Jerome M. Siegel, Ph.D.

Jerome Siegel, Ph.D.

Chief, Neurobiology Research Professor, Psychiatry and Biobehavioral Sciences Professor In-Residence, Jane and Terry Semel Institute for Neuroscience and Human Behavior Member, Brain Research Institute Neuroscience GPB Home Area

818-891-7711

Laboratory
Bldg 7, GLAHS Sepulveda
Los Angeles, CA 91343
UNITED STATES

Office
Bldg 7, GLAHS Sepulveda
Los Angeles, CA 91343
UNITED STATES

Website

Biography

Sleep, Motor control Our primary interest is in understanding the evolution, function and disorders of REM sleep. We are analyzing the brainstem-forebrain interactions responsible for the control of muscle tone in waking and across the sleep cycle. This is of importance in understanding REM sleep behavior disorder, cataplexy and sleep apnea. We are studying the phylogeny of sleep by investigating the physiology and neurochemistry of sleep in reptiles, marine mammals and other species. We are particularly interested in the role of monoamines in the control of arousal and movement. A major focus of the laboratory is on narcolepsy, its anatomy, pathophysiology and treatment. We have identified the cause of human narcolepsy, a loss of hypocretin cells. We are investigating ways of identifying, controlling and reversing the symptoms of narcolepsy in narcoleptic animals and in humans.

Publications

A selected list of publications:

  See: http://www.npi.ucla.edu/sleepresearch , , ; .
Dell Leigh-Anne, Patzke Nina, Bhagwandin Adhil, Bux Faiza, Fuxe Kjell, Barber Grace, Siegel Jerome M, Manger Paul R   Organization and number of orexinergic neurons in the hypothalamus of two species of Cetartiodactyla: A comparison of giraffe (Giraffa camelopardalis) and harbour porpoise (Phocoena phocoena) Journal of chemical neuroanatomy, 2012; .
Lyamin Oleg I, Pavlova Ivetta F, Kosenko Peter O, Mukhametov Lev M, Siegel Jerome M   Regional differences in cortical electroencephalogram (EEG) slow wave activity and interhemispheric EEG asymmetry in the fur seal Journal of sleep research, 2012; .
Gravett Nadine, Bhagwandin Adhil, Lyamin Oleg I, Siegel Jerome M, Manger Paul R   Sleep in the rock hyrax, Procavia capensis Brain, behavior and evolution, 2012; 79(3): 155-69.
Ramanathan Lalini, Siegel Jerome M   Sleep deprivation under sustained hypoxia protects against oxidative stress Free radical biology & medicine, 2011; 51(10): 1842-8.
McGregor Ronald, Wu Ming-Fung, Barber Grace, Ramanathan Lalini, Siegel Jerome M   Highly specific role of hypocretin (orexin) neurons: differential activation as a function of diurnal phase, operant reinforcement versus operant avoidance and light level The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011; 31(43): 15455-67.
Siegel Jerome M   REM sleep: a biological and psychological paradox Sleep medicine reviews, 2011; 15(3): 139-42.
Wu Ming-Fung, Nienhuis Robert, Maidment Nigel, Lam Hoa A, Siegel Jerome M   Role of the hypocretin (orexin) receptor 2 (Hcrt-r2) in the regulation of hypocretin level and cataplexy The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011; 31(17): 6305-10.
Bhagwandin Adhil, Gravett Nadine, Lyamin Oleg I, Oosthuizen Maria K, Bennett Nigel C, Siegel Jerome M, Manger Paul R   Sleep and wake in rhythmic versus arrhythmic chronotypes of a microphthalmic species of African mole rat (Fukomys mechowii) Brain, behavior and evolution, 2011; 78(2): 162-83.
McGregor Ronald, Siegel Jerome M   Illuminating the locus coeruleus: control of posture and arousal Nature neuroscience, 2010; 13(12): 1448-9.
Lai Yuan-Yang, Kodama Tohru, Schenkel Elizabeth, Siegel Jerome M   Behavioral response and transmitter release during atonia elicited by medial medullary stimulation Journal of neurophysiology, 2010; 104(4): 2024-33.
Ramanathan Lalini, Hu Shuxin, Frautschy Sally A, Siegel Jerome M   Short-term total sleep deprivation in the rat increases antioxidant responses in multiple brain regions without impairing spontaneous alternation behavior Behavioural brain research, 2010; 207(2): 305-9.
Siegel Jerome M   Sleep viewed as a state of adaptive inactivity Nature reviews. Neuroscience, 2009; 10(10): 747-53.
Rajendra Arathi, Cohen Seth A, Kasmin Franklin E, Siegel Jerome H, Leitman Michael   Surgical clip migration and stone formation in a gallbladder remnant after laparoscopic cholecystectomy Gastrointestinal endoscopy, 2009; 70(4): 780-1.
Siegel Jerome M   The neurobiology of sleep Seminars in neurology, 2009; 29(4): 277-96.
Thannickal Thomas C, Nienhuis Robert, Siegel Jerome M   Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy Sleep, 2009; 32(8): 993-8.
Pryaslova Julia P, Lyamin Oleg I, Siegel Jerome M, Mukhametov Lev M   Behavioral sleep in the walrus Behavioural brain research, 2009; 201(1): 80-7.
Siegel Jerome M   Narcolepsy. Interview by Norman Sussman CNS spectrums, 2009; 14(6): 295-7.
Scammell Thomas E, Willie Jon T, Guilleminault Christian, Siegel Jerome M, Siegel Jerome M   A consensus definition of cataplexy in mouse models of narcolepsy Sleep, 2009; 32(1): 111-6.
Siegel Jerome M   Gaps that wake you up Sleep, 2008; 31(12): 1625-6.
John Joshi, Ramanathan Lalini, Siegel Jerome M   Rapid changes in glutamate levels in the posterior hypothalamus across sleep-wake states in freely behaving rats American journal of physiology. Regulatory, integrative and comparative physiology, 2008; 295(6): R2041-9.
Lyamin Oleg I, Kosenko Peter O, Lapierre Jennifer L, Mukhametov Lev M, Siegel Jerome M   Fur seals display a strong drive for bilateral slow-wave sleep while on land The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008; 28(48): 12614-21.
Lyamin Oleg I, Manger Paul R, Ridgway Sam H, Mukhametov Lev M, Siegel Jerome M   Cetacean sleep: an unusual form of mammalian sleep Neuroscience and biobehavioral reviews, 2008; 32(8): 1451-84.
Allada Ravi, Siegel Jerome M   Unearthing the phylogenetic roots of sleep Current biology : CB, 2008; 18(15): R670-R679.
Lyamin Oleg I, Lapierre Jennifer L, Kosenko Peter O, Mukhametov Lev M, Siegel Jerome M   Electroencephalogram asymmetry and spectral power during sleep in the northern fur seal Journal of sleep research, 2008; 17(2): 154-65.
Burgess Christian, Lai Diane, Siegel Jerome, Peever John   An endogenous glutamatergic drive onto somatic motoneurons contributes to the stereotypical pattern of muscle tone across the sleep-wake cycle The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008; 28(18): 4649-60.
Siegel Jerome M   Do all animals sleep? Trends in neurosciences, 2008; 31(4): 208-13.
Thannickal Thomas C, Lai Yuan-Yang, Siegel Jerome M   Hypocretin (orexin) and melanin concentrating hormone loss and the symptoms of Parkinson’s disease Brain : a journal of neurology, 2008; 131(Pt 1): e87.
Stupak Daniel, Cohen Seth, Kasmin Franklin, Lee Young, Siegel Jerome H   Intra-abdominal actinomycosis 11 years after spilled gallstones at the time of laparoscopic cholecystectomy Surgical laparoscopy, endoscopy & percutaneous techniques, 2007; 17(6): 542-4.
Deadwyler Sam A, Porrino Linda, Siegel Jerome M, Hampson Robert E   Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007; 27(52): 14239-47.
Lyamin Oleg, Pryaslova Julia, Kosenko Peter, Siegel Jerome   Behavioral aspects of sleep in bottlenose dolphin mothers and their calves Physiology & behavior, 2007; 92(4): 725-33.
Lapierre Jennifer L, Kosenko Peter O, Lyamin Oleg I, Kodama Tohru, Mukhametov Lev M, Siegel Jerome M   Cortical acetylcholine release is lateralized during asymmetrical slow-wave sleep in northern fur seals The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007; 27(44): 11999-2006.
Cohen Seth A, Siegel Jerome H, Kasmin Franklin E   Treatment of pancreatic strictures Current treatment options in gastroenterology, 2007; 10(5): 347-54.
Wayne Michael, Cooperman Avram, Kasmin Franklin, Cohen Seth, Dryska Herbert, Ottaviano Lawrence, Katcherian Chris, Cambronero Neil, Siegel Jerome   Chronic pancreatitis with synchronous and metachronous malignancy: three unusual cases and a literature review Journal of surgical education, 2007; 64(3): 158-61.
Thannickal Thomas C, Lai Yuan-Yang, Siegel Jerome M   Hypocretin (orexin) cell loss in Parkinson’s disease Brain : a journal of neurology, 2007; 130(Pt 6): 1586-95.
Hu Wang-Ping, Li Jia-Da, Zhang Chengkang, Boehmer Lisa, Siegel Jerome M, Zhou Qun-Yong   Altered circadian and homeostatic sleep regulation in prokineticin 2-deficient mice Sleep, 2007; 30(3): 247-56.
Cohen Seth A, Siegel Jerome H   Endotherapy for pancreatic fistulae: inside out or outside in? The American journal of gastroenterology, 2007; 102(3): 525-6.
Cohen Seth A, Kasmin Franklin E, Siegel Jerome H   Do not desert me in my old age Gastrointestinal endoscopy, 2006; 64(6): 906-7.
Li Jia-Da, Hu Wang-Ping, Boehmer Lisa, Cheng Michelle Y, Lee Alex G, Jilek Alexander, Siegel Jerome M, Zhou Qun-Yong   Attenuated circadian rhythms in mice lacking the prokineticin 2 gene The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006; 26(45): 11615-23.
Siegel Jerome H, Cohen Seth A   Pull or push pancreatic sphincterotomy for sphincter of Oddi dysfunction? A conundrum for experts only Gastrointestinal endoscopy, 2006; 64(5): 723-5.
Siegel Jerome M, Boehmer Lisa N   Narcolepsy and the hypocretin system–where motion meets emotion Nature clinical practice. Neurology, 2006; 2(10): 548-56.
Siegel Jerome M   The stuff dreams are made of: anatomical substrates of REM sleep Nature neuroscience, 2006; 9(6): 721-2.
Siegel Jerome M   Clues to the functions of mammalian sleep Nature, 2005; 437(7063): 1264-71.
Pisula Wojciech, Siegel Jerome   Exploratory behavior as a function of environmental novelty and complexity in male and female rats Psychological reports, 2005; 97(2): 631-8.
Vertes Robert P, Siegel Jerome M   Time for the sleep community to take a critical look at the purported role of sleep in memory processing Sleep, 2005; 28(10): 1228-9; discussion 1230-3.
Lyamin Oleg, Pryaslova Julia, Lance Valentine, Siegel Jerome   Animal behaviour: continuous activity in cetaceans after birth Nature, 2005; 435(7046): 1177.
Mileykovskiy Boris Y, Kiyashchenko Lyudmila I, Siegel Jerome M   Behavioral correlates of activity in identified hypocretin/orexin neurons Neuron, 2005; 46(5): 787-98.
Siegel Jerome M   Functional implications of sleep development PLoS biology, 2005; 3(5): e178.
Ramanathan Lalini, Gozal David, Siegel Jerome M   Antioxidant responses to chronic hypoxia in the rat cerebellum and pons Journal of neurochemistry, 2005; 93(1): 47-52.
John Joshi, Wu Ming-Fung, Maidment Nigel T, Lam Hoa A, Boehmer Lisa N, Patton Melanie, Siegel Jerome M   Developmental changes in CSF hypocretin-1 (orexin-A) levels in normal and genetically narcoleptic Doberman pinschers The Journal of physiology, 2004; 560(Pt 2): 587-92.
Siegel Jerome   Brain mechanisms that control sleep and waking Die Naturwissenschaften, 2004; 91(8): 355-65.
John Joshi, Wu Ming-Fung, Boehmer Lisa N, Siegel Jerome M   Cataplexy-active neurons in the hypothalamus: implications for the role of histamine in sleep and waking behavior Neuron, 2004; 42(4): 619-34.
Siegel Jerome M   Hypocretin (orexin): role in normal behavior and neuropathology Annual review of psychology, 2004; 55(4): 125-48.
Greene Robert, Siegel Jerome   Sleep: a functional enigma Neuromolecular medicine, 2004; 5(1): 59-68.
Manger Paul R, Fuxe Kjell, Ridgway Sam H, Siegel Jerome M   The distribution and morphological characteristics of catecholaminergic cells in the diencephalon and midbrain of the bottlenose dolphin (Tursiops truncatus) Brain, behavior and evolution, 2004; 64(1): 42-60.
Siegel Jerome M   The neurotransmitters of sleep The Journal of clinical psychiatry, 2004; 65 Suppl 16(1): 4-7.
Siegel Jerome M   Why we sleep Scientific American, 2003; 289(5): 92-7.
Thannickal Thomas C, Siegel Jerome M, Nienhuis Robert, Moore Robert Y   Pattern of hypocretin (orexin) soma and axon loss, and gliosis, in human narcolepsy Brain pathology (Zurich, Switzerland), 2003; 13(3): 340-51.
Cohen Seth A, Kasmin Franklin E, Siegel Jerome H   Re: ERCP during pregnancy The American journal of gastroenterology, 2003; 98(7): 1658-9; author reply 1659.
Manger Paul R, Ridgway Sam H, Siegel Jerome M   The locus coeruleus complex of the bottlenose dolphin (Tursiops truncatus) as revealed by tyrosine hydroxylase immunohistochemistry Journal of sleep research, 2003; 12(2): 149-55.
Peever John H, Lai Yuan-Yang, Siegel Jerome M   Excitatory effects of hypocretin-1 (orexin-A) in the trigeminal motor nucleus are reversed by NMDA antagonism Journal of neurophysiology, 2003; 89(5): 2591-600.
John Joshi, Wu Ming-Fung, Kodama Tohru, Siegel Jerome M   Intravenously administered hypocretin-1 alters brain amino acid release: an in vivo microdialysis study in rats The Journal of physiology, 2003; 548(Pt 2): 557-62.
Lai Yuan-Yang, Siegel Jerome M   Physiological and anatomical link between Parkinson-like disease and REM sleep behavior disorder Molecular neurobiology, 2003; 27(2): 137-52.
Kodama Tohro, Lai Yuan-Yang, Siegel Jerome M   Changes in inhibitory amino acid release linked to pontine-induced atonia: an in vivo microdialysis study The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003; 23(4): 1548-54.
Siegel Jerome M   The narcoleptic borderland Sleep medicine, 2003; 4(1): 3-4.
Mileykovskiy Boris Y, Kiyashchenko Lyudmila I, Siegel Jerome M   Cessation of activity in red nucleus neurons during stimulation of the medial medulla in decerebrate rats The Journal of physiology, 2002; 545(Pt 3): 997-1006.
Ramanathan Lalini, Gulyani Seema, Nienhuis Robert, Siegel Jerome M   Sleep deprivation decreases superoxide dismutase activity in rat hippocampus and brainstem Neuroreport, 2002; 13(11): 1387-90.
Eiland Monica M, Ramanathan Lalini, Gulyani Seema, Gilliland Marcia, Bergmann Bernard M, Rechtschaffen Allan, Siegel Jerome M   Increases in amino-cupric-silver staining of the supraoptic nucleus after sleep deprivation Brain research, 2002; 945(1): 1-8.
Kiyashchenko Lyudmila I, Mileykovskiy Boris Y, Maidment Nigel, Lam Hoa A, Wu Ming-Fung, John Joshi, Peever John, Siegel Jerome M   Release of hypocretin (orexin) during waking and sleep states The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002; 22(13): 5282-6.
Mileykovskiy Boris Y, Kiyashchenko Lyudmila I, Siegel Jerome M   Muscle tone facilitation and inhibition after orexin-a (hypocretin-1) microinjections into the medial medulla Journal of neurophysiology, 2002; 87(5): 2480-9.
Siegel, J.M.   A tribute to Nathaniel Kleitman, Arch. Ital. Biol. , 2001; 139: 3-10.
Eiland, M.M., Lyamin, O.I. and Siegel, J.M.   State related discharge of neruons in the brainstem of freely moving box turtles, Terapene Carolina major, Arch. Ital. Biol, 2001; 139: 23-36.
Kiyashchenko, LI Mileykovskiy, BY Lai, YY Siegel, JM   Increased and decreased muscle tone with orexin (hypocretin) microinjections in the locus coeruleus and pontine inhibitory area Journal of neurophysiology. , 2001; 85(5): 2008-16.
Mileykovskiy, BY Kiyashchenko, LI Kodama, T Lai, YY Siegel, JM   Activation of pontine and medullary motor inhibitory regions reduces discharge in neurons located in the locus coeruleus and the anatomical equivalent of the midbrain locomotor region The Journal of neuroscience : the official journal of the Society for Neuroscience. , 2000; 20(22): 8551-8.
Hajnik, T Lai, YY Siegel, JM   Atonia-related regions in the rodent pons and medulla Journal of neurophysiology. , 2000; 84(4): 1942-8.
Thannickal, TC Moore, RY Nienhuis, R Ramanathan, L Gulyani, S Aldrich, M Cornford, M Siegel, JM   Reduced number of hypocretin neurons in human narcolepsy Neuron. , 2000; 27(3): 469-74.
Siegel, J. M.   Brainstem mechanisms generating REM sleep, Principles and Practice of Sleep Medicine, 2000; Third Edition: 112-133.
Siegel, J. M.   Brainstem mechanisms generating REM sleep, Principles and Practice of Sleep Medicine, 2000; Third Edition: 112-133.
Siegel, J.M.   Narcolepsy, Scientific American, 2000; 282: 76-81.
Siegel, J.M.   Phylogenetic data bearing on the REM sleep-learning connection, The Behavioral and Brain Sciences, 2000; 23: 1007.
Lyamin, O.I., Manger,P.R. Mukhametov, L.M., Siegel, J.M.and Shpak, O.V.   Rest and activity states in a gray whale, J. Sleep Res, 2000; 9: 261-267.
Rechtschaffen, A. and Siegel, J.M.   Sleep and Dreaming, Principles of Neuroscience, 2000; Fourth Edition: 936-947.
John, J Wu, MF Siegel, JM   Systemic administration of hypocretin-1 reduces cataplexy and normalizes sleep and waking durations in narcoleptic dogs Sleep research online [electronic resource] : SRO. , 2000; 3(1): 23-8.
Wu, MF Gulyani, SA Yau, E Mignot, E Phan, B Siegel, JM   Locus coeruleus neurons: cessation of activity during cataplexy Neuroscience. , 1999; 91(4): 1389-99.
Siegel, J.M.   Narcolepsy: A key role for hypocretins (orexins), Cell, 1999; 98: 409-412.
Lai. Y.Y., Shalita, T., Hajnik, T., Wu, J.-P., Kuo, J.-S., Chia, L.-G., and Siegel, J.M.   Neurotoxic Nmethyl-D-Aspartate lesion of the ventral midbrain and mesopontine junction alters sleep-wake organization, Neuroscience, 1999; 90: 469-483.
Siegel, JM Manger, PR Nienhuis, R Fahringer, HM Shalita, T Pettigrew, JD   Sleep in the platypus Neuroscience. , 1999; 91(1): 391-400.
Siegel, J.M.   Sleep, Encarta Encyclopedia, 1999; 2000: 0000.
Siegel, J.M.   Sleep, Encarta Encyclopedia, 1999; 2000: 0000.
Siegel, J.M.   The evolution of REM sleep, In Handbook of Behavioral State Control, 1999; first edition: pp 87-100.
Lai, YY Clements, JR Wu, XY Shalita, T Wu, JP Kuo, JS Siegel, JM   Brainstem projections to the ventromedial medulla in cat: retrograde transport horseradish peroxidase and immunohistochemical studies The Journal of comparative neurology. , 1999; 408(3): 419-36.
Siegel, JM Nienhuis, R Gulyani, S Ouyang, S Wu, MF Mignot, E Switzer, RC McMurry, G Cornford, M   Neuronal degeneration in canine narcolepsy The Journal of neuroscience : the official journal of the Society for Neuroscience. , 1999; 19(1): 248-57.
Kohyama, J Lai, YY Siegel, JM   Inactivation of the pons blocks medullary-induced muscle tone suppression in the decerebrate cat Sleep. , 1998; 21(7): 695-9.
Siegel, JM Manger, PR Nienhuis, R Fahringer, HM Pettigrew, JD   Monotremes and the evolution of rapid eye movement sleep Philosophical transactions of the Royal Society of London. Series B, Biological sciences. , 1998; 353(1372): 1147-57.
Kohyama, J., Lai, Y.Y. and Siegel, J.M.   Conduction velocity of the reticulospinal system mediating muscle tone suppression, J. Neurophysiol, 1998; 80: 1839-1851.
Lai, Y.Y. and Siegel, J.M.   Muscle atonia and REM sleep, Rapid eye movement sleep, 1998; first edition: 69-90.
Reid, MS Nishino, S Tafti, M Siegel, JM Dement, WC Mignot, E   Neuropharmacological characterization of basal forebrain cholinergic stimulated cataplexy in narcoleptic canines Experimental neurology. , 1998; 151(1): 89-104.
Kodama, T Lai, YY Siegel, JM   Enhanced glutamate release during REM sleep in the rostromedial medulla as measured by in vivo microdialysis Brain research. , 1998; 780(1): 178-81.
Nitz, D Siegel, J   GABA release in the dorsal raphe nucleus: role in the control of REM sleep The American journal of physiology. , 1997; 273(1 Pt 2): R451-5.
Nitz, D. and Siegel, J.M.   GABA release in the locus coeruleus as a function of sleep/wake state, Neuroscience, 1997; 78: 795-801.
Siegel, J.M.   Sleep in monotremes; implications for the evolution of REM sleep, Sleep and sleep disorders: from molecule to behavior, 1997; First edition: 113-128.
Lai, YY Siegel, JM   Brainstem-mediated locomotion and myoclonic jerks. I. Neural substrates Brain research. , 1997; 745(1-2): 257-64.
Lai, YY Siegel, JM   Brainstem-mediated locomotion and myoclonic jerks. II Pharmacological effects Brain research. , 1997; 745(1-2): 265-70.
Nitz, D Siegel, JM   GABA release in posterior hypothalamus across sleep-wake cycle The American journal of physiology. , 1996; 271(6 Pt 2): R1707-12.
Reid, MS Tafti, M Nishino, S Sampathkumaran, R Siegel, JM Mignot, E   Local administration of dopaminergic drugs into the ventral tegmental area modulates cataplexy in the narcoleptic canine Brain research. , 1996; 733(1): 83-100.
Siegel, J.M. and Harper, R.H.   Sleep, Human Physiology, 1996; 1: 1183-1197.
Siegel, J.M. and Harper, R.H.   Sleep, Human Physiology, 1996; 1: 1183-1197.
Siegel, JM Manger, PR Nienhuis, R Fahringer, HM Pettigrew, JD   The echidna Tachyglossus aculeatus combines REM and non-REM aspects in a single sleep state: implications for the evolution of sleep The Journal of neuroscience : the official journal of the Society for Neuroscience. , 1996; 16(10): 3500-6.
Nitz, D Andersen, A Fahringer, H Nienhuis, R Mignot, E Siegel, J   Altered distribution of cholinergic cells in the narcoleptic dog Neuroreport. , 1995; 6(11): 1521-4.
Nishino, S., Tafti, M., Reid, M., Shelton, J., Siegel, J.M., Dement, W.C., and Mignot, E.   Muscle atonia is triggered by cholinergic stimulation of the basal forebrain: Implications for the pathophysiology of narcolepsy, J. Neuroscience , 1995; 15: 4806-4814.
Siegel, JM   Phylogeny and the function of REM sleep Behavioural brain research. , 1995; 69(1-2): 29-34.
Reid, MS Tafti, M Nishino, S Siegel, JM Dement, WC Mignot, E   Cholinergic regulation of cataplexy in canine narcolepsy in the pontine reticular formation is mediated by M2 muscarinic receptors Sleep. , 1994; 17(5): 424-35.
Siegel, J. M.   Brainstem mechanisms generating REM sleep, Principles and Practice of Sleep Medicine, 1994; Third Edition: 125-144.
Siegel, J.M., and Lai, Y.Y.   Brainstem systems mediating the control of muscle tone, Environment and Physiology, 1994; First Edition: 62-78.
Reid, MS Tafti, M Geary, JN Nishino, S Siegel, JM Dement, WC Mignot, E   Cholinergic mechanisms in canine narcolepsy–I. Modulation of cataplexy via local drug administration into the pontine reticular formation Neuroscience. , 1994; 59(3): 511-22.
Carskadon, M.A., Rechtschaffen, A., Richardson, G., Roth, T., Siegel, J.M.v   (Editor), Encyclopedia of Sleep and Dreaming, 1993; 703 pages.
Kodama, T., and Siegel, J.M.   Brainstem acetylcholine release and REM sleep, Sleep Wakefulness, 1993; First edition: 51-56.
Wu, M.F, Jenden, D.J., Fairchild, D.M. and Siegel, J.M.   Cholinergic mechanisms in startle and prepulse inhibition:Effect of the false cholinergic precursor N-aminodeanol, Behavioral Neurosci, 1993; 107: 306-316.
Siegel, J.M.   Function of REM sleep, Encyclopedia of Sleep and Dreaming, 1993; First Edition: 507-510.
Siegel, J.M.   Medulla, Encyclopedia of Sleep and Dreaming, 1993; 358-359.
Siegel, J.M.   Pons, Encyclopedia of Sleep and Dreaming, 1993; First edition: 461-462.
Siegel, J.M.   REM sleep Mechanisms, Encyclopedia of Sleep and Dreaming, 1993; First Edition: 510-513.
Mignot, E Nishino, S Sharp, LH Arrigoni, J Siegel, JM Reid, MS Edgar, DM Ciaranello, RD Dement, WC   Heterozygosity at the canarc-1 locus can confer susceptibility for narcolepsy: induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems The Journal of neuroscience : the official journal of the Society for Neuroscience. , 1993; 13(3): 1057-64.
Baghdoyan, HA Spotts, JL Snyder, SG   Simultaneous pontine and basal forebrain microinjections of carbachol suppress REM sleep The Journal of neuroscience : the official journal of the Society for Neuroscience. , 1993; 13(1): 229-42.
Kodama, T., Lai, Y.Y. and Siegel, J.M.   Enhancement of acetylcholine release during REM sleep in the caudo-medial medulla measured by in vivo microdialysis, Brain Res. , 1992; 580: 348-350.
McGinty, D. J. and Siegel, J. M.   Neuronal unit recording in unrestrained animals: Role in structure-function analysis of sleep-waking mechanisms, Progress in Physiological Psychology , 1992; 15: 85-140.
Siegel, JM Nienhuis, R Fahringer, HM Chiu, C Dement, WC Mignot, E Lufkin, R   Activity of medial mesopontine units during cataplexy and sleep-waking states in the narcoleptic dog The Journal of neuroscience : the official journal of the Society for Neuroscience. , 1992; 12(5): 1640-6.
Lai, YY Siegel, JM   Corticotropin-releasing factor mediated muscle atonia in pons and medulla Brain research. , 1992; 575(1): 63-8.
Mallick, BN Fahringer, HM Wu, MF Siegel, JM   REM sleep deprivation reduces auditory evoked inhibition of dorsolateral pontine neurons Brain research. , 1991; 552(2): 333-7.
Siegel, J.M.   Brain Mechanisms of Sleep and Wakefulness, Basics of Sleep Behavior, 1991; .
Lai, Y.Y. and Siegel, J.M.   Ponto-medullary glutamate receptors mediating locomotion and muscle tone suppression, J. Neurosci, 1991; 11: 2931-2937.
Siegel, JM Nienhuis, R Fahringer, HM Paul, R Shiromani, P Dement, WC Mignot, E Chiu, C   Neuronal activity in narcolepsy: identification of cataplexy-related cells in the medial medulla Science. , 1991; 252(5010): 1315-8.
Wu, MF Siegel, JM   Facilitation of the acoustic startle reflex by ponto-geniculo-occipital waves: effects of PCPA Brain research. , 1990; 532(1-2): 237-41.
Wu, MF Siegel, JM Shouse, MN Schenkel, E   Lesions producing REM sleep without atonia disinhibit the acoustic startle reflex without affecting prepulse inhibition Brain research. , 1990; 528(2): 330-4.
Lai, YY Siegel, JM   Muscle tone suppression and stepping produced by stimulation of midbrain and rostral pontine reticular formation The Journal of neuroscience : the official journal of the Society for Neuroscience. , 1990; 10(8): 2727-34.
Shouse, M. N., King, A., Langer, J., Wellesley, K., Vreeken, T., King, K., Siegel, J., Szymusiak, R.   Basic mechanisms underlying seizure prone and seizure resistant sleep states, Kindling, 1990; 4: 313-327.
Siegel, J. M.   Mechanisms of sleep control, J. Clin Neurophysiol, 1990; 7: 49-65.
Mallick, BN Siegel, JM Fahringer, H   Changes in pontine unit activity with REM sleep deprivation Brain research. , 1990; 515(1-2): 94-8.
Shouse, MN Siegel, JM Wu, MF Szymusiak, R Morrison, AR   Mechanisms of seizure suppression during rapid-eye-movement (REM) sleep in cats Brain research. , 1989; 505(2): 271-82.
Siegel, J. M.   Brainstem mechanisms generating REM sleep, Principles and Practice of Sleep Medicine, 1989; 104-121.
Siegel, J. M.   Brainstem mechanisms generating REM sleep, Principles and Practice of Sleep Medicine, 1989; 104-121.
Wu, M.F., Mallick, B.N. and Siegel J.M.   Lateral geniculate spikes, muscle atonia and startle response elicited by auditory stimuli as a function of stimulus parameters and arousal state, Brain Res, 1989; 499: 7-17.
Schenkel, E Siegel, JM   REM sleep without atonia after lesions of the medial medulla Neuroscience letters. , 1989; 98(2): 159-65.
Schenkel, E Siegel, JM   REM sleep without atonia after lesions of the medial medulla Neuroscience letters. , 1989; 98(2): 159-65.
Schenkel, E Siegel, JM   REM sleep without atonia after lesions of the medial medulla Neuroscience letters. , 1989; 98(2): 159-65.
Schenkel, E Siegel, JM   REM sleep without atonia after lesions of the medial medulla Neuroscience letters. , 1989; 98(2): 159-65.
Nienhuis, R Siegel, JM   Analysis of head movement and position using hall effect devices Physiology & behavior. , 1989; 45(1): 199-203.
Siegel, JM Tomaszewski, KS Fahringer, H Cave, G Kilduff, T Dement, WC   Heart rate and blood pressure changes during sleep-waking cycles and cataplexy in narcoleptic dogs The American journal of physiology. , 1989; 256(1 Pt 2): H111-9.
Lai, YY Siegel, JM   Medullary regions mediating atonia The Journal of neuroscience : the official journal of the Society for Neuroscience. , 1988; 8(12): 4790-6.
Siegel, JM Rogawski, MA   A function for REM sleep: regulation of noradrenergic receptor sensitivity Brain research. , 1988; 472(3): 213-33.
Wu, MF Suzuki, SS Siegel, JM   Anatomical distribution and response patterns of reticular neurons active in relation to acoustic startle Brain research. , 1988; 457(2): 399-406.
Lai, Y. Y., Siegel, J. M. and Wilson, W. J.   Effect of blood pressure manipulations on medial medulla-induced muscle atonia, Am. J. Physiol, 1987; 252: H1249-H1257.
Siegel, J. M., Tomaszewski, K. S. and Nienhuis, R.   Behavioral states in the chronic medullary and mid-pontine cat, Electroenceph. clin Neurophysiol, 1986; 63: 274-288.
Siegel, JM Fahringer, H Tomaszewski, KS Kaitin, K Kilduff, T Dement, WC   Heart rate and blood pressure changes associated with cataplexy in canine narcolepsy Sleep. , 1986; 9(1 Pt 2): 216-21.
Siegel, J. M. and McGinty, D. J.   Location of the systems generating REM sleep: lateral vs. medial pons. Commentary, Behav. Brain Sci, 1986; 9: 420-421.
Shiromani, PJ Siegel, JM Tomaszewski, KS McGinty, DJ   Alterations in blood pressure and REM sleep after pontine carbachol microinfusion Experimental neurology. , 1986; 91(2): 285-92.
Suzuki, SS Siegel, JM   Reticular formation neurons related to tongue movement in the behaving cat Experimental neurology. , 1985; 89(3): 689-97.
Siegel, J. M.   Pontomedullary interactions in the generation of REM sleep, Brain Mechanisms of Sleep, 1985; 157-174.
Siegel, JM Nienhuis, R Tomaszewski, KS   REM sleep signs rostral to chronic transections at the pontomedullary junction Neuroscience letters. , 1984; 45(3): 241-6.
Siegel, JM Tomaszewski, KS Wheeler, RL   Behavioral organization of reticular formation: studies in the unrestrained cat. II. Cells related to facial movements Journal of neurophysiology. , 1983; 50(3): 717-23.
Siegel, J. M.   A behavioral approach to the analysis of reticular formation unit activity, Behavioral Approaches to Brain Research, 1983; 94-116.
Siegel, J. M.   Brainstem mechanisms in REM sleep control, Sleep Functions and Mechanisms in Animals and Man: An Evolutionary Perspective, 1983; 217-231.
Siegel, J. M.   Reticular activity and arousal. Commentary, Behav. Brain Sci, 1983; 6: 741-743.
McGinty, D. J. and Siegel, J. M.   Sleep states, Handbook of Behavioral Neurobiology: Motivation, 1983; 105-181.
Siegel, JM Nienhuis, R Tomaszewski, KS   Rostral brainstem contributes to medullary inhibition of muscle tone Brain research. , 1983; 268(2): 344-8.
Siegel, JM Nienhuis, R Wheeler, RL McGinty, DJ Harper, RM   Discharge pattern of reticular formation unit pairs in waking and REM sleep Experimental neurology. , 1981; 74(3): 875-91.
Siegel, JM Wheeler, RL Breedlove, SM McGinty, DJ   Brain stem units related to movements of the pinna Brain research. , 1980; 202(1): 183-8.
Siegel, JM Wheeler, RL McGinty, DJ   Activity of medullary reticular formation neurons in the unrestrained cat during waking and sleep Brain research. , 1979; 179(1): 49-60.
Siegel, JM   Behavioral relations of medullary reticular formation cells Experimental neurology. , 1979; 65(3): 691-8.
Siegel, JM Sterman, MB Ross, S   Automatic detection and operant reinforcement of slow potential shifts Physiology & behavior. , 1979; 23(2): 411-3.
Siegel, JM Breedlove, SM McGinty, DJ   Photographic analysis of relation between unit activity and movement Journal of neuroscience methods. , 1979; 1(2): 159-64.
Siegel, J. M.   Behavioral functions of the reticular formation, Brain Res. Rev, 1979; 1: 69-105.
Breedlove, SM McGinty, DJ Siegel, JM   Operant conditioning of pontine gigantocellular units Brain research bulletin. , 1979; 4(5): 663-7.
Siegel, J. M.   Reticular formation activity and REM sleep, The Functions of Sleep, 1979; 37-71.
Bowersox, SS Siegel, JM Sterman, MB   Effects of restraint on electroencephalographic variables and monomethylhydrazine-induced seizures in the cat Experimental neurology. , 1978; 61(1): 154-64.
Siegel, J. M. and McGinty, D. J.   Pontine reticular formation neurons and motor activity, Science, 1978; 199: 207-208.
Siegel, JM McGinty, DJ Breedlove, SM   Sleep and waking activity of pontine gigantocellular field neurons Experimental neurology. , 1977; 56(3): 553-73.
McGinty, D. J. and Siegel, J. M.   Neuronal activity patterns during rapid-eye- movement sleep:relation to waking patterns, Neurobiology of Sleep and Memory , 1977; 135-158.
Siegel, JM McGinty, DJ   Pontine reticular formation neurons: relationship of discharge to motor activity Science. , 1977; 196(4290): 678-80.
Siegel, J. M. and McGinty, D. J.   Brainstem neurons without spontaneous unit discharge, Science, 1976; 193: 240-242.
Siegel, JM   REM sleep predicts subsequent food intake Physiology & behavior. , 1975; 15(5): 399-403.
Siegel, JM   A stereotaxic map of the bony tentorium of the cat Physiology & behavior. , 1974; 13(5): 715-7.
Siegel, JM Coleman, PD Riesen, AH   Pattern evoked response deficiency in pattern deprived cats Electroencephalography and clinical neurophysiology. , 1973; 35(6): 569-73.
Zeigler, HP Green, HL Siegel, J   Food and water intake and weight regulation in the pigeon Physiology & behavior. , 1972; 8(1): 127-34.