Posts classified under: Clinical and Preclinical Magnetic Resonance Spectroscopy

Edythe London, Ph.D.

Biography

Dr. London received her Ph.D. in Pharmacology from the University of Maryland and her postdoctoral training at Johns Hopkins School of Medicine. Before coming to UCLA in 2001, she was the Director of the Brain Imaging Center for the National Institute on Drug Abuse, and held faculty appointments at the University of Maryland and Johns Hopkins Schools of Medicine. Dr. London is a Professor-in-Residence in the Departments of Psychiatry and Biobehavioral Sciences and Molecular and Medical Pharmacology. Her work focuses on the use of neuroimaging to study neural circuitry underlying self-control and behaviors related to addiction.

Publications

A selected list of publications:

Lee, B, Groman, S, London, E D, Jentsch, J D   Dopamine D2/D3 receptors play a specific role in the reversal of a learned visual discrimination in monkeys, Neuropsychopharmacology, 2007; 32(10): 2125-2134.
Wong, D F, Kuwabara, H, Schretlen, D J, Bonson, K R, Nandi, A, Brasic, J R, Kimes, A S, Maris, M A, Kumar, A, Contoreggi, C, Links, J, Ernst, M, Rousset, O, Zukin, S, Grace, A A, Lee, J S, Rohde, C, Jasinski, D R, Gjedde, A, London, E D   Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving, Neuropsychopharmacology, 2006; 31(12): 2716-2727.
London, E D, Berman, S M, Voytek, B, Simon, S L, Mandelkern, M A, Monterosso, J, Thompson, P M, Brody, A L, Geaga, J A, Hong, M S, Hayashi, K M, Rawson, R A, Ling, W   Cerebral metabolic dysfunction and impaired vigilance in recently abstinent methamphetamine abusers, Biological Psychiatry, 2005; 58(10): 770-778.
Rotheram-Fuller, E, Shoptaw, S, Berman, S M, London, E D   Impaired performance in a test of decision-making by opiate-dependent tobacco smokers, Drug and Alcohol Dependence, 2004; 73(1): 79-86.
London, E D, Simon, S L, Berman, S M, Mandelkern, M A, Lichtman, A M, Bramen, J, … Ling, W   Mood disturbances and regional cerebral metabolic abnormalities in recently abstinent methamphetamine abusers, Archives of General Psychiatry, 2004; 61(1): 73-84.
Thompson, P M, Hayashi, K M, Simon, S L, Geaga, J A, Hong, M S, Sui, Y, Lee, J Y, Toga, A W, Ling, W, London, E D   Structural abnormalities in the brains of human subjects who use methamphetamine, Journal of Neuroscience, 2004; 24(26): 6028-6036.
Ernst, M, Bolla, K, Mouratidis, M, Contoreggi, C, Matochik, J A, Kurian, V, … London, E D   Decision-making in a risk-taking task: a PET study, Neuropsychopharmacology, 2002; 26(5): 682-691.
Bonson, K R, Grant, S J, Contoreggi C S, Links, J M, Metcalfe J, Weyl, H L, … London, E D   Neural systems and cue-induced cocaine craving, Neuropsychopharmacology, 2002; 26(3): 376-386.
Ernst, M, Heishman, S J, Spurgeon, L, & London, E D   Smoking history and nicotine effects on cognitive performance, Neuropsychopharmacology, 2001; 25(3): 313-319.
Faulkner, P, Ghahremani, D G, Tyndale, R F, Cox, C M, Kazanjian, A S, Paterson, N, Lotfipour, S, Hellemann, G S, Petersen, N, Vigil, C, London, E D   Reduced-Nicotine Cigarettes in Young Smokers: Impact of Nicotine Metabolism on Nicotine Dose Effects Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017; 42(8): 1610-1618.
Okita, K, Mandelkern, M A, London, E D   Cigarette Use and Striatal Dopamine D2/3 Receptors: Possible Role in the Link between Smoking and Nicotine Dependence The international journal of neuropsychopharmacology, 2016; 19(11): 15-22.
Okita, K, Petersen, N, Robertson, C L, Dean, A C, Mandelkern, M A, London, E D   Sex Differences in Midbrain Dopamine D2-Type Receptor Availability and Association with Nicotine Dependence Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016; 41(12): 2913-2919.
Robertson, C L, Ishibashi, K, Chudzynski, J, Mooney, L J, Rawson, R A, Dolezal, B A, Cooper, C B, Brown, A K, Mandelkern, M A, London, E D   Effect of Exercise Training on Striatal Dopamine D2/D3 Receptors in Methamphetamine Users during Behavioral Treatment Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016; 41(6): 1629-36.
Morales, A M, Kohno, M, Robertson, C L, Dean, A C, Mandelkern, M A, London, E D   Gray-matter volume, midbrain dopamine D2/D3 receptors and drug craving in methamphetamine users Molecular psychiatry, 2015; 20(6): 764-71.
Robertson, C L, Ishibashi, K, Mandelkern, M A, Brown, A K, Ghahremani, D G, Sabb, F, Bilder, R, Cannon, T, Borg, J, London, E D   Striatal D1- and D2-type dopamine receptors are linked to motor response inhibition in human subjects The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015; 35(15): 5990-7.
Kohno, M, Ghahremani, D G, Morales, A M, Robertson, C L, Ishibashi, K, Morgan, A T, Mandelkern, M A, London, E D   Risk-taking behavior: dopamine D2/D3 receptors, feedback, and frontolimbic activity Cerebral cortex (New York, N.Y. : 1991), 2015; 25(1): 236-45.
O’Neill, J, Tobias, M C, Hudkins, M, London, E D   Glutamatergic neurometabolites during early abstinence from chronic methamphetamine abuse The international journal of neuropsychopharmacology, 2014; 18(3): 236-45.
Kohno, M, Morales, A M, Ghahremani, D G, Hellemann, G, London, E D   Risky decision making, prefrontal cortex, and mesocorticolimbic functional connectivity in methamphetamine dependence JAMA psychiatry, 2014; 71(7): 812-20.
O’Neill, J, Tobias, M C, Hudkins, M, Oh, E Y, Hellemann, G S, Nurmi, E L, London, E D   Thalamic glutamate decreases with cigarette smoking Psychopharmacology, 2014; 231(13): 2717-24.
Groman, S M, Morales, A M, Lee, B, London, E D, Jentsch, J D   Methamphetamine-induced increases in putamen gray matter associate with inhibitory control Psychopharmacology, 2013; 229(3): 527-38.
Brown, A K, Mandelkern, M A, Farahi, J, Robertson, C, Ghahremani, D G, Sumerel, B, Moallem, N, London, E D   Sex differences in striatal dopamine D2/D3 receptor availability in smokers and non-smokers The international journal of neuropsychopharmacology, 2012; 15(7): 989-94.
Zorick, T, Lee, B, Mandelkern, M A, Fong, T, Robertson, C, Ghahremani, D G, Brown, A K, Sumerel, B, London, E D   Low striatal dopamine receptor availability linked to caloric intake during abstinence from chronic methamphetamine abuse Molecular psychiatry, 2012; 17(6): 569-71.
Ghahremani, D G, Lee, B, Robertson, C L, Tabibnia, G, Morgan, A T, De Shetler, N, Brown, A K, Monterosso, J R, Aron, A R, Mandelkern, M A, Poldrack, R A, London, E D   Striatal dopamine D₂/D₃ receptors mediate response inhibition and related activity in frontostriatal neural circuitry in humans The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012; 32(21): 7316-24.
Ishibashi, K, Berman, S M, Paz-Filho, G, Lee, B, Robertson, C, Mandelkern, M A, Wong, M L, Licinio, J, London, E D   Dopamine D2/D3 receptor availability in genetically leptin-deficient patients after long-term leptin replacement Molecular psychiatry, 2012; 17(4): 352-3.
Groman, S M, Lee, B, Seu, E, James, A S, Feiler, K, Mandelkern, M A, London, E D, Jentsch, J D   Dysregulation of D₂-mediated dopamine transmission in monkeys after chronic escalating methamphetamine exposure The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012; 32(17): 5843-52.
Payer, D E, Nurmi, E L, Wilson, S A, McCracken, J T, London, E D   Effects of methamphetamine abuse and serotonin transporter gene variants on aggression and emotion-processing neurocircuitry Translational psychiatry, 2012; 2(4): e80.
Dean, A C, Sevak, R J, Monterosso, J R, Hellemann, G, Sugar, C A, London, E D   Acute modafinil effects on attention and inhibitory control in methamphetamine-dependent humans Journal of studies on alcohol and drugs, 2011; 72(6): 943-53.
Zorick, T, Sugar, C A, Hellemann, G, Shoptaw, S, London, E D   Poor response to sertraline in methamphetamine dependence is associated with sustained craving for methamphetamine Drug and alcohol dependence, 2011; 118(2-3): 500-3.
Ghahremani, D G, Tabibnia, G, Monterosso, J, Hellemann, G, Poldrack, R A, London, E D   Effect of modafinil on learning and task-related brain activity in methamphetamine-dependent and healthy individuals Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011; 36(5): 950-9.
Zorick, T, Mandelkern, M A, Lee, B, Wong, M-L, Miotto, K, Shabazian, J, London, E D   Elevated plasma prolactin in abstinent methamphetamine-dependent subjects The American journal of drug and alcohol abuse, 2011; 37(1): 62-7.
Zorick, T, Sevak, R J, Miotto, K, Shoptaw, S, Swanson, A-N, Clement, C, De La Garza, R, Newton, T F, London, E D   Pilot safety evaluation of varenicline for the treatment of methamphetamine dependence Journal of experimental pharmacology, 2010; 2(10): 13-8.
Zorick, T, Nestor, L, Miotto, K, Sugar, C, Hellemann, G, Scanlon, G, Rawson, R, London, E D   Withdrawal symptoms in abstinent methamphetamine-dependent subjects Addiction (Abingdon, England), 2010; 105(10): 1809-18.
Azizian, A, Nestor, L J, Payer, D, Monterosso, J R, Brody, A L, London, E D   Smoking reduces conflict-related anterior cingulate activity in abstinent cigarette smokers performing a Stroop task Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010; 35(3): 775-82.
London, E D, Berman, S M, Mohammadian, P, Ritchie, T, Mandelkern, M A, Susselman, M K W, Schlagenhauf, F, Noble, E P   Effect of the TaqIA polymorphism on ethanol response in the brain Psychiatry research, 2009; 174(3): 163-70.
Lee, B, London, E D, Poldrack, R A, Farahi, J, Nacca, A, Monterosso, J R, Mumford, J A, Bokarius, A V, Dahlbom, M, Mukherjee, J, Bilder, R M, Brody, A L, Mandelkern, M A   Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009; 29(47): 14734-40.
Brody, A L, Mandelkern, M A, Olmstead, R E, Allen-Martinez, Z, Scheibal, D, Abrams, A L, Costello, M R, Farahi, J, Saxena, S, Monterosso, J, London, E D   Ventral striatal dopamine release in response to smoking a regular vs a denicotinized cigarette Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009; 34(2): 282-9.
Xu, J, Azizian, A, Monterosso, J, Domier, C P, Brody, A L, Fong, T W, London, E D   Gender effects on mood and cigarette craving during early abstinence and resumption of smoking Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2008; 10(11): 1653-61.
Berman, S M, Voytek, B, Mandelkern, M A, Hassid, B D, Isaacson, A, Monterosso, J, Miotto, K, Ling, W, London, E D   Changes in cerebral glucose metabolism during early abstinence from chronic methamphetamine abuse Molecular psychiatry, 2008; 13(9): 897-908.
Baicy, K, London, E D, Monterosso, J, Wong, M-L, Delibasi, T, Sharma, A, Licinio, J   Leptin replacement alters brain response to food cues in genetically leptin-deficient adults Proceedings of the National Academy of Sciences of the United States of America, 2007; 104(46): 18276-9.
Galynker, I I, Eisenberg, D, Matochik, J A, Gertmenian-King, E, Cohen, L, Kimes, A S, Contoreggi, C, Kurian, V, Ernst, M, Rosenthal, R N, Prosser, J, London, E D   Cerebral metabolism and mood in remitted opiate dependence Drug and alcohol dependence, 2007; 90(2-3): 166-74.
Xu, J, Mendrek, A, Cohen, M S, Monterosso, J, Simon, S, Brody, A L, Jarvik, M, Rodriguez, P, Ernst, M, London, E D   Effects of acute smoking on brain activity vary with abstinence in smokers performing the N-Back task: a preliminary study Psychiatry research, 2006; 148(2-3): 103-9.
Ernst M, Matochik J A, Heishman S J, Van Horn J D, Jons P H, Henningfield J E, London E D   Effect of nicotine on brain activation during performance of a working memory task Proceedings of the National Academy of Sciences of the United States of America, 2001; 98(8): 4728-33.
Mukhin A G, Gündisch D, Horti A G, Koren A O, Tamagnan G, Kimes A S, Chambers J, Vaupel D B, King S L, Picciotto M R, Innis R B, London E D   5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors Molecular pharmacology, 2000; 57(3): 642-9.

James McCracken, M.D.

Biography

Dr. McCracken is the Joseph Campbell Professor of Child Psychiatry and Director of the Division of Child and Adolescent Psychiatry at the UCLA NPI-Semel Institute (formerly the Neuropsychiatric Institute) in Los Angeles. Dr. McCracken is the principal investigator of the National Institute of Mental Health (NIMH) Research Center, “Translational Research to Enhance Cognitive Control,” which aims to develop and test innovative treatments for cognitive defects associated with child psychiatric illness. His other current areas of research include family-genetic studies of childhood disorders and the testing of new pharmacologic treatments for a variety of neuropsychiatric disorders in children, including attention-deficit/hyperactivity disorder (ADHD), autism, obsessive-compulsive disorder, and anxiety disorders.

Dr. McCracken received medical and postgraduate training at Baylor College of Medicine, Duke University, and UCLA before joining the faculty at UCLA in 1987. He is the recipient of several honors and awards, including the American Psychiatric Association (APA) Young Psychiatrist Research Award. He has published more than 150 papers in the area of child psychiatry and serves on the editorial board of the Journal of Child and Adolescent Psychopharmacology.

Dr. McCracken holds memberships in various local, national, and international professional organizations, including the APA, American Academy of Child and Adolescent Psychiatry, International Society for Research in Child and Adolescent Psychopathology, International Society of Psychoneuroendocrinology, and the Society for Neuroscience. He is listed in both the Best Doctors in America and America’s Top Doctors databases.

Lara Ray, Ph.D.

Publications

A selected list of publications:

Bacio Guadalupe A, Lunny Katy F, Webb Jessica N, Ray Lara A   Alcohol Use Following an Alcohol Challenge and a Brief Intervention among Alcohol-Dependent Individuals The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions, 2014; 23(1): 96-101.
Courtney Kelly E, Ashenhurst James, Bacio Guadalupe, Moallem Nathasha, Bujarski Spencer, Hartwell Emily, Ray Lara A   Craving and subjective responses to alcohol administration: validation of the desires for alcohol questionnaire in the human laboratory Journal of studies on alcohol and drugs, 2013; 74(5): 797-802.
Courtney Kelly E, Ghahremani Dara G, Ray Lara A   Fronto-striatal functional connectivity during response inhibition in alcohol dependence Addiction biology, 2013; 18(3): 593-604.
Ray Lara A, Courtney Kelly E, Hutchison Kent E, Mackillop James, Galvan Adriana, Ghahremani Dara G   Initial Evidence that OPRM1 Genotype Moderates Ventral and Dorsal Striatum Functional Connectivity During Alcohol Cues Alcoholism, clinical and experimental research, 2013; 74(5): .
Moallem Nathasha R, Courtney Kelly E, Bacio Guadalupe A, Ray Lara A   Modeling alcohol use disorder severity: an integrative structural equation modeling approach Frontiers in psychiatry, 2013; 4(1): 75.
Hartwell Emily E, Ray Lara A   Sex moderates stress reactivity in heavy drinkers Addictive behaviors, 2013; 38(11): 2643-6.
Ray Lara A, Bujarski Spencer, MacKillop James, Courtney Kelly E, Monti Peter M, Miotto Karen   Subjective response to alcohol among alcohol-dependent individuals: effects of the μ-opioid receptor (OPRM1) gene and alcoholism severity Alcoholism, clinical and experimental research, 2013; 37 Suppl 1(1): E116-24.
Bujarski Spencer, O’Malley Stephanie S, Lunny Katy, Ray Lara A   The effects of drinking goal on treatment outcome for alcoholism Journal of consulting and clinical psychology, 2013; 81(1): 13-22.
Ray Lara A, Lunny Katy, Bujarski Spencer, Moallem Nathasha, Krull Jennifer L, Miotto Karen   The effects of varenicline on stress-induced and cue-induced craving for cigarettes Drug and alcohol dependence, 2013; 131(1-2): 136-42.
Ray, L. A. Miranda, R. Mackillop, J. McGeary, J. Tidey, J. W. Rohsenow, D. J. Gwaltney, C. Swift, R. W. Monti, P. M.   A preliminary pharmacogenetic investigation of adverse events from topiramate in heavy drinkers Exp Clin Psychopharmacol, 2009; 17(2): 122-9.
Ray, L. A. Mackillop, J. Leggio, L. Morgan, M. Hutchison, K. E.   Effects of naltrexone on cortisol levels in heavy drinkers Pharmacol Biochem Behav, 2009; 91(4): 489-94.
Ray, L. A. Bryan, A. Mackillop, J. McGeary, J. Hesterberg, K. Hutchison, K. E.   The dopamine D Receptor (DRD4) gene exon III polymorphism, problematic alcohol use and novelty seeking: direct and mediated genetic effects Addict Biol, 2009; 14(2): 238-44.
Leventhal, A. M. Kahler, C. W. Ray, L. A. Stone, K. Young, D. Chelminski, I. Zimmerman, M.   Anhedonia and amotivation in psychiatric outpatients with fully remitted stimulant use disorder Am J Addict, 2008; 17(3): 218-23.
Ray, L. A. Miranda, R., Jr. Chelminski, I. Young, D. Zimmerman, M.   Diagnostic orphans for alcohol use disorders in a treatment-seeking psychiatric sample Drug Alcohol Depend, 2008; 96(1-2): 187-91.
Filbey, F. M. Ray, L. Smolen, A. Claus, E. D. Audette, A. Hutchison, K. E.   Differential neural response to alcohol priming and alcohol taste cues is associated with DRD4 VNTR and OPRM1 genotypes Alcohol Clin Exp Res, 2008; 32(7): 1113-23.
Ray, L. A. Hutchison, K. E. MacKillop, J. Miranda, R., Jr. Audette, A. Swift, R. Monti, P. M.   Effects of naltrexone during the descending limb of the blood alcohol curve Am J Addict, 2008; 17(4): 257-64.
Miranda, R., Jr. Rohsenow, D. J. Monti, P. M. Tidey, J. Ray, L.   Effects of repeated days of smoking cue exposure on urge to smoke and physiological reactivity Addict Behav, 2008; 33(2): 347-53.
Miranda, R., Jr. MacKillop, J. Monti, P. M. Rohsenow, D. J. Tidey, J. Gwaltney, C. Swift, R. Ray, L. McGeary, J.   Effects of topiramate on urge to drink and the subjective effects of alcohol: a preliminary laboratory study Alcohol Clin Exp Res, 2008; 32(3): 489-97.
MacKillop, J. Murphy, J. G. Ray, L. A. Eisenberg, D. T. Lisman, S. A. Lum, J. K. Wilson, D. S.   Further validation of a cigarette purchase task for assessing the relative reinforcing efficacy of nicotine in college smokers Exp Clin Psychopharmacol, 2008; 16(1): 57-65.
Haughey, H. M. Ray, L. A. Finan, P. Villanueva, R. Niculescu, M. Hutchison, K. E.   Human gamma-aminobutyric acid A receptor alpha2 gene moderates the acute effects of alcohol and brain mRNA expression Genes Brain Behav, 2008; 7(4): 447-54.
Ray, L. A. Kahler, C. W. Young, D. Chelminski, I. Zimmerman, M.   The factor structure and severity of DSM-IV alcohol abuse and dependence symptoms in psychiatric outpatients J Stud Alcohol Drugs, 2008; 69(4): 496-9.
Bryan, A. Ray, L. A. Cooper, M. L.   Alcohol use and protective sexual behaviors among high-risk adolescents J Stud Alcohol Drugs, 2007; 68(3): 327-35.
Ray, L. A. Rhee, S. H. Stallings, M. C. Knopik, V. Hutchison, K. E.   Examining the heritability of a laboratory-based smoking endophenotype: initial results from an experimental twin study Twin Res Hum Genet, 2007; 10(4): 546-53.
Ray, L. A. Miranda, R., Jr. Kahler, C. W. Leventhal, A. M. Monti, P. M. Swift, R. Hutchison, K. E.   Pharmacological effects of naltrexone and intravenous alcohol on craving for cigarettes among light smokers: a pilot study Psychopharmacology (Berl), 2007; 193(4): 449-56.
Ray, L. A. McGeary, J. Marshall, E. Hutchison, K. E.   Risk factors for alcohol misuse: examining heart rate reactivity to alcohol, alcohol sensitivity, and personality constructs Addict Behav, 2006; 31(11): 1959-73.
Hutchison, K. E. Ray, L. Sandman, E. Rutter, M. C. Peters, A. Davidson, D. Swift, R.   The effect of olanzapine on craving and alcohol consumption Neuropsychopharmacology, 2006; 31(6): 1310-7.
Hines, L. M. Ray, L. Hutchison, K. Tabakoff, B.   Alcoholism: the dissection for endophenotypes Dialogues Clin Neurosci, 2005; 7(2): 153-63.
Ray, L. A. Hutchison, K. E.   A polymorphism of the mu-opioid receptor gene (OPRM1) and sensitivity to the effects of alcohol in humans Alcohol Clin Exp Res, 2004; 28(12): 1789-95.
Fromme, K. de Wit, H. Hutchison, K. E. Ray, L. Corbin, W. R. Cook, T. A. Wall, T. L. Goldman, D.   Biological and behavioral markers of alcohol sensitivity Alcohol Clin Exp Res, 2004; 28(2): 247-56.