Julian Whitelegge, Ph.D.

Member, Brain Research Institute CTSI I3T Theme JCCC Patients and Survivors Program Area Adjunct Professor, Psychiatry and Biobehavioral Sciences

jpw@chem.ucla.edu

(310) 794-5156

Office
Box 42
NPI-Semel Insititute
760 Westwood Plaza,
University of California, Los Angeles
Los Angeles, CA 90024
UNITED STATES

Office Address:

NPI-Semel Institute for Neuroscience & Human Behavior
Department of Psychiatry and Biobehavioral Sciences
760 Westwood Plaza
Room 68-146
Los Angeles, CA 90095
UNITED STATES

Website

Biography

Julian Whitelegge received his Ph.D. from Imperial College of Science and Technology, University of London in 1989 and became heavily involved in mass spectrometry research in the mid nineties publishing his most cited paper on “electrospray-ionization mass spectrometry of intact intrinsic membrane proteins” in 1998. Dr. Whitelegge developed a keen interest in Fourier-transform mass spectrometry (FT-MS) while a Visiting Scientist in the Department of Chemistry and Chemical Biology, Cornell University working with Professor Fred McLafferty in 1999 and has nurtured this expertise since returning to UCLA. Currently, Dr. Whitelegge directs the proteomics activities of the Pasarow Mass Spectrometry Laboratory at UCLA, appointed as Adjunct Professor III in the NPI-Semel Institute in the David Geffen School of Medicine. He oversees both top-down and bottom-up mass spectrometry projects and trains post-graduate and post-doctoral associates in protein and peptide mass spectrometry and data interpretation. Dr. Whitelegge has authored and co-authored over one hundred and fifty original research papers. He edited the recently published, five-hundred page, book Protein Mass Spectrometry in Elsevier’s analytical chemistry series and is a member of the editorial board of Molecular and Cellular Proteomics.

Publications

Koo BK, Whitelegge J. Structural Analysis of SOD1 Fibrils with Mass Spectrometry, Limited Proteolysis, and Atomic Force Microscopy (AFM).. Methods in molecular biology (Clifton, N.J.), 2023.
Qian K, Tol MJ, Wu J, Uchiyama LF, Xiao X, Cui L, Bedard AH, Weston TA, Rajendran PS, Vergnes L, Shimanaka Y, Yin Y, Jami-Alahmadi Y, Cohn W, Bajar BT, Lin CH, Jin B, DeNardo LA, Black DL, Whitelegge JP, Wohlschlegel JA, Reue K, Shivkumar K, Chen FJ, Young SG, Li P, Tontonoz P. CLSTN3β enforces adipocyte multilocularity to facilitate lipid utilization.. Nature, 2022.
Waring AJ, Whitelegge JP, Sharma SK, Gordon LM, Walther FJ. Emulation of the structure of the Saposin protein fold by a lung surfactant peptide construct of surfactant Protein B.. PloS one, 2022.
He J, Fu T, Zhang L, Wanrong Gao L, Rensel M, Remage-Healey L, White SA, Gedman G, Whitelegge J, Xiao X, Schlinger BA. Improved zebra finch brain transcriptome identifies novel proteins with sex differences.. Gene, 2022.
Cohn W, Zhu C, Campagna J, Bilousova T, Spilman P, Teter B, Li F, Guo R, Elashoff D, Cole GM, Avidan A, Faull KF, Whitelegge J, Wong DTW, John V. Integrated Multiomics Analysis of Salivary Exosomes to Identify Biomarkers Associated with Changes in Mood States and Fatigue.. International journal of molecular sciences, 2022.
Lambertz J, Liauw P, Whitelegge JP, Nowaczyk MM. Mass spectrometry analysis of the photosystem II assembly factor Psb27 revealed variations in its lipid modification.. Photosynthesis research, 2021.
Garcia YA, Velasquez EF, Gao LW, Gholkar AA, Clutario KM, Cheung K, Williams-Hamilton T, Whitelegge JP, Torres JZ. Mapping Proximity Associations of Core Spindle Assembly Checkpoint Proteins.. Journal of proteome research, 2021.
Micewicz ED, Damoiseaux RD, Deng G, Gomez A, Iwamoto KS, Jung ME, Nguyen C, Norris AJ, Ratikan JA, Ruchala P, Sayre JW, Schaue D, Whitelegge JP, McBride WH. Classes of Drugs that Mitigate Radiation Syndromes.. Frontiers in pharmacology, 2021.
Cohn W, Huguet R, Zabrouskov V, Whitelegge J. Dissociation Strategies to Maximize Coverage of α-Helical Domains in Top-Down Mass Spectrometry of Integral Membrane Proteins.. Journal of the American Society for Mass Spectrometry, 2021.
Guo X, Ramirez I, Garcia YA, Velasquez EF, Gholkar AA, Cohn W, Whitelegge JP, Tofig B, Damoiseaux R, Torres JZ. DUSP7 regulates the activity of ERK2 to promote proper chromosome alignment during cell division.. The Journal of biological chemistry, 2021.
Knoppová J, Yu J, Janouškovec J, Halada P, Nixon PJ, Whitelegge JP, Komenda J. The Photosystem II Assembly Factor Ycf48 from the Cyanobacterium Synechocystis sp. PCC 6803 Is Lipidated Using an Atypical Lipobox Sequence.. International journal of molecular sciences, 2021.
Koo BK, Munroe W, Gralla EB, Valentine JS, Whitelegge JP. A Novel SOD1 Intermediate Oligomer, Role of Free Thiols and Disulfide Exchange.. Frontiers in neuroscience, 2021.
Puppione DL, Tran DP, Zenaidee MA, Charugundla S, Whitelegge JP, Buffenstein R. Naked Mole-Rat, a Rodent with an Apolipoprotein A-I Dimer.. Lipids, 2020.
Drake JL, Whitelegge JP, Jacobs DK. First sequencing of ancient coral skeletal proteins.. Scientific reports, 2020.
Moore TM, Zhou Z, Strumwasser AR, Cohn W, Lin AJ, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Hoang AN, Widjaja K, Abrishami AD, Charugundla S, Stiles L, Whitelegge JP, Turcotte LP, Wanagat J, Hevener AL. Age-induced mitochondrial DNA point mutations are inadequate to alter metabolic homeostasis in response to nutrient challenge.. Aging cell, 2020.
Bhaduri S, Singh SK, Cohn W, Hasan SS, Whitelegge JP, Cramer WA. A novel chloroplast super-complex consisting of the ATP synthase and photosystem I reaction center.. PloS one, 2020.
Gholkar AA, Schmollinger S, Velasquez EF, Lo YC, Cohn W, Capri J, Dharmarajan H, Deardorff WJ, Gao LW, Abdusamad M, Whitelegge JP, Torres JZ. Regulation of Iron Homeostasis through Parkin-Mediated Lactoferrin Ubiquitylation.. Biochemistry, 2020.
Yokota T, McCourt J, Ma F, Ren S, Li S, Kim TH, Kurmangaliyev YZ, Nasiri R, Ahadian S, Nguyen T, Tan XHM, Zhou Y, Wu R, Rodriguez A, Cohn W, Wang Y, Whitelegge J, Ryazantsev S, Khademhosseini A, Teitell MA, Chiou PY, Birk DE, Rowat AC, Crosbie RH, Pellegrini M, Seldin M, Lusis AJ, Deb A. Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury.. Cell, 2020.
Schmidt AE, Vadivel K, Whitelegge J, Bajaj SP. Plasmin-mediated proteolysis of human factor IXa in the presence of calcium/phospholipid: Conversion of procoagulant factor IXa to a fibrinolytic enhancer.. Journal of thrombosis and haemostasis : JTH, 2020.
Marcus EA, Tokhtaeva E, Jimenez JL, Wen Y, Naini BV, Heard AN, Kim S, Capri J, Cohn W, Whitelegge JP, Vagin O. Helicobacter pylori infection impairs chaperone-assisted maturation of Na-K-ATPase in gastric epithelium.. American journal of physiology. Gastrointestinal and liver physiology, 2020.
Whitelegge J. Targeting a Subset of the Membrane Proteome for Top-Down Mass Spectrometry: Introducing the Proteolipidome.. Proteomes, 2020.
Li M, Calteau A, Semchonok DA, Witt TA, Nguyen JT, Sassoon N, Boekema EJ, Whitelegge J, Gugger M, Bruce BD. Physiological and evolutionary implications of tetrameric photosystem I in cyanobacteria.. Nature plants, 2019.
Kalinec GM, Gao L, Cohn W, Whitelegge JP, Faull KF, Kalinec F. Extracellular Vesicles From Auditory Cells as Nanocarriers for Anti-inflammatory Drugs and Pro-resolving Mediators.. Frontiers in cellular neuroscience, 2019.
Kawahara B, Gao L, Cohn W, Whitelegge JP, Sen S, Janzen C, Mascharak PK. Diminished viability of human ovarian cancer cells by antigen-specific delivery of carbon monoxide with a family of photoactivatable antibody-photoCORM conjugates.. Chemical science, 2019.
Amarnani A, Capri JR, Souda P, Elashoff DA, Lopez IA, Whitelegge JP, Singh RR. Quantitative Proteomics Using Formalin-fixed, Paraffin-embedded Biopsy Tissues in Inflammatory Disease.. Journal of proteomics & bioinformatics, 2019.
Liu K, Singer E, Cohn W, Micewicz ED, McBride WH, Whitelegge JP, Loo JA. Time-Dependent Measurement of Nrf2-Regulated Antioxidant Response to Ionizing Radiation Toward Identifying Potential Protein Biomarkers for Acute Radiation Injury.. Proteomics. Clinical applications, 2019.
Sarafian TA, Yacoub A, Kunz A, Aranki B, Serobyan G, Cohn W, Whitelegge JP, Watson JB. Enhanced mitochondrial inhibition by 3,4-dihydroxyphenyl-acetaldehyde (DOPAL)-oligomerized α-synuclein.. Journal of neuroscience research, 2019.
Zhang Y, Roos M, Himburg H, Termini CM, Quarmyne M, Li M, Zhao L, Kan J, Fang T, Yan X, Pohl K, Diers E, Jin Gim H, Damoiseaux R, Whitelegge J, McBride W, Jung ME, Chute JP. PTPσ inhibitors promote hematopoietic stem cell regeneration.. Nature communications, 2019.
Donnelly DP, Rawlins CM, DeHart CJ, Fornelli L, Schachner LF, Lin Z, Lippens JL, Aluri KC, Sarin R, Chen B, Lantz C, Jung W, Johnson KR, Koller A, Wolff JJ, Campuzano IDG, Auclair JR, Ivanov AR, Whitelegge JP, Paša-Tolic L, Chamot-Rooke J, Danis PO, Smith LM, Tsybin YO, Loo JA, Ge Y, Kelleher NL, Agar JN. Best practices and benchmarks for intact protein analysis for top-down mass spectrometry.. Nature methods, 2019.
Cheng WWL, Budelier MM, Sugasawa Y, Bergdoll L, Queralt-Martín M, Rosencrans W, Rostovtseva TK, Chen ZW, Abramson J, Krishnan K, Covey DF, Whitelegge JP, Evers AS. Multiple neurosteroid and cholesterol binding sites in voltage-dependent anion channel-1 determined by photo-affinity labeling.. Biochimica et biophysica acta. Molecular and cell biology of lipids, 2019.
Kalinec GM, Cohn W, Whitelegge JP, Faull KF, Kalinec F. Preliminary Characterization of Extracellular Vesicles From Auditory HEI-OC1 Cells.. The Annals of otology, rhinology, and laryngology, 2019.
Nally JE, Hornsby RL, Alt DP, Whitelegge JP. Phenotypic and proteomic characterization of treponemes associated with bovine digital dermatitis.. Veterinary microbiology, 2019.
Wang J, Yu J, Zhang Y, Kahkoska AR, Wang Z, Fang J, Whitelegge JP, Li S, Buse JB, Gu Z. Glucose transporter inhibitor-conjugated insulin mitigates hypoglycemia.. Proceedings of the National Academy of Sciences of the United States of America, 2019.
Micewicz ED, Iwamoto KS, Ratikan JA, Nguyen C, Xie MW, Cheng G, Boxx GM, Deriu E, Damoiseaux RD, Whitelegge JP, Ruchala PP, Avetisyan R, Jung ME, Lawson G, Nemeth E, Ganz T, Sayre JW, McBride WH, Schaue D. The Aftermath of Surviving Acute Radiation Hematopoietic Syndrome and its Mitigation.. Radiation research, 2019.
Suades A, Alcaraz A, Cruz E, Álvarez-Marimon E, Whitelegge JP, Manyosa J, Cladera J, Perálvarez-Marín A. Structural biology workflow for the expression and characterization of functional human sodium glucose transporter type 1 in Pichia pastoris.. Scientific reports, 2019.
Ruchala P, Waring AJ, Cilluffo M, Whitelegge JP, Gundersen CB. Insights into the structure and molecular topography of the fatty acylated domain of synaptotagmin-1.. Biochimica et biophysica acta. Biomembranes, 2019.
Bömer M, O'Brien JA, Pérez-Salamó I, Krasauskas J, Finch P, Briones A, Daudi A, Souda P, Tsui TL, Whitelegge JP, Paul Bolwell G, Devoto A. COI1-dependent jasmonate signalling affects growth, metabolite production and cell wall protein composition in arabidopsis.. Annals of botany, 2018.
Bhat K, Duhachek-Muggy S, Ramanathan R, Saki M, Alli C, Medina P, Damoiseaux R, Whitelegge J, McBride WH, Schaue D, Vlashi E, Pajonk F. 1-(4-nitrobenzenesulfonyl)-4-penylpiperazine increases the number of Peyer's patch-associated regenerating crypts in the small intestines after radiation injury.. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2018.
Moore TM, Zhou Z, Cohn W, Norheim F, Lin AJ, Kalajian N, Strumwasser AR, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Shirihai O, van der Bliek AM, Whitelegge JP, Seldin MM, Lusis AJ, Lee S, Drevon CA, Mahata SK, Turcotte LP, Hevener AL. The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle.. Molecular metabolism, 2018.
Bortz E, Wu TT, Patel P, Whitelegge JP, Sun R. Proteomics of Bronchoalveolar Lavage Fluid Reveals a Lung Oxidative Stress Response in Murine Herpesvirus-68 Infection.. Viruses, 2018.
Sheng Y, Capri J, Waring A, Valentine JS, Whitelegge J. Exposure of Solvent-Inaccessible Regions in the Amyloidogenic Protein Human SOD1 Determined by Hydroxyl Radical Footprinting.. Journal of the American Society for Mass Spectrometry, 2018.
Atlasi RS, Malik R, Corrales CI, Tzeplaeff L, Whitelegge JP, Cashman NR, Bitan G. Investigation of Anti-SOD1 Antibodies Yields New Structural Insight into SOD1 Misfolding and Surprising Behavior of the Antibodies Themselves.. ACS chemical biology, 2018.
Tanphaichitr N, Kongmanas K, Faull KF, Whitelegge J, Compostella F, Goto-Inoue N, Linton JJ, Doyle B, Oko R, Xu H, Panza L, Saewu A. Properties, metabolism and roles of sulfogalactosylglycerolipid in male reproduction.. Progress in lipid research, 2018.
Angarita SAK, Duarte S, Russell TA, Ruchala P, Elliott IA, Whitelegge JP, Zarrinpar A. Quantitative Measure of Intestinal Permeability Using Blue Food Coloring.. The Journal of surgical research, 2018.
Khachatoorian R, Cohn W, Buzzanco A, Riahi R, Arumugaswami V, Dasgupta A, Whitelegge JP, French SW. HSP70 Copurifies with Zika Virus Particles.. Virology, 2018.
Whitelegge J. Lipid Modulation of Membrane Protein Function.. Cell chemical biology, 2018.
Saelices L, Chung K, Lee JH, Cohn W, Whitelegge JP, Benson MD, Eisenberg DS. Amyloid seeding of transthyretin by ex vivo cardiac fibrils and its inhibition.. Proceedings of the National Academy of Sciences of the United States of America, 2018.
Agarwal R, Whitelegge JP, Saini S, Shrivastav AP. The S-layer biogenesis system of Synechocystis 6803: Role of Sll1180 and Sll1181 (E. coli HlyB and HlyD analogs) as type-I secretion components for Sll1951 export.. Biochimica et biophysica acta. Biomembranes, 2018.
Sallam T, Jones M, Thomas BJ, Wu X, Gilliland T, Qian K, Eskin A, Casero D, Zhang Z, Sandhu J, Salisbury D, Rajbhandari P, Civelek M, Hong C, Ito A, Liu X, Daniel B, Lusis AJ, Whitelegge J, Nagy L, Castrillo A, Smale S, Tontonoz P. Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA.. Nature medicine, 2018.
Waldron RT, Su HY, Piplani H, Capri J, Cohn W, Whitelegge JP, Faull KF, Sakkiah S, Abrol R, Yang W, Zhou B, Freeman MR, Pandol SJ, Lugea A. Ethanol Induced Disordering of Pancreatic Acinar Cell Endoplasmic Reticulum: An ER Stress/Defective Unfolded Protein Response Model.. Cellular and molecular gastroenterology and hepatology, 2018.
Maggi M, Mittelman SD, Parmentier JH, Colombo G, Meli M, Whitmire JM, Merrell DS, Whitelegge J, Scotti C. A protease-resistant Escherichia coli asparaginase with outstanding stability and enhanced anti-leukaemic activity in vitro.. Scientific reports, 2017.
Biczo G, Vegh ET, Shalbueva N, Mareninova OA, Elperin J, Lotshaw E, Gretler S, Lugea A, Malla SR, Dawson D, Ruchala P, Whitelegge J, French SW, Wen L, Husain SZ, Gorelick FS, Hegyi P, Rakonczay Z, Gukovsky I, Gukovskaya AS. Mitochondrial Dysfunction, Through Impaired Autophagy, Leads to Endoplasmic Reticulum Stress, Deregulated Lipid Metabolism, and Pancreatitis in Animal Models.. Gastroenterology, 2017.
Rao NM, Capri J, Cohn W, Abdaljaleel M, Restrepo L, Gornbein JA, Yong WH, Liebeskind DS, Whitelegge JP. Peptide Composition of Stroke Causing Emboli Correlate with Serum Markers of Atherosclerosis and Inflammation.. Frontiers in neurology, 2017.
Le TM, Poddar S, Capri JR, Abt ER, Kim W, Wei L, Uong NT, Cheng CM, Braas D, Nikanjam M, Rix P, Merkurjev D, Zaretsky J, Kornblum HI, Ribas A, Herschman HR, Whitelegge J, Faull KF, Donahue TR, Czernin J, Radu CG. ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways.. Nature communications, 2017.
Kar UK, Simonian M, Whitelegge JP. Integral membrane proteins: bottom-up, top-down and structural proteomics.. Expert review of proteomics, 2017.
Micewicz ED, Kim K, Iwamoto KS, Ratikan JA, Cheng G, Boxx GM, Damoiseaux RD, Whitelegge JP, Ruchala P, Nguyen C, Purbey P, Loo J, Deng G, Jung ME, Sayre JW, Norris AJ, Schaue D, McBride WH. 4-(Nitrophenylsulfonyl)piperazines mitigate radiation damage to multiple tissues.. PloS one, 2017.
Chai H, Diaz-Castro B, Shigetomi E, Monte E, Octeau JC, Yu X, Cohn W, Rajendran PS, Vondriska TM, Whitelegge JP, Coppola G, Khakh BS. Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.. Neuron, 2017.
Budelier MM, Cheng WWL, Bergdoll L, Chen ZW, Janetka JW, Abramson J, Krishnan K, Mydock-McGrane L, Covey DF, Whitelegge JP, Evers AS. Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1.. The Journal of biological chemistry, 2017.
Wang J, Rajbhandari P, Damianov A, Han A, Sallam T, Waki H, Villanueva CJ, Lee SD, Nielsen R, Mandrup S, Reue K, Young SG, Whitelegge J, Saez E, Black DL, Tontonoz P. RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs.. The Journal of clinical investigation, 2017.
Sarafian TA, Littlejohn K, Yuan S, Fernandez C, Cilluffo M, Koo BK, Whitelegge JP, Watson JB. Stimulation of synaptoneurosome glutamate release by monomeric and fibrillated α-synuclein.. Journal of neuroscience research, 2017.
Capri J, Whitelegge JP. Full Membrane Protein Coverage Digestion and Quantitative Bottom-Up Mass Spectrometry Proteomics.. Methods in molecular biology (Clifton, N.J.), 2017.
Ayers JI, McMahon B, Gill S, Lelie HL, Fromholt S, Brown H, Valentine JS, Whitelegge JP, Borchelt DR. Relationship between mutant Cu/Zn superoxide dismutase 1 maturation and inclusion formation in cell models.. Journal of neurochemistry, 2016.
Singh SK, Hasan SS, Zakharov SD, Naurin S, Cohn W, Ma J, Whitelegge JP, Cramer WA. Trans-membrane Signaling in Photosynthetic State Transitions: REDOX- AND STRUCTURE-DEPENDENT INTERACTION IN VITRO BETWEEN STT7 KINASE AND THE CYTOCHROME b6f COMPLEX.. The Journal of biological chemistry, 2016.
Sallam T, Jones MC, Gilliland T, Zhang L, Wu X, Eskin A, Sandhu J, Casero D, Vallim TQ, Hong C, Katz M, Lee R, Whitelegge J, Tontonoz P. Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis.. Nature, 2016.
Ribas V, Drew BG, Zhou Z, Phun J, Kalajian NY, Soleymani T, Daraei P, Widjaja K, Wanagat J, de Aguiar Vallim TQ, Fluitt AH, Bensinger S, Le T, Radu C, Whitelegge JP, Beaven SW, Tontonoz P, Lusis AJ, Parks BW, Vergnes L, Reue K, Singh H, Bopassa JC, Toro L, Stefani E, Watt MJ, Schenk S, Akerstrom T, Kelly M, Pedersen BK, Hewitt SC, Korach KS, Hevener AL. Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females.. Science translational medicine, 2016.
Marcus EA, Tokhtaeva E, Turdikulova S, Capri J, Whitelegge JP, Scott DR, Sachs G, Berditchevski F, Vagin O. Septin oligomerization regulates persistent expression of ErbB2/HER2 in gastric cancer cells.. The Biochemical journal, 2016.
Rajkovic A, Hummels KR, Witzky A, Erickson S, Gafken PR, Whitelegge JP, Faull KF, Kearns DB, Ibba M. Translation Control of Swarming Proficiency in Bacillus subtilis by 5-Amino-pentanolylated Elongation Factor P.. The Journal of biological chemistry, 2016.
Cheung K, Senese S, Kuang J, Bui N, Ongpipattanakul C, Gholkar A, Cohn W, Capri J, Whitelegge JP, Torres JZ. Proteomic Analysis of the Mammalian Katanin Family of Microtubule-severing Enzymes Defines Katanin p80 subunit B-like 1 (KATNBL1) as a Regulator of Mammalian Katanin Microtubule-severing.. Molecular & cellular proteomics : MCP, 2016.
Lu NT, Liu NM, Vu JQ, Patel D, Cohn W, Capri J, Ziegler M, Patel N, Tramontano A, Williams R, Whitelegge J, French SW. Phospho-Network Analysis Identifies and Quantifies Hepatitis C Virus (HCV)-induced Hepatocellular Carcinoma (HCC) Proteins Regulating Viral-mediated Tumor Growth.. Cancer genomics & proteomics, 2016.
Barkhoudarian G, Whitelegge JP, Kelly DF, Simonian M. Proteomics Analysis of Brain Meningiomas in Pursuit of Novel Biomarkers of the Aggressive Behavior.. Journal of proteomics & bioinformatics, 2016.
Gholkar AA, Senese S, Lo YC, Vides E, Contreras E, Hodara E, Capri J, Whitelegge JP, Torres JZ. The X-Linked-Intellectual-Disability-Associated Ubiquitin Ligase Mid2 Interacts with Astrin and Regulates Astrin Levels to Promote Cell Division.. Cell reports, 2015.
Yin JX, Maalouf M, Han P, Zhao M, Gao M, Dharshaun T, Ryan C, Whitelegge J, Wu J, Eisenberg D, Reiman EM, Schweizer FE, Shi J. Ketones block amyloid entry and improve cognition in an Alzheimer's model.. Neurobiology of aging, 2015.
Chattopadhyay M, Nwadibia E, Strong CD, Gralla EB, Valentine JS, Whitelegge JP. The Disulfide Bond, but Not Zinc or Dimerization, Controls Initiation and Seeded Growth in Amyotrophic Lateral Sclerosis-linked Cu,Zn Superoxide Dismutase (SOD1) Fibrillation.. The Journal of biological chemistry, 2015.
Saelices L, Johnson LM, Liang WY, Sawaya MR, Cascio D, Ruchala P, Whitelegge J, Jiang L, Riek R, Eisenberg DS. Uncovering the Mechanism of Aggregation of Human Transthyretin.. The Journal of biological chemistry, 2015.
Dada LA, Trejo Bittar HE, Welch LC, Vagin O, Deiss-Yehiely N, Kelly AM, Baker MR, Capri J, Cohn W, Whitelegge JP, Vadász I, Gruenbaum Y, Sznajder JI. High CO2 Leads to Na,K-ATPase Endocytosis via c-Jun Amino-Terminal Kinase-Induced LMO7b Phosphorylation.. Molecular and cellular biology, 2015.
Rodriguez JA, Ivanova MI, Sawaya MR, Cascio D, Reyes FE, Shi D, Sangwan S, Guenther EL, Johnson LM, Zhang M, Jiang L, Arbing MA, Nannenga BL, Hattne J, Whitelegge J, Brewster AS, Messerschmidt M, Boutet S, Sauter NK, Gonen T, Eisenberg DS. Structure of the toxic core of α-synuclein from invisible crystals.. Nature, 2015.
Micewicz ED, Ratikan JA, Waring AJ, Whitelegge JP, McBride WH, Ruchala P. Lipid-conjugated Smac analogues.. Bioorganic & medicinal chemistry letters, 2015.
Chim N, Torres R, Liu Y, Capri J, Batot G, Whitelegge JP, Goulding CW. The Structure and Interactions of Periplasmic Domains of Crucial MmpL Membrane Proteins from Mycobacterium tuberculosis.. Chemistry & biology, 2015.
Micewicz ED, Bahattab OS, Willars GB, Waring AJ, Navab M, Whitelegge JP, McBride WH, Ruchala P. Small lipidated anti-obesity compounds derived from neuromedin U.. European journal of medicinal chemistry, 2015.
Tanphaichitr N, Kongmanas K, Kruevaisayawan H, Saewu A, Sugeng C, Fernandes J, Souda P, Angel JB, Faull KF, Aitken RJ, Whitelegge J, Hardy D, Berger T, Baker M. Remodeling of the plasma membrane in preparation for sperm-egg recognition: roles of acrosomal proteins.. Asian journal of andrology, 2015.
Rajkovic A, Erickson S, Witzky A, Branson OE, Seo J, Gafken PR, Frietas MA, Whitelegge JP, Faull KF, Navarre W, Darwin AJ, Ibba M. Cyclic Rhamnosylated Elongation Factor P Establishes Antibiotic Resistance in Pseudomonas aeruginosa.. mBio, 2015.
Agarwal R, Hasan SS, Jones LM, Stofleth JT, Ryan CM, Whitelegge JP, Kehoe DM, Cramer WA. Role of domain swapping in the hetero-oligomeric cytochrome b6f lipoprotein complex.. Biochemistry, 2015.
Kongmanas K, Kruevaisayawan H, Saewu A, Sugeng C, Fernandes J, Souda P, Angel JB, Faull KF, Aitken RJ, Whitelegge J, Hardy D, Berger T, Baker MA, Tanphaichitr N. Proteomic Characterization of Pig Sperm Anterior Head Plasma Membrane Reveals Roles of Acrosomal Proteins in ZP3 Binding.. Journal of cellular physiology, 2015.
Tokhtaeva E, Capri J, Marcus EA, Whitelegge JP, Khuzakhmetova V, Bukharaeva E, Deiss-Yehiely N, Dada LA, Sachs G, Fernandez-Salas E, Vagin O. Septin dynamics are essential for exocytosis.. The Journal of biological chemistry, 2015.
Gholkar AA, Senese S, Lo YC, Capri J, Deardorff WJ, Dharmarajan H, Contreras E, Hodara E, Whitelegge JP, Jackson PK, Torres JZ. Tctex1d2 associates with short-rib polydactyly syndrome proteins and is required for ciliogenesis.. Cell cycle (Georgetown, Tex.), 2015.
Deng X, Kohanfars M, Hsu HM, Souda P, Capri J, Whitelegge JP, Chang HR. Combined phosphoproteomics and bioinformatics strategy in deciphering drug resistant related pathways in triple negative breast cancer.. International journal of proteomics, 2014.
Veena MS, Wilken R, Zheng JY, Gholkar A, Venkatesan N, Vira D, Ahmed S, Basak SK, Dalgard CL, Ravichandran S, Batra RK, Kasahara N, Elashoff D, Fishbein MC, Whitelegge JP, Torres JZ, Wang MB, Srivatsan ES. p16 Protein and gigaxonin are associated with the ubiquitination of NFκB in cisplatin-induced senescence of cancer cells.. The Journal of biological chemistry, 2014.
Agarwal R, Zakharov S, Hasan SS, Ryan CM, Whitelegge JP, Cramer WA. Structure-function of cyanobacterial outer-membrane protein, Slr1270: homolog of Escherichia coli drug export/colicin import protein, TolC.. FEBS letters, 2014.
Brumshtein B, Esswein SR, Landau M, Ryan CM, Whitelegge JP, Phillips ML, Cascio D, Sawaya MR, Eisenberg DS. Formation of amyloid fibers by monomeric light chain variable domains.. The Journal of biological chemistry, 2014.
Thompson MC, Wheatley NM, Jorda J, Sawaya MR, Gidaniyan SD, Ahmed H, Yang Z, McCarty KN, Whitelegge JP, Yeates TO. Identification of a unique Fe-S cluster binding site in a glycyl-radical type microcompartment shell protein.. Journal of molecular biology, 2014.
Vagin O, Tokhtaeva E, Garay PE, Souda P, Bassilian S, Whitelegge JP, Lewis R, Sachs G, Wheeler L, Aoki R, Fernandez-Salas E. Recruitment of septin cytoskeletal proteins by botulinum toxin A protease determines its remarkable stability.. Journal of cell science, 2014.
Whitelegge J. Gas-phase structure of the E. coli OmpA dimer.. Structure (London, England : 1993), 2014.
Patananan AN, Capri J, Whitelegge JP, Clarke SG. Non-repair pathways for minimizing protein isoaspartyl damage in the yeast Saccharomyces cerevisiae.. The Journal of biological chemistry, 2014.
Feng Y, Maity R, Whitelegge JP, Hadjikyriacou A, Li Z, Zurita-Lopez C, Al-Hadid Q, Clark AT, Bedford MT, Masson JY, Clarke SG. Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions.. The Journal of biological chemistry, 2013.
Ayers J, Lelie H, Workman A, Prudencio M, Brown H, Fromholt S, Valentine J, Whitelegge J, Borchelt D. Distinctive features of the D101N and D101G variants of superoxide dismutase 1; two mutations that produce rapidly progressing motor neuron disease.. Journal of neurochemistry, 2013.
Puppione D, Whitelegge JP. Proteogenomic Review of the Changes in Primate apoC-I during Evolution.. Frontiers in biology, 2013.
Hinman JD, Rao NM, Yallapragada A, Capri J, Souda P, Whitelegge J, Yong WH, Jahan R, Quinones-Baldrich W, Saver JL. Drip, Ship, and Grip, then Slice and Dice: Comprehensive Stroke Center Management of Cervical and Intracranial Emboli.. Frontiers in neurology, 2013.
Chan PK, Chattopadhyay M, Sharma S, Souda P, Gralla EB, Borchelt DR, Whitelegge JP, Valentine JS. Structural similarity of wild-type and ALS-mutant superoxide dismutase-1 fibrils using limited proteolysis and atomic force microscopy.. Proceedings of the National Academy of Sciences of the United States of America, 2013.
Sarafian TA, Ryan CM, Souda P, Masliah E, Kar UK, Vinters HV, Mathern GW, Faull KF, Whitelegge JP, Watson JB. Impairment of mitochondria in adult mouse brain overexpressing predominantly full-length, N-terminally acetylated human α-synuclein.. PloS one, 2013.
Whitelegge J. Intact protein mass spectrometry and top-down proteomics.. Expert review of proteomics, 2013.
Yang H, Yung M, Li L, Hoch JA, Ryan CM, Kar UK, Souda P, Whitelegge JP, Miller JH. Evidence that YycJ is a novel 5'-3' double-stranded DNA exonuclease acting in Bacillus anthracis mismatch repair.. DNA repair, 2013.
Whitelegge JP. Integral membrane proteins and bilayer proteomics.. Analytical chemistry, 2013.
Howery AE, Elvington S, Abraham SJ, Choi KH, Dworschak-Simpson S, Phillips S, Ryan CM, Sanford RL, Almqvist J, Tran K, Chew TA, Zachariae U, Andersen OS, Whitelegge J, Matulef K, Du Bois J, Maduke MC. A designed inhibitor of a CLC antiporter blocks function through a unique binding mode.. Chemistry & biology, 2012.
Nazmi AR, Ozorowski G, Pejic M, Whitelegge JP, Gerke V, Luecke H. N-terminal acetylation of annexin A2 is required for S100A10 binding.. Biological chemistry, 2012.
Ozorowski G, Ryan CM, Whitelegge JP, Luecke H. Withaferin A binds covalently to the N-terminal domain of annexin A2.. Biological chemistry, 2012.
Whelan SA, He J, Lu M, Souda P, Saxton RE, Faull KF, Whitelegge JP, Chang HR. Mass spectrometry (LC-MS/MS) identified proteomic biosignatures of breast cancer in proximal fluid.. Journal of proteome research, 2012.
Ahuja U, Liu M, Tomida S, Park J, Souda P, Whitelegge J, Li H, Harvill ET, Parkhill J, Miller JF. Phenotypic and genomic analysis of hypervirulent human-associated Bordetella bronchiseptica.. BMC microbiology, 2012.
Fluman N, Ryan CM, Whitelegge JP, Bibi E. Dissection of mechanistic principles of a secondary multidrug efflux protein.. Molecular cell, 2012.
Halgand F, Zabrouskov V, Bassilian S, Souda P, Loo JA, Faull KF, Wong DT, Whitelegge JP. Defining intact protein primary structures from saliva: a step toward the human proteome project.. Analytical chemistry, 2012.
Prudencio M, Lelie H, Brown HH, Whitelegge JP, Valentine JS, Borchelt DR. A novel variant of human superoxide dismutase 1 harboring amyotrophic lateral sclerosis-associated and experimental mutations in metal-binding residues and free cysteines lacks toxicity in vivo.. Journal of neurochemistry, 2012.
Laganowsky A, Liu C, Sawaya MR, Whitelegge JP, Park J, Zhao M, Pensalfini A, Soriaga AB, Landau M, Teng PK, Cascio D, Glabe C, Eisenberg D. Atomic view of a toxic amyloid small oligomer.. Science (New York, N.Y.), 2012.
Puppione DL, Della Donna L, Bassilian S, Souda P, MacDonald MH, Whitelegge JP. Mass spectral measurements of the apoHDL in horse (Equus caballus) cerebrospinal fluid.. Comparative biochemistry and physiology. Part D, Genomics & proteomics, 2012.
O'Brien JA, Daudi A, Finch P, Butt VS, Whitelegge JP, Souda P, Ausubel FM, Bolwell GP. A peroxidase-dependent apoplastic oxidative burst in cultured Arabidopsis cells functions in MAMP-elicited defense.. Plant physiology, 2012.
Ziegler ME, Souda P, Jin YP, Whitelegge JP, Reed EF. Characterization of the endothelial cell cytoskeleton following HLA class I ligation.. PloS one, 2012.
Sheng Y, Chattopadhyay M, Whitelegge J, Valentine JS. SOD1 aggregation and ALS: role of metallation states and disulfide status.. Current topics in medicinal chemistry, 2012.
Hajagos BE, Turetzky JM, Peng ED, Cheng SJ, Ryan CM, Souda P, Whitelegge JP, Lebrun M, Dubremetz JF, Bradley PJ. Molecular dissection of novel trafficking and processing of the Toxoplasma gondii rhoptry metalloprotease toxolysin-1.. Traffic (Copenhagen, Denmark), 2011.
He J, Whelan SA, Lu M, Shen D, Chung DU, Saxton RE, Faull KF, Whitelegge JP, Chang HR. Proteomic-based biosignatures in breast cancer classification and prediction of therapeutic response.. International journal of proteomics, 2011.
Whitelegge J. Structural biology. Up close with membrane lipid-protein complexes.. Science (New York, N.Y.), 2011.
Nally JE, Monahan AM, Miller IS, Bonilla-Santiago R, Souda P, Whitelegge JP. Comparative proteomic analysis of differentially expressed proteins in the urine of reservoir hosts of leptospirosis.. PloS one, 2011.
Della Donna L, Bassilian S, Souda P, Nebbia C, Whitelegge JP, Puppione DL. Mass spectrometric measurements of the apolipoproteins of bovine (Bos taurus) HDL.. Comparative biochemistry and physiology. Part D, Genomics & proteomics, 2011.
Souda P, Ryan CM, Cramer WA, Whitelegge J. Profiling of integral membrane proteins and their post translational modifications using high-resolution mass spectrometry.. Methods (San Diego, Calif.), 2011.
Hasan SS, Yamashita E, Ryan CM, Whitelegge JP, Cramer WA. Conservation of lipid functions in cytochrome bc complexes.. Journal of molecular biology, 2011.
Tokhtaeva E, Sachs G, Souda P, Bassilian S, Whitelegge JP, Shoshani L, Vagin O. Epithelial junctions depend on intercellular trans-interactions between the Na,K-ATPase β₁ subunits.. The Journal of biological chemistry, 2011.
Whitelegge JP, Komatsu S, Jorrin-Novo J. Diverse facets of plant proteomics.. Phytochemistry, 2011.
Tullius MV, Harmston CA, Owens CP, Chim N, Morse RP, McMath LM, Iniguez A, Kimmey JM, Sawaya MR, Whitelegge JP, Horwitz MA, Goulding CW. Discovery and characterization of a unique mycobacterial heme acquisition system.. Proceedings of the National Academy of Sciences of the United States of America, 2011.
Nowaczyk MM, Wulfhorst H, Ryan CM, Souda P, Zhang H, Cramer WA, Whitelegge JP. NdhP and NdhQ: two novel small subunits of the cyanobacterial NDH-1 complex.. Biochemistry, 2011.
Thangaraj B, Jolley CC, Sarrou I, Bultema JB, Greyslak J, Whitelegge JP, Lin S, Kouril R, Subramanyam R, Boekema EJ, Fromme P. Efficient light harvesting in a dark, hot, acidic environment: the structure and function of PSI-LHCI from Galdieria sulphuraria.. Biophysical journal, 2011.
Leuchter AF, Cook IA, Hamilton SP, Narr KL, Toga A, Hunter AM, Faull K, Whitelegge J, Andrews AM, Loo J, Way B, Nelson SF, Horvath S, Lebowitz BD. Biomarkers to predict antidepressant response.. Current psychiatry reports, 2010.
Marques PX, O'Donovan J, Souda P, Gutierrez J, Williams EJ, Worrall S, McElroy M, Proctor A, Brady C, Sammin D, Basset H, Whitelegge JP, Markey BK, Nally JE. Amniotic and allantoic fluids from experimentally infected sheep contain immunoglobulin specific for Chlamydophila abortus.. Veterinary immunology and immunopathology, 2010.
Lelie HL, Liba A, Bourassa MW, Chattopadhyay M, Chan PK, Gralla EB, Miller LM, Borchelt DR, Valentine JS, Whitelegge JP. Copper and zinc metallation status of copper-zinc superoxide dismutase from amyotrophic lateral sclerosis transgenic mice.. The Journal of biological chemistry, 2010.
de Vries S, Momcilovic M, Strampraad MJ, Whitelegge JP, Baghai A, Schröder I. Adaptation to a high-tungsten environment: Pyrobaculum aerophilum contains an active tungsten nitrate reductase.. Biochemistry, 2010.
Thangaraj B, Ryan CM, Souda P, Krause K, Faull KF, Weber AP, Fromme P, Whitelegge JP. Data-directed top-down Fourier-transform mass spectrometry of a large integral membrane protein complex: photosystem II from Galdieria sulphuraria.. Proteomics, 2010.
Prudencio M, Durazo A, Whitelegge JP, Borchelt DR. An examination of wild-type SOD1 in modulating the toxicity and aggregation of ALS-associated mutant SOD1.. Human molecular genetics, 2010.
Webb KJ, Zurita-Lopez CI, Al-Hadid Q, Laganowsky A, Young BD, Lipson RS, Souda P, Faull KF, Whitelegge JP, Clarke SG. A novel 3-methylhistidine modification of yeast ribosomal protein Rpl3 is dependent upon the YIL110W methyltransferase.. The Journal of biological chemistry, 2010.
Liu X, Inbar Y, Dorrestein PC, Wynne C, Edwards N, Souda P, Whitelegge JP, Bafna V, Pevzner PA. Deconvolution and database search of complex tandem mass spectra of intact proteins: a combinatorial approach.. Molecular & cellular proteomics : MCP, 2010.
Lu M, Whelan SA, He J, Saxton RE, Faull KF, Whitelegge JP, Chang HR. Hydrophobic Proteome Analysis of Triple Negative and Hormone-Receptor-Positive-Her2-Negative Breast Cancer by Mass Spectrometer.. Clinical proteomics, 2010.
Keire DA, Whitelegge JP, Souda P, Faull KF, Bassilian S, Reidelberger RD, Haver AC, Reeve JR. PYY(1-36) is the major form of PYY in rat distal small intestine: quantification using high-resolution mass spectrometry.. Regulatory peptides, 2010.
Webb KJ, Lipson RS, Al-Hadid Q, Whitelegge JP, Clarke SG. Identification of protein N-terminal methyltransferases in yeast and humans.. Biochemistry, 2010.
Marques PX, Souda P, O'Donovan J, Gutierrez J, Gutierrez EJ, Worrall S, McElroy M, Proctor A, Brady C, Sammin D, Basset HF, Whitelegge JP, Markey BE, Nally JE. Identification of immunologically relevant proteins of Chlamydophila abortus using sera from experimentally infected pregnant ewes.. Clinical and vaccine immunology : CVI, 2010.
Srikanth S, Jung HJ, Kim KD, Souda P, Whitelegge J, Gwack Y. A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells.. Nature cell biology, 2010.
Gundersen CB, Kohan SA, Souda P, Whitelegge JP, Umbach JA. Cysteine string protein beta is prominently associated with nerve terminals and secretory organelles in mouse brain.. Brain research, 2010.
Crofts AJ, Crofts N, Whitelegge JP, Okita TW. Isolation and identification of cytoskeleton-associated prolamine mRNA binding proteins from developing rice seeds.. Planta, 2010.
Puppione DL, Ryan CM, Bassilian S, Souda P, Xiao X, Ryder OA, Whitelegge JP. Detection of two distinct forms of apoC-I in great apes.. Comparative biochemistry and physiology. Part D, Genomics & proteomics, 2010.
Shoemaker LD, Orozco NM, Geschwind DH, Whitelegge JP, Faull KF, Kornblum HI. Identification of differentially expressed proteins in murine embryonic and postnatal cortical neural progenitors.. PloS one, 2010.
Ryan CM, Souda P, Halgand F, Wong DT, Loo JA, Faull KF, Whitelegge JP. Confident assignment of intact mass tags to human salivary cystatins using top-down Fourier-transform ion cyclotron resonance mass spectrometry.. Journal of the American Society for Mass Spectrometry, 2010.
Halgand F, Zabrouskov V, Bassilian S, Souda P, Wong DT, Loo JA, Faull KF, Whitelegge JP. Micro-heterogeneity of human saliva Peptide P-C characterized by high-resolution top-down Fourier-transform mass spectrometry.. Journal of the American Society for Mass Spectrometry, 2010.
Lu M, Whitelegge JP, Whelan SA, He J, Saxton RE, Faull KF, Chang HR. Hydrophobic Fractionation Enhances Novel Protein Detection by Mass Spectrometry in Triple Negative Breast Cancer.. Journal of proteomics & bioinformatics, 2010.
Ryan CM, Souda P, Bassilian S, Ujwal R, Zhang J, Abramson J, Ping P, Durazo A, Bowie JU, Hasan SS, Baniulis D, Cramer WA, Faull KF, Whitelegge JP. Post-translational modifications of integral membrane proteins resolved by top-down Fourier transform mass spectrometry with collisionally activated dissociation.. Molecular & cellular proteomics : MCP, 2010.
Chim N, Riley R, The J, Im S, Segelke B, Lekin T, Yu M, Hung LW, Terwilliger T, Whitelegge JP, Goulding CW. An extracellular disulfide bond forming protein (DsbF) from Mycobacterium tuberculosis: structural, biochemical, and gene expression analysis.. Journal of molecular biology, 2010.
Shaw BF, Moustakas DT, Whitelegge JP, Faull KF. Taking charge of proteins from neurodegeneration to industrial biotechnology.. Advances in protein chemistry and structural biology, 2010.
Puppione DL, Della Donna L, Laganowsky AD, Bassilian S, Souda P, Ryder OA, Whitelegge JP. Mass spectral analyses of the two major apolipoproteins of great ape high density lipoproteins.. Comparative biochemistry and physiology. Part D, Genomics & proteomics, 2009.
Averette KM, Pratt MR, Yang Y, Bassilian S, Whitelegge JP, Loo JA, Muir TW, Bradley KA. Anthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent.. PloS one, 2009.
Budzik JM, Poor CB, Faull KF, Whitelegge JP, He C, Schneewind O. Intramolecular amide bonds stabilize pili on the surface of bacilli.. Proceedings of the National Academy of Sciences of the United States of America, 2009.
Yuan Q, Kaylor JJ, Miu A, Bassilian S, Whitelegge JP, Travis GH. Rpe65 isomerase associates with membranes through an electrostatic interaction with acidic phospholipid headgroups.. The Journal of biological chemistry, 2009.
Sun S, La Scola B, Bowman VD, Ryan CM, Whitelegge JP, Raoult D, Rossmann MG. Structural studies of the Sputnik virophage.. Journal of virology, 2009.
Durazo A, Shaw BF, Chattopadhyay M, Faull KF, Nersissian AM, Valentine JS, Whitelegge JP. Metal-free superoxide dismutase-1 and three different amyotrophic lateral sclerosis variants share a similar partially unfolded beta-barrel at physiological temperature.. The Journal of biological chemistry, 2009.
He J, Shen D, Chung DU, Saxton RE, Whitelegge JP, Faull KF, Chang HR. Tumor proteomic profiling predicts the susceptibility of breast cancer to chemotherapy.. International journal of oncology, 2009.
Joh NH, Oberai A, Yang D, Whitelegge JP, Bowie JU. Similar energetic contributions of packing in the core of membrane and water-soluble proteins.. Journal of the American Chemical Society, 2009.
Whelan SA, Lu M, He J, Yan W, Saxton RE, Faull KF, Whitelegge JP, Chang HR. Mass spectrometry (LC-MS/MS) site-mapping of N-glycosylated membrane proteins for breast cancer biomarkers.. Journal of proteome research, 2009.
Millar DJ, Whitelegge JP, Bindschedler LV, Rayon C, Boudet AM, Rossignol M, Borderies G, Bolwell GP. The cell wall and secretory proteome of a tobacco cell line synthesising secondary wall.. Proteomics, 2009.
Laganowsky A, Gómez SM, Whitelegge JP, Nishio JN. Hydroponics on a chip: analysis of the Fe deficient Arabidopsis thylakoid membrane proteome.. Journal of proteomics, 2009.
Erales J, Gontero B, Whitelegge J, Halgand F. Mapping of a copper-binding site on the small CP12 chloroplastic protein of Chlamydomonas reinhardtii using top-down mass spectrometry and site-directed mutagenesis.. The Biochemical journal, 2009.
Baniulis D, Yamashita E, Whitelegge JP, Zatsman AI, Hendrich MP, Hasan SS, Ryan CM, Cramer WA. Structure-Function, Stability, and Chemical Modification of the Cyanobacterial Cytochrome b6f Complex from Nostoc sp. PCC 7120.. The Journal of biological chemistry, 2009.
Doolittle MH, Ben-Zeev O, Bassilian S, Whitelegge JP, Péterfy M, Wong H. Hepatic lipase maturation: a partial proteome of interacting factors.. Journal of lipid research, 2009.
Prudencio M, Durazo A, Whitelegge JP, Borchelt DR. Modulation of mutant superoxide dismutase 1 aggregation by co-expression of wild-type enzyme.. Journal of neurochemistry, 2008.
Chattopadhyay M, Durazo A, Sohn SH, Strong CD, Gralla EB, Whitelegge JP, Valentine JS. Initiation and elongation in fibrillation of ALS-linked superoxide dismutase.. Proceedings of the National Academy of Sciences of the United States of America, 2008.
Webb KJ, Laganowsky A, Whitelegge JP, Clarke SG. Identification of two SET domain proteins required for methylation of lysine residues in yeast ribosomal protein Rpl42ab.. The Journal of biological chemistry, 2008.
Puppione DL, Bassilian S, Souda P, MacDonald MH, Halgand F, Hagland F, Whitelegge JP. Mass spectral analysis of the apolipoproteins on dog (Canis lupus familiaris) high density lipoproteins. Detection of apolipoprotein A-II.. Comparative biochemistry and physiology. Part D, Genomics & proteomics, 2008.
Budzik JM, Marraffini LA, Souda P, Whitelegge JP, Faull KF, Schneewind O. Amide bonds assemble pili on the surface of bacilli.. Proceedings of the National Academy of Sciences of the United States of America, 2008.
Lu H, Zong C, Wang Y, Young GW, Deng N, Souda P, Li X, Whitelegge J, Drews O, Yang PY, Ping P. Revealing the dynamics of the 20 S proteasome phosphoproteome: a combined CID and electron transfer dissociation approach.. Molecular & cellular proteomics : MCP, 2008.
Joh NH, Min A, Faham S, Whitelegge JP, Yang D, Woods VL, Bowie JU. Modest stabilization by most hydrogen-bonded side-chain interactions in membrane proteins.. Nature, 2008.
Shaw BF, Schneider GF, Bilgiçer B, Kaufman GK, Neveu JM, Lane WS, Whitelegge JP, Whitesides GM. Lysine acetylation can generate highly charged enzymes with increased resistance toward irreversible inactivation.. Protein science : a publication of the Protein Society, 2008.
Keire DA, Whitelegge JP, Bassilian S, Faull KF, Wiggins BW, Mehdizadeh OB, Reidelberger RD, Haver AC, Sayegh AI, Reeve JR. A new endogenous form of PYY isolated from canine ileum: Gly-extended PYY(1-36).. Regulatory peptides, 2008.
Denny P, Hagen FK, Hardt M, Liao L, Yan W, Arellanno M, Bassilian S, Bedi GS, Boontheung P, Cociorva D, Delahunty CM, Denny T, Dunsmore J, Faull KF, Gilligan J, Gonzalez-Begne M, Halgand F, Hall SC, Han X, Henson B, Hewel J, Hu S, Jeffrey S, Jiang J, Loo JA, Ogorzalek Loo RR, Malamud D, Melvin JE, Miroshnychenko O, Navazesh M, Niles R, Park SK, Prakobphol A, Ramachandran P, Richert M, Robinson S, Sondej M, Souda P, Sullivan MA, Takashima J, Than S, Wang J, Whitelegge JP, Witkowska HE, Wolinsky L, Xie Y, Xu T, Yu W, Ytterberg J, Wong DT, Yates JR, Fisher SJ. The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions.. Journal of proteome research, 2008.
Shaw BF, Lelie HL, Durazo A, Nersissian AM, Xu G, Chan PK, Gralla EB, Tiwari A, Hayward LJ, Borchelt DR, Valentine JS, Whitelegge JP. Detergent-insoluble aggregates associated with amyotrophic lateral sclerosis in transgenic mice contain primarily full-length, unmodified superoxide dismutase-1.. The Journal of biological chemistry, 2008.
Grintsevich EE, Benchaar SA, Warshaviak D, Boontheung P, Halgand F, Whitelegge JP, Faull KF, Loo RR, Sept D, Loo JA, Reisler E. Mapping the cofilin binding site on yeast G-actin by chemical cross-linking.. Journal of molecular biology, 2008.
Fujishige NA, Lum MR, De Hoff PL, Whitelegge JP, Faull KF, Hirsch AM. Rhizobium common nod genes are required for biofilm formation.. Molecular microbiology, 2007.
Farrokhi N, Whitelegge JP, Brusslan JA. Plant peptides and peptidomics.. Plant biotechnology journal, 2007.
Whitelegge JP, Zabrouskov V, Halgand F, Souda P, Bassilian S, Yan W, Wolinsky L, Loo JA, Wong DT, Faull KF. Protein-Sequence Polymorphisms and Post-translational Modifications in Proteins from Human Saliva using Top-Down Fourier-transform Ion Cyclotron Resonance Mass Spectrometry.. International journal of mass spectrometry, 2007.
Lu M, Faull KF, Whitelegge JP, He J, Shen D, Saxton RE, Chang HR. Proteomics and mass spectrometry for cancer biomarker discovery.. Biomarker insights, 2007.
Nally JE, Whitelegge JP, Carroll JA. Proteomic strategies to elucidate pathogenic mechanisms of spirochetes.. Proteomics. Clinical applications, 2007.
Taylor CF, Paton NW, Lilley KS, Binz PA, Julian RK, Jones AR, Zhu W, Apweiler R, Aebersold R, Deutsch EW, Dunn MJ, Heck AJ, Leitner A, Macht M, Mann M, Martens L, Neubert TA, Patterson SD, Ping P, Seymour SL, Souda P, Tsugita A, Vandekerckhove J, Vondriska TM, Whitelegge JP, Wilkins MR, Xenarios I, Yates JR, Hermjakob H. The minimum information about a proteomics experiment (MIAPE).. Nature biotechnology, 2007.
Bortz E, Wang L, Jia Q, Wu TT, Whitelegge JP, Deng H, Zhou ZH, Sun R. Murine gammaherpesvirus 68 ORF52 encodes a tegument protein required for virion morphogenesis in the cytoplasm.. Journal of virology, 2007.
Xie J, Marusich MF, Souda P, Whitelegge J, Capaldi RA. The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11.. FEBS letters, 2007.
Banci L, Bertini I, Durazo A, Girotto S, Gralla EB, Martinelli M, Valentine JS, Vieru M, Whitelegge JP. Metal-free superoxide dismutase forms soluble oligomers under physiological conditions: a possible general mechanism for familial ALS.. Proceedings of the National Academy of Sciences of the United States of America, 2007.
Watanabe J, Chou KJ, Liao JC, Miao Y, Meng HH, Ge H, Grijalva V, Hama S, Kozak K, Buga G, Whitelegge JP, Lee TD, Farias-Eisner R, Navab M, Fogelman AM, Reddy ST. Differential association of hemoglobin with proinflammatory high density lipoproteins in atherogenic/hyperlipidemic mice. A novel biomarker of atherosclerosis.. The Journal of biological chemistry, 2007.
Zabrouskov V, Whitelegge JP. Increased coverage in the transmembrane domain with activated-ion electron capture dissociation for top-down Fourier-transform mass spectrometry of integral membrane proteins.. Journal of proteome research, 2007.
Boutz DR, Cascio D, Whitelegge J, Perry LJ, Yeates TO. Discovery of a thermophilic protein complex stabilized by topologically interlinked chains.. Journal of molecular biology, 2007.
Waldron RT, Whitelegge JP, Faull KF, Rozengurt E. Identification of a novel phosphorylation site in c-jun directly targeted in vitro by protein kinase D.. Biochemical and biophysical research communications, 2007.
Porras-Yakushi TR, Whitelegge JP, Clarke S. Yeast ribosomal/cytochrome c SET domain methyltransferase subfamily: identification of Rpl23ab methylation sites and recognition motifs.. The Journal of biological chemistry, 2007.
Kawaguchi R, Yu J, Honda J, Hu J, Whitelegge J, Ping P, Wiita P, Bok D, Sun H. A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A.. Science (New York, N.Y.), 2007.
He J, Gornbein J, Shen D, Lu M, Rovai LE, Shau H, Katz J, Whitelegge JP, Faull KF, Chang HR. Detection of breast cancer biomarkers in nipple aspirate fluid by SELDI-TOF and their identification by combined liquid chromatography-tandem mass spectrometry.. International journal of oncology, 2007.
Whitelegge J, Halgand F, Souda P, Zabrouskov V. Top-down mass spectrometry of integral membrane proteins.. Expert review of proteomics, 2006.
Nally JE, Whitelegge JP, Bassilian S, Blanco DR, Lovett MA. Characterization of the outer membrane proteome of Leptospira interrogans expressed during acute lethal infection.. Infection and immunity, 2006.
Porras-Yakushi TR, Whitelegge JP, Clarke S. A novel SET domain methyltransferase in yeast: Rkm2-dependent trimethylation of ribosomal protein L12ab at lysine 10.. The Journal of biological chemistry, 2006.
Ding Q, Vaynman S, Souda P, Whitelegge JP, Gomez-Pinilla F. Exercise affects energy metabolism and neural plasticity-related proteins in the hippocampus as revealed by proteomic analysis.. The European journal of neuroscience, 2006.
Puppione DL, Yam LM, Bassilian S, Souda P, Castellani LW, Schumaker VN, Whitelegge JP. Mass spectral analysis of the apolipoproteins on mouse high density lipoproteins. Detection of post-translational modifications.. Biochimica et biophysica acta, 2006.
Shaw BF, Durazo A, Nersissian AM, Whitelegge JP, Faull KF, Valentine JS. Local unfolding in a destabilized, pathogenic variant of superoxide dismutase 1 observed with H/D exchange and mass spectrometry.. The Journal of biological chemistry, 2006.
Whitelegge JP, Laganowsky A, Nishio J, Souda P, Zhang H, Cramer WA. Sequencing covalent modifications of membrane proteins.. Journal of experimental botany, 2006.
Bindschedler LV, Whitelegge JP, Millar DJ, Bolwell GP. A two component chitin-binding protein from French bean -- association of a proline-rich protein with a cysteine-rich polypeptide.. FEBS letters, 2006.
Qiao F, Harada B, Song H, Whitelegge J, Courey AJ, Bowie JU. Mae inhibits Pointed-P2 transcriptional activity by blocking its MAPK docking site.. The EMBO journal, 2005.
Kozak KR, Su F, Whitelegge JP, Faull K, Reddy S, Farias-Eisner R. Characterization of serum biomarkers for detection of early stage ovarian cancer.. Proteomics, 2005.
Puppione DL, Whitelegge JP, Yam LM, Bassilian S, Schumaker VN, MacDonald MH. Mass spectral analysis of domestic and wild equine apoA-I and A-II: detection of unique dimeric forms of apoA-II.. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 2005.
Porras-Yakushi TR, Whitelegge JP, Miranda TB, Clarke S. A novel SET domain methyltransferase modifies ribosomal protein Rpl23ab in yeast.. The Journal of biological chemistry, 2005.
Norris AJ, Whitelegge JP, Yaghoubian A, Alattia JR, Privé GG, Toyokuni T, Sun H, Brooks MN, Panza L, Matto P, Compostella F, Remmel N, Klingenstein R, Sandhoff K, Fluharty C, Fluharty A, Faull KF. A novel mass spectrometric assay for the cerebroside sulfate activator protein (saposin B) and arylsulfatase A.. Journal of lipid research, 2005.
Berhane BT, Zong C, Liem DA, Huang A, Le S, Edmondson RD, Jones RC, Qiao X, Whitelegge JP, Ping P, Vondriska TM. Cardiovascular-related proteins identified in human plasma by the HUPO Plasma Proteome Project pilot phase.. Proteomics, 2005.
Kozak NA, Mattoo S, Foreman-Wykert AK, Whitelegge JP, Miller JF. Interactions between partner switcher orthologs BtrW and BtrV regulate type III secretion in Bordetella.. Journal of bacteriology, 2005.
Lu M, Zhang L, Maul RS, Sartippour MR, Norris A, Whitelegge J, Rao JY, Brooks MN. The novel gene EG-1 stimulates cellular proliferation.. Cancer research, 2005.
Gomes AV, Zong C, Edmondson RD, Berhane BT, Wang GW, Le S, Young G, Zhang J, Vondriska TM, Whitelegge JP, Jones RC, Joshua IG, Thyparambil S, Pantaleon D, Qiao J, Loo J, Ping P. The murine cardiac 26S proteasome: an organelle awaiting exploration.. Annals of the New York Academy of Sciences, 2005.
Blanco DR, Champion CI, Dooley A, Cox DL, Whitelegge JP, Faull K, Lovett MA. A monoclonal antibody that conveys in vitro killing and partial protection in experimental syphilis binds a phosphorylcholine surface epitope of Treponema pallidum.. Infection and immunity, 2005.
Puppione DL, Whitelegge JP, Yam LM, Schumaker VN. Mass spectral analysis of pig (Sus scrofa) apo HDL: Identification of pig apoA-II, a dimeric apolipoprotein.. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 2005.
Whitelegge JP. Mass spectrometry for high throughput quantitative proteomics in plant research: lessons from thylakoid membranes.. Plant physiology and biochemistry : PPB, 2005.
Liu C, Willmund F, Whitelegge JP, Hawat S, Knapp B, Lodha M, Schroda M. J-domain protein CDJ2 and HSP70B are a plastidic chaperone pair that interacts with vesicle-inducing protein in plastids 1.. Molecular biology of the cell, 2005.
Nally JE, Whitelegge JP, Aguilera R, Pereira MM, Blanco DR, Lovett MA. Purification and proteomic analysis of outer membrane vesicles from a clinical isolate of Leptospira interrogans serovar Copenhageni.. Proteomics, 2005.
Weinglass AB, Soskine M, Vazquez-Ibar JL, Whitelegge JP, Faull KF, Kaback HR, Schuldiner S. Exploring the role of a unique carboxyl residue in EmrE by mass spectrometry.. The Journal of biological chemistry, 2004.
Barwe SP, Anilkumar G, Moon SY, Zheng Y, Whitelegge JP, Rajasekaran SA, Rajasekaran AK. Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility.. Molecular biology of the cell, 2004.
Chun HH, Cary RB, Lansigan F, Whitelegge J, Rawlings DJ, Gatti RA. ATM protein purified from vaccinia virus expression system: DNA binding requirements for kinase activation.. Biochemical and biophysical research communications, 2004.
Weinglass AB, Whitelegge JP, Kaback HR. Integrating mass spectrometry into membrane protein drug discovery.. Current opinion in drug discovery & development, 2004.
Crother TR, Champion CI, Whitelegge JP, Aguilera R, Wu XY, Blanco DR, Miller JN, Lovett MA. Temporal analysis of the antigenic composition of Borrelia burgdorferi during infection in rabbit skin.. Infection and immunity, 2004.
Yohannan S, Yang D, Faham S, Boulting G, Whitelegge J, Bowie JU. Proline substitutions are not easily accommodated in a membrane protein.. Journal of molecular biology, 2004.
Weinglass A, Whitelegge JP, Faull KF, Kaback HR. Monitoring conformational rearrangements in the substrate-binding site of a membrane transport protein by mass spectrometry.. The Journal of biological chemistry, 2004.
Puppione DL, Fischer WH, Park M, Whitelegge JP, Schumaker VN, Golfeiz S, MacDonald MH. Sequence of horse (Equus caballus) apoA-II. Another example of a dimer forming apolipoprotein.. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 2004.
Whitelegge JP, Katz JE, Pihakari KA, Hale R, Aguilera R, Gómez SM, Faull KF, Vavilin D, Vermaas W. Subtle modification of isotope ratio proteomics; an integrated strategy for expression proteomics.. Phytochemistry, 2004.
Tu X, Huang A, Bae D, Slaughter N, Whitelegge J, Crother T, Bickel PE, Nel A. Proteome analysis of lipid rafts in Jurkat cells characterizes a raft subset that is involved in NF-kappaB activation.. Journal of proteome research, 2004.
Norris AJ, Whitelegge JP, Strouse MJ, Faull KF, Toyokuni T. Inhibition kinetics of carba- and C-fucosyl analogues of GDP-fucose against fucosyltransferase V: implication for the reaction mechanism.. Bioorganic & medicinal chemistry letters, 2004.
Yohannan S, Faham S, Yang D, Whitelegge JP, Bowie JU. The evolution of transmembrane helix kinks and the structural diversity of G protein-coupled receptors.. Proceedings of the National Academy of Sciences of the United States of America, 2004.
Faham S, Yang D, Bare E, Yohannan S, Whitelegge JP, Bowie JU. Side-chain contributions to membrane protein structure and stability.. Journal of molecular biology, 2004.
Whitelegge JP. HPLC and mass spectrometry of intrinsic membrane proteins.. Methods in molecular biology (Clifton, N.J.), 2004.
Bortz E, Whitelegge JP, Jia Q, Zhou ZH, Stewart JP, Wu TT, Sun R. Identification of proteins associated with murine gammaherpesvirus 68 virions.. Journal of virology, 2003.
Gómez SM, Bil' KY, Aguilera R, Nishio JN, Faull KF, Whitelegge JP. Transit peptide cleavage sites of integral thylakoid membrane proteins.. Molecular & cellular proteomics : MCP, 2003.
Slaughter N, Laux I, Tu X, Whitelegge J, Zhu X, Effros R, Bickel P, Nel A. The flotillins are integral membrane proteins in lipid rafts that contain TCR-associated signaling components: implications for T-cell activation.. Clinical immunology (Orlando, Fla.), 2003.
Whitelegge JP, Ahn V, Norris AJ, Sung H, Waring A, Stevens RL, Fluharty CB, Prive G, Faull KF, Fluharty AL. Characterization of a recombinant molecule covalently indistinguishable from human cerebroside-sulfate activator protein (CSAct or Saposin B).. Cellular and molecular biology (Noisy-le-Grand, France), 2003.
Shau H, Chandler GS, Whitelegge JP, Gornbein JA, Faull KF, Chang HR. Proteomic profiling of cancer biomarkers.. Briefings in functional genomics & proteomics, 2003.
Kinzie SD, Thevis M, Ngo K, Whitelegge J, Loo JA, Abu-Omar MM. Posttranslational hydroxylation of human phenylalanine hydroxylase is a novel example of enzyme self-repair within the second coordination sphere of catalytic iron.. Journal of the American Chemical Society, 2003.
Weinglass AB, Whitelegge JP, Hu Y, Verner GE, Faull KF, Kaback HR. Elucidation of substrate binding interactions in a membrane transport protein by mass spectrometry.. The EMBO journal, 2003.
Ahn VE, Faull KF, Whitelegge JP, Higginson J, Fluharty AL, Privé GG. Expression, purification, crystallization, and preliminary X-ray analysis of recombinant human saposin B.. Protein expression and purification, 2003.
Whitelegge JP, Gómez SM, Faull KF. Proteomics of membrane proteins.. Advances in protein chemistry, 2003.
Whitelegge JP. Thylakoid membrane proteomics.. Photosynthesis research, 2003.
Ahn VE, Faull KF, Whitelegge JP, Fluharty AL, Privé GG. Crystal structure of saposin B reveals a dimeric shell for lipid binding.. Proceedings of the National Academy of Sciences of the United States of America, 2002.
Behnam K, Murray SS, Whitelegge JP, Brochmann EJ. Identification of the molecular chaperone alpha B-crystallin in demineralized bone powder and osteoblast-like cells.. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2002.
Gómez SM, Nishio JN, Faull KF, Whitelegge JP. The chloroplast grana proteome defined by intact mass measurements from liquid chromatography mass spectrometry.. Molecular & cellular proteomics : MCP, 2002.
Norris AJ, Whitelegge JP, Faull KF, Toyokuni T. Kinetic characterization of enzyme inhibitors using electrospray-ionization mass spectrometry coupled with multiple reaction monitoring.. Analytical chemistry, 2001.
Schroda M, Vallon O, Whitelegge JP, Beck CF, Wollman FA. The chloroplastic GrpE homolog of Chlamydomonas: two isoforms generated by differential splicing.. The Plant cell, 2001.
Suhr ST, Senut MC, Whitelegge JP, Faull KF, Cuizon DB, Gage FH. Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression.. The Journal of cell biology, 2001.
Norris AJ, Whitelegge JP, Faull KF, Toyokuni T. Analysis of enzyme kinetics using electrospray ionization mass spectrometry and multiple reaction monitoring: fucosyltransferase V.. Biochemistry, 2001.
Whitelegge JP, le Coutre J. Proteomics. Making sense of genomic information for drug discovery.. American journal of pharmacogenomics : genomics-related research in drug development and clinical practice, 2001.
Faull KF, Johnson J, Kim MJ, To T, Whitelegge JP, Stevens RL, Fluharty CB, Fluharty AL. Structure of the asparagine-linked sugar chains of porcine kidney and human urine cerebroside sulfate activator protein.. Journal of mass spectrometry : JMS, 2000.
Whitelegge JP, Penn B, To T, Johnson J, Waring A, Sherman M, Stevens RL, Fluharty CB, Faull KF, Fluharty AL. Methionine oxidation within the cerebroside-sulfate activator protein (CSAct or Saposin B).. Protein science : a publication of the Protein Society, 2000.
Turk E, Kim O, le Coutre J, Whitelegge JP, Eskandari S, Lam JT, Kreman M, Zampighi G, Faull KF, Wright EM. Molecular characterization of Vibrio parahaemolyticus vSGLT: a model for sodium-coupled sugar cotransporters.. The Journal of biological chemistry, 2000.
le Coutre J, Whitelegge JP, Gross A, Turk E, Wright EM, Kaback HR, Faull KF. Proteomics on full-length membrane proteins using mass spectrometry.. Biochemistry, 2000.
Faull KF, Higginson J, Waring AJ, Johnson J, To T, Whitelegge JP, Stevens RL, Fluharty CB, Fluharty AL. Disulfide connectivity in cerebroside sulfate activator is not necessary for biological activity or alpha-helical content but is necessary for trypsin resistance and strong ligand binding.. Archives of biochemistry and biophysics, 2000.
Faull KF, Higginson J, Waring AJ, To T, Whitelegge JP, Stevens RL, Fluharty CB, Fluharty AL. Hydrogen-deuterium exchange signature of porcine cerebroside sulfate activator protein.. Journal of mass spectrometry : JMS, 2000.
Faull KF, Whitelegge JP, Higginson J, To T, Johnson J, Krutchinsky AN, Standing KG, Waring AJ, Stevens RL, Fluharty CB, Fluharty AL. Cerebroside sulfate activator protein (Saposin B): chromatographic and electrospray mass spectrometric properties.. Journal of mass spectrometry : JMS, 1999.
Whitelegge JP, le Coutre J, Lee JC, Engel CK, Privé GG, Faull KF, Kaback HR. Toward the bilayer proteome, electrospray ionization-mass spectrometry of large, intact transmembrane proteins.. Proceedings of the National Academy of Sciences of the United States of America, 1999.
Blanco DR, Whitelegge JP, Miller JN, Lovett MA. Demonstration by mass spectrometry that purified native Treponema pallidum rare outer membrane protein 1 (Tromp1) has a cleaved signal peptide.. Journal of bacteriology, 1999.
Mastrogiacomo A, Kohan SA, Whitelegge JP, Gundersen CB. Intrinsic membrane association of Drosophila cysteine string proteins.. FEBS letters, 1998.
Whitelegge JP, Gundersen CB, Faull KF. Electrospray-ionization mass spectrometry of intact intrinsic membrane proteins.. Protein science : a publication of the Protein Society, 1998.
Whitelegge JP, Koo D, Diner BA, Domian I, Erickson JM. Assembly of the Photosystem II oxygen-evolving complex is inhibited in psbA site-directed mutants of Chlamydomonas reinhardtii. Aspartate 170 of the D1 polypeptide.. The Journal of biological chemistry, 1995.
Whitelegge JP, Jewess P, Pickering MG, Gerrish C, Camilleri P, Bowyer JR. Sequence analysis of photoaffinity-labelled peptides derived by proteolysis of photosystem-2 reaction centres from thylakoid membranes treated with [14C]azidoatrazine.. European journal of biochemistry, 1992.
Bowyer JR, Packer JC, McCormack BA, Whitelegge JP, Robinson C, Taylor MA. Carboxyl-terminal processing of the D1 protein and photoactivation of water-splitting in photosystem II. Partial purification and characterization of the processing enzyme from Scenedesmus obliquus and Pisum sativum.. The Journal of biological chemistry, 1992.