Sonia C. Okekenwa
Using polysomnography, we evaluated NREM Slow Oscillations (SOs) and Delta Waves (DWs) of BACHD mice and their wild-type littermates under undisturbed and sleep deprived conditions. Raw EEG signal (400Hz) was collected and 10 second epochs were scored as NREM, REM, or wake. NREM SOs and DW were detected in 2-hour bins and normalized (Z-score) using a MATLAB script. We hypothesize that genotype-driven changes in NREM SOs or DWs may be responsible for the sleep disturbances seen in BACHD mice. We report an effect of genotype under baseline conditions which may support this hypothesis, but our current sample size is insufficient to generate statistical significance. Efforts to directly test our hypothesis are ongoing and the data is still being accumulated in the Paul Lab.