Gene Block, Ph.D.

Gene Block, Ph.D.

Publications

• Wang Y, Paul KN, Block GD, Deboer T, Colwell CS. Dim Light at Night Disrupts the Sleep-Wake Cycle and Exacerbates Seizure Activity in Cntnap2 Knockout Mice: Implications for Autism Spectrum Disorders.. bioRxiv : the preprint server for biology, 2025.
• Wang HB, Zhou D, Luk SHC, In Cha H, Mac A, Chae R, Matynia A, Harrison B, Afshari S, Block GD, Ghiani CA, Colwell CS. Long wavelength light reduces the negative consequences of dim light at night.. Neurobiology of disease, 2022.
• Whittaker DS, Tamai TK, Bains RS, Villanueva SAM, Luk SHC, Dell'Angelica D, Block GD, Ghiani CA, Colwell CS. Dietary ketosis improves circadian dysfunction as well as motor symptoms in the BACHD mouse model of Huntington's disease.. Frontiers in nutrition, 2022.
• Miyazaki S, Tahara Y, Colwell CS, Block GD, Nakamura W, Nakamura TJ. Chronic methamphetamine uncovers a circadian rhythm in multiple-unit neural activity in the dorsal striatum which is independent of the suprachiasmatic nucleus.. Neurobiology of sleep and circadian rhythms, 2021.
• Crow MM, Alger J, Amiridis M, Assanis D, Barron E, Becker MP, Blank RM, Block GD, Bollinger LC, Brown RA, Burwell SM, Cassidy CM, Clements JP, Currall S, DeGioia JJ, Frenk J, Fuchs WK, Gabel JTA, Gallagher PD, Gee EG, Isaacs E, Jacobs LA, Jahanian F, Jenkins J, Johnson KM, Kanter M, Kearns PK, Kennedy M, Khosla PK, Leshin L, Lovell M, May GS, Morehead J, Myers RB, Proenza LM, Rose C, Rudd MD, Sands TD, Schlissel MS, Stephens E, Stroble E, Subbaswamy K, Tripathi S, Watkins R, Weinberg A, Wilcox K, Wince-Smith D, Wintersteen W, Woodson WR, Zimmer RJ. Support U.S. research during COVID-19.. Science (New York, N.Y.), 2020.
• Wang HB, Tahara Y, Luk SHC, Kim YS, Hitchcock ON, MacDowell Kaswan ZA, In Kim Y, Block GD, Ghiani CA, Loh DH, Colwell CS. Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder.. Neurobiology of disease, 2020.
• Whittaker DS, Loh DH, Wang HB, Tahara Y, Kuljis D, Cutler T, Ghiani CA, Shibata S, Block GD, Colwell CS. Circadian-based Treatment Strategy Effective in the BACHD Mouse Model of Huntington's Disease.. Journal of biological rhythms, 2018.
• Kim YB, Kim WB, Jung WW, Jin X, Kim YS, Kim B, Han HC, Block GD, Colwell CS, Kim YI. Excitatory GABAergic Action and Increased Vasopressin Synthesis in Hypothalamic Magnocellular Neurosecretory Cells Underlie the High Plasma Level of Vasopressin in Diabetic Rats.. Diabetes, 2017.
• Kudo T, Block GD, Colwell CS. The Circadian Clock Gene Period1 Connects the Molecular Clock to Neural Activity in the Suprachiasmatic Nucleus.. ASN neuro, 2015.
• Nakamura TJ, Nakamura W, Tokuda IT, Ishikawa T, Kudo T, Colwell CS, Block GD. Age-Related Changes in the Circadian System Unmasked by Constant Conditions. eNeuro, 2015.
• Takasu NN, Nakamura TJ, Tokuda IT, Todo T, Block GD, Nakamura W. Recovery from Age-Related Infertility under Environmental Light-Dark Cycles Adjusted to the Intrinsic Circadian Period.. Cell reports, 2015.
• Qian J, Block GD, Colwell CS, Matveyenko AV. Consequences of exposure to light at night on the pancreatic islet circadian clock and function in rats.. Diabetes, 2013.
• Kudo T, Tahara Y, Gamble KL, McMahon DG, Block GD, Colwell CS. Vasoactive intestinal peptide produces long-lasting changes in neural activity in the suprachiasmatic nucleus.. Journal of neurophysiology, 2013.
• Sellix MT, Evans JA, Leise TL, Castanon-Cervantes O, Hill DD, DeLisser P, Block GD, Menaker M, Davidson AJ. Aging differentially affects the re-entrainment response of central and peripheral circadian oscillators.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012.
• Gale JE, Cox HI, Qian J, Block GD, Colwell CS, Matveyenko AV. Disruption of circadian rhythms accelerates development of diabetes through pancreatic beta-cell loss and dysfunction.. Journal of biological rhythms, 2011.
• Nakamura TJ, Nakamura W, Yamazaki S, Kudo T, Cutler T, Colwell CS, Block GD. Age-related decline in circadian output.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011.
• Loh DH, Dragich JM, Kudo T, Schroeder AM, Nakamura TJ, Waschek JA, Block GD, Colwell CS. Effects of vasoactive intestinal peptide genotype on circadian gene expression in the suprachiasmatic nucleus and peripheral organs.. Journal of biological rhythms, 2011.
• Lundkvist GB, Sellix MT, Nygård M, Davis E, Straume M, Kristensson K, Block GD. Clock gene expression during chronic inflammation induced by infection with Trypanosoma brucei brucei in rats.. Journal of biological rhythms, 2010.
• Nakamura TJ, Sellix MT, Kudo T, Nakao N, Yoshimura T, Ebihara S, Colwell CS, Block GD. Influence of the estrous cycle on clock gene expression in reproductive tissues: effects of fluctuating ovarian steroid hormone levels.. Steroids, 2010.
• Yamazaki S, Yoshikawa T, Biscoe EW, Numano R, Gallaspy LM, Soulsby S, Papadimas E, Pezuk P, Doyle SE, Tei H, Sakaki Y, Block GD, Menaker M. Ontogeny of circadian organization in the rat.. Journal of biological rhythms, 2009.
• Nakamura TJ, Sellix MT, Menaker M, Block GD. Estrogen directly modulates circadian rhythms of PER2 expression in the uterus.. American journal of physiology. Endocrinology and metabolism, 2008.
• Kwak Y, Lundkvist GB, Brask J, Davidson A, Menaker M, Kristensson K, Block GD. Interferon-gamma alters electrical activity and clock gene expression in suprachiasmatic nucleus neurons.. Journal of biological rhythms, 2008.
• Nakamura W, Yamazaki S, Nakamura TJ, Shirakawa T, Block GD, Takumi T. In vivo monitoring of circadian timing in freely moving mice.. Current biology : CB, 2008.
• VanderLeest HT, Houben T, Michel S, Deboer T, Albus H, Vansteensel MJ, Block GD, Meijer JH. Seasonal encoding by the circadian pacemaker of the SCN.. Current biology : CB, 2007.
• Davidson AJ, Yamazaki S, Arble DM, Menaker M, Block GD. Resetting of central and peripheral circadian oscillators in aged rats.. Neurobiology of aging, 2006.
• Davidson AJ, Straume M, Block GD, Menaker M. Daily timed meals dissociate circadian rhythms in hepatoma and healthy host liver.. International journal of cancer, 2006.
• Lundkvist GB, Kwak Y, Davis EK, Tei H, Block GD. A calcium flux is required for circadian rhythm generation in mammalian pacemaker neurons.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005.
• Nakamura W, Yamazaki S, Takasu NN, Mishima K, Block GD. Differential response of Period 1 expression within the suprachiasmatic nucleus.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005.
• Albus H, Vansteensel MJ, Michel S, Block GD, Meijer JH. A GABAergic mechanism is necessary for coupling dissociable ventral and dorsal regional oscillators within the circadian clock.. Current biology : CB, 2005.
• Block G. Keep time, stay healthy.. Science of aging knowledge environment : SAGE KE, 2005.
• Lundkvist GB, Block GD. Role of neuronal membrane events in circadian rhythm generation.. Methods in enzymology, 2005.
• Aton SJ, Block GD, Tei H, Yamazaki S, Herzog ED. Plasticity of circadian behavior and the suprachiasmatic nucleus following exposure to non-24-hour light cycles.. Journal of biological rhythms, 2004.
• Davidson AJ, Aujard F, London B, Menaker M, Block GD. Thermochron ibuttons: an inexpensive method for long-term recording of core body temperature in untethered animals.. Journal of biological rhythms, 2003.
• Vansteensel MJ, Yamazaki S, Albus H, Deboer T, Block GD, Meijer JH. Dissociation between circadian Per1 and neuronal and behavioral rhythms following a shifted environmental cycle.. Current biology : CB, 2003.
• Constance CM, Green CB, Tei H, Block GD. Bulla gouldiana period exhibits unique regulation at the mRNA and protein levels.. Journal of biological rhythms, 2002.
• Yamazaki S, Straume M, Tei H, Sakaki Y, Menaker M, Block GD. Effects of aging on central and peripheral mammalian clocks.. Proceedings of the National Academy of Sciences of the United States of America, 2002.
• Abe M, Herzog ED, Yamazaki S, Straume M, Tei H, Sakaki Y, Menaker M, Block GD. Circadian rhythms in isolated brain regions.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002.
• Wilsbacher LD, Yamazaki S, Herzog ED, Song EJ, Radcliffe LA, Abe M, Block G, Spitznagel E, Menaker M, Takahashi JS. Photic and circadian expression of luciferase in mPeriod1-luc transgenic mice invivo.. Proceedings of the National Academy of Sciences of the United States of America, 2001.