Stanley Thomas Carmichael
Department Chair, Neurology, Neurology, University of California Los Angeles
Professor, Neurology, University of California Los Angeles
Professor, Neurobiology, University of California Los Angeles
710 Westwood Plaza
Los Angeles, CA 90095
S. Thomas Carmichael is a neurologist and neuroscientist in the Departments of Neurology and of Neurobiology at the David Geffen School of Medicine at UCLA. Dr. Carmichael is Professor and Chair of the Department of Neurology, co-Director of the UCLA Broad Stem Cell Center and co-Director of the Regenerative Medicine Theme in the David Geffen School of Medicine. He has active laboratory and clinical interests in stroke and neurorehabilitation and how the brain repairs from injury. He received his M.D. and Ph.D. degrees from Washington University School of Medicine in 1993 and 1994, and completed a Neurology residency at Washington University School of Medicine, serving as Chief Resident. Dr. Carmichael was a Howard Hughes Medical Institute postdoctoral fellow at UCLA from 1998-2001. He has been on the UCLA faculty since 2001. Dr. Carmichael’s laboratory studies the molecular and cellular mechanisms of neural repair after stroke and other forms of brain injury. This research focuses on the processes of axonal sprouting and neural stem cell and progenitor responses after stroke, and on neural stem cell transplantation. Dr. Carmichael is an attending physician on the General Neurology and outpatient clinical services at UCLA. Dr. Carmichael has published important papers on stroke recovery that have defined mechanisms of plasticity and repair. These include the fact that the stroke produces partially damage circuits that limit recovery, but can be restored to normal functioning with newly applied experimental drugs. His work has identified a novel brain “growth program” that is activated by stroke and leads to the formation of new connections. These studies have also identified how this growth program changes with age, and how specific molecules in the aged brain block the formation of new connections and of recovery. This and other work has led to new directions in stroke therapeutics, including therapies with stem cell and tissue engineering applications. Dr. Carmichael is in the midst of stroke stem cell development applications with the FDA and with biotechnology companies.
- Prakash R, Carmichael ST. Evaluation of two eco-friendly neutralizers for a spectrum of tissue fixatives for biomedical applications.. Future science OA, 2018.
- Kokaia Z, Llorente IL, Carmichael ST. Customized Brain Cells for Stroke Patients Using Pluripotent Stem Cells.. Stroke, 2018.
- Nih LR, Carmichael ST, Segura T. Hydrogels for brain repair after stroke: an emerging treatment option.. Current opinion in biotechnology, 2016.
- Carmichael ST. The 3 Rs of Stroke Biology: Radial, Relayed, and Regenerative.. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2016.
- Carmichael ST, Kathirvelu B, Schweppe CA, Nie EH. Molecular, cellular and functional events in axonal sprouting after stroke.. Experimental neurology, 2016.
- Carmichael ST, Krakauer JW. The promise of neuro-recovery after stroke: introduction.. Stroke, 2013.
- Carmichael ST. Opinion & special articles: a guide from fellowship to faculty: Nietzsche and the academic neurologist.. Neurology, 2012.
- Carmichael ST. Brain excitability in stroke: the yin and yang of stroke progression.. Archives of neurology, 2011.
- Carmichael ST. Targets for neural repair therapies after stroke.. Stroke, 2010.
- Carmichael ST. Translating the frontiers of brain repair to treatments: starting not to break the rules.. Neurobiology of disease, 2009.
- Carmichael ST, Vespa PM, Saver JL, Coppola G, Geschwind DH, Starkman S, Miller CM, Kidwell CS, Liebeskind DS, Martin NA. Genomic profiles of damage and protection in human intracerebral hemorrhage.. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2008.
- Miller CM, Vespa P, Saver JL, Kidwell CS, Carmichael ST, Alger J, Frazee J, Starkman S, Liebeskind D, Nenov V, Elashoff R, Martin N. Image-guided endoscopic evacuation of spontaneous intracerebral hemorrhage.. Surgical neurology, 2008.
- Carmichael ST. Themes and strategies for studying the biology of stroke recovery in the poststroke epoch.. Stroke, 2008.
- Popa-Wagner A, Carmichael ST, Kokaia Z, Kessler C, Walker LC. The response of the aged brain to stroke: too much, too soon?. Current neurovascular research, 2007.
- Carmichael ST. Cellular and molecular mechanisms of neural repair after stroke: making waves.. Annals of neurology, 2006.
- Carmichael ST. Rodent models of focal stroke: size, mechanism, and purpose.. NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics, 2005.
- Carmichael ST, Archibeque I, Luke L, Nolan T, Momiy J, Li S. Growth-associated gene expression after stroke: evidence for a growth-promoting region in peri-infarct cortex.. Experimental neurology, 2005.
- Carmichael ST, Tatsukawa K, Katsman D, Tsuyuguchi N, Kornblum HI. Evolution of diaschisis in a focal stroke model.. Stroke, 2004.
- Carmichael ST. Gene expression changes after focal stroke, traumatic brain and spinal cord injuries.. Current opinion in neurology, 2003.
- Carmichael ST. Plasticity of cortical projections after stroke.. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2003.
- Carmichael ST, Chesselet MF. Synchronous neuronal activity is a signal for axonal sprouting after cortical lesions in the adult.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002.
- Carmichael ST. New laboratory start-up in the 21st century.. Trends in neurosciences, 2002.
- Carmichael ST, Wei L, Rovainen CM, Woolsey TA. New patterns of intracortical projections after focal cortical stroke.. Neurobiology of disease, 2001.