Michael Sofroniew, M.D., Ph.D.

Publications

• Kim H, Leng K, Park J, Sorets AG, Kim S, Shostak A, Embalabala RJ, Mlouk K, Katdare KA, Rose IVL, Sturgeon SM, Neal EH, Ao Y, Wang S, Sofroniew MV, Brunger JM, McMahon DG, Schrag MS, Kampmann M, Lippmann ES. Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin.. Nature communications, 2022.
• Leng K, Rose IVL, Kim H, Xia W, Romero-Fernandez W, Rooney B, Koontz M, Li E, Ao Y, Wang S, Krawczyk M, Tcw J, Goate A, Zhang Y, Ullian EM, Sofroniew MV, Fancy SPJ, Schrag MS, Lippmann ES, Kampmann M. CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states.. Nature neuroscience, 2022.
• Cheng Y, Yin Y, Zhang A, Bernstein AM, Kawaguchi R, Gao K, Potter K, Gilbert HY, Ao Y, Ou J, Fricano-Kugler CJ, Goldberg JL, He Z, Woolf CJ, Sofroniew MV, Benowitz LI, Geschwind DH. Transcription factor network analysis identifies REST/NRSF as an intrinsic regulator of CNS regeneration in mice.. Nature communications, 2022.
• Burda JE, O'Shea TM, Ao Y, Suresh KB, Wang S, Bernstein AM, Chandra A, Deverasetty S, Kawaguchi R, Kim JH, McCallum S, Rogers A, Wahane S, Sofroniew MV. Divergent transcriptional regulation of astrocyte reactivity across disorders.. Nature, 2022.
• Wahane S, Sofroniew MV. Correction to: Loss-of-function manipulations to identify roles of diverse glia and stromal cells during CNS scar formation.. Cell and tissue research, 2022.
• Mills WA, Woo AM, Jiang S, Martin J, Surendran D, Bergstresser M, Kimbrough IF, Eyo UB, Sofroniew MV, Sontheimer H. Astrocyte plasticity in mice ensures continued endfoot coverage of cerebral blood vessels following injury and declines with age.. Nature communications, 2022.
• Svendsen CN, Sofroniew MV. Lineage tracing: The gold standard to claim direct reprogramming in�vivo.. Molecular therapy : the journal of the American Society of Gene Therapy, 2022.
• Squair JW, Gautier M, Sofroniew MV, Courtine G, Anderson MA. Engineering spinal cord repair.. Current opinion in biotechnology, 2021.
• Diaz-Castro B, Bernstein AM, Coppola G, Sofroniew MV, Khakh BS. Molecular and functional properties of cortical astrocytes during peripherally induced neuroinflammation.. Cell reports, 2021.
• Sofroniew MV. HepaCAM shapes astrocyte territories, stabilizes gap-junction coupling, and influences neuronal excitability.. Neuron, 2021.
• Wahane S, Sofroniew MV. Loss-of-function manipulations to identify roles of diverse glia and stromal cells during CNS scar formation.. Cell and tissue research, 2021.
• Escartin C, Galea E, Lakatos A, O'Callaghan JP, Petzold GC, Serrano-Pozo A, Steinh?user C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Bonvento G, Butt AM, Chen WT, Cohen-Salmon M, Cunningham C, Deneen B, De Strooper B, D?az-Castro B, Farina C, Freeman M, Gallo V, Goldman JE, Goldman SA, G?tz M, Guti?rrez A, Haydon PG, Heiland DH, Hol EM, Holt MG, Iino M, Kastanenka KV, Kettenmann H, Khakh BS, Koizumi S, Lee CJ, Liddelow SA, MacVicar BA, Magistretti P, Messing A, Mishra A, Molofsky AV, Murai KK, Norris CM, Okada S, Oliet SHR, Oliveira JF, Panatier A, Parpura V, Pekna M, Pekny M, Pellerin L, Perea G, P?rez-Nievas BG, Pfrieger FW, Poskanzer KE, Quintana FJ, Ransohoff RM, Riquelme-Perez M, Robel S, Rose CR, Rothstein JD, Rouach N, Rowitch DH, Semyanov A, Sirko S, Sontheimer H, Swanson RA, Vitorica J, Wanner IB, Wood LB, Wu J, Zheng B, Zimmer ER, Zorec R, Sofroniew MV, Verkhratsky A. Reactive astrocyte nomenclature, definitions, and future directions.. Nature neuroscience, 2021.
• Morse LR, Field-Fote EC, Contreras-Vidal J, Noble-Haeusslein LJ, Rodreick M, Shields RK, Sofroniew M, Wudlick R, Zanca JM, SCI 2020 Working Group. Meeting Proceedings for SCI 2020: Launching a Decade of Disruption in Spinal Cord Injury Research.. Journal of neurotrauma, 2021.
• Sofroniew MV. Inflammation drives fibrotic scars in the CNS.. Nature neuroscience, 2021.
• O'Shea TM, Wollenberg AL, Kim JH, Ao Y, Deming TJ, Sofroniew MV. Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions.. Nature communications, 2020.
• Sofroniew MV. Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity.. Trends in immunology, 2020.
• Garrett MC, O'Shea TM, Wollenberg AL, Bernstein AM, Hung D, Staarman B, Soto H, Deming TJ, Sofroniew MV, Kornblum HI. Injectable diblock copolypeptide hydrogel provides platform to deliver effective concentrations of paclitaxel to an intracranial xenograft model of glioblastoma.. PloS one, 2020.
• Tassoni A, Farkhondeh V, Itoh Y, Itoh N, Sofroniew MV, Voskuhl RR. The astrocyte transcriptome in EAE optic neuritis shows complement activation and reveals a sex difference in astrocytic C3 expression.. Scientific reports, 2019.
• Courtine G, Sofroniew MV. Spinal cord repair: advances in biology and technology.. Nature medicine, 2019.
• Liddelow SA, Sofroniew MV. Astrocytes usurp neurons as a disease focus.. Nature neuroscience, 2019.
• Sofroniew MV. Stem-Cell-Derived Astrocytes Divulge Secrets of Mutant GFAP.. Cell stem cell, 2018.
• Anderson MA, O'Shea TM, Burda JE, Ao Y, Barlatey SL, Bernstein AM, Kim JH, James ND, Rogers A, Kato B, Wollenberg AL, Kawaguchi R, Coppola G, Wang C, Deming TJ, He Z, Courtine G, Sofroniew MV. Required growth facilitators propel axon regeneration across complete spinal cord injury.. Nature, 2018.
• Sofroniew MV. Dissecting spinal cord regeneration.. Nature, 2018.
• Wollenberg AL, O'Shea TM, Kim JH, Czechanski A, Reinholdt LG, Sofroniew MV, Deming TJ. Injectable polypeptide hydrogels via methionine modification for neural stem cell delivery.. Biomaterials, 2018.
• Itoh N, Itoh Y, Tassoni A, Ren E, Kaito M, Ohno A, Ao Y, Farkhondeh V, Johnsonbaugh H, Burda J, Sofroniew MV, Voskuhl RR. Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes.. Proceedings of the National Academy of Sciences of the United States of America, 2017.
• Sun Y, Wollenberg AL, O'Shea TM, Cui Y, Zhou ZH, Sofroniew MV, Deming TJ. Conformation-Directed Formation of Self-Healing Diblock Copolypeptide Hydrogels via Polyion Complexation.. Journal of the American Chemical Society, 2017.
• Horng S, Therattil A, Moyon S, Gordon A, Kim K, Argaw AT, Hara Y, Mariani JN, Sawai S, Flodby P, Crandall ED, Borok Z, Sofroniew MV, Chapouly C, John GR. Astrocytic tight junctions control inflammatory CNS lesion pathogenesis.. The Journal of clinical investigation, 2017.
• O'Shea TM, Burda JE, Sofroniew MV. Cell biology of spinal cord injury and repair.. The Journal of clinical investigation, 2017.
• Burda JE, Sofroniew MV. Seducing astrocytes to the dark side.. Cell research, 2017.
• Ren Y, Ao Y, O'Shea TM, Burda JE, Bernstein AM, Brumm AJ, Muthusamy N, Ghashghaei HT, Carmichael ST, Cheng L, Sofroniew MV. Ependymal cell contribution to scar formation after spinal cord injury is minimal, local and dependent on direct ependymal injury.. Scientific reports, 2017.
• Xu J, Bernstein AM, Wong A, Lu XH, Khoja S, Yang XW, Davies DL, Micevych P, Sofroniew MV, Khakh BS. P2X4 Receptor Reporter Mice: Sparse Brain Expression and Feeding-Related Presynaptic Facilitation in the Arcuate Nucleus.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016.
• Anderson MA, Burda JE, Ren Y, Ao Y, O'Shea TM, Kawaguchi R, Coppola G, Khakh BS, Deming TJ, Sofroniew MV. Astrocyte scar formation aids central nervous system axon regeneration.. Nature, 2016.
• Levine J, Kwon E, Paez P, Yan W, Czerwieniec G, Loo JA, Sofroniew MV, Wanner IB. Traumatically injured astrocytes release a proteomic signature modulated by STAT3-dependent cell survival.. Glia, 2015.
• Pekny M, Pekna M, Messing A, Steinh?user C, Lee JM, Parpura V, Hol EM, Sofroniew MV, Verkhratsky A. Astrocytes: a central element in neurological diseases.. Acta neuropathologica, 2015.
• Duan H, Ge W, Zhang A, Xi Y, Chen Z, Luo D, Cheng Y, Fan KS, Horvath S, Sofroniew MV, Cheng L, Yang Z, Sun YE, Li X. Transcriptome analyses reveal molecular mechanisms underlying functional recovery after spinal cord injury.. Proceedings of the National Academy of Sciences of the United States of America, 2015.
• Khakh BS, Sofroniew MV. Diversity of astrocyte functions and phenotypes in neural circuits.. Nature neuroscience, 2015.
• Zhang S, Burda JE, Anderson MA, Zhao Z, Ao Y, Cheng Y, Sun Y, Deming TJ, Sofroniew MV. Thermoresponsive Copolypeptide Hydrogel Vehicles for Central Nervous System Cell Delivery.. ACS biomaterials science & engineering, 2015.
• Sofroniew MV. Astrocyte barriers to neurotoxic inflammation.. Nature reviews. Neuroscience, 2015.
• Burda JE, Bernstein AM, Sofroniew MV. Astrocyte roles in traumatic brain injury.. Experimental neurology, 2015.
• Zhang S, Alvarez DJ, Sofroniew MV, Deming TJ. Design and synthesis of nonionic copolypeptide hydrogels with reversible thermoresponsive and tunable physical properties.. Biomacromolecules, 2015.
• Jiang R, Haustein MD, Sofroniew MV, Khakh BS. Imaging intracellular Ca�? signals in striatal astrocytes from adult mice using genetically-encoded calcium indicators.. Journal of visualized experiments : JoVE, 2014.
• Sofroniew MV. Astrogliosis.. Cold Spring Harbor perspectives in biology, 2014.
• Verkhratsky A, Parpura V, Pekna M, Pekny M, Sofroniew M. Glia in the pathogenesis of neurodegenerative diseases.. Biochemical Society transactions, 2014.
• O'Callaghan JP, Kelly KA, VanGilder RL, Sofroniew MV, Miller DB. Early activation of STAT3 regulates reactive astrogliosis induced by diverse forms of neurotoxicity.. PloS one, 2014.
• Kim RY, Hoffman AS, Itoh N, Ao Y, Spence R, Sofroniew MV, Voskuhl RR. Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis.. Journal of neuroimmunology, 2014.
• L?pez-Vald?s HE, Clarkson AN, Ao Y, Charles AC, Carmichael ST, Sofroniew MV, Brennan KC. Memantine enhances recovery from stroke.. Stroke, 2014.
• Khakh BS, Sofroniew MV. Astrocytes and Huntington's disease.. ACS chemical neuroscience, 2014.
• Assi H, Espinosa J, Suprise S, Sofroniew M, Doherty R, Zamler D, Lowenstein PR, Castro MG. Assessing the role of STAT3 in DC differentiation and autologous DC immunotherapy in mouse models of GBM.. PloS one, 2014.
• Thomsen GM, Le Belle JE, Harnisch JA, Mc Donald WS, Hovda DA, Sofroniew MV, Kornblum HI, Harris NG. Traumatic brain injury reveals novel cell lineage relationships within the subventricular zone.. Stem cell research, 2014.
• Tong X, Ao Y, Faas GC, Nwaobi SE, Xu J, Haustein MD, Anderson MA, Mody I, Olsen ML, Sofroniew MV, Khakh BS. Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice.. Nature neuroscience, 2014.
• Burda JE, Sofroniew MV. Reactive gliosis and the multicellular response to CNS damage and disease.. Neuron, 2014.
• Anderson MA, Ao Y, Sofroniew MV. Heterogeneity of reactive astrocytes.. Neuroscience letters, 2013.
• Zhang S, Anderson MA, Ao Y, Khakh BS, Fan J, Deming TJ, Sofroniew MV. Tunable diblock copolypeptide hydrogel depots for local delivery of hydrophobic molecules in healthy and injured central nervous system.. Biomaterials, 2013.
• Sofroniew MV. Multiple roles for astrocytes as effectors of cytokines and inflammatory mediators.. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2013.
• Wanner IB, Anderson MA, Song B, Levine J, Fernandez A, Gray-Thompson Z, Ao Y, Sofroniew MV. Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013.
• Spence RD, Wisdom AJ, Cao Y, Hill HM, Mongerson CR, Stapornkul B, Itoh N, Sofroniew MV, Voskuhl RR. Estrogen mediates neuroprotection and anti-inflammatory effects during EAE through ERa signaling on astrocytes but not through ER� signaling on astrocytes or neurons.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013.
• Shigetomi E, Bushong EA, Haustein MD, Tong X, Jackson-Weaver O, Kracun S, Xu J, Sofroniew MV, Ellisman MH, Khakh BS. Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses.. The Journal of general physiology, 2013.
• Hamby ME, Coppola G, Ao Y, Geschwind DH, Khakh BS, Sofroniew MV. Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012.
• Song B, Song J, Zhang S, Anderson MA, Ao Y, Yang CY, Deming TJ, Sofroniew MV. Sustained local delivery of bioactive nerve growth factor in the central nervous system via tunable diblock copolypeptide hydrogel depots.. Biomaterials, 2012.
• Nobuta H, Ghiani CA, Paez PM, Spreuer V, Dong H, Korsak RA, Manukyan A, Li J, Vinters HV, Huang EJ, Rowitch DH, Sofroniew MV, Campagnoni AT, de Vellis J, Waschek JA. STAT3-mediated astrogliosis protects myelin development in neonatal brain injury.. Annals of neurology, 2012.
• Argaw AT, Asp L, Zhang J, Navrazhina K, Pham T, Mariani JN, Mahase S, Dutta DJ, Seto J, Kramer EG, Ferrara N, Sofroniew MV, John GR. Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease.. The Journal of clinical investigation, 2012.
• Verkhratsky A, Sofroniew MV, Messing A, deLanerolle NC, Rempe D, Rodr?guez JJ, Nedergaard M. Neurological diseases as primary gliopathies: a reassessment of neurocentrism.. ASN neuro, 2012.
• Cushman JD, Maldonado J, Kwon EE, Garcia AD, Fan G, Imura T, Sofroniew MV, Fanselow MS. Juvenile neurogenesis makes essential contributions to adult brain structure and plays a sex-dependent role in fear memories.. Frontiers in behavioral neuroscience, 2012.
• Sofroniew MV. Transgenic techniques for cell ablation or molecular deletion to investigate functions of astrocytes and other GFAP-expressing cell types.. Methods in molecular biology (Clifton, N.J.), 2012.
• Tao J, Wu H, Lin Q, Wei W, Lu XH, Cantle JP, Ao Y, Olsen RW, Yang XW, Mody I, Sofroniew MV, Sun YE. Deletion of astroglial Dicer causes non-cell-autonomous neuronal dysfunction and degeneration.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011.
• Spence RD, Hamby ME, Umeda E, Itoh N, Du S, Wisdom AJ, Cao Y, Bondar G, Lam J, Ao Y, Sandoval F, Suriany S, Sofroniew MV, Voskuhl RR. Neuroprotection mediated through estrogen receptor-alpha in astrocytes.. Proceedings of the National Academy of Sciences of the United States of America, 2011.
• Wang X, Imura T, Sofroniew MV, Fushiki S. Loss of adenomatous polyposis coli in Bergmann glia disrupts their unique architecture and leads to cell nonautonomous neurodegeneration of cerebellar Purkinje neurons.. Glia, 2011.
• Sofroniew MV. Neuromyelitis optica: circulating autoantibodies provoke astrocyte-mediated neural dysfunction.. Neurology, 2011.
• Imura T, Wang X, Noda T, Sofroniew MV, Fushiki S. Adenomatous polyposis coli is essential for both neuronal differentiation and maintenance of adult neural stem cells in subventricular zone and hippocampus.. Stem cells (Dayton, Ohio), 2010.
• Hamby ME, Sofroniew MV. Reactive astrocytes as therapeutic targets for CNS disorders.. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2010.
• Crawford DK, Mangiardi M, Song B, Patel R, Du S, Sofroniew MV, Voskuhl RR, Tiwari-Woodruff SK. Oestrogen receptor beta ligand: a novel treatment to enhance endogenous functional remyelination.. Brain : a journal of neurology, 2010.
• Shigetomi E, Kracun S, Sofroniew MV, Khakh BS. A genetically targeted optical sensor to monitor calcium signals in astrocyte processes.. Nature neuroscience, 2010.
• Sarafian TA, Montes C, Imura T, Qi J, Coppola G, Geschwind DH, Sofroniew MV. Disruption of astrocyte STAT3 signaling decreases mitochondrial function and increases oxidative stress in vitro.. PloS one, 2010.
• Sofroniew MV, Vinters HV. Astrocytes: biology and pathology.. Acta neuropathologica, 2009.
• Gregorian C, Nakashima J, Dry SM, Nghiemphu PL, Smith KB, Ao Y, Dang J, Lawson G, Mellinghoff IK, Mischel PS, Phelps M, Parada LF, Liu X, Sofroniew MV, Eilber FC, Wu H. PTEN dosage is essential for neurofibroma development and malignant transformation.. Proceedings of the National Academy of Sciences of the United States of America, 2009.
• Sofroniew MV. Molecular dissection of reactive astrogliosis and glial scar formation.. Trends in neurosciences, 2009.
• Courtine G, Gerasimenko Y, van den Brand R, Yew A, Musienko P, Zhong H, Song B, Ao Y, Ichiyama RM, Lavrov I, Roy RR, Sofroniew MV, Edgerton VR. Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.. Nature neuroscience, 2009.
• Voskuhl RR, Peterson RS, Song B, Ao Y, Morales LB, Tiwari-Woodruff S, Sofroniew MV. Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009.
• Madison RD, Sofroniew MV, Robinson GA. Schwann cell influence on motor neuron regeneration accuracy.. Neuroscience, 2009.
• Yang CY, Song B, Ao Y, Nowak AP, Abelowitz RB, Korsak RA, Havton LA, Deming TJ, Sofroniew MV. Biocompatibility of amphiphilic diblock copolypeptide hydrogels in the central nervous system.. Biomaterials, 2009.
• Gregorian C, Nakashima J, Le Belle J, Ohab J, Kim R, Liu A, Smith KB, Groszer M, Garcia AD, Sofroniew MV, Carmichael ST, Kornblum HI, Liu X, Wu H. Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009.
• Herrmann JE, Imura T, Song B, Qi J, Ao Y, Nguyen TK, Korsak RA, Takeda K, Akira S, Sofroniew MV. STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008.
• Shigetomi E, Bowser DN, Sofroniew MV, Khakh BS. Two forms of astrocyte calcium excitability have distinct effects on NMDA receptor-mediated slow inward currents in pyramidal neurons.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008.
• Otis TS, Sofroniew MV. Glia get excited.. Nature neuroscience, 2008.
• Lepore AC, Dejea C, Carmen J, Rauck B, Kerr DA, Sofroniew MV, Maragakis NJ. Selective ablation of proliferating astrocytes does not affect disease outcome in either acute or chronic models of motor neuron degeneration.. Experimental neurology, 2008.
• Courtine G, Song B, Roy RR, Zhong H, Herrmann JE, Ao Y, Qi J, Edgerton VR, Sofroniew MV. Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury.. Nature medicine, 2008.
• Savidge TC, Sofroniew MV, Neunlist M. Starring roles for astroglia in barrier pathologies of gut and brain.. Laboratory investigation; a journal of technical methods and pathology, 2007.
• Saxe MD, Malleret G, Vronskaya S, Mendez I, Garcia AD, Sofroniew MV, Kandel ER, Hen R. Paradoxical influence of hippocampal neurogenesis on working memory.. Proceedings of the National Academy of Sciences of the United States of America, 2007.
• Savidge TC, Newman P, Pothoulakis C, Ruhl A, Neunlist M, Bourreille A, Hurst R, Sofroniew MV. Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione.. Gastroenterology, 2007.
• Saxe MD, Battaglia F, Wang JW, Malleret G, David DJ, Monckton JE, Garcia AD, Sofroniew MV, Kandel ER, Santarelli L, Hen R, Drew MR. Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus.. Proceedings of the National Academy of Sciences of the United States of America, 2006.
• Myer DJ, Gurkoff GG, Lee SM, Hovda DA, Sofroniew MV. Essential protective roles of reactive astrocytes in traumatic brain injury.. Brain : a journal of neurology, 2006.
• Imura T, Nakano I, Kornblum HI, Sofroniew MV. Phenotypic and functional heterogeneity of GFAP-expressing cells in vitro: differential expression of LeX/CD15 by GFAP-expressing multipotent neural stem cells and non-neurogenic astrocytes.. Glia, 2006.
• Dougherty JD, Garcia AD, Nakano I, Livingstone M, Norris B, Polakiewicz R, Wexler EM, Sofroniew MV, Kornblum HI, Geschwind DH. PBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005.
• Sofroniew MV. Reactive astrocytes in neural repair and protection.. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2005.
• Nakano I, Paucar AA, Bajpai R, Dougherty JD, Zewail A, Kelly TK, Kim KJ, Ou J, Groszer M, Imura T, Freije WA, Nelson SF, Sofroniew MV, Wu H, Liu X, Terskikh AV, Geschwind DH, Kornblum HI. Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation.. The Journal of cell biology, 2005.
• Garcia AD, Doan NB, Imura T, Bush TG, Sofroniew MV. GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain.. Nature neuroscience, 2004.
• Faulkner JR, Herrmann JE, Woo MJ, Tansey KE, Doan NB, Sofroniew MV. Reactive astrocytes protect tissue and preserve function after spinal cord injury.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004.
• Morshead CM, Garcia AD, Sofroniew MV, van Der Kooy D. The ablation of glial fibrillary acidic protein-positive cells from the adult central nervous system results in the loss of forebrain neural stem cells but not retinal stem cells.. The European journal of neuroscience, 2003.
• Imura T, Kornblum HI, Sofroniew MV. The predominant neural stem cell isolated from postnatal and adult forebrain but not early embryonic forebrain expresses GFAP.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003.
• Kelly S, Bieneman A, Horsburgh K, Hughes D, Sofroniew MV, McCulloch J, Uney JB. Targeting expression of hsp70i to discrete neuronal populations using the Lmo-1 promoter: assessment of the neuroprotective effects of hsp70i in vivo and in vitro.. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2001.
• Sofroniew MV, Howe CL, Mobley WC. Nerve growth factor signaling, neuroprotection, and neural repair.. Annual review of neuroscience, 2001.
• Takei N, Torres E, Yuhara A, Jongsma H, Otto C, Korhonen L, Abiru Y, Skoglösa Y, Schütz G, Hatanaka H, Sofroniew MV, Lindholm D. Pituitary adenylate cyclase-activating polypeptide promotes the survival of basal forebrain cholinergic neurons in vitro and in vivo: comparison with effects of nerve growth factor.. The European journal of neuroscience, 2000.
• Sofroniew MV. Astrocyte failure as a cause of CNS dysfunction.. Molecular psychiatry, 2000.
• Sofroniew MV, Bush TG, Blumauer N, Mucke L, Johnson MH. Genetically-targeted and conditionally-regulated ablation of astroglial cells in the central, enteric and peripheral nervous systems in adult transgenic mice.. Brain research, 1999.
• Bush TG, Puvanachandra N, Horner CH, Polito A, Ostenfeld T, Svendsen CN, Mucke L, Johnson MH, Sofroniew MV. Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice.. Neuron, 1999.
• Kimonides VG, Spillantini MG, Sofroniew MV, Fawcett JW, Herbert J. Dehydroepiandrosterone antagonizes the neurotoxic effects of corticosterone and translocation of stress-activated protein kinase 3 in hippocampal primary cultures.. Neuroscience, 1999.
• Bussmann KA, Sofroniew MV. Re-expression of p75NTR by adult motor neurons after axotomy is triggered by retrograde transport of a positive signal from axons regrowing through damaged or denervated peripheral nerve tissue.. Neuroscience, 1999.
• Bush TG, Savidge TC, Freeman TC, Cox HJ, Campbell EA, Mucke L, Johnson MH, Sofroniew MV. Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice.. Cell, 1998.
• Kimonides VG, Khatibi NH, Svendsen CN, Sofroniew MV, Herbert J. Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity.. Proceedings of the National Academy of Sciences of the United States of America, 1998.
• Hinks GL, Shah B, French SJ, Campos LS, Staley K, Hughes J, Sofroniew MV. Expression of LIM protein genes Lmo1, Lmo2, and Lmo3 in adult mouse hippocampus and other forebrain regions: differential regulation by seizure activity.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997.
• Kew JN, Sofroniew MV. Brain-derived neurotrophic factor, acidic and basic fibroblast growth factors, insulin-like growth factor-I, and various antioxidants do not prevent the apoptotic death of developing septal cholinergic neurons following nerve growth factor withdrawal in vitro.. Neuroscience, 1997.
• Cooper JD, Sofroniew MV. Increased vulnerability of septal cholinergic neurons to partial loss of target neurons in aged rats.. Neuroscience, 1996.
• De Lacalle S, Cooper JD, Svendsen CN, Dunnett SB, Sofroniew MV. Reduced retrograde labelling with fluorescent tracer accompanies neuronal atrophy of basal forebrain cholinergic neurons in aged rats.. Neuroscience, 1996.
• Cooper JD, Skepper JN, Berzaghi MD, Lindholm D, Sofroniew MV. Delayed death of septal cholinergic neurons after excitotoxic ablation of hippocampal neurons during early postnatal development in the rat.. Experimental neurology, 1996.
• Svendsen CN, Sofroniew MV. Do central nervous system neurons require target-derived neurotrophic support for survival throughout adult life and aging?. Perspectives on developmental neurobiology, 1996.
• Kew JN, Sofroniew MV. Ciliary neurotrophic factor supports p75NGFR-immunoreactive non-cholinergic, but not cholinergic, developing septal neurons in vitro.. Neuroscience, 1995.
• Cooper JD, Lindholm D, Sofroniew MV. Reduced transport of [125I]nerve growth factor by cholinergic neurons and down-regulated TrkA expression in the medial septum of aged rats.. Neuroscience, 1994.
• Wilson VJ, Oddiah D, Sofroniew MV, Panni MK, Rattray M. Down-regulation of protein kinase C isoform gene expression in degenerating thalamic neurones--lack of induction in reactive glial cells.. Biochemical Society transactions, 1994.
• Panni MK, Wilson VJ, Capoor U, Sofroniew MV, Rattray M. Changes in CCK mRNA in hippocampal neurones following fimbria fornix transection.. Neuroreport, 1994.
• Heisenberg CP, Cooper JD, Berke J, Sofroniew MV. NMDA potentiates NGF-induced sprouting of septal cholinergic fibres.. Neuroreport, 1994.
• Svendsen CN, Kew JN, Staley K, Sofroniew MV. Death of developing septal cholinergic neurons following NGF withdrawal in vitro: protection by protein synthesis inhibition.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1994.
• Sofroniew MV, Cooper JD, Svendsen CN, Crossman P, Ip NY, Lindsay RM, Zafra F, Lindholm D. Atrophy but not death of adult septal cholinergic neurons after ablation of target capacity to produce mRNAs for NGF, BDNF, and NT3.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1993.
• da Penha Berzaghi M, Cooper J, Castrén E, Zafra F, Sofroniew M, Thoenen H, Lindholm D. Cholinergic regulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) but not neurotrophin-3 (NT-3) mRNA levels in the developing rat hippocampus.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1993.
• Broadwell RD, Sofroniew MV. Serum proteins bypass the blood-brain fluid barriers for extracellular entry to the central nervous system.. Experimental neurology, 1993.
• Isacson O, Sofroniew MV. Neuronal loss or replacement in the injured adult cerebral neocortex induces extensive remodeling of intrinsic and afferent neural systems.. Experimental neurology, 1992.
• Sofroniew MV, Staley K. Transgenic modelling of neurodegenerative events gathers momentum.. Trends in neurosciences, 1991.
• Svendsen CN, Cooper JD, Sofroniew MV. Trophic factor effects on septal cholinergic neurons.. Annals of the New York Academy of Sciences, 1991.
• Greenberg JM, Boehm T, Sofroniew MV, Keynes RJ, Barton SC, Norris ML, Surani MA, Spillantini MG, Rabbitts TH. Segmental and developmental regulation of a presumptive T-cell oncogene in the central nervous system.. Nature, 1990.
• O'Brien TS, Svendsen CN, Isacson O, Sofroniew MV. Loss of true blue labelling from the medial septum following transection of the fimbria-fornix: evidence for the death of cholinergic and non-cholinergic neurons.. Brain research, 1990.
• Sofroniew MV, Galletly NP, Isacson O, Svendsen CN. Survival of adult basal forebrain cholinergic neurons after loss of target neurons.. Science (New York, N.Y.), 1990.
• Broadwell RD, Charlton HM, Ganong WF, Salcman M, Sofroniew M. Allografts of CNS tissue possess a blood-brain barrier. I. Grafts of medial preoptic area in hypogonadal mice.. Experimental neurology, 1989.
• Isacson O, Riche D, Hantraye P, Sofroniew MV, Maziere M. A primate model of Huntington's disease: cross-species implantation of striatal precursor cells to the excitotoxically lesioned baboon caudate-putamen.. Experimental brain research, 1989.
• Sofroniew MV, Isacson O. Distribution of degeneration of cholinergic neurons in the septum following axotomy in different portions of the fimbria-fornix: a correlation between degree of cell loss and proximity of neuronal somata to the lesion.. Journal of chemical neuroanatomy, 1988.
• Kowall NW, Ferrante RJ, Beal MF, Richardson EP, Sofroniew MV, Cuello AC, Martin JB. Neuropeptide Y, somatostatin, and reduced nicotinamide adenine dinucleotide phosphate diaphorase in the human striatum: a combined immunocytochemical and enzyme histochemical study.. Neuroscience, 1987.
• Morris R, Salt TE, Sofroniew MV, Hill RG. Actions of microiontophoretically applied oxytocin, and immunohistochemical localization of oxytocin, vasopressin and neurophysin in the rat caudal medulla.. Neuroscience letters, 1980.