S. Lawrence Zipursky, Ph.D.

lzipursky@mednet.ucla.edu

Faculty Member

Distinguished Professor
Department of Biological Chemistry
David Geffen School of Medicine
University of California, Los Angeles

MacDonald Research Laboratories
675 Charles E. Young Dr. South
Los Angeles, CA 90095

Lab: 5619, 5629
Office: 5784

Publications

Dombrovski M, Zang Y, Frighetto G, Vaccari A, Jang H, Mirshahidi PS, Xie F, Sanfilippo P, Hina BW, Rehan A, Hussein RH, Mirshahidi PS, Lee C, Morris A, Frye MA, von Reyn CR, Kurmangaliyev YZ, Card GM, Zipursky SL. Molecular gradients shape synaptic specificity of a visuomotor transformation.. Nature, 2025.
Lee JH, Sergeeva AP, Ahlsén G, Mannepalli S, Bahna F, Goodman KM, Xu R, Khakh BS, Weiner JA, Shapiro L, Honig B, Zipursky SL. Astrocyte morphogenesis requires self-recognition.. Nature, 2025.
Sanfilippo P, Kim AJ, Bhukel A, Yoo J, Mirshahidi PS, Pandey V, Bevir H, Yuen A, Mirshahidi PS, Guo P, Li HS, Wohlschlegel JA, Aso Y, Zipursky SL. Mapping of multiple neurotransmitter receptor subtypes and distinct protein complexes to the connectome.. Neuron, 2024.
Yoo J, Dombrovski M, Mirshahidi P, Nern A, LoCascio SA, Zipursky SL, Kurmangaliyev YZ. Brain wiring determinants uncovered by integrating connectomes and transcriptomes.. Current biology : CB, 2023.
Dombrovski M, Peek MY, Park JY, Vaccari A, Sumathipala M, Morrow C, Breads P, Zhao A, Kurmangaliyev YZ, Sanfilippo P, Rehan A, Polsky J, Alghailani S, Tenshaw E, Namiki S, Zipursky SL, Card GM. Publisher Correction: Synaptic gradients transform object location to action.. Nature, 2023.
Dombrovski M, Peek MY, Park JY, Vaccari A, Sumathipala M, Morrow C, Breads P, Zhao A, Kurmangaliyev YZ, Sanfilippo P, Rehan A, Polsky J, Alghailani S, Tenshaw E, Namiki S, Zipursky SL, Card GM. Synaptic gradients transform object location to action.. Nature, 2023.
Jain S, Lin Y, Kurmangaliyev YZ, Valdes-Aleman J, LoCascio SA, Mirshahidi P, Parrington B, Zipursky SL. A global timing mechanism regulates cell-type-specific wiring programmes.. Nature, 2022.
Cheng S, Butrus S, Tan L, Xu R, Sagireddy S, Trachtenberg JT, Shekhar K, Zipursky SL. Vision-dependent specification of cell types and function in the developing cortex.. Cell, 2022.
Kurmangaliyev YZ, Yoo J, Valdes-Aleman J, Sanfilippo P, Zipursky SL. Transcriptional Programs of Circuit Assembly in the Drosophila Visual System.. Neuron, 2020.
Sanes JR, Zipursky SL. Synaptic Specificity, Recognition Molecules, and Assembly of Neural Circuits.. Cell, 2020.
Akin O, Bajar BT, Keles MF, Frye MA, Zipursky SL. Cell-type-Specific Patterned Stimulus-Independent Neuronal Activity in the Drosophila Visual System during Synapse Formation.. Neuron, 2019.
Xu S, Xiao Q, Cosmanescu F, Sergeeva AP, Yoo J, Lin Y, Katsamba PS, Ahlsen G, Kaufman J, Linaval NT, Lee PT, Bellen HJ, Shapiro L, Honig B, Tan L, Zipursky SL. Interactions between the Ig-Superfamily Proteins DIP-α and Dpr6/10 Regulate Assembly of Neural Circuits.. Neuron, 2018.
Cosmanescu F, Katsamba PS, Sergeeva AP, Ahlsen G, Patel SD, Brewer JJ, Tan L, Xu S, Xiao Q, Nagarkar-Jaiswal S, Nern A, Bellen HJ, Zipursky SL, Honig B, Shapiro L. Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr Cell Recognition Proteins.. Neuron, 2018.
Sarin S, Zuniga-Sanchez E, Kurmangaliyev YZ, Cousins H, Patel M, Hernandez J, Zhang KX, Samuel MA, Morey M, Sanes JR, Zipursky SL. Role for Wnt Signaling in Retinal Neuropil Development: Analysis via RNA-Seq and In Vivo Somatic CRISPR Mutagenesis.. Neuron, 2018.
Tadros W, Xu S, Akin O, Yi CH, Shin GJ, Millard SS, Zipursky SL. Dscam Proteins Direct Dendritic Targeting through Adhesion.. Neuron, 2016.
Zhang KX, Tan L, Pellegrini M, Zipursky SL, McEwen JM. Rapid Changes in the Translatome during the Conversion of Growth Cones to Synaptic Terminals.. Cell reports, 2016.
Tan L, Zhang KX, Pecot MY, Nagarkar-Jaiswal S, Lee PT, Takemura SY, McEwen JM, Nern A, Xu S, Tadros W, Chen Z, Zinn K, Bellen HJ, Morey M, Zipursky SL. Ig Superfamily Ligand and Receptor Pairs Expressed in Synaptic Partners in Drosophila.. Cell, 2015.
Pecot MY, Chen Y, Akin O, Chen Z, Tsui CY, Zipursky SL. Sequential axon-derived signals couple target survival and layer specificity in the Drosophila visual system.. Neuron, 2014.
Chen Y, Akin O, Nern A, Tsui CY, Pecot MY, Zipursky SL. Cell-type-specific labeling of synapses in vivo through synaptic tagging with recombination.. Neuron, 2014.
Akin O, Zipursky SL. The shape of things to come.. Cell, 2014.
Zipursky SL, Grueber WB. The molecular basis of self-avoidance.. Annual review of neuroscience, 2013.
Zipursky SL, Sanes JR. Chemoaffinity revisited: dscams, protocadherins, and neural circuit assembly.. Cell, 2010.
Zipursky SL, Wojtowicz WM, Hattori D. Got diversity? Wiring the fly brain with Dscam.. Trends in biochemical sciences, 2006.
Thomas BJ, Gunning DA, Cho J, Zipursky L. Cell cycle progression in the developing Drosophila eye: roughex encodes a novel protein required for the establishment of G1.. Cell, 1994.