Jie Zheng, Ph.D.
Faculty Member
Professor
Department of Ophthalmology
David Geffen School of Medicine
University of California, Los Angeles
Center for Health Sciences BH-973B
10833 Le Conte Ave,
Los Angeles, CA 90095
Research Area
Dr. Jie Zheng’s research combines chemical, computational, structural and systems biology with therapeutic development. In an effort to better understand the biological functions of different signaling pathways in the visual system and to explore the therapeutic potential of targeting abnormal signaling pathways, his laboratory focuses on structure-based drug discovery with an emphasis on developing proteins and small molecules that can systematically modulate signal transduction pathways. In addition, his laboratory is interested in structure-based drug repositioning.
Publications
- Bonnet C, Han CS, Deng SX, Zheng JJ. Positive cooperativity in synergistic activation of Wnt proteins.. Molecular biology reports, 2024.
- Bonnet C, González S, Deng SX, Zheng JJ. Wnt activation as a potential therapeutic approach to treat partial limbal stem cell deficiency.. Scientific reports, 2023.
- Graybeal K, Sanchez L, Zhang C, Stiles L, Zheng JJ. Characterizing the metabolic profile of dexamethasone treated human trabecular meshwork cells.. Experimental eye research, 2021.
- Zhang C, Mei H, Robertson SYT, Lee HJ, Deng SX, Zheng JJ. A Small-Molecule Wnt Mimic Improves Human Limbal Stem Cell Ex Vivo Expansion.. iScience, 2020.
- Zhang C, Miller DJ, Guibao CD, Donato DM, Hanks SK, Zheng JJ. Structural and functional insights into the interaction between the Cas family scaffolding protein p130Cas and the focal adhesion-associated protein paxillin.. The Journal of biological chemistry, 2017.
- Ahadome SD, Zhang C, Tannous E, Shen J, Zheng JJ. Small-molecule inhibition of Wnt signaling abrogates dexamethasone-induced phenotype of primary human trabecular meshwork cells.. Experimental cell research, 2017.
- Qi J, Lee HJ, Saquet A, Cheng XN, Shao M, Zheng JJ, Shi DL. Autoinhibition of Dishevelled protein regulated by its extreme C terminus plays a distinct role in Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways.. The Journal of biological chemistry, 2017.
- Bao J, Marathe B, Govorkova EA, Zheng JJ. Drug Repurposing Identifies Inhibitors of Oseltamivir-Resistant Influenza Viruses.. Angewandte Chemie (International ed. in English), 2016.
- Lee HJ, Bao J, Miller A, Zhang C, Wu J, Baday YC, Guibao C, Li L, Wu D, Zheng JJ. Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled.. The Journal of biological chemistry, 2015.