Jeff Bronstein, M.D., Ph.D.

Professor of Molecular Toxicology, Neurology Member, Brain Research Institute Center for Neurodegenerative Disease Studies Neuroengineering Training Program Neuroscience GPB Home Area

0000-0002-2961-8918

jbronste@ucla.edu

(310) 206-9799

UCLA neuro
BOX 951769, A-153 RNRC
Los Angeles, CA 90095
UNITED STATES

Website

Biography

Jeff Bronstein received his bachelor’s degree from the University of California, Berkeley and M.D. and Ph.D. from UCLA as a recipient of the Medical Scientist Training Program Award. He completed a residency in Neurology and fellowship training in Movement Disorders at UCLA. Dr. Bronstein also completed a postdoctoral fellowship in molecular biology before being appointed an Assistant Professor of Neurology. He was later appointed Director of the Movement Disorders Program at UCLA. His interests and expertise include the management of Parkinson’s disease (PD) and other movement disorders, surgical treatment of PD, and developing new therapies for patients. Dr. Bronstein was recently awarded one of 6 National Parkinson’s Disease Centers at the Veterans Administration Medical Center with the goal of furthering research, education and clinical care in the Southwest US. His laboratory studies the cause of PD using cell models and a newly developed zebrafish model. His work supported by the NIH and private foundations. Dr. Bronstein also directs clinical trials in order to develop new therapies for PD that include transplantation and deep brain stimulation. He has received several awards and is widely published in the field.

Publications

Paul KC, Cockburn M, Gong Y, Bronstein J, Ritz B. Agricultural paraquat dichloride use and Parkinson's disease in California's Central Valley.. International journal of epidemiology, 2024.
Paul KC, Zhang K, Walker DI, Sinsheimer J, Yu Y, Kusters C, Del Rosario I, Folle AD, Keener AM, Bronstein J, Jones DP, Ritz B. Untargeted serum metabolomics reveals novel metabolite associations and disruptions in amino acid and lipid metabolism in Parkinson's disease.. Molecular neurodegeneration, 2023.
Kwon D, Paul KC, Yu Y, Zhang K, Folle AD, Wu J, Bronstein JM, Ritz B. Traffic-related air pollution and Parkinson's disease in central California.. Environmental research, 2023.
Kwon D, Folle AD, Del Rosario I, Zhang K, Paul KC, Keener AM, Bronstein JM, Ritz B. Diet quality and Parkinson's disease: Potential strategies for non-motor symptom management.. Parkinsonism & related disorders, 2023.
Bronstein JM, Zeiger WA, Peng C. Abandoning the Proteinopathy Paradigm in Parkinson Disease-Not So Fast.. JAMA neurology, 2023.
Duarte Folle A, Flores MES, Kusters C, Paul KC, Del Rosario I, Zhang K, Ruiz C, Castro E, Bronstein J, Ritz B, Keener AM. Ethnicity and Parkinson's Disease: Motor and Nonmotor Features and Disease Progression in Latino Patients Living in Rural California.. The journals of gerontology. Series A, Biological sciences and medical sciences, 2023.
Paul KC, Krolewski RC, Lucumi Moreno E, Blank J, Holton KM, Ahfeldt T, Furlong M, Yu Y, Cockburn M, Thompson LK, Kreymerman A, Ricci-Blair EM, Li YJ, Patel HB, Lee RT, Bronstein J, Rubin LL, Khurana V, Ritz B. Publisher Correction: A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides.. Nature communications, 2023.
Paul KC, Krolewski RC, Lucumi Moreno E, Blank J, Holton KM, Ahfeldt T, Furlong M, Yu Y, Cockburn M, Thompson LK, Kreymerman A, Ricci-Blair EM, Li YJ, Patel HB, Lee RT, Bronstein J, Rubin LL, Khurana V, Ritz B. A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides.. Nature communications, 2023.
Taha HB, Hornung S, Dutta S, Fenwick L, Lahgui O, Howe K, Elabed N, Del Rosario I, Wong DY, Duarte Folle A, Markovic D, Palma JA, Kang UJ, Alcalay RN, Sklerov M, Kaufmann H, Fogel BL, Bronstein JM, Ritz B, Bitan G. Toward a biomarker panel measured in CNS-originating extracellular vesicles for improved differential diagnosis of Parkinson's disease and multiple system atrophy.. Translational neurodegeneration, 2023.
Hariz M, Lang AE, Bronstein JM, Cosgrove GR, de Bie RMA, DeLong MR, Gross RE, Krack P, Krauss JK, Lees AJ, Lozano AM, Obeso JA, Schuurman PR, Vitek JL. WITHDRAWN: European Academy of Neurology/Movement Disorder Society European Section's guidelines on pallidotomy for Parkinson's disease: let's remain accurate.. European journal of neurology, 2022.
Li S, Ritz B, Gong Y, Cockburn M, Folle AD, Del Rosario I, Yu Y, Zhang K, Castro E, Keener AM, Bronstein J, Paul KC. Proximity to residential and workplace pesticides application and the risk of progression of Parkinson's diseases in Central California.. The Science of the total environment, 2022.
Ha SM, Barnhill LM, Li S, Bronstein JM. Neurotoxicity of diesel exhaust extracts in zebrafish and its implications for neurodegenerative disease.. Scientific reports, 2022.
. Withdrawn: Evidence-Based Reviews and Guidelines: Let's Avoid Future Confusion.. Movement disorders : official journal of the Movement Disorder Society, 2022.
Paul KC, Kusters C, Furlong M, Zhang K, Yu Y, Folle AD, Del Rosario I, Keener A, Bronstein J, Sinsheimer JS, Horvath S, Ritz B. Immune system disruptions implicated in whole blood epigenome-wide association study of depression among Parkinson's disease patients.. Brain, behavior, & immunity - health, 2022.
Hariz M, Bronstein JM, Cosgrove GR, de Bie RMA, DeLong MR, Gross RE, Krack P, Krauss JK, Lang AE, Lees AJ, Lozano AM, Obeso JA, Schuurman PR, Vitek JL. Concerns about the European Academy's Recommendations and Guidelines Regarding Pallidotomy for Parkinson's Disease.. European journal of neurology, 2022.
Hariz M, Bronstein JM, Cosgrove GR, de Bie RMA, DeLong MR, Gross RE, Krack P, Krauss JK, Lang AE, Lees AJ, Lozano AM, Obeso JA, Schuurman PR, Vitek JL. Concerns About the European Academy's Recommendations and Guidelines Regarding Pallidotomy for Parkinson's Disease.. Movement disorders : official journal of the Movement Disorder Society, 2022.
Kusters CDJ, Paul KC, Duarte Folle A, Keener AM, Bronstein JM, Bertram L, Hansen J, Horvath S, Sinsheimer JS, Lill CM, Ritz BR. Erratum to "Increased Menopausal Age Reduces the Risk of Parkinson's Disease: A Mendelian Approach".. Movement disorders : official journal of the Movement Disorder Society, 2022.
Murata H, Barnhill LM, Bronstein JM. Air Pollution and the Risk of Parkinson's Disease: A Review.. Movement disorders : official journal of the Movement Disorder Society, 2022.
Zhang K, Paul KC, Jacobs JP, Chou HL, Duarte Folle A, Del Rosario I, Yu Y, Bronstein JM, Keener AM, Ritz B. Parkinson's Disease and the Gut Microbiome in Rural California.. Journal of Parkinson's disease, 2022.
Chen GK, Yan Q, Paul KC, Kusters CDJ, Folle AD, Furlong M, Keener A, Bronstein J, Horvath S, Ritz B. Stochastic Epigenetic Mutations Influence Parkinson's Disease Risk, Progression, and Mortality.. Journal of Parkinson's disease, 2022.
Fu KA, Paul KC, Lu AT, Horvath S, Keener AM, Bordelon Y, Bronstein JM, Ritz B. DNA methylation-based surrogates of plasma proteins are associated with Parkinson's disease risk.. Journal of the neurological sciences, 2021.
Paul KC, Binder AM, Horvath S, Kusters C, Yan Q, Rosario ID, Yu Y, Bronstein J, Ritz B. Accelerated hematopoietic mitotic aging measured by DNA methylation, blood cell lineage, and Parkinson's disease.. BMC genomics, 2021.
Dutta S, Hornung S, Kruayatidee A, Maina KN, Del Rosario I, Paul KC, Wong DY, Duarte Folle A, Markovic D, Palma JA, Serrano GE, Adler CH, Perlman SL, Poon WW, Kang UJ, Alcalay RN, Sklerov M, Gylys KH, Kaufmann H, Fogel BL, Bronstein JM, Ritz B, Bitan G. Correction to: α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson's disease from multiple system atrophy.. Acta neuropathologica, 2021.
Kusters CDJ, Paul KC, Duarte Folle A, Keener AM, Bronstein JM, Bertram L, Hansen J, Horvath S, Sinsheimer JS, Lill CM, Ritz BR. Increased Menopausal Age Reduces the Risk of Parkinson's Disease: A Mendelian Randomization Approach.. Movement disorders : official journal of the Movement Disorder Society, 2021.
Jami MS, Murata H, Barnhill LM, Li S, Bronstein JM. Diesel exhaust exposure alters the expression of networks implicated in neurodegeneration in zebrafish brains.. Cell biology and toxicology, 2021.
Dutta S, Hornung S, Kruayatidee A, Maina KN, Del Rosario I, Paul KC, Wong DY, Duarte Folle A, Markovic D, Palma JA, Serrano GE, Adler CH, Perlman SL, Poon WW, Kang UJ, Alcalay RN, Sklerov M, Gylys KH, Kaufmann H, Fogel BL, Bronstein JM, Ritz B, Bitan G. α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson's disease from multiple system atrophy.. Acta neuropathologica, 2021.
Paul KC, Horvath S, Del Rosario I, Bronstein JM, Ritz B. DNA methylation biomarker for cumulative lead exposure is associated with Parkinson's disease.. Clinical epigenetics, 2021.
Kyle K, Mason X, Bordelon Y, Pouratian N, Bronstein J. Adult onset POLR3A leukodystrophy presenting with parkinsonism treated with pallidal deep brain stimulation.. Parkinsonism & related disorders, 2021.
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, Ávalos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, Bánréti Á, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Barilà D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touzé N, Bellarosa C, Belleudi F, Belló Pérez M, Bello-Morales R, Beltran JSO, Beltran S, Benbrook DM, Bendorius M, Benitez BA, Benito-Cuesta I, Bensalem J, Berchtold MW, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli CG, Besteiro S, Betin VM, Beyaert R, Bezbradica JS, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan MS, Bhutia SK, Bi L, Bi X, Biden TJ, Bijian K, Billes VA, Binart N, Bincoletto C, Birgisdottir AB, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum JS, Boada-Romero E, Boban M, Boesze-Battaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam SR, Bonfili L, Bonifacino JS, Boone BA, Bootman MD, Bordi M, Borner C, Bornhauser BC, Borthakur G, Bosch J, Bose S, Botana LM, Botas J, Boulanger CM, Boulton ME, Bourdenx M, Bourgeois B, Bourke NM, Bousquet G, Boya P, Bozhkov PV, Bozi LHM, Bozkurt TO, Brackney DE, Brandts CH, Braun RJ, Braus GH, Bravo-Sagua R, Bravo-San Pedro JM, Brest P, Bringer MA, Briones-Herrera A, Broaddus VC, Brodersen P, Brodsky JL, Brody SL, Bronson PG, Bronstein JM, Brown CN, Brown RE, Brum PC, Brumell JH, Brunetti-Pierri N, Bruno D, Bryson-Richardson RJ, Bucci C, Buchrieser C, Bueno M, Buitrago-Molina LE, Buraschi S, Buch S, Buchan JR, Buckingham EM, Budak H, Budini M, Bultynck G, Burada F, Burgoyne JR, Burón MI, Bustos V, Büttner S, Butturini E, Byrd A, Cabas I, Cabrera-Benitez S, Cadwell K, Cai J, Cai L, Cai Q, Cairó M, Calbet JA, Caldwell GA, Caldwell KA, Call JA, Calvani R, Calvo AC, Calvo-Rubio Barrera M, Camara NO, Camonis JH, Camougrand N, Campanella M, Campbell EM, Campbell-Valois FX, Campello S, Campesi I, Campos JC, Camuzard O, Cancino J, Candido de Almeida D, Canesi L, Caniggia I, Canonico B, Cantí C, Cao B, Caraglia M, Caramés B, Carchman EH, Cardenal-Muñoz E, Cardenas C, Cardenas L, Cardoso SM, Carew JS, Carle GF, Carleton G, Carloni S, Carmona-Gutierrez D, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.. Autophagy, 2021.
Maple-Grødem J, Paul KC, Dalen I, Ngo KJ, Wong D, Macleod AD, Counsell CE, Bäckström D, Forsgren L, Tysnes OB, Kusters CDJ, Fogel BL, Bronstein JM, Ritz B, Alves G. Lack of Association Between GBA Mutations and Motor Complications in European and American Parkinson's Disease Cohorts.. Journal of Parkinson's disease, 2021.
Furlong MA, Paul KC, Cockburn M, Bronstein J, Keener A, Rosario ID, Folle AD, Ritz B. Ambient Pyrethroid Pesticide Exposures in Adult Life and Depression in Older Residents of California's Central Valley.. Environmental epidemiology (Philadelphia, Pa.), 2020.
Kyle K, Bronstein JM. Treatment of Psychosis in Parkinson's disease and sudden death.. Parkinsonism & related disorders, 2020.
Kusters CDJ, Paul KC, Duarte Folle A, Keener AM, Bronstein JM, Dobricic V, Tysnes OB, Bertram L, Alves G, Sinsheimer JS, Lill CM, Maple-Grødem J, Ritz BR. Genetic risk scores and hallucinations in patients with Parkinson disease.. Neurology. Genetics, 2020.
Furlong MA, Paul KC, Yan Q, Chuang YH, Cockburn MG, Bronstein JM, Horvath S, Ritz B. An epigenome-wide association study of ambient pyrethroid pesticide exposures in California's central valley.. International journal of hygiene and environmental health, 2020.
Barnhill LM, Murata H, Bronstein JM. Studying the Pathophysiology of Parkinson's Disease Using Zebrafish.. Biomedicines, 2020.
Barnhill LM, Khuansuwan S, Juarez D, Murata H, Araujo JA, Bronstein JM. Diesel Exhaust Extract Exposure Induces Neuronal Toxicity by Disrupting Autophagy.. Toxicological sciences : an official journal of the Society of Toxicology, 2020.
Kyle K, Bronstein JM. Treatment of psychosis in Parkinson's disease and dementia with Lewy Bodies: A review.. Parkinsonism & related disorders, 2020.
Joshi R, Bronstein JM, Keener A, Alcazar J, Yang DD, Joshi M, Hermanowicz N. PKG Movement Recording System Use Shows Promise in Routine Clinical Care of Patients With Parkinson's Disease.. Frontiers in neurology, 2019.
Chen Z, Chen JA, Shatunov A, Jones AR, Kravitz SN, Huang AY, Lawrence L, Lowe JK, Lewis CM, Payan CAM, Lieb W, Franke A, Deloukas P, Amouyel P, Tzourio C, Dartigues JF, NNIPPS and BBBIPPS Study Groups, Ludolph A, Bensimon G, Leigh PN, Bronstein JM, Coppola G, Geschwind DH, Al-Chalabi A. Genome-wide survey of copy number variants finds MAPT duplications in progressive supranuclear palsy.. Movement disorders : official journal of the Movement Disorder Society, 2019.
Khuansuwan S, Barnhill LM, Cheng S, Bronstein JM. A novel transgenic zebrafish line allows for in vivo quantification of autophagic activity in neurons.. Autophagy, 2019.
Chuang YH, Paul KC, Sinsheimer JS, Bronstein JM, Bordelon YM, Ritz B. Genetic variants in nicotinic receptors and smoking cessation in Parkinson's disease.. Parkinsonism & related disorders, 2019.
Duarte Folle A, Paul KC, Bronstein JM, Keener AM, Ritz B. Clinical progression in Parkinson's disease with features of REM sleep behavior disorder: A population-based longitudinal study.. Parkinsonism & related disorders, 2019.
Chuang YH, Lu AT, Paul KC, Folle AD, Bronstein JM, Bordelon Y, Horvath S, Ritz B. Longitudinal Epigenome-Wide Methylation Study of Cognitive Decline and Motor Progression in Parkinson's Disease.. Journal of Parkinson's disease, 2019.
Paul KC, Chuang YH, Shih IF, Keener A, Bordelon Y, Bronstein JM, Ritz B. The association between lifestyle factors and Parkinson's disease progression and mortality.. Movement disorders : official journal of the Movement Disorder Society, 2019.
Chen JA, Chen Z, Won H, Huang AY, Lowe JK, Wojta K, Yokoyama JS, Bensimon G, Leigh PN, Payan C, Shatunov A, Jones AR, Lewis CM, Deloukas P, Amouyel P, Tzourio C, Dartigues JF, Ludolph A, Boxer AL, Bronstein JM, Al-Chalabi A, Geschwind DH, Coppola G. Joint genome-wide association study of progressive supranuclear palsy identifies novel susceptibility loci and genetic correlation to neurodegenerative diseases.. Molecular neurodegeneration, 2018.
Paul KC, Chuang YH, Cockburn M, Bronstein JM, Horvath S, Ritz B. Organophosphate pesticide exposure and differential genome-wide DNA methylation.. The Science of the total environment, 2018.
Paul KC, Sinsheimer JS, Cockburn M, Bronstein JM, Bordelon Y, Ritz B. NFE2L2, PPARGC1α, and pesticides and Parkinson's disease risk and progression.. Mechanisms of ageing and development, 2018.
Paul KC, Schulz J, Bronstein JM, Lill CM, Ritz BR. Association of Polygenic Risk Score With Cognitive Decline and Motor Progression in Parkinson Disease.. JAMA neurology, 2018.
Lee PC, Ahmed I, Loriot MA, Mulot C, Paul KC, Bronstein JM, Ritz B, Elbaz A. Smoking and Parkinson disease: Evidence for gene-by-smoking interactions.. Neurology, 2018.
Keener AM, Paul KC, Folle A, Bronstein JM, Ritz B. Cognitive Impairment and Mortality in a Population-Based Parkinson's Disease Cohort.. Journal of Parkinson's disease, 2018.
Kusters CDJ, Paul KC, Guella I, Bronstein JM, Sinsheimer JS, Farrer MJ, Ritz BR. Dopamine receptors and BDNF-haplotypes predict dyskinesia in Parkinson's disease.. Parkinsonism & related disorders, 2017.
Weiss KH, Askari FK, Czlonkowska A, Ferenci P, Bronstein JM, Bega D, Ala A, Nicholl D, Flint S, Olsson L, Plitz T, Bjartmar C, Schilsky ML. Bis-choline tetrathiomolybdate in patients with Wilson's disease: an open-label, multicentre, phase 2 study.. The lancet. Gastroenterology & hepatology, 2017.
Chuang YH, Paul KC, Bronstein JM, Bordelon Y, Horvath S, Ritz B. Parkinson's disease is associated with DNA methylation levels in human blood and saliva.. Genome medicine, 2017.
Narayan S, Liew Z, Bronstein JM, Ritz B. Occupational pesticide use and Parkinson's disease in the Parkinson Environment Gene (PEG) study.. Environment international, 2017.
Paul KC, Sinsheimer JS, Cockburn M, Bronstein JM, Bordelon Y, Ritz B. Organophosphate pesticides and PON1 L55M in Parkinson's disease progression.. Environment international, 2017.
Sanders LH, Paul KC, Howlett EH, Lawal H, Boppana S, Bronstein JM, Ritz B, Greenamyre JT. Editor's Highlight: Base Excision Repair Variants and Pesticide Exposure Increase Parkinson's Disease Risk.. Toxicological sciences : an official journal of the Society of Toxicology, 2017.
Pham T, Bronstein JM. Neuropsychological outcomes from deep brain stimulation-stimulation versus micro-lesion.. Annals of translational medicine, 2017.
Gatto NM, Paul KC, Sinsheimer JS, Bronstein JM, Bordelon Y, Rausch R, Ritz B. Vitamin D receptor gene polymorphisms and cognitive decline in Parkinson's disease.. Journal of the neurological sciences, 2016.
Lulla A, Barnhill L, Bitan G, Ivanova MI, Nguyen B, O'Donnell K, Stahl MC, Yamashiro C, Klärner FG, Schrader T, Sagasti A, Bronstein JM. Neurotoxicity of the Parkinson Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish Embryos.. Environmental health perspectives, 2016.
Massano J, Bronstein JM. Writeclick: Neuropsychological outcome after deep brain stimulation for Parkinson disease.. Neurology, 2016.
Paul KC, Rausch R, Creek MM, Sinsheimer JS, Bronstein JM, Bordelon Y, Ritz B. APOE, MAPT, and COMT and Parkinson's Disease Susceptibility and Cognitive Symptom Progression.. Journal of Parkinson's disease, 2016.
Ritz BR, Paul KC, Bronstein JM. Of Pesticides and Men: a California Story of Genes and Environment in Parkinson's Disease.. Current environmental health reports, 2016.
Bronstein JM. Neuropsychological outcome after deep brain stimulation for Parkinson disease.. Neurology, 2015.
Narayan S, Sinsheimer JS, Paul KC, Liew Z, Cockburn M, Bronstein JM, Ritz B. Genetic variability in ABCB1, occupational pesticide exposure, and Parkinson's disease.. Environmental research, 2015.
Paul KC, Sinsheimer JS, Rhodes SL, Cockburn M, Bronstein J, Ritz B. Organophosphate Pesticide Exposures, Nitric Oxide Synthase Gene Variants, and Gene-Pesticide Interactions in a Case-Control Study of Parkinson's Disease, California (USA).. Environmental health perspectives, 2015.
Bronstein JM, Paul K, Yang L, Haas RH, Shults CW, Le T, Ritz B. Platelet mitochondrial activity and pesticide exposure in early Parkinson's disease.. Movement disorders : official journal of the Movement Disorder Society, 2015.
Burke WJ, Bronstein JM, Fitzmaurice A. Aldehyde dehydrogenase variation enhances effect of pesticides associated with Parkinson disease.. Neurology, 2014.
Bronstein JM, Fitzmaurice A. Author response.. Neurology, 2014.
Bronstein JM, Tagliati M, McIntyre C, Chen R, Cheung T, Hargreaves EL, Israel Z, Moffitt M, Montgomery EB, Stypulkowski P, Shils J, Denison T, Vitek J, Volkman J, Wertheimer J, Okun MS. The rationale driving the evolution of deep brain stimulation to constant-current devices.. Neuromodulation : journal of the International Neuromodulation Society, 2014.
Koppel BS, Brust JC, Fife T, Bronstein J, Youssof S, Gronseth G, Gloss D. Systematic review: efficacy and safety of medical marijuana in selected neurologic disorders: report of the Guideline Development Subcommittee of the American Academy of Neurology.. Neurology, 2014.
O'Donnell KC, Lulla A, Stahl MC, Wheat ND, Bronstein JM, Sagasti A. Axon degeneration and PGC-1α-mediated protection in a zebrafish model of α-synuclein toxicity.. Disease models & mechanisms, 2014.
Fitzmaurice AG, Rhodes SL, Cockburn M, Ritz B, Bronstein JM. Aldehyde dehydrogenase variation enhances effect of pesticides associated with Parkinson disease.. Neurology, 2014.
Wang A, Cockburn M, Ly TT, Bronstein JM, Ritz B. The association between ambient exposure to organophosphates and Parkinson's disease risk.. Occupational and environmental medicine, 2014.
Liew Z, Wang A, Bronstein J, Ritz B. Job exposure matrix (JEM)-derived estimates of lifetime occupational pesticide exposure and the risk of Parkinson's disease.. Archives of environmental & occupational health, 2014.
Barnhill LM, Bronstein JM. Pesticides and Parkinson's disease: is it in your genes?. Neurodegenerative disease management, 2014.
Rhodes SL, Buchanan DD, Ahmed I, Taylor KD, Loriot MA, Sinsheimer JS, Bronstein JM, Elbaz A, Mellick GD, Rotter JI, Ritz B. Pooled analysis of iron-related genes in Parkinson's disease: association with transferrin.. Neurobiology of disease, 2013.
Narayan S, Liew Z, Paul K, Lee PC, Sinsheimer JS, Bronstein JM, Ritz B. Household organophosphorus pesticide use and Parkinson's disease.. International journal of epidemiology, 2013.
Rhodes SL, Fitzmaurice AG, Cockburn M, Bronstein JM, Sinsheimer JS, Ritz B. Pesticides that inhibit the ubiquitin-proteasome system: effect measure modification by genetic variation in SKP1 in Parkinson׳s disease.. Environmental research, 2013.
Lee PC, Rhodes SL, Sinsheimer JS, Bronstein J, Ritz B. Functional paraoxonase 1 variants modify the risk of Parkinson's disease due to organophosphate exposure.. Environment international, 2013.
Fitzmaurice AG, Rhodes SL, Lulla A, Murphy NP, Lam HA, O'Donnell KC, Barnhill L, Casida JE, Cockburn M, Sagasti A, Stahl MC, Maidment NT, Ritz B, Bronstein JM. Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease.. Proceedings of the National Academy of Sciences of the United States of America, 2012.
Lee PC, Bordelon Y, Bronstein J, Ritz B. Traumatic brain injury, paraquat exposure, and their relationship to Parkinson disease.. Neurology, 2012.
Pouratian N, Thakkar S, Kim W, Bronstein JM. Deep brain stimulation for the treatment of Parkinson's disease: efficacy and safety.. Degenerative neurological and neuromuscular disease, 2012.
Weaver FM, Follett KA, Stern M, Luo P, Harris CL, Hur K, Marks WJ, Rothlind J, Sagher O, Moy C, Pahwa R, Burchiel K, Hogarth P, Lai EC, Duda JE, Holloway K, Samii A, Horn S, Bronstein JM, Stoner G, Starr PA, Simpson R, Baltuch G, De Salles A, Huang GD, Reda DJ, CSP 468 Study Group. Randomized trial of deep brain stimulation for Parkinson disease: thirty-six-month outcomes.. Neurology, 2012.
Ritz B, Rhodes SL, Bordelon Y, Bronstein J. α-Synuclein genetic variants predict faster motor symptom progression in idiopathic Parkinson disease.. PloS one, 2012.
Prabhudesai S, Sinha S, Attar A, Kotagiri A, Fitzmaurice AG, Lakshmanan R, Lakshmanan R, Ivanova MI, Loo JA, Klärner FG, Schrader T, Stahl M, Bitan G, Bronstein JM. A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2012.
Bordelon YM, Hays RD, Vassar SD, Diaz N, Bronstein J, Vickrey BG. Medication responsiveness of motor symptoms in a population-based study of Parkinson disease.. Parkinson's disease, 2011.
Chan N, Le C, Shieh P, Mozaffar T, Khare M, Bronstein J, Kimonis V. Valosin-containing protein mutation and Parkinson's disease.. Parkinsonism & related disorders, 2011.
Wang A, Costello S, Cockburn M, Zhang X, Bronstein J, Ritz B. Parkinson's disease risk from ambient exposure to pesticides.. European journal of epidemiology, 2011.
Rosenbloom B, Balwani M, Bronstein JM, Kolodny E, Sathe S, Gwosdow AR, Taylor JS, Cole JA, Zimran A, Weinreb NJ. The incidence of Parkinsonism in patients with type 1 Gaucher disease: data from the ICGG Gaucher Registry.. Blood cells, molecules & diseases, 2010.
Rhodes SL, Sinsheimer JS, Bordelon Y, Bronstein JM, Ritz B. Replication of GWAS associations for GAK and MAPT in Parkinson's disease.. Annals of human genetics, 2010.
Bronstein JM, Tagliati M, Alterman RL, Lozano AM, Volkmann J, Stefani A, Horak FB, Okun MS, Foote KD, Krack P, Pahwa R, Henderson JM, Hariz MI, Bakay RA, Rezai A, Marks WJ, Moro E, Vitek JL, Weaver FM, Gross RE, DeLong MR. Deep brain stimulation for Parkinson disease: an expert consensus and review of key issues.. Archives of neurology, 2010.
Gatto NM, Rhodes SL, Manthripragada AD, Bronstein J, Cockburn M, Farrer M, Ritz B. α-Synuclein gene may interact with environmental factors in increasing risk of Parkinson's disease.. Neuroepidemiology, 2010.
Follett KA, Weaver FM, Stern M, Hur K, Harris CL, Luo P, Marks WJ, Rothlind J, Sagher O, Moy C, Pahwa R, Burchiel K, Hogarth P, Lai EC, Duda JE, Holloway K, Samii A, Horn S, Bronstein JM, Stoner G, Starr PA, Simpson R, Baltuch G, De Salles A, Huang GD, Reda DJ, CSP 468 Study Group. Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease.. The New England journal of medicine, 2010.
Chou AP, Li S, Fitzmaurice AG, Bronstein JM. Mechanisms of rotenone-induced proteasome inhibition.. Neurotoxicology, 2010.
Manthripragada AD, Costello S, Cockburn MG, Bronstein JM, Ritz B. Paraoxonase 1, agricultural organophosphate exposure, and Parkinson disease.. Epidemiology (Cambridge, Mass.), 2010.
Plaitakis A, Latsoudis H, Kanavouras K, Ritz B, Bronstein JM, Skoula I, Mastorodemos V, Papapetropoulos S, Borompokas N, Zaganas I, Xiromerisiou G, Hadjigeorgiou GM, Spanaki C. Gain-of-function variant in GLUD2 glutamate dehydrogenase modifies Parkinson's disease onset.. European journal of human genetics : EJHG, 2009.
Farag ES, Vinters HV, Bronstein J. Pathologic findings in retinal pigment epithelial cell implantation for Parkinson disease.. Neurology, 2009.
Gatto NM, Cockburn M, Bronstein J, Manthripragada AD, Ritz B. Well-water consumption and Parkinson's disease in rural California.. Environmental health perspectives, 2009.
Costello S, Cockburn M, Bronstein J, Zhang X, Ritz B. Parkinson's disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of California.. American journal of epidemiology, 2009.
Ritz BR, Manthripragada AD, Costello S, Lincoln SJ, Farrer MJ, Cockburn M, Bronstein J. Dopamine transporter genetic variants and pesticides in Parkinson's disease.. Environmental health perspectives, 2009.
Weaver FM, Follett K, Stern M, Hur K, Harris C, Marks WJ, Rothlind J, Sagher O, Reda D, Moy CS, Pahwa R, Burchiel K, Hogarth P, Lai EC, Duda JE, Holloway K, Samii A, Horn S, Bronstein J, Stoner G, Heemskerk J, Huang GD, CSP 468 Study Group. Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: a randomized controlled trial.. JAMA, 2009.
Chou AP, Maidment N, Klintenberg R, Casida JE, Li S, Fitzmaurice AG, Fernagut PO, Mortazavi F, Chesselet MF, Bronstein JM. Ziram causes dopaminergic cell damage by inhibiting E1 ligase of the proteasome.. The Journal of biological chemistry, 2008.
Bronstein J, Carvey P, Chen H, Cory-Slechta D, DiMonte D, Duda J, English P, Goldman S, Grate S, Hansen J, Hoppin J, Jewell S, Kamel F, Koroshetz W, Langston JW, Logroscino G, Nelson L, Ravina B, Rocca W, Ross GW, Schettler T, Schwarzschild M, Scott B, Seegal R, Singleton A, Steenland K, Tanner CM, Van Den Eeden S, Weisskopf M. Meeting report: consensus statement-Parkinson's disease and the environment: collaborative on health and the environment and Parkinson's Action Network (CHE PAN) conference 26-28 June 2007.. Environmental health perspectives, 2008.
Wahner AD, Bronstein JM, Bordelon YM, Ritz B. Statin use and the risk of Parkinson disease.. Neurology, 2008.
Wahner AD, Bronstein JM, Bordelon YM, Ritz B. Nonsteroidal anti-inflammatory drugs may protect against Parkinson disease.. Neurology, 2007.
Wahner AD, Sinsheimer JS, Bronstein JM, Ritz B. Inflammatory cytokine gene polymorphisms and increased risk of Parkinson disease.. Archives of neurology, 2007.
Wahner AD, Glatt CE, Bronstein JM, Ritz B. Glutathione S-transferase mu, omega, pi, and theta class variants and smoking in Parkinson's disease.. Neuroscience letters, 2006.
Bronstein JM, Chou AP. Peripheral proteasome and caspase activity in Parkinson disease and Alzheimer disease.. Neurology, 2006.
Wang XF, Li S, Chou AP, Bronstein JM. Inhibitory effects of pesticides on proteasome activity: implication in Parkinson's disease.. Neurobiology of disease, 2006.
Tiwari-Woodruff S, Beltran-Parrazal L, Charles A, Keck T, Vu T, Bronstein J. K+ channel KV3.1 associates with OSP/claudin-11 and regulates oligodendrocyte development.. American journal of physiology. Cell physiology, 2006.
Follett K, Weaver F, Stern M, Marks W, Hogarth P, Holloway K, Bronstein J, Duda J, Horn S, Lai E, Samii A. Multisite randomized trial of deep brain stimulation.. Archives of neurology, 2005.
Kang GA, Bronstein JM, Masterman DL, Redelings M, Crum JA, Ritz B. Clinical characteristics in early Parkinson's disease in a central California population-based study.. Movement disorders : official journal of the Movement Disorder Society, 2005.
Bhidayasiri R, Bronstein JM, Sinha S, Krahl SE, Ahn S, Behnke EJ, Cohen MS, Frysinger R, Shellock FG. Bilateral neurostimulation systems used for deep brain stimulation: in vitro study of MRI-related heating at 1.5 T and implications for clinical imaging of the brain.. Magnetic resonance imaging, 2005.
Bhidayasiri R, Bronstein JM. Improvement of cervical dystonia: possible role of transcranial magnetic stimulation simulating sensory tricks effect.. Medical hypotheses, 2005.
Diaz N, Bronstein JM. Parkinson's Disease Research Education and Clinical Centers (PADRECC): background and overview.. NeuroRehabilitation, 2005.
Bhidayasiri R, Miyata H, Bronstein JM, Schweitzer J, Saber PA, Vinters HV. Postmortem analysis of pallidotomy in Parkinson's disease.. Journal of neurology, 2005.
Tiwari-Woodruff SK, Kaplan R, Kornblum HI, Bronstein JM. Developmental expression of OAP-1/Tspan-3, a member of the tetraspanin superfamily.. Journal of neuroscience research, 2004.
Kang GA, Bronstein JM. Psychosis in nursing home patients with Parkinson's disease.. Journal of the American Medical Directors Association, 2004.
Bryant JA, De Salles A, Cabatan C, Frysinger R, Behnke E, Bronstein J. The impact of thalamic stimulation on activities of daily living for essential tremor.. Surgical neurology, 2003.
Sage JR, Anagnostaras SG, Mitchell S, Bronstein JM, De Salles A, Masterman D, Knowlton BJ. Analysis of probabilistic classification learning in patients with Parkinson's disease before and after pallidotomy surgery.. Learning & memory (Cold Spring Harbor, N.Y.), 2003.