Mayumi Prins, Ph.D.

mprins@mednet.ucla.edu

Faculty Member

Assistant Professor
Department of Neurosurgery
David Geffen School of Medicine
University of California, Los Angeles

10833 Le Conte Avenue, NPI 18-228
Box 957039
Los Angeles, CA 90095

Research Interests

Dr. Prins’s research interests include understanding the changes in brain metabolism that occur after pediatric traumatic brain injury and how alternative fuels can be used as therapeutic options for the young brain after head injury. In addition to this main focus, she is interested in repeat mild head injuries as they apply to both children and young adult athletes.

Publications

Kamins JL, Karimi R, Hoffman A, Prins ML, Giza CC. Biomarkers and Endophenotypes of Post-traumatic Headaches.. Current pain and headache reports, 2024.
Flavin WP, Hosseini H, Ruberti JW, Kavehpour HP, Giza CC, Prins ML. Traumatic brain injury and the pathways to cerebral tau accumulation.. Frontiers in neurology, 2023.
Robert H, Ferguson L, Reins O, Greco T, Prins ML, Folkerts M. Rodent Estrous Cycle Monitoring Utilizing Vaginal Lavage: No Such Thing As a Normal Cycle.. Journal of visualized experiments : JoVE, 2021.
Ferguson L, Giza CC, Serpa RO, Greco T, Robert H, Folkerts M, Prins ML. Sex Differences in Neurophysiological Changes Following Voluntary Exercise in Adolescent Rats.. Frontiers in neurology, 2021.
Serpa RO, Ferguson L, Larson C, Bailard J, Cooke S, Greco T, Prins ML. Pathophysiology of Pediatric Traumatic Brain Injury.. Frontiers in neurology, 2021.
Ferguson L, Giza CC, Serpa RO, Greco T, Folkerts M, Prins ML. Recovery From Repeat Mild Traumatic Brain Injury in Adolescent Rats Is Dependent on Pre-injury Activity State.. Frontiers in neurology, 2021.
Greco T, Vespa PM, Prins ML. Alternative substrate metabolism depends on cerebral metabolic state following traumatic brain injury.. Experimental neurology, 2020.
Sta Maria NS, Sargolzaei S, Prins ML, Dennis EL, Asarnow RF, Hovda DA, Harris NG, Giza CC. Bridging the gap: Mechanisms of plasticity and repair after pediatric TBI.. Experimental neurology, 2019.
Greco T, Ferguson L, Giza C, Prins ML. Mechanisms underlying vulnerabilities after repeat mild traumatic brain injuries.. Experimental neurology, 2019.
Agoston DV, Vink R, Helmy A, Risling M, Nelson D, Prins M. How to Translate Time: The Temporal Aspects of Rodent and Human Pathobiological Processes in Traumatic Brain Injury.. Journal of neurotrauma, 2019.
Stewart W, Allinson K, Al-Sarraj S, Bachmeier C, Barlow K, Belli A, Burns MP, Carson A, Crawford F, Dams-O'Connor K, Diaz-Arrastia R, Dixon CE, Edlow BL, Ferguson S, Fischl B, Folkerth RD, Gentleman S, Giza CC, Grady MS, Helmy A, Herceg M, Holton JL, Howell D, Hutchinson PJ, Iacono D, Iglesias JE, Ikonomovic MD, Johnson VE, Keene CD, Kofler JK, Koliatsos VE, Lee EB, Levin H, Lifshitz J, Ling H, Loane DJ, Love S, Maas AI, Marklund N, Master CL, McElvenny DM, Meaney DF, Menon DK, Montine TJ, Mouzon B, Mufson EJ, Ojo JO, Prins M, Revesz T, Ritchie CW, Smith C, Sylvester R, Tang CY, Trojanowski JQ, Urankar K, Vink R, Wellington C, Wilde EA, Wilson L, Yeates K, Smith DH. Primum non nocere: a call for balance when reporting on CTE.. The Lancet. Neurology, 2019.
Giza CC, Stewart W, Prins ML. Building Good Policy From Good Science-The Case for Concussion and Chronic Traumatic Encephalopathy.. JAMA pediatrics, 2018.
Giza C, Greco T, Prins ML. Concussion: pathophysiology and clinical translation.. Handbook of clinical neurology, 2018.
Grant DA, Serpa R, Moattari CR, Brown A, Greco T, Prins ML, Teng E. Repeat Mild Traumatic Brain Injury in Adolescent Rats Increases Subsequent β-Amyloid Pathogenesis.. Journal of neurotrauma, 2017.
Prins ML. Glucose metabolism in pediatric traumatic brain injury.. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2017.
Giza CC, Prins ML, Hovda DA. It's Not All Fun and Games: Sports, Concussions, and Neuroscience.. Neuron, 2017.
Kamins J, Bigler E, Covassin T, Henry L, Kemp S, Leddy JJ, Mayer A, McCrea M, Prins M, Schneider KJ, Valovich McLeod TC, Zemek R, Giza CC. What is the physiological time to recovery after concussion? A systematic review.. British journal of sports medicine, 2017.
Wolahan SM, Prins ML, McArthur DL, Real CR, Hovda DA, Martin NA, Vespa PM, Glenn TC. Influence of Glycemic Control on Endogenous Circulating Ketone Concentrations in Adults Following Traumatic Brain Injury.. Neurocritical care, 2017.
Vespa P, Tubi M, Claassen J, Buitrago-Blanco M, McArthur D, Velazquez AG, Tu B, Prins M, Nuwer M. Metabolic crisis occurs with seizures and periodic discharges after brain trauma.. Annals of neurology, 2016.
Greco T, Glenn TC, Hovda DA, Prins ML. Ketogenic diet decreases oxidative stress and improves mitochondrial respiratory complex activity.. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015.
Semple BD, Lee S, Sadjadi R, Fritz N, Carlson J, Griep C, Ho V, Jang P, Lamb A, Popolizio B, Saini S, Bazarian JJ, Prins ML, Ferriero DM, Basso DM, Noble-Haeusslein LJ. Repetitive concussions in adolescent athletes - translating clinical and experimental research into perspectives on rehabilitation strategies.. Frontiers in neurology, 2015.
Prins ML, Matsumoto J. Metabolic Response of Pediatric Traumatic Brain Injury.. Journal of child neurology, 2014.
Greco T, Hovda DA, Prins ML. Adolescent TBI-induced hypopituitarism causes sexual dysfunction in adult male rats.. Developmental neurobiology, 2014.
Prins ML, Matsumoto JH. The collective therapeutic potential of cerebral ketone metabolism in traumatic brain injury.. Journal of lipid research, 2014.
Greco T, Hovda D, Prins M. The effects of repeat traumatic brain injury on the pituitary in adolescent rats.. Journal of neurotrauma, 2013.
Prins M, Greco T, Alexander D, Giza CC. The pathophysiology of traumatic brain injury at a glance.. Disease models & mechanisms, 2013.
Greco T, Prins ML. Traumatic brain injury and diet.. Journal of child neurology, 2013.
Prins ML, Alexander D, Giza CC, Hovda DA. Repeated mild traumatic brain injury: mechanisms of cerebral vulnerability.. Journal of neurotrauma, 2013.
Prins ML. Cerebral ketone metabolism during development and injury.. Epilepsy research, 2011.
Deng-Bryant Y, Prins ML, Hovda DA, Harris NG. Ketogenic diet prevents alterations in brain metabolism in young but not adult rats after traumatic brain injury.. Journal of neurotrauma, 2011.
Prins ML, Giza CC. Repeat traumatic brain injury in the developing brain.. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2011.
Babikian T, Prins ML, Cai Y, Barkhoudarian G, Hartonian I, Hovda DA, Giza CC. Molecular and physiological responses to juvenile traumatic brain injury: focus on growth and metabolism.. Developmental neuroscience, 2010.
Prins ML, Hales A, Reger M, Giza CC, Hovda DA. Repeat traumatic brain injury in the juvenile rat is associated with increased axonal injury and cognitive impairments.. Developmental neuroscience, 2010.
Prins ML, Hovda DA. The effects of age and ketogenic diet on local cerebral metabolic rates of glucose after controlled cortical impact injury in rats.. Journal of neurotrauma, 2009.
Appelberg KS, Hovda DA, Prins ML. The effects of a ketogenic diet on behavioral outcome after controlled cortical impact injury in the juvenile and adult rat.. Journal of neurotrauma, 2009.
Giza CC, Kolb B, Harris NG, Asarnow RF, Prins ML. Hitting a moving target: Basic mechanisms of recovery from acquired developmental brain injury.. Developmental neurorehabilitation, 2009.
Prins M. Diet, ketones, and neurotrauma.. Epilepsia, 2008.
Prins ML. Cerebral metabolic adaptation and ketone metabolism after brain injury.. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2007.
Wu HM, Sui G, Lee CC, Prins ML, Ladno W, Lin HD, Yu AS, Phelps ME, Huang SC. In vivo quantitation of glucose metabolism in mice using small-animal PET and a microfluidic device.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2007.
Kreissl MC, Wu HM, Stout DB, Ladno W, Schindler TH, Zhang X, Prior JO, Prins ML, Chatziioannou AF, Huang SC, Schelbert HR. Noninvasive measurement of cardiovascular function in mice with high-temporal-resolution small-animal PET.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2006.
Prins ML, Giza CC. Induction of monocarboxylate transporter 2 expression and ketone transport following traumatic brain injury in juvenile and adult rats.. Developmental neuroscience, 2006.
Giza CC, Prins ML. Is being plastic fantastic? Mechanisms of altered plasticity after developmental traumatic brain injury.. Developmental neuroscience, 2006.
Prins ML, Fujima LS, Hovda DA. Age-dependent reduction of cortical contusion volume by ketones after traumatic brain injury.. Journal of neuroscience research, 2005.
Wu HM, Kreissl MC, Schelbert HR, Ladno W, Prins M, Shoghi-Jadid K, Chatziioannou A, Phelps ME, Huang SC. First-Pass Angiography in Mice Using FDG-PET: A Simple Method of Deriving the Cardiovascular Transit Time Without the Need of Region-of-Interest Drawing.. IEEE transactions on nuclear science, 2005.
Prins ML, Lee SM, Fujima LS, Hovda DA. Increased cerebral uptake and oxidation of exogenous betaHB improves ATP following traumatic brain injury in adult rats.. Journal of neurochemistry, 2004.
Reeves TM, Prins ML, Zhu J, Povlishock JT, Phillips LL. Matrix metalloproteinase inhibition alters functional and structural correlates of deafferentation-induced sprouting in the dentate gyrus.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003.
Prins ML, Hovda DA. Developing experimental models to address traumatic brain injury in children.. Journal of neurotrauma, 2003.
Prins ML, Povlishock JT, Phillips LL. The effects of combined fluid percussion traumatic brain injury and unilateral entorhinal deafferentation on the juvenile rat brain.. Brain research. Developmental brain research, 2003.
Giza CC, Prins ML, Hovda DA, Herschman HR, Feldman JD. Genes preferentially induced by depolarization after concussive brain injury: effects of age and injury severity.. Journal of neurotrauma, 2002.