Jerome Engel, M.D., Ph.D.

Publications

• Mosh? SL, Engel J. In Memoriam: Juhn Atsushi Wada, MD (1924-2023).. Epilepsia open, 2023.
• Engel J, Mosh? SL, Nehlig A, Fujikawa DG, Sankar R, Naylor DE, Mazarati AM, Wasterlain CG. Introduction to the Special Issue Status Epilepticus: Neuronal injury, Plasticity and Therapies: Celebrating the Legacy of Dr. Claude G. Wasterlain.. Epilepsia open, 2023.
• Weiss SA, Fried I, Wu C, Sharan A, Rubinstein D, Engel J, Sperling MR, Staba RJ. Graph theoretical measures of fast ripple networks improve the accuracy of post-operative seizure outcome prediction.. Scientific reports, 2023.
• Hickman LB, Patel AB, Dubey I, Karimi AH, Zhang X, Janio EA, Allas CH, Sreenivasan SS, Bauirjan J, D'Ambrosio S, Al Banna M, Cho AY, Engel J, Stern JM, Kerr WT. Self-Reported Severity and Causes of Traumatic Brain Injury in Patients With Epileptic or Functional Seizures.. Neurology. Clinical practice, 2022.
• Shamas M, Yeh HJ, Fried I, Engel J, Staba R. Interictal Gamma Event Connectivity Differentiates the Seizure Network and Outcome in Patients After Temporal Lobe Epilepsy Surgery.. eNeuro, 2022.
• Weiss SA, Sheybani L, Seenarine N, Fried I, Wu C, Sharan A, Engel J, Sperling MR, Nir Y, Staba RJ. Delta oscillation coupled propagating fast ripples precede epileptiform discharges in patients with focal epilepsy.. Neurobiology of disease, 2022.
• Zhou Y, You J, Kumar U, Weiss SA, Bragin A, Engel J, Papadelis C, Li L. An approach for reliably identifying high-frequency oscillations and reducing false-positive detections.. Epilepsia open, 2022.
• Kerr WT, Tatekawa H, Lee JK, Karimi AH, Sreenivasan SS, O'Neill J, Smith JM, Hickman LB, Savic I, Nasrullah N, Espinoza R, Narr K, Salamon N, Beimer NJ, Hadjiiski LM, Eliashiv DS, Stacey WC, Engel J, Feusner JD, Stern JM. Clinical MRI morphological analysis of functional seizures compared to seizure-naïve and psychiatric controls.. Epilepsy & behavior : E&B, 2022.
• Mazumder R, Lagoro DK, Nariai H, Danieli A, Eliashiv D, Engel J, Dalla Bernardina B, Kegele J, Lerche H, Sejvar J, Matuja W, Schmutzhard E, Bonanni P, De Polo G, Wagner T, Winkler AS. Ictal Electroencephalographic Characteristics of Nodding Syndrome: A Comparative Case-Series from South Sudan, Tanzania, and Uganda.. Annals of neurology, 2022.
• Weiss SA, Pastore T, Orosz I, Rubinstein D, Gorniak R, Waldman Z, Fried I, Wu C, Sharan A, Slezak D, Worrell G, Engel J, Sperling MR, Staba RJ. Graph theoretical measures of fast ripples support the epileptic network hypothesis.. Brain communications, 2022.
• Mishra NK, Engel J, Liebeskind DS, Sharma VK, Hirsch LJ, Kasner SE, French JA, Devinsky O, Friedman A, Dawson J, Quinn TJ, Selim M, de Havenon A, Yasuda CL, Cendes F, Benninger F, Zaveri HP, Burneo JG, Srivastava P, Bhushan Singh M, Bhatia R, Vishnu VY, Bentes C, Ferro J, Weiss S, Sivaraju A, Kim JA, Galovic M, Gilmore EJ, Pitkänen A, Davis K, Sansing LH, Sheth KN, Paz JT, Singh A, Sheth S, Worrall BB, Grotta JC, Casillas-Espinos PM, Chen Z, Nicolo JP, Yan B, Kwan P, for International Post Stroke Epilepsy Research Consortium (IPSERC). International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke.. Epilepsy & behavior : E&B, 2021.
• Kerr WT, Sreenivasan SS, Allas CH, Janio EA, Karimi AH, Dubey I, D'Ambrosio SR, Smith JM, Engel J, Feusner JD, Stern JM. Corrigendum to 'Functional seizures across the adult lifespan: female sex, delay to diagnosis and disability' [Seizure: European Journal of Epilepsy (2021) 476-483].. Seizure, 2021.
• Santana-Gomez CE, Engel J, Staba R. Drug-resistant epilepsy and the hypothesis of intrinsic severity: What about the high-frequency oscillations?. Epilepsia open, 2021.
• Zhang Y, Lu Q, Monsoor T, Hussain SA, Qiao JX, Salamon N, Fallah A, Sim MS, Asano E, Sankar R, Staba RJ, Engel J, Speier W, Roychowdhury V, Nariai H. Refining epileptogenic high-frequency oscillations using deep learning: a reverse engineering approach.. Brain communications, 2021.
• Weiss SA, Staba RJ, Sharan A, Wu C, Rubinstein D, Das S, Waldman Z, Orosz I, Worrell G, Engel J, Sperling MR. Accuracy of high-frequency oscillations recorded intraoperatively for classification of epileptogenic regions.. Scientific reports, 2021.
• French JA, Bebin M, Dichter MA, Engel J, Hartman AL, Józwiak S, Klein P, McNamara J, Twyman R, Vespa P. Antiepileptogenesis and disease modification: Clinical and regulatory issues.. Epilepsia open, 2021.
• Kerr WT, Sreenivasan SS, Allas CH, Janio EA, Karimi AH, Dubey I, D'Ambrosio SR, Smith JM, Engel J, Feusner JD, Stern JM. Title: Functional seizures across the adult lifespan: female sex, delay to diagnosis and disability.. Seizure, 2021.
• Stern JM, Spivak NM, Becerra SA, Kuhn TP, Korb AS, Kronemyer D, Khanlou N, Reyes SD, Monti MM, Schnakers C, Walshaw P, Keselman I, Cohen MS, Yong W, Fried I, Jordan SE, Schafer ME, Engel J, Bystritsky A. Safety of focused ultrasound neuromodulation in humans with temporal lobe epilepsy.. Brain stimulation, 2021.
• Kumar U, Li L, Bragin A, Engel J. Spike and wave discharges and fast ripples during posttraumatic epileptogenesis.. Epilepsia, 2021.
• Kerr WT, Lee JK, Karimi AH, Tatekawa H, Hickman LB, Connerney M, Sreenivasan SS, Dubey I, Allas CH, Smith JM, Savic I, Silverman DHS, Hadjiiski LM, Beimer NJ, Stacey WC, Cohen MS, Engel J, Feusner JD, Salamon N, Stern JM. A minority of patients with functional seizures have abnormalities on neuroimaging.. Journal of the neurological sciences, 2021.
• Wu T, Avidan AY, Engel J. Sleep and Epilepsy, Clinical Spectrum and Updated Review.. Sleep medicine clinics, 2021.
• Tatekawa H, Uetani H, Hagiwara A, Hotta M, Stern JM, Engel J, Salamon N. Association of hypometabolic extension of 18F-FDG PET with diffusion tensor imaging indices in mesial temporal lobe epilepsy with hippocampal sclerosis.. Seizure, 2021.
• Li L, He L, Harris N, Zhou Y, Engel J, Bragin A. Topographical reorganization of brain functional connectivity during an early period of epileptogenesis.. Epilepsia, 2021.
• Kerr WT, Zhang X, Hill CE, Janio EA, Chau AM, Braesch CT, Le JM, Hori JM, Patel AB, Allas CH, Karimi AH, Dubey I, Sreenivasan SS, Gallardo NL, Bauirjan J, Hwang ES, Davis EC, D'Ambrosio SR, Al Banna M, Cho AY, Dewar SR, Engel J, Feusner JD, Stern JM. Factors associated with delay to video-EEG in dissociative seizures.. Seizure, 2021.
• Kerr WT, Zhang X, Hill CE, Janio EA, Chau AM, Braesch CT, Le JM, Hori JM, Patel AB, Allas CH, Karimi AH, Dubey I, Sreenivasan SS, Gallardo NL, Bauirjan J, Hwang ES, Davis EC, D'Ambrosio SR, Al Banna M, Cho AY, Dewar SR, Engel J, Feusner JD, Stern JM. Epilepsy, dissociative seizures, and mixed: Associations with time to video-EEG.. Seizure, 2021.
• Kerr WT, Zhang X, Janio EA, Karimi AH, Allas CH, Dubey I, Sreenivasan SS, Bauirjan J, D'Ambrosio SR, Al Banna M, Cho AY, Engel J, Cohen MS, Feusner JD, Stern JM. Reliability of additional reported seizure manifestations to identify dissociative seizures.. Epilepsy & behavior : E&B, 2021.
• Pieters HC, Dewar SR, Ranit L, Iwaki TJ, Engel J. Surgical decision-making among patients with uncontrolled epilepsy: "Making important decisions about my brain, which I happen to love".. Chronic illness, 2020.
• Kerr WT, Janio EA, Chau AM, Braesch CT, Le JM, Hori JM, Patel AB, Gallardo NL, Allas CH, Karimi AH, Dubey I, Sreenivasan SS, Bauirjan J, Hwang ES, Davis EC, D'Ambrosio SR, Al Banna M, Mazumder R, Wu T, DeCant ZA, Gibbs MG, Chang E, Zhang X, Cho AY, Beimer NJ, Engel J, Cohen MS, Stern JM. Objective score from initial interview identifies patients with probable dissociative seizures.. Epilepsy & behavior : E&B, 2020.
• Weiss SA, Song I, Leng M, Pastore T, Slezak D, Waldman Z, Orosz I, Gorniak R, Donmez M, Sharan A, Wu C, Fried I, Sperling MR, Bragin A, Engel J, Nir Y, Staba R. Ripples Have Distinct Spectral Properties and Phase-Amplitude Coupling With Slow Waves, but Indistinct Unit Firing, in Human Epileptogenic Hippocampus.. Frontiers in neurology, 2020.
• Tatekawa H, Kerr WT, Savic I, Engel J, Salamon N. Reduced left amygdala volume in patients with dissociative seizures (psychogenic nonepileptic seizures).. Seizure, 2019.
• Ferando I, Soss JR, Elder C, Shah V, Lo Russo G, Tassi L, Tassinari CA, Engel J. Hand posture as localizing sign in adult focal epileptic seizures.. Annals of neurology, 2019.
• Engel J. Evolution of concepts in epilepsy surgery.. Epileptic disorders : international epilepsy journal with videotape, 2019.
• Engel J, Pitkänen A. Biomarkers for epileptogenesis and its treatment.. Neuropharmacology, 2019.
• Li L, Bragin A, Staba R, Engel J. Unit firing and oscillations at seizure onset in epileptic rodents.. Neurobiology of disease, 2019.
• Kerr WT, Chau AM, Janio EA, Braesch CT, Le JM, Hori JM, Patel AB, Gallardo NL, Bauirjan J, Allas CH, Karimi AH, Hwang ES, Davis EC, Buchard A, Torres-Barba D, D'Ambrosio S, Al Banna M, Cho AY, Engel J, Cohen MS, Stern JM. Reliability of reported peri-ictal behavior to identify psychogenic nonepileptic seizures.. Seizure, 2019.
• Weiss SA, Staba R, Bragin A, Moxon K, Sperling M, Avoli M, Engel J. "Interneurons and principal cell firing in human limbic areas at focal seizure onset".. Neurobiology of disease, 2018.
• Galanopoulou AS, Engel J, Moshé SL. PREFACE: Antiepileptogenesis following traumatic brain injury.. Neurobiology of disease, 2018.
• Elahian B, Lado NE, Mankin E, Vangala S, Misra A, Moxon K, Fried I, Sharan A, Yeasin M, Staba R, Bragin A, Avoli M, Sperling MR, Engel J, Weiss SA. Low-voltage fast seizures in humans begin with increased interneuron firing.. Annals of neurology, 2018.
• Engel J, Bragin A, Staba R. Nonictal EEG biomarkers for diagnosis and treatment.. Epilepsia open, 2018.
• Vespa PM, Shrestha V, Abend N, Agoston D, Au A, Bell MJ, Bleck TP, Blanco MB, Claassen J, Diaz-Arrastia R, Duncan D, Ellingson B, Foreman B, Gilmore EJ, Hirsch L, Hunn M, Kamnaksh A, McArthur D, Morokoff A, O'Brien T, O'Phelan K, Robertson CL, Rosenthal E, Staba R, Toga A, Willyerd FA, Zimmermann L, Yam E, Martinez S, Real C, Engel J. The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol.. Neurobiology of disease, 2018.
• Weiss SA, Berry B, Chervoneva I, Waldman Z, Guba J, Bower M, Kucewicz M, Brinkmann B, Kremen V, Khadjevand F, Varatharajah Y, Guragain H, Sharan A, Wu C, Staba R, Engel J, Sperling M, Worrell G. Visually validated semi-automatic high-frequency oscillation detection aides the delineation of epileptogenic regions during intra-operative electrocorticography.. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2018.
• Ogren JA, Tripathi R, Macey PM, Kumar R, Stern JM, Eliashiv DS, Allen LA, Diehl B, Engel J, Rani MRS, Lhatoo SD, Harper RM. Regional cortical thickness changes accompanying generalized tonic-clonic seizures.. NeuroImage. Clinical, 2018.
• Tubi MA, Lutkenhoff E, Blanco MB, McArthur D, Villablanca P, Ellingson B, Diaz-Arrastia R, Van Ness P, Real C, Shrestha V, Engel J, Vespa PM. Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal study.. Neurobiology of disease, 2018.
• Vakharia VN, Duncan JS, Witt JA, Elger CE, Staba R, Engel J. Getting the best outcomes from epilepsy surgery.. Annals of neurology, 2018.
• Engel J. Epileptogenesis, traumatic brain injury, and biomarkers.. Neurobiology of disease, 2018.
• Engel J. The current place of epilepsy surgery.. Current opinion in neurology, 2018.
• Li L, Patel M, Almajano J, Engel J, Bragin A. Extrahippocampal high-frequency oscillations during epileptogenesis.. Epilepsia, 2018.
• Kerr WT, Janio EA, Braesch CT, Le JM, Hori JM, Patel AB, Gallardo NL, Bauirjan J, Chau AM, Hwang ES, Davis EC, Buchard A, Torres-Barba D, D'Ambrosio S, Al Banna M, Cho AY, Engel J, Cohen MS, Stern JM. An objective score to identify psychogenic seizures based on age of onset and history.. Epilepsy & behavior : E&B, 2018.
• Li L, Kriukova K, Engel J, Bragin A. Seizure development in the acute intrahippocampal epileptic focus.. Scientific reports, 2018.
• Klein P, Dingledine R, Aronica E, Bernard C, Blümcke I, Boison D, Brodie MJ, Brooks-Kayal AR, Engel J, Forcelli PA, Hirsch LJ, Kaminski RM, Klitgaard H, Kobow K, Lowenstein DH, Pearl PL, Pitkänen A, Puhakka N, Rogawski MA, Schmidt D, Sillanpää M, Sloviter RS, Steinhäuser C, Vezzani A, Walker MC, Löscher W. Commonalities in epileptogenic processes from different acute brain insults: Do they translate?. Epilepsia, 2017.
• Shimamoto S, Waldman ZJ, Orosz I, Song I, Bragin A, Fried I, Engel J, Staba R, Sharan A, Wu C, Sperling MR, Weiss SA. Utilization of independent component analysis for accurate pathological ripple detection in intracranial EEG recordings recorded extra- and intra-operatively.. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2017.
• Reed CM, Dewar S, Fried I, Engel J, Eliashiv D. Failed epilepsy surgery deserves a second chance.. Clinical neurology and neurosurgery, 2017.
• Waldman ZJ, Shimamoto S, Song I, Orosz I, Bragin A, Fried I, Engel J, Staba R, Sperling MR, Weiss SA. A method for the topographical identification and quantification of high frequency oscillations in intracranial electroencephalography recordings.. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2017.
• Song I, Orosz I, Chervoneva I, Waldman ZJ, Fried I, Wu C, Sharan A, Salamon N, Gorniak R, Dewar S, Bragin A, Engel J, Sperling MR, Staba R, Weiss SA. Bimodal coupling of ripples and slower oscillations during sleep in patients with focal epilepsy.. Epilepsia, 2017.
• Kerr WT, Janio EA, Braesch CT, Le JM, Hori JM, Patel AB, Gallardo NL, Bauirjan J, D'Ambrosio SR, Chau AM, Hwang ES, Davis EC, Buchard A, Torres-Barba D, Al Banna M, Barritt SE, Cho AY, Engel J, Cohen MS, Stern JM. Identifying psychogenic seizures through comorbidities and medication history.. Epilepsia, 2017.
• Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, Engel J, Forsgren L, French JA, Hesdorffer DC, Lee BI, Mathern GW, Moshe SL, Perucca E, Scheffer IE, Tomson T, Watanabe M, Wiebe S. How long for epilepsy remission in the ILAE definition?. Epilepsia, 2017.
• Frauscher B, Bartolomei F, Kobayashi K, Cimbalnik J, van 't Klooster MA, Rampp S, Otsubo H, Höller Y, Wu JY, Asano E, Engel J, Kahane P, Jacobs J, Gotman J. High-frequency oscillations: The state of clinical research.. Epilepsia, 2017.
• Jozwiak S, Becker A, Cepeda C, Engel J, Gnatkovsky V, Huberfeld G, Kaya M, Kobow K, Simonato M, Loeb JA. WONOEP appraisal: Development of epilepsy biomarkers-What we can learn from our patients?. Epilepsia, 2017.
• Kerr WT, Janio EA, Braesch CT, Le JM, Hori JM, Patel AB, Barritt SE, Gallardo NL, Bauirjan J, Chau AM, Hwang ES, Davis EC, Torres-Barba D, Cho AY, Engel J, Cohen MS, Stern JM. Diagnostic implications of review-of-systems questionnaires to differentiate epileptic seizures from psychogenic seizures.. Epilepsy & behavior : E&B, 2017.
• Weiss SA, Asadi-Pooya AA, Vangala S, Moy S, Wyeth DH, Orosz I, Gibbs M, Schrader L, Lerner J, Cheng CK, Chang E, Rajaraman R, Keselman I, Churchman P, Bower-Baca C, Numis AL, Ho MG, Rao L, Bhat A, Suski J, Asadollahi M, Ambrose T, Fernandez A, Nei M, Skidmore C, Mintzer S, Eliashiv DS, Mathern GW, Nuwer MR, Sperling M, Engel J, Stern JM. AR2, a novel automatic artifact reduction software method for ictal EEG interpretation: Validation and comparison of performance with commercially available software.. F1000Research, 2017.
• Engel J. What can we do for people with drug-resistant epilepsy? The 2016 Wartenberg Lecture.. Neurology, 2016.
• Engel J. Go with the flow.. Epilepsy & behavior : E&B, 2016.
• Weiss SA, Orosz I, Salamon N, Moy S, Wei L, Van't Klooster MA, Knight RT, Harper RM, Bragin A, Fried I, Engel J, Staba RJ. Ripples on spikes show increased phase-amplitude coupling in mesial temporal lobe epilepsy seizure-onset zones.. Epilepsia, 2016.
• Reid AY, Bragin A, Giza CC, Staba RJ, Engel J. The progression of electrophysiologic abnormalities during epileptogenesis after experimental traumatic brain injury.. Epilepsia, 2016.
• Kerr WT, Janio EA, Le JM, Hori JM, Patel AB, Gallardo NL, Bauirjan J, Chau AM, D'Ambrosio SR, Cho AY, Engel J, Cohen MS, Stern JM. Diagnostic delay in psychogenic seizures and the association with anti-seizure medication trials.. Seizure, 2016.
• Bragin A, Li L, Almajano J, Alvarado-Rojas C, Reid AY, Staba RJ, Engel J. Pathologic electrographic changes after experimental traumatic brain injury.. Epilepsia, 2016.
• Engel J. When is temporal lobe epilepsy not temporal lobe epilepsy?. Brain : a journal of neurology, 2016.
• Weiss SA, Alvarado-Rojas C, Bragin A, Behnke E, Fields T, Fried I, Engel J, Staba R. Ictal onset patterns of local field potentials, high frequency oscillations, and unit activity in human mesial temporal lobe epilepsy.. Epilepsia, 2015.
• Dewar S, Eliashiv D, Walshaw PD, Engel J, Fried I, Moseley BD. Safety, efficacy, and life satisfaction following epilepsy surgery in patients aged 60 years and older.. Journal of neurosurgery, 2015.
• Jehi L, Friedman D, Carlson C, Cascino G, Dewar S, Elger C, Engel J, Knowlton R, Kuzniecky R, McIntosh A, O'Brien TJ, Spencer D, Sperling MR, Worrell G, Bingaman B, Gonzalez-Martinez J, Doyle W, French J. The evolution of epilepsy surgery between 1991 and 2011 in nine major epilepsy centers across the United States, Germany, and Australia.. Epilepsia, 2015.
• Memarian N, Kim S, Dewar S, Engel J, Staba RJ. Multimodal data and machine learning for surgery outcome prediction in complicated cases of mesial temporal lobe epilepsy.. Computers in biology and medicine, 2015.
• Chiang S, Stern JM, Engel J, Haneef Z. Structural-functional coupling changes in temporal lobe epilepsy.. Brain research, 2015.
• Haneef Z, Chiang S, Yeh HJ, Engel J, Stern JM. Functional connectivity homogeneity correlates with duration of temporal lobe epilepsy.. Epilepsy & behavior : E&B, 2015.
• Memarian N, Madsen SK, Macey PM, Fried I, Engel J, Thompson PM, Staba RJ. Ictal depth EEG and MRI structural evidence for two different epileptogenic networks in mesial temporal lobe epilepsy.. PloS one, 2015.
• Engel J. Who will use epilepsy surgery nomograms, and why?. The Lancet. Neurology, 2015.
• Del Brutto OH, Engel J, Eliashiv DS, Salamon N, García HH. Hippocampal sclerosis: the missing link of cysticercosis epileptogenesis?. Epilepsia, 2014.
• Chiang S, Stern JM, Engel J, Levin HS, Haneef Z. Differences in graph theory functional connectivity in left and right temporal lobe epilepsy.. Epilepsy research, 2014.
• Simonato M, Brooks-Kayal AR, Engel J, Galanopoulou AS, Jensen FE, Moshé SL, O'Brien TJ, Pitkanen A, Wilcox KS, French JA. The challenge and promise of anti-epileptic therapy development in animal models.. The Lancet. Neurology, 2014.
• Haneef Z, Lenartowicz A, Yeh HJ, Engel J, Stern JM. Network analysis of the default mode network using functional connectivity MRI in Temporal Lobe Epilepsy.. Journal of visualized experiments : JoVE, 2014.
• Engel J, Wiebe S, Radhakrishnan K, Palmini A. Surgical treatment for epilepsy.. Neurologisch : fachmagazin fur neurologie, 2014.
• Kerr WT, Hwang ES, Raman KR, Barritt SE, Patel AB, Le JM, Hori JM, Davis EC, Braesch CT, Janio EA, Lau EP, Cho AY, Anderson A, Silverman DH, Salamon N, Engel J, Stern JM, Cohen MS. Multimodal diagnosis of epilepsy using conditional dependence and multiple imputation.. ... International Workshop on Pattern Recognition in NeuroImaging. International Workshop on Pattern Recognition in NeuroImaging, 2014.
• Dedeurwaerdere S, Shultz SR, Federico P, Engel J. Workshop on Neurobiology of Epilepsy appraisal: new systemic imaging technologies to study the brain in experimental models of epilepsy.. Epilepsia, 2014.
• Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, Engel J, Forsgren L, French JA, Glynn M, Hesdorffer DC, Lee BI, Mathern GW, Moshé SL, Perucca E, Scheffer IE, Tomson T, Watanabe M, Wiebe S. ILAE official report: a practical clinical definition of epilepsy.. Epilepsia, 2014.
• Pitkänen A, Engel J. Past and present definitions of epileptogenesis and its biomarkers.. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2014.
• Engel J. Approaches to refractory epilepsy.. Annals of Indian Academy of Neurology, 2014.
• Bragin A, Almajano J, Kheiri F, Engel J. Functional connectivity in the brain estimated by analysis of gamma events.. PloS one, 2014.
• Haneef Z, Lenartowicz A, Yeh HJ, Levin HS, Engel J, Stern JM. Functional connectivity of hippocampal networks in temporal lobe epilepsy.. Epilepsia, 2013.
• Alvarado-Rojas C, Lehongre K, Bagdasaryan J, Bragin A, Staba R, Engel J, Navarro V, Le Van Quyen M. Single-unit activities during epileptic discharges in the human hippocampal formation.. Frontiers in computational neuroscience, 2013.
• Burneo JG, Sirven JI, Kiesel LW, Vecht CJ, Jehi L, Chung SS, Uhm J, Politsky JM, Chang EF, Husain AM, Tatum WO, Meador KJ, Noe K, Hesdorffer DC, Herman ST, Wiebe S, Engel J, Schrader S, Parko KL, Dichter MA, Kwan P, Kossoff E, Sperling MR. Managing common complex symptomatic epilepsies: tumors and trauma: american epilepsy society - 2012 annual course summary.. Epilepsy currents, 2013.
• Engel J, Pitkänen A, Loeb JA, Dudek FE, Bertram EH, Cole AJ, Moshé SL, Wiebe S, Jensen FE, Mody I, Nehlig A, Vezzani A. Epilepsy biomarkers.. Epilepsia, 2013.
• Rektor I, Schachter SC, Arzy S, Baloyannis SJ, Bazil C, Brázdil M, Engel J, Helmstaedter G, Hesdorffer DC, Jones-Gotman M, Kesner L, Komárek V, Krämer G, Leppik IE, Mann MW, Mula M, Risse GL, Stoker GW, Kasteleijn-Nolst Trenité DG, Trimble M, Tyrliková I, Korczyn AD. Epilepsy, behavior, and art (Epilepsy, Brain, and Mind, part 1).. Epilepsy & behavior : E&B, 2013.
• Korczyn AD, Schachter SC, Brodie MJ, Dalal SS, Engel J, Guekht A, Hecimovic H, Jerbi K, Kanner AM, Johannessen Landmark C, Mares P, Marusic P, Meletti S, Mula M, Patsalos PN, Reuber M, Ryvlin P, Štillová K, Tuchman R, Rektor I. Epilepsy, cognition, and neuropsychiatry (Epilepsy, Brain, and Mind, part 2).. Epilepsy & behavior : E&B, 2013.
• Memarian N, Thompson PM, Engel J, Staba RJ. Quantitative analysis of structural neuroimaging of mesial temporal lobe epilepsy.. Imaging in medicine, 2013.
• Engel J, Thompson PM, Stern JM, Staba RJ, Bragin A, Mody I. Connectomics and epilepsy.. Current opinion in neurology, 2013.
• Kheiri F, Bragin A, Engel J. Functional connectivity between brain areas estimated by analysis of gamma waves.. Journal of neuroscience methods, 2013.
• Haneef Z, Lenartowicz A, Yeh HJ, Engel J, Stern JM. Effect of lateralized temporal lobe epilepsy on the default mode network.. Epilepsy & behavior : E&B, 2012.
• Bateman LM, Begley CE, Ben-Menachem E, Berg AT, Berkovic SF, Cascino GD, Drazkowski J, Edwards JC, Engel J, French JA, Gilliam FD, Hoerth MT, Jehi LE, Kanner AM, Krauss GL, Labiner DM, Loddenkemper T, Luders HO, McKhann GM, McLachlan R, Modi A, Pennell PB, Shafer PO, Sirven JI, Stern JM, Szaflarski JP, Theodore WH. Overcoming barriers to successful epilepsy management.. Epilepsy currents, 2012.
• Simonato M, Löscher W, Cole AJ, Dudek FE, Engel J, Kaminski RM, Loeb JA, Scharfman H, Staley KJ, Velíšek L, Klitgaard H. Finding a better drug for epilepsy: preclinical screening strategies and experimental trial design.. Epilepsia, 2012.
• Engel J, McDermott MP, Wiebe S, Langfitt JT, Stern JM, Dewar S, Sperling MR, Gardiner I, Erba G, Fried I, Jacobs M, Vinters HV, Mintzer S, Kieburtz K, Early Randomized Surgical Epilepsy Trial (ERSET) Study Group. Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial.. JAMA, 2012.
• Engel J, da Silva FL. High-frequency oscillations - where we are and where we need to go.. Progress in neurobiology, 2012.
• Kheiri F, Bragin A, Engel J, Almajano J, Winden E. Non-linear classification of heart rate parameters as a biomarker for epileptogenesis.. Epilepsy research, 2012.
• Galanopoulou AS, Buckmaster PS, Staley KJ, Moshé SL, Perucca E, Engel J, Löscher W, Noebels JL, Pitkänen A, Stables J, White HS, O'Brien TJ, Simonato M, American Epilepsy Society Basic Science Committee And The International League Against Epilepsy Work. Identification of new epilepsy treatments: issues in preclinical methodology.. Epilepsia, 2012.
• Engel J, Thompson PM. Going beyond hippocampocentricity in the concept of mesial temporal lobe epilepsy.. Epilepsia, 2012.
• Engel J, Wiebe S. Who is a surgical candidate?. Handbook of clinical neurology, 2012.
• Staba RJ, Ekstrom AD, Suthana NA, Burggren A, Fried I, Engel J, Bookheimer SY. Gray matter loss correlates with mesial temporal lobe neuronal hyperexcitability inside the human seizure-onset zone.. Epilepsia, 2011.
• Engel J. Biomarkers in epilepsy: foreword.. Biomarkers in medicine, 2011.
• Engel J. Biomarkers in epilepsy: introduction.. Biomarkers in medicine, 2011.
• Cendes F, Engel J. Extending applications for high-frequency oscillations: the ripple effect.. Neurology, 2011.
• Winden KD, Karsten SL, Bragin A, Kudo LC, Gehman L, Ruidera J, Geschwind DH, Engel J. A systems level, functional genomics analysis of chronic epilepsy.. PloS one, 2011.
• Engel J. Another good reason to consider surgical treatment for epilepsy more often and sooner.. Archives of neurology, 2011.
• Engel J. The etiologic classification of epilepsy.. Epilepsia, 2011.
• Bragin A, Benassi SK, Kheiri F, Engel J. Further evidence that pathologic high-frequency oscillations are bursts of population spikes derived from recordings of identified cells in dentate gyrus.. Epilepsia, 2011.
• Wilson SJ, Engel J. Diverse perspectives on developments in epilepsy surgery.. Seizure, 2010.
• Engel J. Do we belittle epilepsy by calling it a disorder rather than a disease?. Epilepsia, 2010.
• Engel J, McDermott MP, Wiebe S, Langfitt JT, Erba G, Gardiner I, Stern J, Dewar S, Sperling MR, Jacobs M, Kieburtz K, Early Randomized Surgical Epilepsy Trial (ERSET) Study Group. Design considerations for a multicenter randomized controlled trial of early surgery for mesial temporal lobe epilepsy.. Epilepsia, 2010.
• Haneef Z, Stern J, Dewar S, Engel J. Referral pattern for epilepsy surgery after evidence-based recommendations: a retrospective study.. Neurology, 2010.
• Bragin A, Engel J, Staba RJ. High-frequency oscillations in epileptic brain.. Current opinion in neurology, 2010.
• Engel J, Akhtari M, Bragin A, Fried I, Ogren JA, Staba RJ, Salamon N, Thompson PM. New approaches to structural and functional imaging in focal epilepsy.. Epilepsia, 2010.
• Upchurch K, Stern JM, Salamon N, Dewar S, Engel J, Vinters HV, Fried I. Epileptogenic temporal cavernous malformations: operative strategies and postoperative seizure outcomes.. Seizure, 2009.
• Ogren JA, Wilson CL, Bragin A, Lin JJ, Salamon N, Dutton RA, Luders E, Fields TA, Fried I, Toga AW, Thompson PM, Engel J, Staba RJ. Three-dimensional surface maps link local atrophy and fast ripples in human epileptic hippocampus.. Annals of neurology, 2009.
• Engel J, Moshé SL. Commentary: hormones, diet, and botanicals.. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2009.
• Bragin A, Azizyan A, Almajano J, Engel J. The cause of the imbalance in the neuronal network leading to seizure activity can be predicted by the electrographic pattern of the seizure onset.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009.
• Engel J. The ILAE --where it was, and where it is going: a personal view.. Epilepsia, 2009.
• He DF, Ma DL, Tang YC, Engel J, Bragin A, Tang FR. Morpho-physiologic characteristics of dorsal subicular network in mice after pilocarpine-induced status epilepticus.. Brain pathology (Zurich, Switzerland), 2009.
• Lerner JT, Salamon N, Hauptman JS, Velasco TR, Hemb M, Wu JY, Sankar R, Donald Shields W, Engel J, Fried I, Cepeda C, Andre VM, Levine MS, Miyata H, Yong WH, Vinters HV, Mathern GW. Assessment and surgical outcomes for mild type I and severe type II cortical dysplasia: a critical review and the UCLA experience.. Epilepsia, 2009.
• Engel J, Bragin A, Staba R, Mody I. High-frequency oscillations: what is normal and what is not?. Epilepsia, 2008.
• Engel J. Surgical treatment for epilepsy: too little, too late?. JAMA, 2008.
• Ogren JA, Bragin A, Wilson CL, Hoftman GD, Lin JJ, Dutton RA, Fields TA, Toga AW, Thompson PM, Engel J, Staba RJ. Three-dimensional hippocampal atrophy maps distinguish two common temporal lobe seizure-onset patterns.. Epilepsia, 2008.
• Engel J. More on the history of temporal lobe surgery.. Epilepsia, 2008.
• Le Van Quyen M, Bragin A, Staba R, Crépon B, Wilson CL, Engel J. Cell type-specific firing during ripple oscillations in the hippocampal formation of humans.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008.
• Akhtari M, Bragin A, Cohen M, Moats R, Brenker F, Lynch MD, Vinters HV, Engel J. Functionalized magnetonanoparticles for MRI diagnosis and localization in epilepsy.. Epilepsia, 2008.
• Engel J. Progress in epilepsy: reducing the treatment gap and the promise of biomarkers.. Current opinion in neurology, 2008.
• Avanzini G, Engel J. Dealing with drug dependency: a commentary on ILAE's partnership with the pharmaceutical industry.. Epilepsia, 2007.
• Staba RJ, Frighetto L, Behnke EJ, Mathern GW, Fields T, Bragin A, Ogren J, Fried I, Wilson CL, Engel J. Increased fast ripple to ripple ratios correlate with reduced hippocampal volumes and neuron loss in temporal lobe epilepsy patients.. Epilepsia, 2007.
• Bragin A, Claeys P, Vonck K, Van Roost D, Wilson C, Boon P, Engel J. Analysis of initial slow waves (ISWs) at the seizure onset in patients with drug resistant temporal lobe epilepsy.. Epilepsia, 2007.
• Co JP, Elia M, Engel J, Guerrini R, Mizrahi EM, Moshé SL, Plouin P. Proposal of an algorithm for diagnosis and treatment of neonatal seizures in developing countries.. Epilepsia, 2007.
• Bragin A, Wilson CL, Engel J. Voltage depth profiles of high-frequency oscillations after kainic acid-induced status epilepticus.. Epilepsia, 2007.
• Lin JJ, Salamon N, Lee AD, Dutton RA, Geaga JA, Hayashi KM, Luders E, Toga AW, Engel J, Thompson PM. Reduced neocortical thickness and complexity mapped in mesial temporal lobe epilepsy with hippocampal sclerosis.. Cerebral cortex (New York, N.Y. : 1991), 2006.
• Engel J. Report of the ILAE classification core group.. Epilepsia, 2006.
• Engel J. ILAE classification of epilepsy syndromes.. Epilepsy research, 2006.
• Engel J, Berg A, Andermann F, Avanzini G, Berkovic S, Blume W, Dulac O, van Emde Boas W, Fejerman N, Plouin P, Scheffer I, Seino M, Williamson P, Wolf P. Are epilepsy classifications based on epileptic syndromes and seizure types outdated?. Epileptic disorders : international epilepsy journal with videotape, 2006.
• Zeitzer JM, Morales-Villagran A, Maidment NT, Behnke EJ, Ackerson LC, Lopez-Rodriguez F, Fried I, Engel J, Wilson CL. Extracellular adenosine in the human brain during sleep and sleep deprivation: an in vivo microdialysis study.. Sleep, 2006.
• Engel J. Classification is not EZ.. Epileptic disorders : international epilepsy journal with videotape, 2005.
• Bragin A, Azizyan A, Almajano J, Wilson CL, Engel J. Analysis of chronic seizure onsets after intrahippocampal kainic acid injection in freely moving rats.. Epilepsia, 2005.
• Fisher RS, van Emde Boas W, Blume W, Elger C, Genton P, Lee P, Engel J. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE).. Epilepsia, 2005.
• Bookheimer S, Schrader LM, Rausch R, Sankar R, Engel J. Reduced anesthetization during the intracarotid amobarbital (Wada) test in patients taking carbonic anhydrase-inhibiting medications.. Epilepsia, 2005.
• Bragin A, Wilson CL, Fields T, Fried I, Engel J. Analysis of seizure onset on the basis of wideband EEG recordings.. Epilepsia, 2005.
• Schrader LM, Stern JM, Koski L, Nuwer MR, Engel J. Seizure incidence during single- and paired-pulse transcranial magnetic stimulation (TMS) in individuals with epilepsy.. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2004.
• Bragin A, Wilson CL, Almajano J, Mody I, Engel J. High-frequency oscillations after status epilepticus: epileptogenesis and seizure genesis.. Epilepsia, 2004.
• Staba RJ, Wilson CL, Bragin A, Jhung D, Fried I, Engel J. High-frequency oscillations recorded in human medial temporal lobe during sleep.. Annals of neurology, 2004.
• Mintzer S, Cendes F, Soss J, Andermann F, Engel J, Dubeau F, Olivier A, Fried I. Unilateral hippocampal sclerosis with contralateral temporal scalp ictal onset.. Epilepsia, 2004.
• Bragin A, Karsten SL, Almajano J, Wilson CL, Geschwind DH, Engel J. Large-scale microarray gene expression analysis in discrete electrophysiologically identified neuronal clusters.. Journal of neuroscience methods, 2004.
• Engel J. The goal of epilepsy therapy: no seizures, no side effects, as soon as possible.. CNS spectrums, 2004.
• Engel J. Models of focal epilepsy.. Supplements to Clinical neurophysiology, 2004.
• Engel J, Wiebe S, French J, Sperling M, Williamson P, Spencer D, Gumnit R, Zahn C, Westbrook E, Enos B. Practice parameter: temporal lobe and localized neocortical resections for epilepsy.. Epilepsia, 2003.
• Engel J, Wiebe S, French J, Sperling M, Williamson P, Spencer D, Gumnit R, Zahn C, Westbrook E, Enos B, Quality Standards Subcommittee of the American Academy of Neurology, American Epilepsy Society, American Association of Neurological Surgeons. Practice parameter: temporal lobe and localized neocortical resections for epilepsy: report of the Quality Standards Subcommittee of the American Academy of Neurology, in association with the American Epilepsy Society and the American Association of Neurological Surgeons.. Neurology, 2003.
• Swarztrauber K, Dewar S, Engel J. Patient attitudes about treatments for intractable epilepsy.. Epilepsy & behavior : E&B, 2003.
• Engel J, Wilson C, Bragin A. Advances in understanding the process of epileptogenesis based on patient material: what can the patient tell us?. Epilepsia, 2003.
• Goldman RI, Stern JM, Engel J, Cohen MS. Simultaneous EEG and fMRI of the alpha rhythm.. Neuroreport, 2002.
• Staba RJ, Wilson CL, Bragin A, Fried I, Engel J. Sleep states differentiate single neuron activity recorded from human epileptic hippocampus, entorhinal cortex, and subiculum.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002.
• Bragin A, Mody I, Wilson CL, Engel J. Local generation of fast ripples in epileptic brain.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002.
• Engel J. Early versus late surgery for intractable seizures.. Advances in experimental medicine and biology, 2002.
• Bragin A, Wilson CL, Engel J. Rate of interictal events and spontaneous seizures in epileptic rats after electrical stimulation of hippocampus and its afferents.. Epilepsia, 2002.
• Staba RJ, Wilson CL, Fried I, Engel J. Single neuron burst firing in the human hippocampus during sleep.. Hippocampus, 2002.
• Engel J. So what can we conclude--do seizures damage the brain?. Progress in brain research, 2002.
• Engel J, International League Against Epilepsy (ILAE). A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology.. Epilepsia, 2001.
• Engel J. When is imaging enough?. Epileptic disorders : international epilepsy journal with videotape, 1999.
• Engel J. The timing of surgical intervention for mesial temporal lobe epilepsy: a plan for a randomized clinical trial.. Archives of neurology, 1999.
• Engel J. Research on the human brain in an epilepsy surgery setting.. Epilepsy research, 1998.