Nigel Maidment, Ph.D.

Professor, Psychiatry and Biobehavioral Sciences Hatos Center for Neuropharmacology Member, Brain Research Institute Center for Neurodegenerative Disease Studies Neuroscience GPB Home Area

nmaidmen@ucla.edu

(310) 206-7767

Laboratory
MRL Building
Los Angeles, CA 90095
UNITED STATES

Office
MRL Building, Room 2770
675 Charles Young Drive So.
Los Angeles, CA 90095
UNITED STATES

Website

Biography

Professor Maidment received B.Sc., M.Sc. and Ph.D. degrees from the Universities of Reading, Southampton and Nottingham, U.K. His doctorate work was on in vivo voltammetry and microdialysis studies of the action of antipsychotic drugs on dopamine transmission in the laboratory of Prof. Charles Marsden. He received post-doctoral training at Stanford University in the laboratory of Prof. Jack Barchas where he developed microdialysis-radioimmunoassy procedures for studying neuropeptide transmission in the limbic system, joining the UCLA faculty in 1990.

Publications

Videlock EJ, Hatami A, Zhu C, Kawaguchi R, Chen H, Khan T, Yehya AHS, Stiles L, Joshi S, Hoffman JM, Law KM, Rankin CR, Chang L, Maidment NT, John V, Geschwind DH, Pothoulakis C. Distinct Patterns of Gene Expression Changes in the Colon and Striatum of Young Mice Overexpressing Alpha-Synuclein Support Parkinson's Disease as a Multi-System Process.. Journal of Parkinson's disease, 2023.
Lindberg I, Shu Z, Lam H, Helwig M, Yucer N, Laperle A, Svendsen CN, Di Monte DA, Maidment NT. The proSAAS Chaperone Provides Neuroprotection and Attenuates Transsynaptic α-Synuclein Spread in Rodent Models of Parkinson's Disease.. Journal of Parkinson's disease, 2022.
McGregor R, Wu MF, Holmes B, Lam HA, Maidment NT, Gera J, Yamanaka A, Siegel JM. Hypocretin/Orexin Interactions with Norepinephrine Contribute to the Opiate Withdrawal Syndrome.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021.
Marshall AT, Munson CN, Maidment NT, Ostlund SB. Reward-predictive cues elicit excessive reward seeking in adolescent rats.. Developmental cognitive neuroscience, 2020.
Wang B, Wen X, Cao Y, Huang S, Lam HA, Liu TL, Chung PS, Monbouquette HG, Chiou PY, Maidment NT. An implantable multifunctional neural microprobe for simultaneous multi-analyte sensing and chemical delivery.. Lab on a chip, 2020.
Laperle AH, Sances S, Yucer N, Dardov VJ, Garcia VJ, Ho R, Fulton AN, Jones MR, Roxas KM, Avalos P, West D, Banuelos MG, Shu Z, Murali R, Maidment NT, Van Eyk JE, Tagliati M, Svendsen CN. iPSC modeling of young-onset Parkinson's disease reveals a molecular signature of disease and novel therapeutic candidates.. Nature medicine, 2020.
Wen X, Wang B, Huang S, Liu TL, Lee MS, Chung PS, Chow YT, Huang IW, Monbouquette HG, Maidment NT, Chiou PY. Flexible, multifunctional neural probe with liquid metal enabled, ultra-large tunable stiffness for deep-brain chemical sensing and agent delivery.. Biosensors & bioelectronics, 2019.
Kosheleff AR, Araki J, Tsan L, Chen G, Murphy NP, Maidment NT, Ostlund SB. Junk Food Exposure Disrupts Selection of Food-Seeking Actions in Rats.. Frontiers in psychiatry, 2018.
Kosheleff AR, Araki J, Hsueh J, Le A, Quizon K, Ostlund SB, Maidment NT, Murphy NP. Pattern of access determines influence of junk food diet on cue sensitivity and palatability.. Appetite, 2017.
Marshall AT, Liu AT, Murphy NP, Maidment NT, Ostlund SB. Sex-specific enhancement of palatability-driven feeding in adolescent rats.. PloS one, 2017.
Richter F, Gabby L, McDowell KA, Mulligan CK, De La Rosa K, Sioshansi PC, Mortazavi F, Cely I, Ackerson LC, Tsan L, Murphy NP, Maidment NT, Chesselet MF. Effects of decreased dopamine transporter levels on nigrostriatal neurons and paraquat/maneb toxicity in mice.. Neurobiology of aging, 2016.
Ostlund SB, Liu AT, Wassum KM, Maidment NT. Modulation of cue-triggered reward seeking by cholinergic signaling in the dorsomedial striatum.. The European journal of neuroscience, 2016.
Mendez IA, Maidment NT, Murphy NP. Parsing the hedonic and motivational influences of nociceptin on feeding using licking microstructure analysis in mice.. Behavioural pharmacology, 2016.
Jarvela TS, Lam HA, Helwig M, Lorenzen N, Otzen DE, McLean PJ, Maidment NT, Lindberg I. The neural chaperone proSAAS blocks α-synuclein fibrillation and neurotoxicity.. Proceedings of the National Academy of Sciences of the United States of America, 2016.
Mendez IA, Ostlund SB, Maidment NT, Murphy NP. Involvement of Endogenous Enkephalins and β-Endorphin in Feeding and Diet-Induced Obesity.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015.
Peñagarikano O, Lázaro MT, Lu XH, Gordon A, Dong H, Lam HA, Peles E, Maidment NT, Murphy NP, Yang XW, Golshani P, Geschwind DH. Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism.. Science translational medicine, 2015.
Wassum KM, Greenfield VY, Linker KE, Maidment NT, Ostlund SB. Inflated reward value in early opiate withdrawal.. Addiction biology, 2014.
Grygoruk A, Chen A, Martin CA, Lawal HO, Fei H, Gutierrez G, Biedermann T, Najibi R, Hadi R, Chouhan AK, Murphy NP, Schweizer FE, Macleod GT, Maidment NT, Krantz DE. The redistribution of Drosophila vesicular monoamine transporter mutants from synaptic vesicles to large dense-core vesicles impairs amine-dependent behaviors.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014.
Ostlund SB, LeBlanc KH, Kosheleff AR, Wassum KM, Maidment NT. Phasic mesolimbic dopamine signaling encodes the facilitation of incentive motivation produced by repeated cocaine exposure.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014.
Cui Y, Ostlund SB, James AS, Park CS, Ge W, Roberts KW, Mittal N, Murphy NP, Cepeda C, Kieffer BL, Levine MS, Jentsch JD, Walwyn WM, Sun YE, Evans CJ, Maidment NT, Yang XW. Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward.. Nature neuroscience, 2014.
Ostlund SB, Kosheleff AR, Maidment NT. Differential effects of systemic cholinergic receptor blockade on Pavlovian incentive motivation and goal-directed action selection.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013.
LeBlanc KH, Maidment NT, Ostlund SB. Impact of repeated intravenous cocaine administration on incentive motivation depends on mode of drug delivery.. Addiction biology, 2013.
LeBlanc KH, Maidment NT, Ostlund SB. Repeated cocaine exposure facilitates the expression of incentive motivation and induces habitual control in rats.. PloS one, 2013.
Ostlund SB, Kosheleff A, Maidment NT, Murphy NP. Decreased consumption of sweet fluids in μ opioid receptor knockout mice: a microstructural analysis of licking behavior.. Psychopharmacology, 2013.
Wassum KM, Ostlund SB, Loewinger GC, Maidment NT. Phasic mesolimbic dopamine release tracks reward seeking during expression of Pavlovian-to-instrumental transfer.. Biological psychiatry, 2013.
Blouin AM, Fried I, Wilson CL, Staba RJ, Behnke EJ, Lam HA, Maidment NT, Karlsson KÆ, Lapierre JL, Siegel JM. Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction.. Nature communications, 2013.
Fitzmaurice AG, Rhodes SL, Lulla A, Murphy NP, Lam HA, O'Donnell KC, Barnhill L, Casida JE, Cockburn M, Sagasti A, Stahl MC, Maidment NT, Ritz B, Bronstein JM. Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease.. Proceedings of the National Academy of Sciences of the United States of America, 2012.
Lawal HO, Terrell A, Lam HA, Djapri C, Jang J, Hadi R, Roberts L, Shahi V, Chou MT, Biedermann T, Huang B, Lawless GM, Maidment NT, Krantz DE. Drosophila modifier screens to identify novel neuropsychiatric drugs including aminergic agents for the possible treatment of Parkinson's disease and depression.. Molecular psychiatry, 2012.
Tolosa VM, Wassum KM, Maidment NT, Monbouquette HG. Electrochemically deposited iridium oxide reference electrode integrated with an electroenzymatic glutamate sensor on a multi-electrode array microprobe.. Biosensors & bioelectronics, 2012.
Chen A, Ng F, Lebestky T, Grygoruk A, Djapri C, Lawal HO, Zaveri HA, Mehanzel F, Najibi R, Seidman G, Murphy NP, Kelly RL, Ackerson LC, Maidment NT, Jackson FR, Krantz DE. Dispensable, redundant, complementary, and cooperative roles of dopamine, octopamine, and serotonin in Drosophila melanogaster.. Genetics, 2012.
LeBlanc KH, Ostlund SB, Maidment NT. Pavlovian-to-instrumental transfer in cocaine seeking rats.. Behavioral neuroscience, 2012.
Ostlund SB, Kosheleff AR, Maidment NT. Relative response cost determines the sensitivity of instrumental reward seeking to dopamine receptor blockade.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012.
Wang L, Murphy NP, Stengel A, Goebel-Stengel M, St Pierre DH, Maidment NT, Taché Y. Ghrelin prevents levodopa-induced inhibition of gastric emptying and increases circulating levodopa in fasted rats.. Neurogastroenterology and motility, 2012.
Wassum KM, Tolosa VM, Tseng TC, Balleine BW, Monbouquette HG, Maidment NT. Transient extracellular glutamate events in the basolateral amygdala track reward-seeking actions.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012.
Wassum KM, Ostlund SB, Maidment NT. Phasic mesolimbic dopamine signaling precedes and predicts performance of a self-initiated action sequence task.. Biological psychiatry, 2012.
Laurent V, Leung B, Maidment N, Balleine BW. μ- and δ-opioid-related processes in the accumbens core and shell differentially mediate the influence of reward-guided and stimulus-guided decisions on choice.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012.
Ostlund SB, Maidment NT. Dopamine receptor blockade attenuates the general incentive motivational effects of noncontingently delivered rewards and reward-paired cues without affecting their ability to bias action selection.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011.
Remage-Healey L, Dong S, Maidment NT, Schlinger BA. Presynaptic control of rapid estrogen fluctuations in the songbird auditory forebrain.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011.
Wassum KM, Ostlund SB, Balleine BW, Maidment NT. Differential dependence of Pavlovian incentive motivation and instrumental incentive learning processes on dopamine signaling.. Learning & memory (Cold Spring Harbor, N.Y.), 2011.
Wu MF, Nienhuis R, Maidment N, Lam HA, Siegel JM. Role of the hypocretin (orexin) receptor 2 (Hcrt-r2) in the regulation of hypocretin level and cataplexy.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011.
Lam H, Maga M, Pradhan A, Evans CJ, Maidment NT, Hales TG, Walwyn W. Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking β-arrestin 2.. Molecular pain, 2011.
Lam HA, Wu N, Cely I, Kelly RL, Hean S, Richter F, Magen I, Cepeda C, Ackerson LC, Walwyn W, Masliah E, Chesselet MF, Levine MS, Maidment NT. Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α-synuclein.. Journal of neuroscience research, 2011.
Wassum KM, Cely IC, Balleine BW, Maidment NT. Micro-opioid receptor activation in the basolateral amygdala mediates the learning of increases but not decreases in the incentive value of a food reward.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011.
Ostlund SB, Wassum KM, Murphy NP, Balleine BW, Maidment NT. Extracellular dopamine levels in striatal subregions track shifts in motivation and response cost during instrumental conditioning.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011.
Ostlund SB, Maidment NT, Balleine BW. Alcohol-Paired Contextual Cues Produce an Immediate and Selective Loss of Goal-directed Action in Rats.. Frontiers in integrative neuroscience, 2010.
Fei H, Chow DM, Chen A, Romero-Calderón R, Ong WS, Ackerson LC, Maidment NT, Simpson JH, Frye MA, Krantz DE. Mutation of the Drosophila vesicular GABA transporter disrupts visual figure detection.. The Journal of experimental biology, 2010.
Wassum KM, Cely IC, Maidment NT, Balleine BW. Disruption of endogenous opioid activity during instrumental learning enhances habit acquisition.. Neuroscience, 2009.
Wassum KM, Ostlund SB, Maidment NT, Balleine BW. Distinct opioid circuits determine the palatability and the desirability of rewarding events.. Proceedings of the National Academy of Sciences of the United States of America, 2009.
Lu XH, Fleming SM, Meurers B, Ackerson LC, Mortazavi F, Lo V, Hernandez D, Sulzer D, Jackson GR, Maidment NT, Chesselet MF, Yang XW. Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009.
Simon AF, Daniels R, Romero-Calderón R, Grygoruk A, Chang HY, Najibi R, Shamouelian D, Salazar E, Solomon M, Ackerson LC, Maidment NT, Diantonio A, Krantz DE. Drosophila vesicular monoamine transporter mutants can adapt to reduced or eliminated vesicular stores of dopamine and serotonin.. Genetics, 2008.
Romero-Calderón R, Uhlenbrock G, Borycz J, Simon AF, Grygoruk A, Yee SK, Shyer A, Ackerson LC, Maidment NT, Meinertzhagen IA, Hovemann BT, Krantz DE. A glial variant of the vesicular monoamine transporter is required to store histamine in the Drosophila visual system.. PLoS genetics, 2008.
Remage-Healey L, Maidment NT, Schlinger BA. Forebrain steroid levels fluctuate rapidly during social interactions.. Nature neuroscience, 2008.
Chou AP, Maidment N, Klintenberg R, Casida JE, Li S, Fitzmaurice AG, Fernagut PO, Mortazavi F, Chesselet MF, Bronstein JM. Ziram causes dopaminergic cell damage by inhibiting E1 ligase of the proteasome.. The Journal of biological chemistry, 2008.
Wassum KM, Tolosa VM, Wang J, Walker E, Monbouquette HG, Maidment NT. Silicon Wafer-Based Platinum Microelectrode Array Biosensor for Near Real-Time Measurement of Glutamate in Vivo.. Sensors (Basel, Switzerland), 2008.
Shoblock JR, Maidment NT. Enkephalin release promotes homeostatic increases in constitutively active mu opioid receptors during morphine withdrawal.. Neuroscience, 2007.
Walker E, Wang J, Hamdi N, Monbouquette HG, Maidment NT. Selective detection of extracellular glutamate in brain tissue using microelectrode arrays coated with over-oxidized polypyrrole.. The Analyst, 2007.
Kliem MA, Maidment NT, Ackerson LC, Chen S, Smith Y, Wichmann T. Activation of nigral and pallidal dopamine D1-like receptors modulates basal ganglia outflow in monkeys.. Journal of neurophysiology, 2007.
Sang TK, Chang HY, Lawless GM, Ratnaparkhi A, Mee L, Ackerson LC, Maidment NT, Krantz DE, Jackson GR. A Drosophila model of mutant human parkin-induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007.
Walwyn WM, Wei W, Xie CW, Chiu K, Kieffer BL, Evans CJ, Maidment NT. Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neurons.. Neuroscience, 2006.
Zeitzer JM, Morales-Villagran A, Maidment NT, Behnke EJ, Ackerson LC, Lopez-Rodriguez F, Fried I, Engel J, Wilson CL. Extracellular adenosine in the human brain during sleep and sleep deprivation: an in vivo microdialysis study.. Sleep, 2006.
Walwyn WM, Matsuka Y, Arai D, Bloom DC, Lam H, Tran C, Spigelman I, Maidment NT. HSV-1-mediated NGF delivery delays nociceptive deficits in a genetic model of diabetic neuropathy.. Experimental neurology, 2006.
Phillips JM, Lam HA, Ackerson LC, Maidment NT. Blockade of mGluR glutamate receptors in the subthalamic nucleus ameliorates motor asymmetry in an animal model of Parkinson's disease.. The European journal of neuroscience, 2006.
Shoblock JR, Maidment NT. Constitutively active micro opioid receptors mediate the enhanced conditioned aversive effect of naloxone in morphine-dependent mice.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006.
Chang HY, Grygoruk A, Brooks ES, Ackerson LC, Maidment NT, Bainton RJ, Krantz DE. Overexpression of the Drosophila vesicular monoamine transporter increases motor activity and courtship but decreases the behavioral response to cocaine.. Molecular psychiatry, 2006.
Shoblock JR, Wichmann J, Maidment NT. The effect of a systemically active ORL-1 agonist, Ro 64-6198, on the acquisition, expression, extinction, and reinstatement of morphine conditioned place preference.. Neuropharmacology, 2005.
Walwyn W, Maidment NT, Sanders M, Evans CJ, Kieffer BL, Hales TG. Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons.. Molecular pharmacology, 2005.
Galvan A, Villalba RM, West SM, Maidment NT, Ackerson LC, Smith Y, Wichmann T. GABAergic modulation of the activity of globus pallidus neurons in primates: in vivo analysis of the functions of GABA receptors and GABA transporters.. Journal of neurophysiology, 2005.
Skoubis PD, Lam HA, Shoblock J, Narayanan S, Maidment NT. Endogenous enkephalins, not endorphins, modulate basal hedonic state in mice.. The European journal of neuroscience, 2005.
John J, Wu MF, Maidment NT, Lam HA, Boehmer LN, Patton M, Siegel JM. Developmental changes in CSF hypocretin-1 (orexin-A) levels in normal and genetically narcoleptic Doberman pinschers.. The Journal of physiology, 2004.
West AB, Kapatos G, O'Farrell C, Gonzalez-de-Chavez F, Chiu K, Farrer MJ, Maidment NT. N-myc regulates parkin expression.. The Journal of biological chemistry, 2004.
West AB, Maidment NT. Genetics of parkin-linked disease.. Human genetics, 2004.
Narayanan S, Lam H, Christian L, Levine MS, Grandy D, Rubinstein M, Maidment NT. Endogenous opioids mediate basal hedonic tone independent of dopamine D-1 or D-2 receptor activation.. Neuroscience, 2004.
Walwyn WM, Keith DE, Wei W, Tan AM, Xie CW, Evans CJ, Kieffer BL, Maidment NT. Functional coupling, desensitization and internalization of virally expressed mu opioid receptors in cultured dorsal root ganglion neurons from mu opioid receptor knockout mice.. Neuroscience, 2004.
Murphy NP, Tan AM, Lam HA, Maidment NT. Nociceptin/orphanin FQ modulation of rat midbrain dopamine neurons in primary culture.. Neuroscience, 2004.
Lutfy K, Eitan S, Bryant CD, Yang YC, Saliminejad N, Walwyn W, Kieffer BL, Takeshima H, Carroll FI, Maidment NT, Evans CJ. Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003.
Goldberg MS, Fleming SM, Palacino JJ, Cepeda C, Lam HA, Bhatnagar A, Meloni EG, Wu N, Ackerson LC, Klapstein GJ, Gajendiran M, Roth BL, Chesselet MF, Maidment NT, Levine MS, Shen J. Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons.. The Journal of biological chemistry, 2003.
Skoubis PD, Maidment NT. Blockade of ventral pallidal opioid receptors induces a conditioned place aversion and attenuates acquisition of cocaine place preference in the rat.. Neuroscience, 2003.
Lopez-Rodriguez F, Wilson CL, Maidment NT, Poland RE, Engel J. Total sleep deprivation increases extracellular serotonin in the rat hippocampus.. Neuroscience, 2003.
Murphy NP, Lam HA, Chen Z, Pintar JE, Maidment NT. Heroin-induced locomotion and mesolimbic dopamine release is unchanged in mice lacking the ORL.1 receptor gene.. Brain research, 2002.
Lutfy K, Khaliq I, Carroll FI, Maidment NT. Orphanin FQ/nociceptin blocks cocaine-induced behavioral sensitization in rats.. Psychopharmacology, 2002.
Maidment NT, Chen Y, Tan AM, Murphy NP, Leslie FM. Rat ventral midbrain dopamine neurons express the orphanin FQ/nociceptin receptor ORL-1.. Neuroreport, 2002.
Kiyashchenko LI, Mileykovskiy BY, Maidment N, Lam HA, Wu MF, John J, Peever J, Siegel JM. Release of hypocretin (orexin) during waking and sleep states.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002.
Lutfy K, Maidment NT. Sensitization does not develop to cocaine-induced potentiation of the antinociceptive effect of morphine.. Brain research bulletin, 2002.
Narayanan S, Lutfy K, Maidment N. Sensitization to cocaine after a single intra-cerebral injection of orphanin FQ/nociceptin.. Behavioural brain research, 2002.
Murphy NP, Lam HA, Maidment NT. A comparison of morphine-induced locomotor activity and mesolimbic dopamine release in C57BL6, 129Sv and DBA2 mice.. Journal of neurochemistry, 2001.
Lutfy K, Hossain SM, Khaliq I, Maidment NT. Orphanin FQ/nociceptin attenuates the development of morphine tolerance in rats.. British journal of pharmacology, 2001.
Fried I, Wilson CL, Morrow JW, Cameron KA, Behnke ED, Ackerson LC, Maidment NT. Increased dopamine release in the human amygdala during performance of cognitive tasks.. Nature neuroscience, 2001.
Lutfy K, Do T, Maidment NT. Orphanin FQ/nociceptin attenuates motor stimulation and changes in nucleus accumbens extracellular dopamine induced by cocaine in rats.. Psychopharmacology, 2001.
Lutfy K, Maidment NT. Blockade of mu-opioid receptors reveals the hyperalgesic effect of orphanin FQ/nociceptin in the rat hot plate test.. British journal of pharmacology, 2000.
Neubert JK, Maidment NT, Matsuka Y, Adelson DW, Kruger L, Spigelman I. Inflammation-induced changes in primary afferent-evoked release of substance P within trigeminal ganglia in vivo.. Brain research, 2000.
Rocha L, Cano A, Cruz C, Omaña-Zapata I, Villalobos R, Maidment NT. Opioid peptide systems following a subconvulsant dose of pentylenetetrazol in rats.. Epilepsy research, 1999.
Fried I, Wilson CL, Maidment NT, Engel J, Behnke E, Fields TA, MacDonald KA, Morrow JW, Ackerson L. Cerebral microdialysis combined with single-neuron and electroencephalographic recording in neurosurgical patients. Technical note.. Journal of neurosurgery, 1999.
Walwyn WM, Ta-Haung J, Ackerson L, Maidment NT, Edgerton VR. Extracellular glutamate in the dorsal horn of the lumbar spinal cord in the freely moving rat during hindlimb stepping.. Pharmacology, biochemistry, and behavior, 1999.
Murphy NP, Maidment NT. Orphanin FQ/nociceptin modulation of mesolimbic dopamine transmission determined by microdialysis.. Journal of neurochemistry, 1999.
Murphy NP, Lee Y, Maidment NT. Orphanin FQ/nociceptin blocks acquisition of morphine place preference.. Brain research, 1999.
Narayanan S, Maidment NT. Orphanin FQ and behavioral sensitization to cocaine.. Pharmacology, biochemistry, and behavior, 1999.
Rocha L, Ondarza-Rovira R, Maidment NT. Gabapentin modifies extracellular opioid peptide content in amygdala: a microdialysis study.. Epilepsy research, 1999.
Lutfy K, Sharza SA, Maidment NT. Tolerance develops to the inhibitory effect of orphanin FQ on morphine-induced antinociception in the rat.. Neuroreport, 1999.
Olive MF, Maidment NT. Repeated heroin administration increases extracellular opioid peptide-like immunoreactivity in the globus pallidus/ventral pallidum of freely moving rats.. Psychopharmacology, 1998.
Olive MF, Maidment NT. Opioid regulation of pallidal enkephalin release: bimodal effects of locally administered mu and delta opioid agonists in freely moving rats.. The Journal of pharmacology and experimental therapeutics, 1998.
King BH, Cromwell HC, Lee HT, Behrstock SP, Schmanke T, Maidment NT. Dopaminergic and glutamatergic interactions in the expression of self-injurious behavior.. Developmental neuroscience, 1998.
Olive MF, Anton B, Micevych P, Evans CJ, Maidment NT. Presynaptic versus postsynaptic localization of mu and delta opioid receptors in dorsal and ventral striatopallidal pathways.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997.
Maidment NT, Villafranca NP. Persistence of the releasable pool of CCK in the rat nucleus accumbens and caudate-putamen following lesions of the midbrain.. Brain research, 1997.
Rocha LL, Evans CJ, Maidment NT. Amygdala kindling modifies extracellular opioid peptide content in rat hippocampus measured by microdialysis.. Journal of neurochemistry, 1997.
Bergasa NV, Mohajer B, Maisonneuve IM, Ho A, Maidment NT, Olive F, Gunduz M, Kreek MJ. Basal total opioid peptide release in the striatum of rats with cholestasis from bile duct resection: a study by the use of in vivo microdialysis.. Life sciences, 1997.
Wilson CL, Maidment NT, Shomer MH, Behnke EJ, Ackerson L, Fried I, Engel J. Comparison of seizure related amino acid release in human epileptic hippocampus versus a chronic, kainate rat model of hippocampal epilepsy.. Epilepsy research, 1996.
Rocha L, Briones M, Ackermann RF, Anton B, Maidment NT, Evans CJ, Engel J. Pentylenetetrazol-induced kindling: early involvement of excitatory and inhibitory systems.. Epilepsy research, 1996.
Murphy NP, Ly HT, Maidment NT. Intracerebroventricular orphanin FQ/nociceptin suppresses dopamine release in the nucleus accumbens of anaesthetized rats.. Neuroscience, 1996.
Maidment NT, Tan AM, Bloom DC, Anton B, Feldman LT, Stevens JG. Expression of the lacZ reporter gene in the rat basal forebrain, hippocampus, and nigrostriatal pathway using a nonreplicating herpes simplex vector.. Experimental neurology, 1996.
Cromwell HC, Witte EA, Crawford CA, Ly HT, Maidment NT, King BH. Pemoline produces ipsilateral turning behavior in unilateral 6-OHDA-lesioned rats.. Progress in neuro-psychopharmacology & biological psychiatry, 1996.
Rocha L, Maidment NT, Evans CJ, Ackermann RF, Engel J. Opioid peptide release and mu-receptor binding during amygdala kindling in rats: regional discordances.. Epilepsy research. Supplement, 1996.
Bloom DC, Maidment NT, Tan A, Dissette VB, Feldman LT, Stevens JG. Long-term expression of a reporter gene from latent herpes simplex virus in the rat hippocampus.. Brain research. Molecular brain research, 1995.
Olive MF, Bertolucci M, Evans CJ, Maidment NT. Microdialysis reveals a morphine-induced increase in pallidal opioid peptide release.. Neuroreport, 1995.
Rocha L, Maidment NT, Evans CJ, Ackermann RF, Engel J. Microdialysis reveals changes in extracellular opioid peptide levels in the amygdala induced by amygdaloid kindling stimulation.. Experimental neurology, 1994.
Sulzer D, Maidment NT, Rayport S. Amphetamine and other weak bases act to promote reverse transport of dopamine in ventral midbrain neurons.. Journal of neurochemistry, 1993.
Sulzer D, Pothos E, Sung HM, Maidment NT, Hoebel BG, Rayport S. Weak base model of amphetamine action.. Annals of the New York Academy of Sciences, 1992.
Maidment NT, Siddall B, Rudolph VD, Evans CJ. Postmortem changes in rat brain extracellular opioid peptides revealed by microdialysis.. Journal of neurochemistry, 1991.
Maidment NT, Siddall BJ, Rudolph VR, Erdelyi E, Evans CJ. Dual determination of extracellular cholecystokinin and neurotensin fragments in rat forebrain: microdialysis combined with a sequential multiple antigen radioimmunoassay.. Neuroscience, 1991.
Gonzalez-Mora JL, Maidment NT, Guadalupe T, Mas M. Post-mortem dopamine dynamics assessed by voltammetry and microdialysis.. Brain research bulletin, 1989.
Maidment NT, Brumbaugh DR, Rudolph VD, Erdelyi E, Evans CJ. Microdialysis of extracellular endogenous opioid peptides from rat brain in vivo.. Neuroscience, 1989.
Yeomans JS, Maidment NT, Bunney BS. Excitability properties of medial forebrain bundle axons of A9 and A10 dopamine cells.. Brain research, 1988.
Maidment NT, Marsden CA. Acute administration of clozapine, thioridazine and metoclopramide increases extracellular DOPAC and decreases extracellular 5-HIAA, measured in the nucleus accumbens and striatum of the rat using in vivo voltammetry.. Neuropharmacology, 1987.
Maidment NT, Marsden CA. In vivo voltammetric and behavioural evidence for somatodendritic autoreceptor control of mesolimbic dopamine neurones.. Brain research, 1985.
Crespi F, Sharp T, Maidment NT, Marsden CA. Differential pulse voltammetry: simultaneous in vivo measurement of ascorbic acid, catechols and 5-hydroxyindoles in the rat striatum.. Brain research, 1984.