Guoping Fan, Ph.D.

Professor, Human Genetics Member, Bioinformatics GPB Home Area Brain Research Institute Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research Gene Regulation GPB Home Area Genetics & Genomics GPB Home Area JCCC Gene Regulation Program Area Neuroscience GPB Home Area

gfan@mednet.ucla.edu

(310) 267-0439

Office
695 Charles Young Drive South
UCLA
Los Angeles, CA 90095
UNITED STATES

Room 6357C, Gonda Building
Campus - 708822
CA
UNITED STATES

Laboratory
695 Charles Young Drive South
UCLA
Los Angeles, CA 90095
UNITED STATES

Website

Biography

Guoping Fan is a Professor in the Department of Human Genetics, David Geffen School of Medicine at UCLA. He has been a faculty member at UCLA since 2001. Pior to that, he was a postdoctoral fellow at the Whitehead Institute for Biomedical Institute/MIT, where he studies the role of DNA methylation and neurotrophins in neural development. Dr. Fan earned his B.S. in Biochemistry at Nanjing University, China and Ph.D. in Neuroscience at Case Western Reserve University. His current research focuses on the actions of DNA methylation and chromatin-remodeling in regulating neural gene expression, neuronal function, and stem cell differentiation and reprogramming.

Publications

Wang J, Deng X, Jian T, Yin S, Chen L, Vergnes L, Li Z, Liu H, Lee R, Lim SY, Bahn JH, Xiao X, Zhu X, Hu G, Reue K, Liu Y, Fan G. DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation.. Molecular cell, 2025.
Liu J, Liu Q, Guo M, Jiang C, Chen J, Wang T, Sung TC, Chou SJ, Chiou SH, Fan G, Higuchi A. Differentiation of human induced pluripotent stem cells into retinal pigment epithelium cells during culture on peptide-grafted hydrogels.. Regenerative biomaterials, 2025.
Deng X, Fan G. Tuning up gene transcription via direct crosstalk of DNA and RNA methylation.. Molecular cell, 2025.
Zhang W, Qian S, Chen J, Jian T, Wang X, Zhu X, Dong Y, Fan G. Photo-Crosslinked Pro-Angiogenic Hydrogel Dressing for Wound Healing.. International journal of molecular sciences, 2024.
Zhang S, Xiao Y, Mo X, Chen X, Zhong J, Chen Z, Liu X, Qiu Y, Dai W, Chen J, Jin X, Fan G, Hu Y. Simultaneous profiling of RNA isoforms and chromatin accessibility of single cells of human retinal organoids.. Nature communications, 2024.
Tian Z, Liu Q, Lin HY, Zhu YR, Ling L, Sung TC, Wang T, Li W, Gao M, Cheng S, Renuka RR, Subbiah SK, Fan G, Wu GJ, Higuchi A. Effects of ECM protein-coated surfaces on the generation of retinal pigment epithelium cells differentiated from human pluripotent stem cells.. Regenerative biomaterials, 2024.
Liu Q, Liu J, Guo M, Sung TC, Wang T, Yu T, Tian Z, Fan G, Wu W, Higuchi A. Comparison of retinal degeneration treatment with four types of different mesenchymal stem cells, human induced pluripotent stem cells and RPE cells in a rat retinal degeneration model.. Journal of translational medicine, 2023.
Ma L, Wang F, Li Y, Wang J, Chang Q, Du Y, Sadan J, Zhao Z, Fan G, Yao B, Chen JF. Brain methylome remodeling selectively regulates neuronal activity genes linking to emotional behaviors in mice exposed to maternal immune activation.. Nature communications, 2023.
Xu D, Wan B, Qiu K, Wang Y, Zhang X, Jiao N, Yan E, Wu J, Yu R, Gao S, Du M, Liu C, Li M, Fan G, Yin J. Single-Cell RNA-Sequencing Provides Insight into Skeletal Muscle Evolution during the Selection of Muscle Characteristics.. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023.
Wang T, Shi S, Shi Y, Jiang P, Hu G, Ye Q, Shi Z, Yu K, Wang C, Fan G, Zhao S, Ma H, Chang ACY, Li Z, Bian Q, Lin CP. Chemical-induced phase transition and global conformational reorganization of chromatin.. Nature communications, 2023.
Tian C, Wang J, Ye X, Chen J, Zheng R, Yu H, Li J, Yin G, Liu L, Zhao N, Feng G, Zhu Z, Wang J, Fan G, Liu L. Culture conditions of mouse ESCs impact the tumor appearance in vivo.. Cell reports, 2023.
Ding X, An Q, Zhao W, Song Y, Tang X, Wang J, Chang CC, Zhao G, Hsiai T, Fan G, Fan Y, Li S. Distinct patterns of responses in endothelial cells and smooth muscle cells following vascular injury.. JCI insight, 2022.
Deng X, Lee R, Lim SY, Zhong Z, Wang J, Liu Y, Fan G. Global Transcriptional and Epigenetic Reconfiguration during Chemical Reprogramming of Human Retinal Pigment Epithelial Cells into Photoreceptor-like Cells.. Cells, 2022.
Jansova D, Aleshkina D, Jindrova A, Iyyappan R, An Q, Fan G, Susor A. Single Molecule RNA Localization and Translation in the Mammalian Oocyte and Embryo.. Journal of molecular biology, 2021.
Ma L, Wang J, Ge J, Wang Y, Zhang W, Du Y, Luo J, Li Y, Wang F, Fan G, Chen R, Yao B, Zhao Z, Guo ML, Kim WK, Chai Y, Chen JF. Reversing neural circuit and behavior deficit in mice exposed to maternal inflammation by Zika virus.. EMBO reports, 2021.
Wei Y, Zhang C, Fan G, Meng L. Organoids as Novel Models for Embryo Implantation Study.. Reproductive sciences (Thousand Oaks, Calif.), 2021.
Song Y, Soto J, Wang P, An Q, Zhang X, Hong S, Lee LP, Fan G, Yang L, Li S. Asymmetric Cell Division of Fibroblasts is An Early Deterministic Step to Generate Elite Cells during Cell Reprogramming.. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021.
Deng P, Yuan Q, Cheng Y, Li J, Liu Z, Liu Y, Li Y, Su T, Wang J, Salvo ME, Wang W, Fan G, Lyons K, Yu B, Wang CY. Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging.. Cell stem cell, 2021.
Hu Y, Huang K, Zeng Q, Feng Y, Ke Q, An Q, Qin LJ, Cui Y, Guo Y, Zhao D, Peng Y, Tian D, Xia K, Chen Y, Ni B, Wang J, Zhu X, Wei L, Liu Y, Xiang P, Liu JY, Xue Z, Fan G. Single-cell analysis of nonhuman primate preimplantation development in comparison to humans and mice.. Developmental dynamics : an official publication of the American Association of Anatomists, 2021.
Lu P, Yang G, Jiang L, He W, Wu W, Qi L, Shen S, Rao J, Zhang P, Xue Z, Jiang C, Fan G, Zhu X. Characterizing disease progression of nonalcoholic steatohepatitis in Leptin-deficient rats by integrated transcriptome analysis.. Experimental biology and medicine (Maywood, N.J.), 2020.
He D, Wang D, Lu P, Yang N, Xue Z, Zhu X, Zhang P, Fan G. Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations.. Oncogene, 2020.
Hu Y, Zhong J, Xiao Y, Xing Z, Sheu K, Fan S, An Q, Qiu Y, Zheng Y, Liu X, Fan G, Liu Y. Single-cell RNA cap and tail sequencing (scRCAT-seq) reveals subtype-specific isoforms differing in transcript demarcation.. Nature communications, 2020.
Pan B, Fan G. Stem cell-based treatment of kidney diseases.. Experimental biology and medicine (Maywood, N.J.), 2020.
Lv B, An Q, Zeng Q, Zhang X, Lu P, Wang Y, Zhu X, Ji Y, Fan G, Xue Z. Single-cell RNA sequencing reveals regulatory mechanism for trophoblast cell-fate divergence in human peri-implantation conceptuses.. PLoS biology, 2019.
An Q, Hu Y, Li Q, Chen X, Huang J, Pellegrini M, Zhou XJ, Rettig M, Fan G. The size of cell-free mitochondrial DNA in blood is inversely correlated with tumor burden in cancer patients.. Precision clinical medicine, 2019.
Mao X, An Q, Xi H, Yang XJ, Zhang X, Yuan S, Wang J, Hu Y, Liu Q, Fan G. Single-Cell RNA Sequencing of hESC-Derived 3D Retinal Organoids Reveals Novel Genes Regulating RPC Commitment in Early Human Retinogenesis.. Stem cell reports, 2019.
Fan S, Ding X, Rao P, Zheng Y, Mao F, Hu Y, Liu X, Fan G. Multimodal imaging of the retina and choroid in healthy Macaca fascicularis at different ages.. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2019.
Hu Y, An Q, Guo Y, Zhong J, Fan S, Rao P, Liu X, Liu Y, Fan G. Simultaneous Profiling of mRNA Transcriptome and DNA Methylome from a Single Cell.. Methods in molecular biology (Clifton, N.J.), 2019.
Li Y, Zhang Z, Chen J, Liu W, Lai W, Liu B, Li X, Liu L, Xu S, Dong Q, Wang M, Duan X, Tan J, Zheng Y, Zhang P, Fan G, Wong J, Xu GL, Wang Z, Wang H, Gao S, Zhu B. Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1.. Nature, 2018.
Liu G, Ouyang Q, Xia F, Fan G, Yu J, Zhang C, Wang D. Alpha-fetoprotein response following transarterial chemoembolization indicates improved survival for intermediate-stage hepatocellular carcinoma.. HPB : the official journal of the International Hepato Pancreato Biliary Association, 2018.
Yang J, Yi N, Zhang J, He W, He D, Wu W, Xu S, Li F, Fan G, Zhu X, Xue Z, Zhou W. Generation and characterization of a hypothyroidism rat model with truncated thyroid stimulating hormone receptor.. Scientific reports, 2018.
Guo C, Pei L, Xiao X, Wei Q, Chen JK, Ding HF, Huang S, Fan G, Shi H, Dong Z. DNA methylation protects against cisplatin-induced kidney injury by regulating specific genes, including interferon regulatory factor 8.. Kidney international, 2017.
Yuan GC, Cai L, Elowitz M, Enver T, Fan G, Guo G, Irizarry R, Kharchenko P, Kim J, Orkin S, Quackenbush J, Saadatpour A, Schroeder T, Shivdasani R, Tirosh I. Challenges and emerging directions in single-cell analysis.. Genome biology, 2017.
Xue C, Raveendran M, Harris RA, Fawcett GL, Liu X, White S, Dahdouli M, Rio Deiros D, Below JE, Salerno W, Cox L, Fan G, Ferguson B, Horvath J, Johnson Z, Kanthaswamy S, Kubisch HM, Liu D, Platt M, Smith DG, Sun B, Vallender EJ, Wang F, Wiseman RW, Chen R, Muzny DM, Gibbs RA, Yu F, Rogers J. The population genomics of rhesus macaques (Macaca mulatta) based on whole-genome sequences.. Genome research, 2016.
Lu P, Chen X, Feng Y, Zeng Q, Jiang C, Zhu X, Fan G, Xue Z. Integrated transcriptome analysis of human iPS cells derived from a fragile X syndrome patient during neuronal differentiation.. Science China. Life sciences, 2016.
King AD, Huang K, Rubbi L, Liu S, Wang CY, Wang Y, Pellegrini M, Fan G. Reversible Regulation of Promoter and Enhancer Histone Landscape by DNA Methylation in Mouse Embryonic Stem Cells.. Cell reports, 2016.
Hu G, Huang K, Hu Y, Du G, Xue Z, Zhu X, Fan G. Single-cell RNA-seq reveals distinct injury responses in different types of DRG sensory neurons.. Scientific reports, 2016.
Song Q, Yuan S, An Q, Chen Y, Mao FF, Liu Y, Liu Q, Fan G. Directed differentiation of human embryonic stem cells to corneal endothelial cell-like cells: A transcriptomic analysis.. Experimental eye research, 2016.
Xu S, Zhu X, Li H, Hu Y, Zhou J, He D, Feng Y, Lu L, Du G, Hu Y, Liu T, Wang Z, Ding G, Chen J, Gao S, Wu F, Xue Z, Li Y, Fan G. The 14th Ile residue is essential for Leptin function in regulating energy homeostasis in rat.. Scientific reports, 2016.
Huang B, Ning S, Zhang Q, Chen A, Jiang C, Cui Y, Hu J, Li H, Fan G, Qin L, Liu J. Bisphenol A Represses Dopaminergic Neuron Differentiation from Human Embryonic Stem Cells through Downregulating the Expression of Insulin-like Growth Factor 1.. Molecular neurobiology, 2016.
Lu L, Lv B, Huang K, Xue Z, Zhu X, Fan G. Recent advances in preimplantation genetic diagnosis and screening.. Journal of assisted reproduction and genetics, 2016.
Li X, Zhang Q, Ding Y, Liu Y, Zhao D, Zhao K, Shen Q, Liu X, Zhu X, Li N, Cheng Z, Fan G, Wang Q, Cao X. Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity.. Nature immunology, 2016.
Hu Y, Huang K, An Q, Du G, Hu G, Xue J, Zhu X, Wang CY, Xue Z, Fan G. Simultaneous profiling of transcriptome and DNA methylome from a single cell.. Genome biology, 2016.
Moyon S, Huynh JL, Dutta D, Zhang F, Ma D, Yoo S, Lawrence R, Wegner M, John GR, Emery B, Lubetzki C, Franklin RJM, Fan G, Zhu J, Dupree JL, Casaccia P. Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage.. Cell reports, 2016.
Huang B, Ning S, Zhuang L, Jiang C, Cui Y, Fan G, Qin L, Liu J. Ethanol Inactivated Mouse Embryonic Fibroblasts Maintain the Self-Renew and Proliferation of Human Embryonic Stem Cells.. PloS one, 2015.
Yuan S, Fan G. Stem cell-based therapy of corneal epithelial and endothelial diseases.. Regenerative medicine, 2015.
Feng J, Shao N, Szulwach KE, Vialou V, Huynh J, Zhong C, Le T, Ferguson D, Cahill ME, Li Y, Koo JW, Ribeiro E, Labonte B, Laitman BM, Estey D, Stockman V, Kennedy P, Couroussé T, Mensah I, Turecki G, Faull KF, Ming GL, Song H, Fan G, Casaccia P, Shen L, Jin P, Nestler EJ. Role of Tet1 and 5-hydroxymethylcytosine in cocaine action.. Nature neuroscience, 2015.
Hou S, Choi JS, Chen KJ, Zhang Y, Peng J, Garcia MA, Yu JH, Thakore-Shah K, Ro T, Chen JF, Peyda P, Fan G, Pyle AD, Wang H, Tseng HR. Supramolecular nanosubstrate-mediated delivery for reprogramming and transdifferentiation of mammalian cells.. Small (Weinheim an der Bergstrasse, Germany), 2015.
Kohno D, Lee S, Harper MJ, Kim KW, Sone H, Sasaki T, Kitamura T, Fan G, Elmquist JK. Dnmt3a in Sim1 neurons is necessary for normal energy homeostasis.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014.
Huang K, Maruyama T, Fan G. The naive state of human pluripotent stem cells: a synthesis of stem cell and preimplantation embryo transcriptome analyses.. Cell stem cell, 2014.
Zhang X, Li B, Li W, Ma L, Zheng D, Li L, Yang W, Chu M, Chen W, Mailman RB, Zhu J, Fan G, Archer TK, Wang Y. Transcriptional repression by the BRG1-SWI/SNF complex affects the pluripotency of human embryonic stem cells.. Stem cell reports, 2014.
Narayanan M, Huynh JL, Wang K, Yang X, Yoo S, McElwee J, Zhang B, Zhang C, Lamb JR, Xie T, Suver C, Molony C, Melquist S, Johnson AD, Fan G, Stone DJ, Schadt EE, Casaccia P, Emilsson V, Zhu J. Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases.. Molecular systems biology, 2014.
Huang K, Wu Z, Liu Z, Hu G, Yu J, Chang KH, Kim KP, Le T, Faull KF, Rao N, Gennery A, Xue Z, Wang CY, Pellegrini M, Fan G. Selective demethylation and altered gene expression are associated with ICF syndrome in human-induced pluripotent stem cells and mesenchymal stem cells.. Human molecular genetics, 2014.
Liu Z, Jiang R, Yuan S, Wang N, Feng Y, Hu G, Zhu X, Huang K, Ma J, Xu G, Liu Q, Xue Z, Fan G. Integrated analysis of DNA methylation and RNA transcriptome during in vitro differentiation of human pluripotent stem cells into retinal pigment epithelial cells.. PloS one, 2014.
Liu B, Tahk S, Yee KM, Yang R, Yang Y, Mackie R, Hsu C, Chernishof V, O'Brien N, Jin Y, Fan G, Lane TF, Rao J, Slamon D, Shuai K. PIAS1 regulates breast tumorigenesis through selective epigenetic gene silencing.. PloS one, 2014.
Huang K, Shen Y, Xue Z, Bibikova M, April C, Liu Z, Cheng L, Nagy A, Pellegrini M, Fan JB, Fan G. A panel of CpG methylation sites distinguishes human embryonic stem cells and induced pluripotent stem cells.. Stem cell reports, 2013.
Guo JU, Su Y, Shin JH, Shin J, Li H, Xie B, Zhong C, Hu S, Le T, Fan G, Zhu H, Chang Q, Gao Y, Ming GL, Song H. Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain.. Nature neuroscience, 2013.
Xue Z, Huang K, Cai C, Cai L, Jiang CY, Feng Y, Liu Z, Zeng Q, Cheng L, Sun YE, Liu JY, Horvath S, Fan G. Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing.. Nature, 2013.
Vincent JJ, Huang Y, Chen PY, Feng S, Calvopiña JH, Nee K, Lee SA, Le T, Yoon AJ, Faull K, Fan G, Rao A, Jacobsen SE, Pellegrini M, Clark AT. Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells.. Cell stem cell, 2013.
Chen Y, Huang K, Nakatsu MN, Xue Z, Deng SX, Fan G. Identification of novel molecular markers through transcriptomic analysis in human fetal and adult corneal endothelial cells.. Human molecular genetics, 2012.
Hu G, Huang K, Yu J, Gopalakrishna-Pillai S, Kong J, Xu H, Liu Z, Zhang K, Xu J, Luo Y, Li S, Sun YE, Iverson LE, Xue Z, Fan G. Identification of miRNA signatures during the differentiation of hESCs into retinal pigment epithelial cells.. PloS one, 2012.
Moore LD, Le T, Fan G. DNA methylation and its basic function.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012.
Li J, Jiang TX, Hughes MW, Wu P, Yu J, Widelitz RB, Fan G, Chuong CM. Progressive alopecia reveals decreasing stem cell activation probability during aging of mice with epidermal deletion of DNA methyltransferase 1.. The Journal of investigative dermatology, 2012.
Wu Z, Huang K, Yu J, Le T, Namihira M, Liu Y, Zhang J, Xue Z, Cheng L, Fan G. Dnmt3a regulates both proliferation and differentiation of mouse neural stem cells.. Journal of neuroscience research, 2012.
Biswas A, Liu Y, Liu T, Fan G, Tang Y. Polyethylene glycol-based protein nanocapsules for functional delivery of a differentiation transcription factor.. Biomaterials, 2012.
Cushman JD, Maldonado J, Kwon EE, Garcia AD, Fan G, Imura T, Sofroniew MV, Fanselow MS. Juvenile neurogenesis makes essential contributions to adult brain structure and plays a sex-dependent role in fear memories.. Frontiers in behavioral neuroscience, 2012.
Wang A, Huang K, Shen Y, Xue Z, Cai C, Horvath S, Fan G. Functional modules distinguish human induced pluripotent stem cells from embryonic stem cells.. Stem cells and development, 2011.
Fan G, Tran J. X chromosome inactivation in human and mouse pluripotent stem cells.. Human genetics, 2011.
Huang K, Fan G. Epigenetic modifications in distinction: histone versus DNA methylation in ESCs.. Cell stem cell, 2011.
Dhawan S, Georgia S, Tschen SI, Fan G, Bhushan A. Pancreatic β cell identity is maintained by DNA methylation-mediated repression of Arx.. Developmental cell, 2011.
Biswas A, Joo KI, Liu J, Zhao M, Fan G, Wang P, Gu Z, Tang Y. Endoprotease-mediated intracellular protein delivery using nanocapsules.. ACS nano, 2011.
Le T, Kim KP, Fan G, Faull KF. A sensitive mass spectrometry method for simultaneous quantification of DNA methylation and hydroxymethylation levels in biological samples.. Analytical biochemistry, 2011.
Chen J, Shi ZP, Dong J, Liao TT, Wang YP, Sun XP, Yan ZJ, Qian XQ, Cui YG, Xue ZG, Fan G, Liu JY. Evaluation of x-inactivation status and cytogenetic stability of human dermal fibroblasts after long-term culture.. International journal of cell biology, 2010.
Liu B, Tahk S, Yee KM, Fan G, Shuai K. The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression.. Science (New York, N.Y.), 2010.
Liao JL, Yu J, Huang K, Hu J, Diemer T, Ma Z, Dvash T, Yang XJ, Travis GH, Williams DS, Bok D, Fan G. Molecular signature of primary retinal pigment epithelium and stem-cell-derived RPE cells.. Human molecular genetics, 2010.
Huang K, Fan G. DNA methylation in cell differentiation and reprogramming: an emerging systematic view.. Regenerative medicine, 2010.
Dvash T, Lavon N, Fan G. Variations of X chromosome inactivation occur in early passages of female human embryonic stem cells.. PloS one, 2010.
Zhong J, Chan A, Morad L, Kornblum HI, Fan G, Carmichael ST. Hydrogel matrix to support stem cell survival after brain transplantation in stroke.. Neurorehabilitation and neural repair, 2010.
Hutnick LK, Huang X, Loo TC, Ma Z, Fan G. Repression of retrotransposal elements in mouse embryonic stem cells is primarily mediated by a DNA methylation-independent mechanism.. The Journal of biological chemistry, 2010.
Feng J, Zhou Y, Campbell SL, Le T, Li E, Sweatt JD, Silva AJ, Fan G. Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons.. Nature neuroscience, 2010.
Mason MJ, Fan G, Plath K, Zhou Q, Horvath S. Signed weighted gene co-expression network analysis of transcriptional regulation in murine embryonic stem cells.. BMC genomics, 2009.
Fan Z, Yamaza T, Lee JS, Yu J, Wang S, Fan G, Shi S, Wang CY. BCOR regulates mesenchymal stem cell function by epigenetic mechanisms.. Nature cell biology, 2009.
Hutnick LK, Golshani P, Namihira M, Xue Z, Matynia A, Yang XW, Silva AJ, Schweizer FE, Fan G. DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation.. Human molecular genetics, 2009.
Dvash T, Fan G. Epigenetic regulation of X-inactivation in human embryonic stem cells.. Epigenetics, 2009.
Shen Y, Fouse SD, Fan G. Genome-wide DNA methylation profiling: the mDIP-chip technology.. Methods in molecular biology (Clifton, N.J.), 2009.
Feng J, Fan G. The role of DNA methylation in the central nervous system and neuropsychiatric disorders.. International review of neurobiology, 2009.
Wu H, Kim KJ, Mehta K, Paxia S, Sundstrom A, Anantharaman T, Kuraishy AI, Doan T, Ghosh J, Pyle AD, Clark A, Lowry W, Fan G, Baxter T, Mishra B, Sun Y, Teitell MA. Copy number variant analysis of human embryonic stem cells.. Stem cells (Dayton, Ohio), 2008.
Shen Y, Matsuno Y, Fouse SD, Rao N, Root S, Xu R, Pellegrini M, Riggs AD, Fan G. X-inactivation in female human embryonic stem cells is in a nonrandom pattern and prone to epigenetic alterations.. Proceedings of the National Academy of Sciences of the United States of America, 2008.
Fouse SD, Shen Y, Pellegrini M, Cole S, Meissner A, Van Neste L, Jaenisch R, Fan G. Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation.. Cell stem cell, 2008.
Coskun V, Wu H, Blanchi B, Tsao S, Kim K, Zhao J, Biancotti JC, Hutnick L, Krueger RC, Fan G, de Vellis J, Sun YE. CD133+ neural stem cells in the ependyma of mammalian postnatal forebrain.. Proceedings of the National Academy of Sciences of the United States of America, 2008.
Feng J, Fouse S, Fan G. Epigenetic regulation of neural gene expression and neuronal function.. Pediatric research, 2007.
Lu YC, Song J, Cho HY, Fan G, Yokoyama KK, Chiu R. Cyclophilin a protects Peg3 from hypermethylation and inactive histone modification.. The Journal of biological chemistry, 2006.
Shen Y, Chow J, Wang Z, Fan G. Abnormal CpG island methylation occurs during in vitro differentiation of human embryonic stem cells.. Human molecular genetics, 2006.
Golshani P, Hutnick L, Schweizer F, Fan G. Conditional Dnmt1 deletion in dorsal forebrain disrupts development of somatosensory barrel cortex and thalamocortical long-term potentiation.. Thalamus & related systems, 2005.
Fan G, Martinowich K, Chin MH, He F, Fouse SD, Hutnick L, Hattori D, Ge W, Shen Y, Wu H, ten Hoeve J, Shuai K, Sun YE. DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling.. Development (Cambridge, England), 2005.
He F, Ge W, Martinowich K, Becker-Catania S, Coskun V, Zhu W, Wu H, Castro D, Guillemot F, Fan G, de Vellis J, Sun YE. A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis.. Nature neuroscience, 2005.
Fan G, Hutnick L. Methyl-CpG binding proteins in the nervous system.. Cell research, 2005.
Feng J, Chang H, Li E, Fan G. Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system.. Journal of neuroscience research, 2005.
Martinowich K, Hattori D, Wu H, Fouse S, He F, Hu Y, Fan G, Sun YE. DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation.. Science (New York, N.Y.), 2003.
Ge W, Martinowich K, Wu X, He F, Miyamoto A, Fan G, Weinmaster G, Sun YE. Notch signaling promotes astrogliogenesis via direct CSL-mediated glial gene activation.. Journal of neuroscience research, 2002.