets CJ, Nibbeling EA, Boddeke E, Sinke RJ, Kampinga HH, Papazian DM, Verbeek DS. Spinocerebellar ataxia type 19/22 mutations alter heterocomplex Kv4.3 channel function and gating in a dominant manner.. Cellular and molecular life sciences : CMLS, 2015.
• Hsieh JY, Ulrich B, Issa FA, Wan J, Papazian DM. Rapid development of Purkinje cell excitability, functional cerebellar circuit, and afferent sensory input to cerebellum in zebrafish.. Frontiers in neural circuits, 2014.
• Lee H, Lin MC, Kornblum HI, Papazian DM, Nelson SF. Exome sequencing identifies de novo gain of function missense mutation in KCND2 in identical twins with autism and seizures that slows potassium channel inactivation.. Human molecular genetics, 2014.
• Issa FA, Mock AF, Sagasti A, Papazian DM. Spinocerebellar ataxia type 13 mutation that is associated with disease onset in infancy disrupts axonal pathfinding during neuronal development.. Disease models & mechanisms, 2012.
• Minassian NA, Lin MC, Papazian DM. Altered Kv3.3 channel gating in early-onset spinocerebellar ataxia type 13.. The Journal of physiology, 2012.
• Lin MC, Hsieh JY, Mock AF, Papazian DM. R1 in the Shaker S4 occupies the gating charge transfer center in the resting state.. The Journal of general physiology, 2011.
• Issa FA, Mazzochi C, Mock AF, Papazian DM. Spinocerebellar ataxia type 13 mutant potassium channel alters neuronal excitability and causes locomotor deficits in zebrafish.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011.
• Figueroa KP, Waters MF, Garibyan V, Bird TD, Gomez CM, Ranum LP, Minassian NA, Papazian DM, Pulst SM. Frequency of KCNC3 DNA variants as causes of spinocerebellar ataxia 13 (SCA13).. PloS one, 2011.
• Issa FA, O'Brien G, Kettunen P, Sagasti A, Glanzman DL, Papazian DM. Neural circuit activity in freely behaving zebrafish (Danio rerio).. The Journal of experimental biology, 2011.
• Mock AF, Richardson JL, Hsieh JY, Rinetti G, Papazian DM. Functional effects of spinocerebellar ataxia type 13 mutations are conserved in zebrafish Kv3.3 channels.. BMC neuroscience, 2010.
• Lin MC, Abramson J, Papazian DM. Transfer of ion binding site from ether-a-go-go to Shaker: Mg2+ binds to resting state to modulate channel opening.. The Journal of general physiology, 2010.
• Koag MC, Papazian DM. Voltage-dependent conformational changes of KVAP S4 segment in bacterial membrane environment.. Channels (Austin, Tex.), 2009.
• Papazian DM. S0, where is it?. The Journal of general physiology, 2008.
• Lin MC, Papazian DM. Differences between ion binding to eag and HERG voltage sensors contribute to differential regulation of activation and deactivation gating.. Channels (Austin, Tex.), 2008.
• Richardson J, Blunck R, Ge P, Selvin PR, Bezanilla F, Papazian DM, Correa AM. Distance measurements reveal a common topology of prokaryotic voltage-gated ion channels in the lipid bilayer.. Proceedings of the National Academy of Sciences of the United States of America, 2006.
• Waters MF, Minassian NA, Stevanin G, Figueroa KP, Bannister JP, Nolte D, Mock AF, Evidente VG, Fee DB, Müller U, Dürr A, Brice A, Papazian DM, Pulst SM. Mutations in voltage-gated potassium channel KCNC3 cause degenerative and developmental central nervous system phenotypes.. Nature genetics, 2006.
• Bannister JP, Chanda B, Bezanilla F, Papazian DM. Optical detection of rate-determining ion-modulated conformational changes of the ether-à-go-go K+ channel voltage sensor.. Proceedings of the National Academy of Sciences of the United States of America, 2005.
• Silverman WR, Bannister JP, Papazian DM. Binding site in eag voltage sensor accommodates a variety of ions and is accessible in closed channel.. Biophysical journal, 2004.
• Myers MP, Khanna R, Lee EJ, Papazian DM. Voltage sensor mutations differentially target misfolded K+ channel subunits to proteasomal and non-proteasomal disposal pathways.. FEBS letters, 2004.
• Papazian DM. BK channels: the spring between sensor and gate.. Neuron, 2004.
• Khanna R, Lee EJ, Papazian DM. Transient calnexin interaction confers long-term stability on folded K+ channel protein in the ER.. Journal of cell science, 2004.
• Lainé M, Papazian DM, Roux B. Critical assessment of a proposed model of Shaker.. FEBS letters, 2004.
• Lainé M, Lin MC, Bannister JP, Silverman WR, Mock AF, Roux B, Papazian DM. Atomic proximity between S4 segment and pore domain in Shaker potassium channels.. Neuron, 2003.
• Silverman WR, Roux B, Papazian DM. Structural basis of two-stage voltage-dependent activation in K+ channels.. Proceedings of the National Academy of Sciences of the United States of America, 2003.
• Papazian DM, Silverman WR, Lin MC, Tiwari-Woodruff SK, Tang CY. Structural organization of the voltage sensor in voltage-dependent potassium channels.. Novartis Foundation symposium, 2002.
• Papazian DM. Potassium channels: some assembly required.. Neuron, 1999.