
Riccardo Olcese, Ph.D.
Professor, Anesthesiology Physiology Member, Molecular Medicine Biochemistry, Biophysics & Structural Biology GPB Home Area Brain Research Institute Molecular, Cellular & Integrative Physiology GPB Home Area Neuroscience GPB Home Area Faculty, Cardiovascular Research Laboratory
rolcese@ucla.edu
310-206-2214
Office
100 Jules Stein Plaza
Division of Molecular Medicine
Dept. of Anesthesiology and Perioperative Medicine
Los Angeles, CA 90095
UNITED STATES
Work Address:
Laboratory
CHS
Los Angeles, CA 90095
UNITED STATES
Publications
- Wang K, Nilsson M, Angelini M, Olcese R, Elinder F, Pantazis A. A Rich Conformational Palette Underlies Human CaV2.1-Channel Availability.. bioRxiv : the preprint server for biology, 2024.
- Nilsson M, Wang K, Mínguez-Viñas T, Angelini M, Berglund S, Olcese R, Pantazis A. Voltage-dependent G-protein regulation of CaV2.2 (N-type) channels.. Science advances, 2024.
- Nilsson M, Wang K, Mínguez-Viñas T, Angelini M, Berglund S, Olcese R, Pantazis A. Electrical and G-protein Regulation of CaV2.2 (N-type) Channels.. bioRxiv : the preprint server for biology, 2024.
- Fischer MA, Arrieta A, Angelini M, Soehalim E, Chapski DJ, Shemin RJ, Vondriska TM, Olcese R. Decreased Left Atrial Cardiomyocyte Fibroblast Growth Factor 13 Expression Increases Vulnerability to Postoperative Atrial Fibrillation in Humans.. Journal of the American Heart Association, 2024.
- Scranton K, John S, Angelini M, Steccanella F, Umar S, Zhang R, Goldhaber JI, Olcese R, Ottolia M. Cardiac function is regulated by the sodium-dependent inhibition of the sodium-calcium exchanger NCX1.. Nature communications, 2024.
- Fischer MA, Arrieta A, Angelini M, Soehalim E, Chapski DJ, Shemin RJ, Vondriska TM, Olcese R. Decreased Left Atrial Cardiomyocyte FGF13 Expression Increases Vulnerability to Postoperative Atrial Fibrillation in Humans.. bioRxiv : the preprint server for biology, 2024.
- Wang Y, Li Q, Tao B, Angelini M, Ramadoss S, Sun B, Wang P, Krokhaleva Y, Ma F, Gu Y, Espinoza A, Yamauchi K, Pellegrini M, Novitch B, Olcese R, Qu Z, Song Z, Deb A. Fibroblasts in heart scar tissue directly regulate cardiac excitability and arrhythmogenesis.. Science (New York, N.Y.), 2023.
- Servettini I, Talani G, Megaro A, Setzu MD, Biggio F, Briffa M, Guglielmi L, Savalli N, Binda F, Delicata F, Bru-Mercier G, Vassallo N, Maglione V, Cauchi RJ, Di Pardo A, Collu M, Imbrici P, Catacuzzeno L, D'Adamo MC, Olcese R, Pessia M. An activator of voltage-gated K+ channels Kv1.1 as a therapeutic candidate for episodic ataxia type 1.. Proceedings of the National Academy of Sciences of the United States of America, 2023.
- Medzikovic L, Aryan L, Ruffenach G, Li M, Savalli N, Sun W, Sarji S, Hong J, Sharma S, Olcese R, Fishbein G, Eghbali M. Myocardial fibrosis and calcification are attenuated by microRNA-129-5p targeting Asporin and Sox9 in cardiac fibroblasts.. JCI insight, 2023.
- Zyrianova T, Zou K, Lopez B, Liao A, Gu C, Olcese R, Schwingshackl A. Activation of Endothelial Large Conductance Potassium Channels Protects against TNF-α-Induced Inflammation.. International journal of molecular sciences, 2023.
- Zyrianova T, Lopez B, Zou K, Gu C, Pham D, Talapaneni S, Waters CM, Olcese R, Schwingshackl A. Activation of TREK-1 (K2P2.1) potassium channels protects against influenza A-induced lung injury.. American journal of physiology. Lung cellular and molecular physiology, 2022.
- Nilsson M, Lindström SH, Kaneko M, Wang K, Minguez-Viñas T, Angelini M, Steccanella F, Holder D, Ottolia M, Olcese R, Pantazis A. An epilepsy-associated KV1.2 charge-transfer-center mutation impairs KV1.2 and KV1.4 trafficking.. Proceedings of the National Academy of Sciences of the United States of America, 2022.
- Qu Z, Liu MB, Olcese R, Karagueuzian H, Garfinkel A, Chen PS, Weiss JN. R-on-T and the initiation of reentry revisited: Integrating old and new concepts.. Heart rhythm, 2022.
- Angelini M, Pezhouman A, Savalli N, Chang MG, Steccanella F, Scranton K, Calmettes G, Ottolia M, Pantazis A, Karagueuzian HS, Weiss JN, Olcese R. Suppression of ventricular arrhythmias by targeting late L-type Ca2+ current.. The Journal of general physiology, 2021.
- Savalli N, Angelini M, Steccanella F, Wier J, Wu F, Quinonez M, DiFranco M, Neely A, Cannon SC, Olcese R. The distinct role of the four voltage sensors of the skeletal CaV1.1 channel in voltage-dependent activation.. The Journal of general physiology, 2021.
- Zyrianova T, Lopez B, Liao A, Gu C, Wong L, Ottolia M, Olcese R, Schwingshackl A. BK Channels Regulate LPS-induced CCL-2 Release from Human Pulmonary Endothelial Cells.. American journal of respiratory cell and molecular biology, 2021.
- Zyrianova T, Lopez B, Olcese R, Belperio J, Waters CM, Wong L, Nguyen V, Talapaneni S, Schwingshackl A. K2P2.1 (TREK-1) potassium channel activation protects against hyperoxia-induced lung injury.. Scientific reports, 2020.
- Pantazis A, Kaneko M, Angelini M, Steccanella F, Westerlund AM, Lindström SH, Nilsson M, Delemotte L, Saitta SC, Olcese R. Tracking the motion of the KV1.2 voltage sensor reveals the molecular perturbations caused by a de novo mutation in a case of epilepsy.. The Journal of physiology, 2020.
- Landaw J, Zhang Z, Song Z, Liu MB, Olcese R, Chen PS, Weiss JN, Qu Z. Small-conductance Ca2+-activated K+ channels promote J-wave syndrome and phase 2 reentry.. Heart rhythm, 2020.
- Seki S, Yamamoto T, Quinn K, Spigelman I, Pantazis A, Olcese R, Wiedau-Pazos M, Chandler SH, Venugopal S. Circuit-Specific Early Impairment of Proprioceptive Sensory Neurons in the SOD1G93A Mouse Model for ALS.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019.
- Balderas E, Torres NS, Rosa-Garrido M, Chaudhuri D, Toro L, Stefani E, Olcese R. MitoBKCa channel is functionally associated with its regulatory β1 subunit in cardiac mitochondria.. The Journal of physiology, 2019.
- Venugopal S, Seki S, Terman DH, Pantazis A, Olcese R, Wiedau-Pazos M, Chandler SH. Resurgent Na+ Current Offers Noise Modulation in Bursting Neurons.. PLoS computational biology, 2019.
- Pantazis A, Westerberg K, Althoff T, Abramson J, Olcese R. Harnessing photoinduced electron transfer to optically determine protein sub-nanoscale atomic distances.. Nature communications, 2018.
- Olcese R, Silvestri M, Del Barba P, Brolatti N, Barberi S, Tosca MA, Ciprandi G. Mal d 1 and Bet v 1 sensitization pattern in children with Pollen Food Syndrome.. Allergology international : official journal of the Japanese Society of Allergology, 2018.
- John S, Kim B, Olcese R, Goldhaber JI, Ottolia M. Molecular determinants of pH regulation in the cardiac Na+-Ca2+ exchanger.. The Journal of general physiology, 2018.
- Schwingshackl A, Lopez B, Teng B, Luellen C, Lesage F, Belperio J, Olcese R, Waters CM. Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins.. American journal of physiology. Lung cellular and molecular physiology, 2017.
- Karagueuzian HS, Pezhouman A, Angelini M, Olcese R. Enhanced Late Na and Ca Currents as Effective Antiarrhythmic Drug Targets.. Frontiers in pharmacology, 2017.
- Zhang J, Li M, Zhang Z, Zhu R, Olcese R, Stefani E, Toro L. The mitochondrial BKCa channel cardiac interactome reveals BKCa association with the mitochondrial import receptor subunit Tom22, and the adenine nucleotide translocator.. Mitochondrion, 2016.
- Savalli N, Pantazis A, Sigg D, Weiss JN, Neely A, Olcese R. The α2δ-1 subunit remodels CaV1.2 voltage sensors and allows Ca2+ influx at physiological membrane potentials.. The Journal of general physiology, 2016.
- Pantazis A, Olcese R. Biophysics of BK Channel Gating.. International review of neurobiology, 2016.
- Prudat Y, Madhvani RV, Angelini M, Borgstom NP, Garfinkel A, Karagueuzian HS, Weiss JN, de Lange E, Olcese R, Kucera JP. Stochastic pacing reveals the propensity to cardiac action potential alternans and uncovers its underlying dynamics.. The Journal of physiology, 2016.
- Madhvani RV, Angelini M, Xie Y, Pantazis A, Suriany S, Borgstrom NP, Garfinkel A, Qu Z, Weiss JN, Olcese R. Targeting the late component of the cardiac L-type Ca2+ current to suppress early afterdepolarizations.. The Journal of general physiology, 2015.
- Weiss JN, Garfinkel A, Karagueuzian HS, Nguyen TP, Olcese R, Chen PS, Qu Z. Perspective: a dynamics-based classification of ventricular arrhythmias.. Journal of molecular and cellular cardiology, 2015.
- Pantazis A, Savalli N, Sigg D, Neely A, Olcese R. Functional heterogeneity of the four voltage sensors of a human L-type calcium channel.. Proceedings of the National Academy of Sciences of the United States of America, 2014.
- Hoshi T, Pantazis A, Olcese R. Transduction of voltage and Ca2+ signals by Slo1 BK channels.. Physiology (Bethesda, Md.), 2013.
- Qu Z, Xie LH, Olcese R, Karagueuzian HS, Chen PS, Garfinkel A, Weiss JN. Early afterdepolarizations in cardiac myocytes: beyond reduced repolarization reserve.. Cardiovascular research, 2013.
- Pantazis A, Olcese R. Relative transmembrane segment rearrangements during BK channel activation resolved by structurally assigned fluorophore-quencher pairing.. The Journal of general physiology, 2012.
- Savalli N, Pantazis A, Yusifov T, Sigg D, Olcese R. The contribution of RCK domains to human BK channel allosteric activation.. The Journal of biological chemistry, 2012.
- Madhvani RV, Xie Y, Pantazis A, Garfinkel A, Qu Z, Weiss JN, Olcese R. Shaping a new Ca²⁺ conductance to suppress early afterdepolarizations in cardiac myocytes.. The Journal of physiology, 2011.
- Olcese R. I(KACh) at the whim of a capricious M2R.. The Journal of physiology, 2011.
- Javaherian AD, Yusifov T, Pantazis A, Franklin S, Gandhi CS, Olcese R. Metal-driven operation of the human large-conductance voltage- and Ca2+-dependent potassium channel (BK) gating ring apparatus.. The Journal of biological chemistry, 2011.
- Pantazis A, Kohanteb AP, Olcese R. Relative motion of transmembrane segments S0 and S4 during voltage sensor activation in the human BK(Ca) channel.. The Journal of general physiology, 2010.
- Yusifov T, Javaherian AD, Pantazis A, Gandhi CS, Olcese R. The RCK1 domain of the human BKCa channel transduces Ca2+ binding into structural rearrangements.. The Journal of general physiology, 2010.
- Pantazis A, Gudzenko V, Savalli N, Sigg D, Olcese R. Operation of the voltage sensor of a human voltage- and Ca2+-activated K+ channel.. Proceedings of the National Academy of Sciences of the United States of America, 2010.
- Olcese R. It's spring-time for slow inactivation.. The Journal of general physiology, 2009.
- Mahajan A, Shiferaw Y, Sato D, Baher A, Olcese R, Xie LH, Yang MJ, Chen PS, Restrepo JG, Karma A, Garfinkel A, Qu Z, Weiss JN. A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates.. Biophysical journal, 2008.
- Mahajan A, Sato D, Shiferaw Y, Baher A, Xie LH, Peralta R, Olcese R, Garfinkel A, Qu Z, Weiss JN. Modifying L-type calcium current kinetics: consequences for cardiac excitation and arrhythmia dynamics.. Biophysical journal, 2008.
- Gandhi CS, Olcese R. The voltage-clamp fluorometry technique.. Methods in molecular biology (Clifton, N.J.), 2008.
- Yusifov T, Savalli N, Gandhi CS, Ottolia M, Olcese R. The RCK2 domain of the human BKCa channel is a calcium sensor.. Proceedings of the National Academy of Sciences of the United States of America, 2007.
- Savalli N, Kondratiev A, de Quintana SB, Toro L, Olcese R. Modes of operation of the BKCa channel beta2 subunit.. The Journal of general physiology, 2007.
- Olcese R. And yet it moves: conformational States of the Ca2+ channel pore.. The Journal of general physiology, 2007.
- Gudzenko V, Shiferaw Y, Savalli N, Vyas R, Weiss JN, Olcese R. Influence of channel subunit composition on L-type Ca2+ current kinetics and cardiac wave stability.. American journal of physiology. Heart and circulatory physiology, 2007.
- Savalli N, Kondratiev A, Toro L, Olcese R. Voltage-dependent conformational changes in human Ca(2+)- and voltage-activated K(+) channel, revealed by voltage-clamp fluorometry.. Proceedings of the National Academy of Sciences of the United States of America, 2006.
- Chen ZW, Chang CS, Leil TA, Olcese R, Olsen RW. GABAA receptor-associated protein regulates GABAA receptor cell-surface number in Xenopus laevis oocytes.. Molecular pharmacology, 2005.
- Haug T, Sigg D, Ciani S, Toro L, Stefani E, Olcese R. Regulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part I: Aspartate 292 modulates K+ conduction by external surface charge effect.. The Journal of general physiology, 2004.
- Haug T, Olcese R, Toro L, Stefani E. Regulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part II: Neutralization of aspartate 292 reduces long channel openings and gating current slow component.. The Journal of general physiology, 2004.
- Latorre R, Olcese R, Basso C, Gonzalez C, Munoz F, Cosmelli D, Alvarez O. Molecular coupling between voltage sensor and pore opening in the Arabidopsis inward rectifier K+ channel KAT1.. The Journal of general physiology, 2003.
- Chang CS, Olcese R, Olsen RW. A single M1 residue in the beta2 subunit alters channel gating of GABAA receptor in anesthetic modulation and direct activation.. The Journal of biological chemistry, 2003.
- Eghbali M, Olcese R, Zarei MM, Toro L, Stefani E. External pore collapse as an inactivation mechanism for Kv4.3 K+ channels.. The Journal of membrane biology, 2002.
- Helguera G, Olcese R, Song M, Toro L, Stefani E. Tissue-specific regulation of Ca(2+) channel protein expression by sex hormones.. Biochimica et biophysica acta, 2002.
- Song M, Helguera G, Eghbali M, Zhu N, Zarei MM, Olcese R, Toro L, Stefani E. Remodeling of Kv4.3 potassium channel gene expression under the control of sex hormones.. The Journal of biological chemistry, 2001.
- Olcese R, Sigg D, Latorre R, Bezanilla F, Stefani E. A conducting state with properties of a slow inactivated state in a shaker K(+) channel mutant.. The Journal of general physiology, 2001.
- Platano D, Qin N, Noceti F, Birnbaumer L, Stefani E, Olcese R. Expression of the alpha(2)delta subunit interferes with prepulse facilitation in cardiac L-type calcium channels.. Biophysical journal, 2000.
- Song M, Zhu N, Olcese R, Barila B, Toro L, Stefani E. Hormonal control of protein expression and mRNA levels of the MaxiK channel alpha subunit in myometrium.. FEBS letters, 1999.
- Qin N, Olcese R, Bransby M, Lin T, Birnbaumer L. Ca2+-induced inhibition of the cardiac Ca2+ channel depends on calmodulin.. Proceedings of the National Academy of Sciences of the United States of America, 1999.
- Birnbaumer L, Qin N, Olcese R, Tareilus E, Platano D, Costantin J, Stefani E. Structures and functions of calcium channel beta subunits.. Journal of bioenergetics and biomembranes, 1998.
- Roux MJ, Olcese R, Toro L, Bezanilla F, Stefani E. Fast inactivation in Shaker K+ channels. Properties of ionic and gating currents.. The Journal of general physiology, 1998.
- Ottolia M, Platano D, Qin N, Noceti F, Birnbaumer M, Toro L, Birnbaumer L, Stefani E, Olcese R. Functional coupling between human E-type Ca2+ channels and mu opioid receptors expressed in Xenopus oocytes.. FEBS letters, 1998.
- Qin N, Olcese R, Stefani E, Birnbaumer L. Modulation of human neuronal alpha 1E-type calcium channel by alpha 2 delta-subunit.. The American journal of physiology, 1998.
- Qin N, Platano D, Olcese R, Costantin JL, Stefani E, Birnbaumer L. Unique regulatory properties of the type 2a Ca2+ channel beta subunit caused by palmitoylation.. Proceedings of the National Academy of Sciences of the United States of America, 1998.
- Noceti F, Olcese R, Qin N, Zhou J, Stefani E. Effect of bay K 8644 (-) and the beta2a subunit on Ca2+-dependent inactivation in alpha1C Ca2+ channels.. The Journal of general physiology, 1998.
- Olcese R, Latorre R, Toro L, Bezanilla F, Stefani E. Correlation between charge movement and ionic current during slow inactivation in Shaker K+ channels.. The Journal of general physiology, 1997.
- Qin N, Platano D, Olcese R, Stefani E, Birnbaumer L. Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.. Proceedings of the National Academy of Sciences of the United States of America, 1997.
- Stefani E, Ottolia M, Noceti F, Olcese R, Wallner M, Latorre R, Toro L. Voltage-controlled gating in a large conductance Ca2+-sensitive K+channel (hslo).. Proceedings of the National Academy of Sciences of the United States of America, 1997.
- Zhou J, Olcese R, Qin N, Noceti F, Birnbaumer L, Stefani E. Feedback inhibition of Ca2+ channels by Ca2+ depends on a short sequence of the C terminus that does not include the Ca2+ -binding function of a motif with similarity to Ca2+ -binding domains.. Proceedings of the National Academy of Sciences of the United States of America, 1997.
- Tareilus E, Roux M, Qin N, Olcese R, Zhou J, Stefani E, Birnbaumer L. A Xenopus oocyte beta subunit: evidence for a role in the assembly/expression of voltage-gated calcium channels that is separate from its role as a regulatory subunit.. Proceedings of the National Academy of Sciences of the United States of America, 1997.
- Nobile M, Olcese R, Toro L, Stefani E. Fast inactivation of Shaker K+ channels is highly temperature dependent.. Experimental brain research, 1997.
- Olcese R, Neely A, Qin N, Wei X, Birnbaumer L, Stefani E. Coupling between charge movement and pore opening in vertebrate neuronal alpha 1E calcium channels.. The Journal of physiology, 1996.
- Qin N, Olcese R, Zhou J, Cabello OA, Birnbaumer L, Stefani E. Identification of a second region of the beta-subunit involved in regulation of calcium channel inactivation.. The American journal of physiology, 1996.
- Wei X, Neely A, Olcese R, Lang W, Stefani E, Birnbaumer L. Increase in Ca2+ channel expression by deletions at the amino terminus of the cardiac alpha 1C subunit.. Receptors & channels, 1996.
- Neely A, Olcese R, Baldelli P, Wei X, Birnbaumer L, Stefani E. Dual activation of the cardiac Ca2+ channel alpha 1C-subunit and its modulation by the beta-subunit.. The American journal of physiology, 1995.
- Olcese R, Qin N, Schneider T, Neely A, Wei X, Stefani E, Birnbaumer L. The amino terminus of a calcium channel beta subunit sets rates of channel inactivation independently of the subunit's effect on activation.. Neuron, 1994.
- Neely A, Olcese R, Wei X, Birnbaumer L, Stefani E. Ca(2+)-dependent inactivation of a cloned cardiac Ca2+ channel alpha 1 subunit (alpha 1C) expressed in Xenopus oocytes.. Biophysical journal, 1994.
- Olcese R, Usai C, Maestrone E, Nobile M. The general anesthetic propofol inhibits transmembrane calcium current in chick sensory neurons.. Anesthesia and analgesia, 1994.
- Wei X, Neely A, Lacerda AE, Olcese R, Stefani E, Perez-Reyes E, Birnbaumer L. Modification of Ca2+ channel activity by deletions at the carboxyl terminus of the cardiac alpha 1 subunit.. The Journal of biological chemistry, 1994.
- Schneider T, Wei X, Olcese R, Costantin JL, Neely A, Palade P, Perez-Reyes E, Qin N, Zhou J, Crawford GD. Molecular analysis and functional expression of the human type E neuronal Ca2+ channel alpha 1 subunit.. Receptors & channels, 1994.
- Neely A, Wei X, Olcese R, Birnbaumer L, Stefani E. Potentiation by the beta subunit of the ratio of the ionic current to the charge movement in the cardiac calcium channel.. Science (New York, N.Y.), 1993.