Gary Mathern, M.D.

Director, Epilepsy Surgery Pediatric Epilepsy Program Professor In-Residence, Neurosurgery Surgery Member, Brain Research Institute Neuroscience GPB Home Area Pediatric Neuro-oncology and Neural Tumors Center

0000-0002-7294-7610

gmathern@ucla.edu

(310) 825-7961

710 Westwood Plaza
Los Angeles, CA 90095
UNITED STATES

Website

Biography

Dr. Mathern graduated from the Case Western Reserve University School of Medicine in 1982. He completed his Rotating Internship at the Cleveland Clinic Foundation in 1983 and his Residencies in Surgery (1985) and Neurosurgery (1986-1991) at UCLA Harbor Medical Center and UCLA School of Medicine, respectively. Dr. Mathern received his Board Certification in Neurological Surgery in 1996. He currently practices medicine at the David Geffen UCLA School of Medicine and specializes in Neurological Surgery and Pediatric Neurological Surgery. Dr. Mathern is affiliated with both Santa Monica UCLA Medical Center and Ronald Reagan UCLA Medical Center.

Publications

Kim YE, Kim YS, Lee HE, So KH, Choe Y, Suh BC, Kim JH, Park SK, Mathern GW, Gleeson JG, Rah JC, Baek ST. Reversibility and developmental neuropathology of linear nevus sebaceous syndrome caused by dysregulation of the RAS pathway.. Cell reports, 2023.
Chung C, Yang X, Bae T, Vong KI, Mittal S, Donkels C, Westley Phillips H, Li Z, Marsh APL, Breuss MW, Ball LL, Garcia CAB, George RD, Gu J, Xu M, Barrows C, James KN, Stanley V, Nidhiry AS, Khoury S, Howe G, Riley E, Xu X, Copeland B, Wang Y, Kim SH, Kang HC, Schulze-Bonhage A, Haas CA, Urbach H, Prinz M, Limbrick DD, Gurnett CA, Smyth MD, Sattar S, Nespeca M, Gonda DD, Imai K, Takahashi Y, Chen HH, Tsai JW, Conti V, Guerrini R, Devinsky O, Silva WA, Machado HR, Mathern GW, Abyzov A, Baldassari S, Baulac S, Focal Cortical Dysplasia Neurogenetics Consortium, Brain Somatic Mosaicism Network, Gleeson JG. Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development.. Nature genetics, 2023.
Leitner DF, Lin Z, Sawaged Z, Kanshin E, Friedman D, Devore S, Ueberheide B, Chang JW, Mathern GW, Anink JJ, Aronica E, Wisniewski T, Devinsky O. Brain molecular mechanisms in Rasmussen encephalitis.. Epilepsia, 2022.
Phillips HW, Chen JS, Tucker AM, Ding K, Kashanian A, Nagahama Y, Mathern GW, Weil AG, Fallah A. Preliminary Experience Suggests the Addition of Choroid Plexus Cauterization to Functional Hemispherectomy May Reduce Posthemispherectomy Hydrocephalus.. Neurosurgery, 2022.
Ghochani Y, Muthukrishnan SD, Sohrabi A, Kawaguchi R, Condro MC, Bastola S, Gao F, Qin Y, Mottahedeh J, Iruela-Arispe ML, Rao N, Laks DR, Liau LM, Mathern GW, Goldman SA, Carmichael ST, Nakano I, Coppola G, Seidlits SK, Kornblum HI. A molecular interactome of the glioblastoma perivascular niche reveals integrin binding sialoprotein as a mediator of tumor cell migration.. Cell reports, 2022.
Bae T, Fasching L, Wang Y, Shin JH, Suvakov M, Jang Y, Norton S, Dias C, Mariani J, Jourdon A, Wu F, Panda A, Pattni R, Chahine Y, Yeh R, Roberts RC, Huttner A, Kleinman JE, Hyde TM, Straub RE, Walsh CA, Brain Somatic Mosaicism Network§, Urban AE, Leckman JF, Weinberger DR, Vaccarino FM, Abyzov A. Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability.. Science (New York, N.Y.), 2022.
Krawczyk MC, Haney JR, Pan L, Caneda C, Khankan RR, Reyes SD, Chang JW, Morselli M, Vinters HV, Wang AC, Cobos I, Gandal MJ, Bergsneider M, Kim W, Liau LM, Yong W, Jalali A, Deneen B, Grant GA, Mathern GW, Fallah A, Zhang Y. Human Astrocytes Exhibit Tumor Microenvironment-, Age-, and Sex-Related Transcriptomic Signatures.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022.
Emin D, Fallah A, Salamon N, Mathern G, Akhtari M. Distinctive ionic transport of freshly excised human epileptogenic brain tissue.. Applied physics letters, 2021.
Puka K, Jones M, Mathern GW. Functional cognitive and language outcomes after cerebral hemispherectomy for hemimegalencephaly.. Epilepsia, 2021.
Fallah A, Lewis E, Ibrahim GM, Kola O, Tseng CH, Harris WB, Chen JS, Lin KM, Cai LX, Liu QZ, Lin JL, Zhou WJ, Mathern GW, Smyth MD, O'Neill BR, Dudley RWR, Ragheb J, Bhatia S, Delev D, Ramantani G, Zentner J, Wang AC, Dorfer C, Feucht M, Czech T, Bollo RJ, Issabekov G, Zhu H, Connolly M, Steinbok P, Zhang JG, Zhang K, Hidalgo ET, Weiner HL, Wong-Kisiel L, Lapalme-Remis S, Tripathi M, Sarat Chandra P, Hader W, Wang FP, Yao Y, Champagne PO, Brunette-Clément T, Guo Q, Li SC, Budke M, Pérez-Jiménez MA, Raftopoulos C, Finet P, Michel P, Schaller K, Stienen MN, Baro V, Cantillano Malone C, Pociecha J, Chamorro N, Muro VL, von Lehe M, Vieker S, Oluigbo C, Gaillard WD, Al-Khateeb M, Al Otaibi F, Krayenbühl N, Bolton J, Pearl PL, Weil AG. Comparison of the real-world effectiveness of vertical versus lateral functional hemispherotomy techniques for pediatric drug-resistant epilepsy: A post hoc analysis of the HOPS study.. Epilepsia, 2021.
Meer EA, Chen MF, Jones M, Mathern GW, Pineles SL. Long-Term Patient-Reported Outcomes of Visual Field Defects and Compensatory Mechanisms in Patients After Cerebral Hemispherectomy.. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2021.
Emin D, Fallah A, Salamon N, Yong W, Frew A, Mathern G, Akhtari M. Understanding the sodium cation conductivity of human epileptic brain tissue.. AIP advances, 2021.
Chang JW, Reyes SD, Faure-Kumar E, Lam SK, Lawlor MW, Leventer RJ, Lew SM, Lockhart PJ, Pope K, Weiner HL, Salamon N, Vinters HV, Mathern GW, Fallah A, Owens GC. Clonally Focused Public and Private T Cells in Resected Brain Tissue From Surgeries to Treat Children With Intractable Seizures.. Frontiers in immunology, 2021.
Weil AG, Lewis EC, Ibrahim GM, Kola O, Tseng CH, Zhou X, Lin KM, Cai LX, Liu QZ, Lin JL, Zhou WJ, Mathern GW, Smyth MD, O'Neill BR, Dudley R, Ragheb J, Bhatia S, Delev D, Ramantani G, Zentner J, Ojemann J, Wang AC, Dorfer C, Feucht M, Czech T, Bollo RJ, Issabekov G, Zhu H, Connelly M, Steinbok P, Zhang JG, Zhang K, Hidalgo ET, Weiner HL, Wong-Kisiel L, Lapalme-Remis S, Tripathi M, Sarat Chandra P, Hader W, Wang FP, Yao Y, Olivier Champagne P, Guo Q, Li SC, Budke M, Pérez-Jiménez MA, Raftapoulos C, Finet P, Michel P, Schaller K, Stienen MN, Baro V, Cantillano Malone C, Pociecha J, Chamorro N, Muro VL, von Lehe M, Vieker S, Oluigbo C, Gaillard WD, Al Khateeb M, Al Otaibi F, Krayenbühl N, Bolton J, Pearl PL, Fallah A. Hemispherectomy Outcome Prediction Scale: Development and validation of a seizure freedom prediction tool.. Epilepsia, 2021.
Fallah A, Subramaniam T, Phillips HW, Michalet X, Vinters HV, Yong WH, Wu JY, Salamon N, Ellingson BM, Wang AC, Reyes SD, Ibrahim GM, Weil AG, Chang JW, Babayan D, Nguyen JC, Behnke E, Tseng CH, Mathern GW. Novel tonometer device distinguishes brain stiffness in epilepsy surgery.. Scientific reports, 2020.
Mathern GW, Bertram EH. Recurrent limbic seizures do not cause hippocampal neuronal loss: A prolonged laboratory study.. Neurobiology of disease, 2020.
Chivukula S, Modiri O, Kashanian A, Babayan D, Ibrahim GM, Weil AG, Tu A, Wu JY, Mathern GW, Fallah A. Effect of Gene Mutation on Seizures in Surgery for Tuberous Sclerosis Complex.. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2020.
Bellamkonda N, Phillips HW, Chen JS, Tucker AM, Maniquis C, Mathern GW, Fallah A. Epilepsy surgery for Rasmussen encephalitis: the UCLA experience.. Journal of neurosurgery. Pediatrics, 2020.
Levinson S, Tran CH, Barry J, Viker B, Levine MS, Vinters HV, Mathern GW, Cepeda C. Paroxysmal Discharges in Tissue Slices From Pediatric Epilepsy Surgery Patients: Critical Role of GABAB Receptors in the Generation of Ictal Activity.. Frontiers in cellular neuroscience, 2020.
Cepeda C, Levinson S, Nariai H, Yazon VW, Tran C, Barry J, Oikonomou KD, Vinters HV, Fallah A, Mathern GW, Wu JY. Pathological high frequency oscillations associate with increased GABA synaptic activity in pediatric epilepsy surgery patients.. Neurobiology of disease, 2019.
Chen MF, Meer E, Velez FG, Jones M, Mathern GW, Pineles SL. Etiology and Age Modifies Subjective Visual Function After Cerebral Hemispherectomy.. Journal of child neurology, 2019.
Pan PJ, Ullman HE, Mathern GW, Salamon N. Physical Growth of the Contralateral Cerebrum is Preserved After Hemispherotomy in Childhood.. Pediatric neurology, 2019.
Owens GC, Garcia AJ, Mochizuki AY, Chang JW, Reyes SD, Salamon N, Prins RM, Mathern GW, Fallah A. Evidence for Innate and Adaptive Immune Responses in a Cohort of Intractable Pediatric Epilepsy Surgery Patients.. Frontiers in immunology, 2019.
Paredes MF, Sorrells SF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez Martin AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A. Does Adult Neurogenesis Persist in the Human Hippocampus?. Cell stem cell, 2018.
Cepeda C, Levinson S, Yazon VW, Barry J, Mathern GW, Fallah A, Vinters HV, Levine MS, Wu JY. Cellular antiseizure mechanisms of everolimus in pediatric tuberous sclerosis complex, cortical dysplasia, and non-mTOR-mediated etiologies.. Epilepsia open, 2018.
Jacobs J, Wu JY, Perucca P, Zelmann R, Mader M, Dubeau F, Mathern GW, Schulze-Bonhage A, Gotman J. Removing high-frequency oscillations: A prospective multicenter study on seizure outcome.. Neurology, 2018.
Arend J, Kegler A, Caprara ALF, Almeida C, Gabbi P, Pascotini ET, de Freitas LAV, Miraglia C, Bertazzo TL, Palma R, Arceno P, Duarte MMMF, Furian AF, Oliveira MS, Royes LFF, Mathern GW, Fighera MR. Depressive, inflammatory, and metabolic factors associated with cognitive impairment in patients with epilepsy.. Epilepsy & behavior : E&B, 2018.
Correa DJ, Kwon CS, Connors S, Fureman B, Whittemore V, Jetté N, Mathern GW, Moshé SL, EpiBioS4Rx Public Engagement Core. Applying participatory action research in traumatic brain injury studies to prevent post-traumatic epilepsy.. Neurobiology of disease, 2018.
Sorrells SF, Paredes MF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A. Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults.. Nature, 2018.
Zhao X, Liao Y, Morgan S, Mathur R, Feustel P, Mazurkiewicz J, Qian J, Chang J, Mathern GW, Adamo MA, Ritaccio AL, Gruenthal M, Zhu X, Huang Y. Noninflammatory Changes of Microglia Are Sufficient to Cause Epilepsy.. Cell reports, 2018.
D'Gama AM, Woodworth MB, Hossain AA, Bizzotto S, Hatem NE, LaCoursiere CM, Najm I, Ying Z, Yang E, Barkovich AJ, Kwiatkowski DJ, Vinters HV, Madsen JR, Mathern GW, Blümcke I, Poduri A, Walsh CA. Somatic Mutations Activating the mTOR Pathway in Dorsal Telencephalic Progenitors Cause a Continuum of Cortical Dysplasias.. Cell reports, 2017.
Wang AC, Ibrahim GM, Poliakov AV, Wang PI, Fallah A, Mathern GW, Buckley RT, Collins K, Weil AG, Shurtleff HA, Warner MH, Perez FA, Shaw DW, Wright JN, Saneto RP, Novotny EJ, Lee A, Browd SR, Ojemann JG. Corticospinal tract atrophy and motor fMRI predict motor preservation after functional cerebral hemispherectomy.. Journal of neurosurgery. Pediatrics, 2017.
Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, Engel J, Forsgren L, French JA, Hesdorffer DC, Lee BI, Mathern GW, Moshe SL, Perucca E, Scheffer IE, Tomson T, Watanabe M, Wiebe S. How long for epilepsy remission in the ILAE definition?. Epilepsia, 2017.
Hussain SA, Mathern GW, Hung P, Weng J, Sankar R, Wu JY. Intraoperative fast ripples independently predict postsurgical epilepsy outcome: Comparison with other electrocorticographic phenomena.. Epilepsy research, 2017.
Nehlig A, Sperling M, Mathern G. An interview with Sarah Weckhuysen, 2017 Epilepsia Prize Winner for Clinical Research.. Epilepsia, 2017.
Nehlig A, Sperling M, Mathern G. An interview with Tiwalade Sobayo, 2017 Epilepsia Prize Winner for Basic Science Research.. Epilepsia, 2017.
Scheffer IE, Berkovic S, Capovilla G, Connolly MB, French J, Guilhoto L, Hirsch E, Jain S, Mathern GW, Moshé SL, Nordli DR, Perucca E, Tomson T, Wiebe S, Zhang YH, Zuberi SM. ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology.. Epilepsia, 2017.
Weiss SA, Asadi-Pooya AA, Vangala S, Moy S, Wyeth DH, Orosz I, Gibbs M, Schrader L, Lerner J, Cheng CK, Chang E, Rajaraman R, Keselman I, Churchman P, Bower-Baca C, Numis AL, Ho MG, Rao L, Bhat A, Suski J, Asadollahi M, Ambrose T, Fernandez A, Nei M, Skidmore C, Mintzer S, Eliashiv DS, Mathern GW, Nuwer MR, Sperling M, Engel J, Stern JM. AR2, a novel automatic artifact reduction software method for ictal EEG interpretation: Validation and comparison of performance with commercially available software.. F1000Research, 2017.
Dandekar S, Wijesuriya H, Geiger T, Hamm D, Mathern GW, Owens GC. Shared HLA Class I and II Alleles and Clonally Restricted Public and Private Brain-Infiltrating αβ T Cells in a Cohort of Rasmussen Encephalitis Surgery Patients.. Frontiers in immunology, 2016.
Galanopoulou AS, Schmidt D, Wang X, Mathern GW. Minimizing publication bias in Epilepsia Open: Negative or confirmatory studies and preliminary reports.. Epilepsia open, 2016.
Hussain SA, Mathern GW, Sankar R, Wu JY. Prospective and "live" fast ripple detection and localization in the operating room: Impact on epilepsy surgery outcomes in children.. Epilepsy research, 2016.
Fallah A, Weil AG, Wang S, Lewis E, Baca CB, Mathern GW. Cost-utility analysis of competing treatment strategies for drug-resistant epilepsy in children with Tuberous Sclerosis Complex.. Epilepsy & behavior : E&B, 2016.
Nehlig A, Sperling M, Mathern G. An interview with Saadet Mahmutoglu, 2016 Epilepsia prize winner for Clinical Research.. Epilepsia, 2016.
Nehlig A, Sperling M, Mathern G. Interview with Lena Nguyen, 2016 Epilepsia prize winner for Basic Science Research.. Epilepsia, 2016.
Pieters HC, Iwaki T, Vickrey BG, Mathern GW, Baca CB. "It was five years of hell": Parental experiences of navigating and processing the slow and arduous time to pediatric resective epilepsy surgery.. Epilepsy & behavior : E&B, 2016.
Sauro KM, Holroyd-Leduc J, Wiebe S, Quan H, Cooke L, Cross JH, Mathern GW, Armson H, Stromer J, Jetté N. Knowledge translation of an online tool to determine candidacy for epilepsy surgery evaluation.. Neurology. Clinical practice, 2016.
Scheffer IE, French J, Hirsch E, Jain S, Mathern GW, Moshé SL, Perucca E, Tomson T, Wiebe S, Zhang YH, Zuberi SM. Classification of the epilepsies: New concepts for discussion and debate-Special report of the ILAE Classification Task Force of the Commission for Classification and Terminology.. Epilepsia open, 2016.
Schmidt D, Galanopoulou AS, Mathern G, Wang X. Why Epilepsia Open?. Epilepsia open, 2016.
Kruse CA, Pardo CA, Hartman AL, Jallo G, Vining EP, Voros J, Gaillard WD, Liu J, Oluigbo C, Malone S, Bleasel AF, Dexter M, Micati A, Velasco TR, Machado HR, Martino AM, Huang A, Wheatley BM, Grant GA, Granata T, Freri E, Garbelli R, Koh S, Nordli DR, Campos AR, O'Neill B, Handler MH, Chapman KE, Wilfong AA, Curry DJ, Yaun A, Madsen JR, Smyth MD, Mercer D, Bingaman W, Harvey AS, Leventer RJ, Lockhart PJ, Gillies G, Pope K, Giller CA, Park YD, Rojiani AM, Sharma SJ, Jenkins P, Tung S, Huynh MN, Chirwa TW, Cepeda C, Levine MS, Chang JW, Owens GC, Vinters HV, Mathern GW. Rasmussen encephalitis tissue transfer program.. Epilepsia, 2016.
Owens GC, Chang JW, Huynh MN, Chirwa T, Vinters HV, Mathern GW. Evidence for Resident Memory T Cells in Rasmussen Encephalitis.. Frontiers in immunology, 2016.
Yogi A, Hirata Y, Karavaeva E, Harris RJ, Wu JY, Yudovin SL, Linetsky M, Mathern GW, Ellingson BM, Salamon N. DTI of tuber and perituberal tissue can predict epileptogenicity in tuberous sclerosis complex.. Neurology, 2015.
Baek ST, Copeland B, Yun EJ, Kwon SK, Guemez-Gamboa A, Schaffer AE, Kim S, Kang HC, Song S, Mathern GW, Gleeson JG. An AKT3-FOXG1-reelin network underlies defective migration in human focal malformations of cortical development.. Nature medicine, 2015.
Ellingson BM, Hirata Y, Yogi A, Karavaeva E, Leu K, Woodworth DC, Harris RJ, Enzmann DR, Wu JY, Mathern GW, Salamon N. Topographical Distribution of Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex.. Journal of child neurology, 2015.
de Bode S, Smets L, Mathern GW, Dubinsky S. Complex syntax in the isolated right hemisphere: Receptive grammatical abilities after cerebral hemispherectomy.. Epilepsy & behavior : E&B, 2015.
Owens GC, Erickson KL, Malone CC, Pan C, Huynh MN, Chang JW, Chirwa T, Vinters HV, Mathern GW, Kruse CA. Evidence for the involvement of gamma delta T cells in the immune response in Rasmussen encephalitis.. Journal of neuroinflammation, 2015.
Diamond M, Mathern G, Nehlig A, Sperling M. Interview with Matthew Diamond, 2014 Epilepsia prize winner.. Epilepsia, 2015.
Baca CB, Pieters HC, Iwaki TJ, Mathern GW, Vickrey BG. "A journey around the world": Parent narratives of the journey to pediatric resective epilepsy surgery and beyond.. Epilepsia, 2015.
de Bode S, Chanturidze M, Mathern GW, Dubinsky S. Literacy after cerebral hemispherectomy: Can the isolated right hemisphere read?. Epilepsy & behavior : E&B, 2015.
D'Gama AM, Geng Y, Couto JA, Martin B, Boyle EA, LaCoursiere CM, Hossain A, Hatem NE, Barry BJ, Kwiatkowski DJ, Vinters HV, Barkovich AJ, Shendure J, Mathern GW, Walsh CA, Poduri A. Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia.. Annals of neurology, 2015.
Jehi L, Mathern GW. Who's responsible to refer for epilepsy surgery? We all are!. Neurology, 2014.
Mathern GW, Beninsig L, Nehlig A. Should consciousness describe seizures and what terms should be applied? Epilepsia's survey results.. Epilepsia, 2014.
Cepeda C, Chang JW, Owens GC, Huynh MN, Chen JY, Tran C, Vinters HV, Levine MS, Mathern GW. In Rasmussen encephalitis, hemichannels associated with microglial activation are linked to cortical pyramidal neuron coupling: a possible mechanism for cellular hyperexcitability.. CNS neuroscience & therapeutics, 2014.
Mathern GW, Beninsig L, Nehlig A. Reasons for discrepancy between incidence and prevalence of epilepsy in lower income countries: Epilepsia's survey results.. Epilepsia, 2014.
Mathern GW, Beninsig L, Nehlig A. Fewer specialists support using medical marijuana and CBD in treating epilepsy patients compared with other medical professionals and patients: result of Epilepsia's survey.. Epilepsia, 2014.
Abdijadid S, Mathern GW, Levine MS, Cepeda C. Basic mechanisms of epileptogenesis in pediatric cortical dysplasia.. CNS neuroscience & therapeutics, 2014.
Mathern GW, Nehlig A. Global awareness and International Epilepsy Day.. Epilepsia, 2014.
Mathern GW, Beninsig L, Nehlig A. From the editors: Epilepsia's 2014 Operational Definition of Epilepsy survey.. Epilepsia, 2014.
Mathern GW, Beninsig L, Nehlig A. From the editors: Epilepsia's survey on the necessity of the Wada test and intracranial electrodes for cortical mapping.. Epilepsia, 2014.
Mathern G, Nehlig A, Hesdorffer DC. SUDEP's health burden and when to talk about it.. Epilepsia, 2014.
Mathern GW, Beninsig L, Nehlig A. From the editors: our paper (first) anniversary and launching Epilepsia's new look.. Epilepsia, 2014.
Mathern GW, Nehlig A. From the editors: using consciousness to describe seizures and classify the epilepsies.. Epilepsia, 2014.
Mathern G, Nehlig A. From the editors: the discrepancy between accumulative incidence and lifetime prevalence of epilepsy.. Epilepsia, 2014.
Mathern G, Nehlig A, Sperling M. Cannabidiol and medical marijuana for the treatment of epilepsy.. Epilepsia, 2014.
Mathern G, Nehlig A. Interview with Cristina Roseti, 2013 Morris-Coole/Epilepsia prize winner (interview by Gary Mathern and Astrid Nehlig).. Epilepsia, 2014.
Mathern G, Nehlig A. From the editors: Introducing Epilepsia's Controversy in Epilepsy series.. Epilepsia, 2014.
Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, Engel J, Forsgren L, French JA, Glynn M, Hesdorffer DC, Lee BI, Mathern GW, Moshé SL, Perucca E, Scheffer IE, Tomson T, Watanabe M, Wiebe S. ILAE official report: a practical clinical definition of epilepsy.. Epilepsia, 2014.
Mathern G, Nehlig A. Editorial: reducing stigma by changing the name of epilepsy.. Epilepsia, 2014.
Lewis DV, Shinnar S, Hesdorffer DC, Bagiella E, Bello JA, Chan S, Xu Y, MacFall J, Gomes WA, Moshé SL, Mathern GW, Pellock JM, Nordli DR, Frank LM, Provenzale J, Shinnar RC, Epstein LG, Masur D, Litherland C, Sun S, FEBSTAT Study Team. Hippocampal sclerosis after febrile status epilepticus: the FEBSTAT study.. Annals of neurology, 2014.
Rosenow F, Alonso-Vanegas MA, Baumgartner C, Blümcke I, Carreño M, Gizewski ER, Hamer HM, Knake S, Kahane P, Lüders HO, Mathern GW, Menzler K, Miller J, Otsuki T, Ozkara C, Pitkänen A, Roper SN, Sakamoto AC, Sure U, Walker MC, Steinhoff BJ, Surgical Task Force, Commission on Therapeutic Strategies of the ILAE. In response to commentary on cavernoma-related epilepsy: review and recommendations for management-report of the surgical task force of the ILAE commission on therapeutic strategies.. Epilepsia, 2014.
Jayakar P, Gaillard WD, Tripathi M, Libenson MH, Mathern GW, Cross JH, Task Force for Paediatric Epilepsy Surgery, Commission for Paediatrics, and the Diagnostic Commissio. Diagnostic test utilization in evaluation for resective epilepsy surgery in children.. Epilepsia, 2014.
Varadkar S, Bien CG, Kruse CA, Jensen FE, Bauer J, Pardo CA, Vincent A, Mathern GW, Cross JH. Rasmussen's encephalitis: clinical features, pathobiology, and treatment advances.. The Lancet. Neurology, 2014.
Rosenow F, Alonso-Vanegas MA, Baumgartner C, Blümcke I, Carreño M, Gizewski ER, Hamer HM, Knake S, Kahane P, Lüders HO, Mathern GW, Menzler K, Miller J, Otsuki T, Ozkara C, Pitkänen A, Roper SN, Sakamoto AC, Sure U, Walker MC, Steinhoff BJ, Surgical Task Force, Commission on Therapeutic Strategies of the ILAE. Cavernoma-related epilepsy: review and recommendations for management--report of the Surgical Task Force of the ILAE Commission on Therapeutic Strategies.. Epilepsia, 2013.
Phung J, Krogstad P, Mathern GW. Fevers and abnormal blood and cerebrospinal fluid studies after pediatric cerebral hemispherectomy: impact of etiology and age at surgery.. Journal of neurosurgery. Pediatrics, 2013.
Cepeda C, Chen JY, Wu JY, Fisher RS, Vinters HV, Mathern GW, Levine MS. Pacemaker GABA synaptic activity may contribute to network synchronization in pediatric cortical dysplasia.. Neurobiology of disease, 2013.
Mathern GW, Nehlig A. Epilepsia editorial: publications by country.. Epilepsia, 2013.
Phung J, Krogstad P, Mathern GW. Etiology associated with developing posthemispherectomy hydrocephalus after resection-disconnection procedures.. Journal of neurosurgery. Pediatrics, 2013.
Mathern GW, Nehlig A. Introduction of new Editors-in-Chief, Epilepsia.. Epilepsia, 2013.
Hauptman JS, Dadour A, Oh T, Baca CB, Vickrey BG, Vassar S, Sankar R, Salamon N, Vinters HV, Mathern GW. Time to pediatric epilepsy surgery is longer and developmental outcomes lower for government compared with private insurance.. Neurosurgery, 2013.
Akhtari M, Pope W, Mathern G, Moats R, Frew A, Mandelkern M. Functionalized magnetonanoparticles in visualization of intracranial tumors on MRI.. Molecular imaging and biology, 2013.
Blümcke I, Thom M, Aronica E, Armstrong DD, Bartolomei F, Bernasconi A, Bernasconi N, Bien CG, Cendes F, Coras R, Cross JH, Jacques TS, Kahane P, Mathern GW, Miyata H, Moshé SL, Oz B, Özkara Ç, Perucca E, Sisodiya S, Wiebe S, Spreafico R. International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: a Task Force report from the ILAE Commission on Diagnostic Methods.. Epilepsia, 2013.
Sarafian TA, Ryan CM, Souda P, Masliah E, Kar UK, Vinters HV, Mathern GW, Faull KF, Whitelegge JP, Watson JB. Impairment of mitochondria in adult mouse brain overexpressing predominantly full-length, N-terminally acetylated human α-synuclein.. PloS one, 2013.
Owens GC, Huynh MN, Chang JW, McArthur DL, Hickey MJ, Vinters HV, Mathern GW, Kruse CA. Differential expression of interferon-γ and chemokine genes distinguishes Rasmussen encephalitis from cortical dysplasia and provides evidence for an early Th1 immune response.. Journal of neuroinflammation, 2013.
Phung J, Mathern GW, Krogstad P. Timing and predictors of fever and infection after craniotomy for epilepsy in children.. The Pediatric infectious disease journal, 2013.
Mathern GW, Miller JW. Outcomes for temporal lobe epilepsy operations may not be equal: a call for an RCT of ATL vs SAH.. Neurology, 2013.
Baek ST, Gibbs EM, Gleeson JG, Mathern GW. Hemimegalencephaly, a paradigm for somatic postzygotic neurodevelopmental disorders.. Current opinion in neurology, 2013.
Baca CB, Vickrey BG, Vassar S, Hauptman JS, Dadour A, Oh T, Salamon N, Vinters HV, Sankar R, Mathern GW. Time to pediatric epilepsy surgery is related to disease severity and nonclinical factors.. Neurology, 2013.
Hauptman JS, Dadour A, Oh T, Baca CB, Vickrey BG, Vassar SD, Sankar R, Salamon N, Vinters HV, Mathern GW. Sociodemographic changes over 25 years of pediatric epilepsy surgery at UCLA.. Journal of neurosurgery. Pediatrics, 2013.
Hauptman JS, Pedram K, Sison CA, Sankar R, Salamon N, Vinters HV, Mathern GW. Pediatric epilepsy surgery: long-term 5-year seizure remission and medication use.. Neurosurgery, 2012.
Hauptman JS, Mathern GW. Vagal nerve stimulation for pharmacoresistant epilepsy in children.. Surgical neurology international, 2012.
Chang JW, Arnold MM, Rozenbaum A, Caputo A, Schweizer FE, Huynh M, Mathern GW, Sarafian TA, Watson JB. Synaptoneurosome micromethod for fractionation of mouse and human brain, and primary neuronal cultures.. Journal of neuroscience methods, 2012.
Hauptman JS, Mathern GW. Surgical treatment of epilepsy associated with cortical dysplasia: 2012 update.. Epilepsia, 2012.
Langfitt JT, Mathern GW. Web-based eight-question tool to determine epilepsy surgery evaluation: the future is here.. Neurology, 2012.
Hauptman JS, Salamon N, Mathern GW. Neuroimaging in the definition and organization of the epilepsies: we're not there yet.. Epilepsia, 2012.
Lee JH, Huynh M, Silhavy JL, Kim S, Dixon-Salazar T, Heiberg A, Scott E, Bafna V, Hill KJ, Collazo A, Funari V, Russ C, Gabriel SB, Mathern GW, Gleeson JG. De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly.. Nature genetics, 2012.
Wagner AS, Yin NS, Tung S, Mathern GW, Vinters HV. Intimal thickening of meningeal arteries after serial corticectomies for Rasmussen encephalitis.. Human pathology, 2012.
Hauptman JS, Mathern GW. Epilepsy neurosurgery in children.. Handbook of clinical neurology, 2012.
Moshé SL, Perucca E, Wiebe S, Mathern GW. The International League Against Epilepsy at the threshold of its second century: year 2.. Epilepsia, 2012.
de Bode S, Fritz S, Mathern GW. Cerebral hemispherectomy: sensory scores before and after intensive mobility training.. Brain & development, 2011.
Cepeda C, André VM, Hauptman JS, Yamazaki I, Huynh MN, Chang JW, Chen JY, Fisher RS, Vinters HV, Levine MS, Mathern GW. Enhanced GABAergic network and receptor function in pediatric cortical dysplasia Type IIB compared with Tuberous Sclerosis Complex.. Neurobiology of disease, 2011.
Velasco TR, Wichert-Ana L, Mathern GW, Araújo D, Walz R, Bianchin MM, Dalmagro CL, Leite JP, Santos AC, Assirati JA, Carlotti CG, Sakamoto AC. Utility of ictal single photon emission computed tomography in mesial temporal lobe epilepsy with hippocampal atrophy: a randomized trial.. Neurosurgery, 2011.
Moshé SL, Perucca E, Wiebe S, Mathern GW. The International League Against Epilepsy at the threshold of its second century: year 1.. Epilepsia, 2011.
Blümcke I, Thom M, Aronica E, Armstrong DD, Vinters HV, Palmini A, Jacques TS, Avanzini G, Barkovich AJ, Battaglia G, Becker A, Cepeda C, Cendes F, Colombo N, Crino P, Cross JH, Delalande O, Dubeau F, Duncan J, Guerrini R, Kahane P, Mathern G, Najm I, Ozkara C, Raybaud C, Represa A, Roper SN, Salamon N, Schulze-Bonhage A, Tassi L, Vezzani A, Spreafico R. The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission.. Epilepsia, 2010.
Mathern GW. Cerebral hemispherectomy: when half a brain is good enough.. Neurology, 2010.
Thom M, Mathern GW, Cross JH, Bertram EH. Mesial temporal lobe epilepsy: How do we improve surgical outcome?. Annals of neurology, 2010.
Qin W, Chan JA, Vinters HV, Mathern GW, Franz DN, Taillon BE, Bouffard P, Kwiatkowski DJ. Analysis of TSC cortical tubers by deep sequencing of TSC1, TSC2 and KRAS demonstrates that small second-hit mutations in these genes are rare events.. Brain pathology (Zurich, Switzerland), 2010.
Cepeda C, André VM, Yamazaki I, Hauptman JS, Chen JY, Vinters HV, Mathern GW, Levine MS. Comparative study of cellular and synaptic abnormalities in brain tissue samples from pediatric tuberous sclerosis complex and cortical dysplasia type II.. Epilepsia, 2010.
André VM, Cepeda C, Vinters HV, Huynh M, Mathern GW, Levine MS. Interneurons, GABAA currents, and subunit composition of the GABAA receptor in type I and type II cortical dysplasia.. Epilepsia, 2010.
Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde Boas W, Engel J, French J, Glauser TA, Mathern GW, Moshé SL, Nordli D, Plouin P, Scheffer IE. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009.. Epilepsia, 2010.
Mathern GW. Commentary.. Surgical neurology, 2009.
Kwan P, Arzimanoglou A, Berg AT, Brodie MJ, Allen Hauser W, Mathern G, Moshé SL, Perucca E, Wiebe S, French J. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies.. Epilepsia, 2009.
Mathern GW. Challenges in the surgical treatment of epilepsy patients with cortical dysplasia.. Epilepsia, 2009.
Mehta RI, Cutler AR, Lasky JL, Yong WH, Lerner JT, Hirota BK, Salamon N, Mathern GW, Vinters HV. "Primary" leptomeningeal medulloblastoma.. Human pathology, 2009.
Berg AT, Mathern GW, Bronen RA, Fulbright RK, DiMario F, Testa FM, Levy SR. Frequency, prognosis and surgical treatment of structural abnormalities seen with magnetic resonance imaging in childhood epilepsy.. Brain : a journal of neurology, 2009.
Khanlou N, Mathern GW, Mitchell WG, Salamon N, Pope WB, Yong WH, Vinters HV. Cortical dysplasia with prominent Rosenthal fiber formation in a case of intractable pediatric epilepsy.. Human pathology, 2009.
Wirenfeldt M, Clare R, Tung S, Bottini A, Mathern GW, Vinters HV. Increased activation of Iba1+ microglia in pediatric epilepsy patients with Rasmussen's encephalitis compared with cortical dysplasia and tuberous sclerosis complex.. Neurobiology of disease, 2009.
de Bode S, Fritz SL, Weir-Haynes K, Mathern GW. Constraint-induced movement therapy for individuals after cerebral hemispherectomy: a case series.. Physical therapy, 2009.
Lerner JT, Salamon N, Hauptman JS, Velasco TR, Hemb M, Wu JY, Sankar R, Donald Shields W, Engel J, Fried I, Cepeda C, Andre VM, Levine MS, Miyata H, Yong WH, Vinters HV, Mathern GW. Assessment and surgical outcomes for mild type I and severe type II cortical dysplasia: a critical review and the UCLA experience.. Epilepsia, 2009.
Mathern GW. Epilepsy surgery patients with cortical dysplasia: present and future therapeutic challenges.. Neurology, 2008.
André VM, Cepeda C, Vinters HV, Huynh M, Mathern GW, Levine MS. Pyramidal cell responses to gamma-aminobutyric acid differ in type I and type II cortical dysplasia.. Journal of neuroscience research, 2008.
Wu JY, Koh S, Sankar R, Mathern GW. Paroxysmal fast activity: an interictal scalp EEG marker of epileptogenesis in children.. Epilepsy research, 2008.
Harvey AS, Cross JH, Shinnar S, Mathern GW, Mathern BW, ILAE Pediatric Epilepsy Surgery Survey Taskforce. Defining the spectrum of international practice in pediatric epilepsy surgery patients.. Epilepsia, 2007.
Staba RJ, Frighetto L, Behnke EJ, Mathern GW, Fields T, Bragin A, Ogren J, Fried I, Wilson CL, Engel J. Increased fast ripple to ripple ratios correlate with reduced hippocampal volumes and neuron loss in temporal lobe epilepsy patients.. Epilepsia, 2007.
André VM, Wu N, Yamazaki I, Nguyen ST, Fisher RS, Vinters HV, Mathern GW, Levine MS, Cepeda C. Cytomegalic interneurons: a new abnormal cell type in severe pediatric cortical dysplasia.. Journal of neuropathology and experimental neurology, 2007.
de Bode S, Sininger Y, Healy EW, Mathern GW, Zaidel E. Dichotic listening after cerebral hemispherectomy: methodological and theoretical observations.. Neuropsychologia, 2007.
de Bode S, Mathern GW, Bookheimer S, Dobkin B. Locomotor training remodels fMRI sensorimotor cortical activations in children after cerebral hemispherectomy.. Neurorehabilitation and neural repair, 2007.
Mathern GW, Andres M, Salamon N, Chandra PS, Andre VM, Cepeda C, Levine MS, Leite JP, Neder L, Vinters HV. A hypothesis regarding the pathogenesis and epileptogenesis of pediatric cortical dysplasia and hemimegalencephaly based on MRI cerebral volumes and NeuN cortical cell densities.. Epilepsia, 2007.
Cepeda C, André VM, Wu N, Yamazaki I, Uzgil B, Vinters HV, Levine MS, Mathern GW. Immature neurons and GABA networks may contribute to epileptogenesis in pediatric cortical dysplasia.. Epilepsia, 2007.
Mathern GW, Trevathan E. Childhood-onset temporal lobe epilepsy: neuroimaging predicts seizure control.. Neurology, 2006.
Huang SY, Wolahan SM, Mathern GW, Chute DJ, Akhtari M, Nguyen ST, Huynh MN, Salamon N, Lin YY. Improving MRI differentiation of gray and white matter in epileptogenic lesions based on nonlinear feedback.. Magnetic resonance in medicine, 2006.
Chandra PS, Salamon N, Huang J, Wu JY, Koh S, Vinters HV, Mathern GW. FDG-PET/MRI coregistration and diffusion-tensor imaging distinguish epileptogenic tubers and cortex in patients with tuberous sclerosis complex: a preliminary report.. Epilepsia, 2006.
Cepeda C, André VM, Levine MS, Salamon N, Miyata H, Vinters HV, Mathern GW. Epileptogenesis in pediatric cortical dysplasia: the dysmature cerebral developmental hypothesis.. Epilepsy & behavior : E&B, 2006.
Cross JH, Jayakar P, Nordli D, Delalande O, Duchowny M, Wieser HG, Guerrini R, Mathern GW, International League against Epilepsy, Subcommission for Paediatric Epilepsy Surgery, Commissions of Neurosurgery and Paediatrics. Proposed criteria for referral and evaluation of children for epilepsy surgery: recommendations of the Subcommission for Pediatric Epilepsy Surgery.. Epilepsia, 2006.
Leppik IE, Kelly KM, deToledo-Morrell L, Patrylo PR, DeLorenzo RJ, Mathern GW, White HS. Basic research in epilepsy and aging.. Epilepsy research, 2005.
Koh S, Mathern GW, Glasser G, Wu JY, Shields WD, Jonas R, Yudovin S, Cepeda C, Salamon N, Vinters HV, Sankar R. Status epilepticus and frequent seizures: incidence and clinical characteristics in pediatric epilepsy surgery patients.. Epilepsia, 2005.
Salamon N, Andres M, Chute DJ, Nguyen ST, Chang JW, Huynh MN, Chandra PS, Andre VM, Cepeda C, Levine MS, Leite JP, Neder L, Vinters HV, Mathern GW. Contralateral hemimicrencephaly and clinical-pathological correlations in children with hemimegalencephaly.. Brain : a journal of neurology, 2005.
Cepeda C, André VM, Vinters HV, Levine MS, Mathern GW. Are cytomegalic neurons and balloon cells generators of epileptic activity in pediatric cortical dysplasia?. Epilepsia, 2005.
de Bode S, Firestine A, Mathern GW, Dobkin B. Residual motor control and cortical representations of function following hemispherectomy: effects of etiology.. Journal of child neurology, 2005.
Andres M, Andre VM, Nguyen S, Salamon N, Cepeda C, Levine MS, Leite JP, Neder L, Vinters HV, Mathern GW. Human cortical dysplasia and epilepsy: an ontogenetic hypothesis based on volumetric MRI and NeuN neuronal density and size measurements.. Cerebral cortex (New York, N.Y. : 1991), 2004.
Koh S, Nguyen S, Asarnow RF, LoPresti C, Yudovin S, Shields WD, Vinters HV, Mathern GW. Five or more acute postoperative seizures predict hospital course and long-term seizure control after hemispherectomy.. Epilepsia, 2004.
André VM, Flores-Hernández J, Cepeda C, Starling AJ, Nguyen S, Lobo MK, Vinters HV, Levine MS, Mathern GW. NMDA receptor alterations in neurons from pediatric cortical dysplasia tissue.. Cerebral cortex (New York, N.Y. : 1991), 2004.
Cook SW, Nguyen ST, Hu B, Yudovin S, Shields WD, Vinters HV, Van de Wiele BM, Harrison RE, Mathern GW. Cerebral hemispherectomy in pediatric patients with epilepsy: comparison of three techniques by pathological substrate in 115 patients.. Journal of neurosurgery, 2004.
Stables JP, Bertram E, Dudek FE, Holmes G, Mathern G, Pitkanen A, White HS. Therapy discovery for pharmacoresistant epilepsy and for disease-modifying therapeutics: summary of the NIH/NINDS/AES models II workshop.. Epilepsia, 2003.
Bender RA, Soleymani SV, Brewster AL, Nguyen ST, Beck H, Mathern GW, Baram TZ. Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003.
Cepeda C, Hurst RS, Flores-Hernández J, Hernández-Echeagaray E, Klapstein GJ, Boylan MK, Calvert CR, Jocoy EL, Nguyen OK, André VM, Vinters HV, Ariano MA, Levine MS, Mathern GW. Morphological and electrophysiological characterization of abnormal cell types in pediatric cortical dysplasia.. Journal of neuroscience research, 2003.
Shusta EV, Boado RJ, Mathern GW, Pardridge WM. Vascular genomics of the human brain.. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2002.
Caplan R, Siddarth P, Mathern G, Vinters H, Curtiss S, Levitt J, Asarnow R, Shields WD. Developmental outcome with and without successful intervention.. International review of neurobiology, 2002.
Mathern GW, Adelson PD, Cahan LD, Leite JP. Hippocampal neuron damage in human epilepsy: Meyer's hypothesis revisited.. Progress in brain research, 2002.
Mathern GW, Leiphart JL, De Vera A, Adelson PD, Seki T, Neder L, Leite JP. Seizures decrease postnatal neurogenesis and granule cell development in the human fascia dentata.. Epilepsia, 2002.
Mathern GW, Cepeda C, Hurst RS, Flores-Hernandez J, Mendoza D, Levine MS. Neurons recorded from pediatric epilepsy surgery patients with cortical dysplasia.. Epilepsia, 2000.
Mathern GW, Giza CC, Yudovin S, Vinters HV, Peacock WJ, Shewmon DA, Shields WD. Postoperative seizure control and antiepileptic drug use in pediatric epilepsy surgery patients: the UCLA experience, 1986-1997.. Epilepsia, 1999.
Mathern GW, Mendoza D, Lozada A, Pretorius JK, Dehnes Y, Danbolt NC, Nelson N, Leite JP, Chimelli L, Born DE, Sakamoto AC, Assirati JA, Fried I, Peacock WJ, Ojemann GA, Adelson PD. Hippocampal GABA and glutamate transporter immunoreactivity in patients with temporal lobe epilepsy.. Neurology, 1999.
Mathern GW, Pretorius JK, Mendoza D, Lozada A, Kornblum HI. Hippocampal AMPA and NMDA mRNA levels correlate with aberrant fascia dentata mossy fiber sprouting in the pilocarpine model of spontaneous limbic epilepsy.. Journal of neuroscience research, 1998.
Mathern GW, Pretorius JK, Leite JP, Kornblum HI, Mendoza D, Lozada A, Bertram EH. Hippocampal AMPA and NMDA mRNA levels and subunit immunoreactivity in human temporal lobe epilepsy patients and a rodent model of chronic mesial limbic epilepsy.. Epilepsy research, 1998.
Mathern GW, Price G, Rosales C, Pretorius JK, Lozada A, Mendoza D. Anoxia during kainate status epilepticus shortens behavioral convulsions but generates hippocampal neuron loss and supragranular mossy fiber sprouting.. Epilepsy research, 1998.
Mathern GW, Babb TL, Leite JP, Pretorius K, Yeoman KM, Kuhlman PA. The pathogenic and progressive features of chronic human hippocampal epilepsy.. Epilepsy research, 1996.