Eain Cornford, Ph.D.
Professor, Neurology Member, Brain Research Institute
cornford@ucla.edu
310-268-4426
Healthcare Sys Bldg.
Los Angeles, CA 90095
UNITED STATES
Biography
Glucose transporter modulations in the blood-brain barrier Our laboratory studies brain metabolism and blood-brain barrier function. Recent work has focused on analysis of subcellular mechanisms involved in regulation of blood-brain barrier nutrient transport, correlation of physiological measurements of transport (in experimental animals, in vivo) with subcellular location of the transporter protein. Methods include quantitative electron microscopic analyses of cell and membrane transporters, in vivomeasurement of brain uptake, internal carotid artery perfusion analyses of blood-brain barrier transfer, and measurement of cerebral blood flow rates in vivo. We have also been active in defining the role of the Glut1 glucose transporter isoform in brain tumors. A secondary interest is in transport and metabolism in schistosome parasites, with particular reference to gender-specific specialization.
Publications
- Peeters SF, Uhr L, Chivukula S, Everson R, Duong D, McBride D, Kim W, Cornford M, Mlikotic A, Yang I. Intraoperative discovery of a radiographically occult subependymoma obstructing the obex in a patient with a Chiari malformation - A rare case.. Surgical neurology international, 2024.
- Peeters SM, Uhr L, Chivukula S, McBride D, Everson R, Duong D, Yang I, Cornford M, Mlikotic A, Yong W, Kim W. Cervicomedullary junction mature teratoma with pulmonary differentiation and diastematomyelia in an adult - A rare case.. Surgical neurology international, 2023.
- McGregor R, Matzeu A, Thannickal TC, Wu F, Cornford M, Martin-Fardon R, Siegel JM. Sensitivity of Hypocretin System to Chronic Alcohol Exposure: A Human and Animal Study.. Neuroscience, 2023.
- Vogel C, Manwani P, Cornford ME, Heinze ER. Nemaline myopathy in newly diagnosed systemic lupus erythematosus and Sjögren's overlap syndrome complicated by macrophage activation syndrome.. BMC rheumatology, 2022.
- Jia Y, Samadzadeh S, Cornford M, Ji P, French SW. Educational Case: Incidental Gallbladder Adenocarcinoma.. Academic pathology, 2020.
- Thannickal TC, John J, Shan L, Swaab DF, Wu MF, Ramanathan L, McGregor R, Chew KT, Cornford M, Yamanaka A, Inutsuka A, Fronczek R, Lammers GJ, Worley PF, Siegel JM. Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy.. Science translational medicine, 2018.
- Byers JT, Kurtz JL, Mendoza AS, Oster CD, Sun NCJ, Qing X, Cornford ME. An unusual presentation of primary pulmonary extranodal marginal zone lymphoma of mucosal associated lymphoid tissue: An autopsy case report.. Experimental and molecular pathology, 2018.
- Cornford EM, Hyman S, Cornford ME, Chytrova G, Rhee J, Suzuki T, Yamagata T, Yamakawa K, Penichet ML, Pardridge WM. Non-invasive gene targeting to the fetal brain after intravenous administration and transplacental transfer of plasmid DNA using PEGylated immunoliposomes.. Journal of drug targeting, 2015.
- John J, Thannickal TC, McGregor R, Ramanathan L, Ohtsu H, Nishino S, Sakai N, Yamanaka A, Stone C, Cornford M, Siegel JM. Greatly increased numbers of histamine cells in human narcolepsy with cataplexy.. Annals of neurology, 2013.
- Mulholland CB, Barkhoudarian G, Cornford ME, McBride DQ. Intraspinal primitive neuroectodermal tumor in a man with neurofibromatosis type 1: Case report and review of the literature.. Surgical neurology international, 2011.
- Sinha-Hikim I, Cornford M, Gaytan H, Lee ML, Bhasin S. Effects of testosterone supplementation on skeletal muscle fiber hypertrophy and satellite cells in community-dwelling older men.. The Journal of clinical endocrinology and metabolism, 2006.
- Yoo TW, Mlikotic A, Cornford ME, Beck CK. Concurrent cerebral american trypanosomiasis and toxoplasmosis in a patient with AIDS.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2004.
- Choi HJ, Cornford M, Wang L, Sun J, Friedman TC. Acute chagas' disease presenting with a suprasellar mass and panhypopituitarism.. Pituitary, 2004.
- Cornford EM, Hyman S, Cornford ME. Immunogold detection of microvascular proteins in the compromised blood-brain barrier.. Methods in molecular medicine, 2003.
- Cornford EM, Cornford ME. New systems for delivery of drugs to the brain in neurological disease.. The Lancet. Neurology, 2002.
- Itti E, Huff K, Cornford ME, Itti L, Poruri K, Mishkin FS. Postinfectious encephalitis: a coregistered SPECT and magnetic resonance imaging study.. Clinical nuclear medicine, 2002.
- Wang L, Cornford ME. Coincident choroid plexus carcinoma and adrenocortical carcinoma with elevated p53 expression: a case report of an 18-month-old boy with no family history of cancer.. Archives of pathology & laboratory medicine, 2002.