Ernest Wright, Ph.D., D.Sc.

Professor, Physiology Member, Brain Research Institute CTSI JCCC Cancer Molecular Imaging JCCC Genitourinary Oncology Program Area Molecular, Cellular & Integrative Physiology GPB Home Area Workforce Development

ewright@mednet.ucla.edu

310-825-6905

Laboratory
10833 Le Conte Ave.
CHS 53-317
Los Angeles, CA 90095
UNITED STATES

Website

Publications

Khan F, Elgeti M, Grandfield S, Paz A, Naughton FB, Marcoline FV, Althoff T, Ermolova N, Wright EM, Hubbell WL, Grabe M, Abramson J. Membrane potential accelerates sugar uptake by stabilizing the outward facing conformation of the Na/glucose symporter vSGLT.. Nature communications, 2023.
Wright EM. Correction to: SGLT2 and cancer.. Pflugers Archiv : European journal of physiology, 2021.
Wright EM. SGLT2 Inhibitors: Physiology and Pharmacology.. Kidney360, 2021.
Loo DDF, Wright EM. Regulation of Neutral Amino Acid Transport By the SARS-CoV-2 Receptor ACE2.. Function (Oxford, England), 2021.
Lostao MP, Loo DD, Hernell O, Meeuwisse G, Martin MG, Wright EM. The Molecular Basis of Glucose Galactose Malabsorption in a Large Swedish Pedigree.. Function (Oxford, England), 2021.
Abramson J, Wright EM. Function Trumps Form in Two Sugar Symporters, LacY and vSGLT.. International journal of molecular sciences, 2021.
Wright EM, Loo DDF. Active Glucose Transport 2020 and Beyond.. Function (Oxford, England), 2020.
Wright EM. SGLT2 and cancer.. Pflugers Archiv : European journal of physiology, 2020.
Bisignano P, Ghezzi C, Jo H, Polizzi NF, Althoff T, Kalyanaraman C, Friemann R, Jacobson MP, Wright EM, Grabe M. Inhibitor binding mode and allosteric regulation of Na+-glucose symporters.. Nature communications, 2018.
Ghezzi C, Loo DDF, Wright EM. Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2.. Diabetologia, 2018.
Sala-Rabanal M, Ghezzi C, Hirayama BA, Kepe V, Liu J, Barrio JR, Wright EM. Intestinal absorption of glucose in mice as determined by positron emission tomography.. The Journal of physiology, 2018.
Kepe V, Scafoglio C, Liu J, Yong WH, Bergsneider M, Huang SC, Barrio JR, Wright EM. Positron emission tomography of sodium glucose cotransport activity in high grade astrocytomas.. Journal of neuro-oncology, 2018.
Paz A, Claxton DP, Kumar JP, Kazmier K, Bisignano P, Sharma S, Nolte SA, Liwag TM, Nayak V, Wright EM, Grabe M, Mchaourab HS, Abramson J. Conformational transitions of the sodium-dependent sugar transporter, vSGLT.. Proceedings of the National Academy of Sciences of the United States of America, 2018.
Wright EM, Ghezzi C, Loo DDF. Novel and Unexpected Functions of SGLTs.. Physiology (Bethesda, Md.), 2017.
Gorraitz E, Hirayama BA, Paz A, Wright EM, Loo DDF. Active site voltage clamp fluorometry of the sodium glucose cotransporter hSGLT1.. Proceedings of the National Academy of Sciences of the United States of America, 2017.
Zeuthen T, Gorraitz E, Her K, Wright EM, Loo DD. Structural and functional significance of water permeation through cotransporters.. Proceedings of the National Academy of Sciences of the United States of America, 2016.
Ghezzi C, Yu AS, Hirayama BA, Kepe V, Liu J, Scafoglio C, Powell DR, Huang SC, Satyamurthy N, Barrio JR, Wright EM. Dapagliflozin Binds Specifically to Sodium-Glucose Cotransporter 2 in the Proximal Renal Tubule.. Journal of the American Society of Nephrology : JASN, 2016.
Adelman JL, Ghezzi C, Bisignano P, Loo DD, Choe S, Abramson J, Rosenberg JM, Wright EM, Grabe M. Stochastic steps in secondary active sugar transport.. Proceedings of the National Academy of Sciences of the United States of America, 2016.
Sala-Rabanal M, Hirayama BA, Ghezzi C, Liu J, Huang SC, Kepe V, Koepsell H, Yu A, Powell DR, Thorens B, Wright EM, Barrio JR. Revisiting the physiological roles of SGLTs and GLUTs using positron emission tomography in mice.. The Journal of physiology, 2016.
Scafoglio C, Hirayama BA, Kepe V, Liu J, Ghezzi C, Satyamurthy N, Moatamed NA, Huang J, Koepsell H, Barrio JR, Wright EM. Functional expression of sodium-glucose transporters in cancer.. Proceedings of the National Academy of Sciences of the United States of America, 2015.
Gallo LA, Wright EM, Vallon V. Probing SGLT2 as a therapeutic target for diabetes: basic physiology and consequences.. Diabetes & vascular disease research, 2015.
Ghezzi C, Hirayama BA, Gorraitz E, Loo DD, Liang Y, Wright EM. SGLT2 inhibitors act from the extracellular surface of the cell membrane.. Physiological reports, 2014.
Adelman JL, Sheng Y, Choe S, Abramson J, Wright EM, Rosenberg JM, Grabe M. Structural determinants of water permeation through the sodium-galactose transporter vSGLT.. Biophysical journal, 2014.
Ghezzi C, Gorraitz E, Hirayama BA, Loo DD, Grempler R, Mayoux E, Wright EM. Fingerprints of hSGLT5 sugar and cation selectivity.. American journal of physiology. Cell physiology, 2014.
Loo DD, Jiang X, Gorraitz E, Hirayama BA, Wright EM. Functional identification and characterization of sodium binding sites in Na symporters.. Proceedings of the National Academy of Sciences of the United States of America, 2013.
Wright EM. Glucose transport families SLC5 and SLC50.. Molecular aspects of medicine, 2013.
Yu AS, Hirayama BA, Timbol G, Liu J, Diez-Sampedro A, Kepe V, Satyamurthy N, Huang SC, Wright EM, Barrio JR. Regional distribution of SGLT activity in rat brain in vivo.. American journal of physiology. Cell physiology, 2012.
Jiang X, Loo DD, Hirayama BA, Wright EM. The importance of being aromatic: π interactions in sodium symporters.. Biochemistry, 2012.
Ghezzi C, Wright EM. Regulation of the human Na+-dependent glucose cotransporter hSGLT2.. American journal of physiology. Cell physiology, 2012.
Sala-Rabanal M, Hirayama BA, Loo DD, Chaptal V, Abramson J, Wright EM. Bridging the gap between structure and kinetics of human SGLT1.. American journal of physiology. Cell physiology, 2011.
Hummel CS, Lu C, Liu J, Ghezzi C, Hirayama BA, Loo DD, Kepe V, Barrio JR, Wright EM. Structural selectivity of human SGLT inhibitors.. American journal of physiology. Cell physiology, 2011.
Wright EM, Loo DD, Hirayama BA. Biology of human sodium glucose transporters.. Physiological reviews, 2011.
Zampighi GA, Schietroma C, Zampighi LM, Woodruff M, Wright EM, Brecha NC. Conical tomography of a ribbon synapse: structural evidence for vesicle fusion.. PloS one, 2011.
Watanabe A, Choe S, Chaptal V, Rosenberg JM, Wright EM, Grabe M, Abramson J. The mechanism of sodium and substrate release from the binding pocket of vSGLT.. Nature, 2010.
Hummel CS, Lu C, Loo DD, Hirayama BA, Voss AA, Wright EM. Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2.. American journal of physiology. Cell physiology, 2010.
Choe S, Rosenberg JM, Abramson J, Wright EM, Grabe M. Water permeation through the sodium-dependent galactose cotransporter vSGLT.. Biophysical journal, 2010.
Yu AS, Hirayama BA, Timbol G, Liu J, Basarah E, Kepe V, Satyamurthy N, Huang SC, Wright EM, Barrio JR. Functional expression of SGLTs in rat brain.. American journal of physiology. Cell physiology, 2010.
Abramson J, Wright EM. Structure and function of Na(+)-symporters with inverted repeats.. Current opinion in structural biology, 2009.
Bakris GL, Fonseca VA, Sharma K, Wright EM. Renal sodium-glucose transport: role in diabetes mellitus and potential clinical implications.. Kidney international, 2009.
Faham S, Watanabe A, Besserer GM, Cascio D, Specht A, Hirayama BA, Wright EM, Abramson J. The crystal structure of a sodium galactose transporter reveals mechanistic insights into Na+/sugar symport.. Science (New York, N.Y.), 2008.
Loo DD, Hirayama BA, Sala-Rabanal M, Wright EM. How drugs interact with transporters: SGLT1 as a model.. The Journal of membrane biology, 2008.
Zampighi GA, Fain N, Zampighi LM, Cantele F, Lanzavecchia S, Wright EM. Conical electron tomography of a chemical synapse: polyhedral cages dock vesicles to the active zone.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008.
Sala-Rabanal M, Loo DD, Hirayama BA, Wright EM. Molecular mechanism of dipeptide and drug transport by the human renal H+/oligopeptide cotransporter hPEPT2.. American journal of physiology. Renal physiology, 2008.
Hirayama BA, Loo DD, Díez-Sampedro A, Leung DW, Meinild AK, Lai-Bing M, Turk E, Wright EM. Sodium-dependent reorganization of the sugar-binding site of SGLT1.. Biochemistry, 2007.
Wright EM, Hirayama BA, Loo DF. Active sugar transport in health and disease.. Journal of internal medicine, 2007.
Loo DD, Hirayama BA, Karakossian MH, Meinild AK, Wright EM. Conformational dynamics of hSGLT1 during Na+/glucose cotransport.. The Journal of general physiology, 2006.
Voss AA, Díez-Sampedro A, Hirayama BA, Loo DD, Wright EM. Imino sugars are potent agonists of the human glucose sensor SGLT3.. Molecular pharmacology, 2006.
Sala-Rabanal M, Loo DD, Hirayama BA, Turk E, Wright EM. Molecular interactions between dipeptides, drugs and the human intestinal H+ -oligopeptide cotransporter hPEPT1.. The Journal of physiology, 2006.
Turk E, Gasymov OK, Lanza S, Horwitz J, Wright EM. A reinvestigation of the secondary structure of functionally active vSGLT, the vibrio sodium/galactose cotransporter.. Biochemistry, 2006.
Loo DD, Hirayama BA, Cha A, Bezanilla F, Wright EM. Perturbation analysis of the voltage-sensitive conformational changes of the Na+/glucose cotransporter.. The Journal of general physiology, 2004.
Wright EM, Loo DD, Hirayama BA, Turk E. Surprising versatility of Na+-glucose cotransporters: SLC5.. Physiology (Bethesda, Md.), 2004.
Díez-Sampedro A, Loo DD, Wright EM, Zampighi GA, Hirayama BA. Coupled sodium/glucose cotransport by SGLT1 requires a negative charge at position 454.. Biochemistry, 2004.
Veenstra M, Lanza S, Hirayama BA, Turk E, Wright EM. Local conformational changes in the Vibrio Na+/galactose cotransporter.. Biochemistry, 2004.
Wright EM, Martín MG, Turk E. Intestinal absorption in health and disease--sugars.. Best practice & research. Clinical gastroenterology, 2003.
Diez-Sampedro A, Hirayama BA, Osswald C, Gorboulev V, Baumgarten K, Volk C, Wright EM, Koepsell H. A glucose sensor hiding in a family of transporters.. Proceedings of the National Academy of Sciences of the United States of America, 2003.
Quick M, Tomasevic J, Wright EM. Functional asymmetry of the human Na+/glucose transporter (hSGLT1) in bacterial membrane vesicles.. Biochemistry, 2003.
Wright EM, Turk E. The sodium/glucose cotransport family SLC5.. Pflugers Archiv : European journal of physiology, 2003.
Zampighi GA, Kreman M, Lanzavecchia S, Turk E, Eskandari S, Zampighi L, Wright EM. Structure of functional single AQP0 channels in phospholipid membranes.. Journal of molecular biology, 2003.
Sarkar HK, Wright EM, Boorer KJ, Loo DD. Electrophysiological properties of the mouse Na+/Cl(-)-dependent taurine transporter (mTauT-1): steady-state kinetics: stoichiometry of taurine transport.. Advances in experimental medicine and biology, 2003.
Loo DD, Wright EM, Zeuthen T. Water pumps.. The Journal of physiology, 2002.
le Coutre J, Turk E, Kaback HR, Wright EM. Ligand-induced differences in secondary structure of the Vibrio parahaemolyticus Na+/galactose cotransporter.. Biochemistry, 2002.
Quick M, Wright EM. Employing Escherichia coli to functionally express, purify, and characterize a human transporter.. Proceedings of the National Academy of Sciences of the United States of America, 2002.
Fischer WN, Loo DD, Koch W, Ludewig U, Boorer KJ, Tegeder M, Rentsch D, Wright EM, Frommer WB. Low and high affinity amino acid H+-cotransporters for cellular import of neutral and charged amino acids.. The Plant journal : for cell and molecular biology, 2002.
Meinild AK, Hirayama BA, Wright EM, Loo DD. Fluorescence studies of ligand-induced conformational changes of the Na(+)/glucose cotransporter.. Biochemistry, 2002.
Wright EM, Turk E, Martin MG. Molecular basis for glucose-galactose malabsorption.. Cell biochemistry and biophysics, 2002.
Wright EM. Renal Na(+)-glucose cotransporters.. American journal of physiology. Renal physiology, 2001.
Wright EM, Loo DD. Coupling between Na+, sugar, and water transport across the intestine.. Annals of the New York Academy of Sciences, 2000.
Loo DD, Wright EM, Meinild AK, Klaerke DA, Zeuthen T. Commentary on "Epithelial Fluid Transport--A Century of Investigation". News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society, 1999.