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Posts classified under: Clinical and Preclinical Magnetic Resonance Spectroscopy

HomeUCLA Brain Research Institute (BRI)  > People  > Affinity Groups  > Clinical and Preclinical Magnetic Resonance Spectroscopy
Christopher J. Evans, Ph.D.

Christopher J. Evans, Ph.D.

Biography

Christopher Evans received his Ph.D. from Imperial College London, conducting his thesis research on endorphins and enkephalins, at the Medical Research Council Institute in Mill Hill. After a postdoctoral fellowship at Stanford University, Dr. Evans joined the UCLA faculty in the Department of Psychiatry and Biobehavioral Science. His research accomplishments have included identification of a number of novel endogenous opioid peptides and the cloning of the first opioid receptor. Dr. Evans was Director of the UCLA Brain Research Institute from 2004-2017 and is the Stefan Hatos Professor directing the Shirley and Stefan Hatos Center for Neurophamacology in the UCLA Semel Institute. Dr. Evans is also director of a NIH-funded center – The Center for Opioid Receptors and Drugs of Abuse or CSORDA. CSORDA, with continuous NIH funding for over 30 years. The aims of CSORDA are to understand the action of opioid drugs such as morphine and heroin at the molecular, cellular and behavioral levels.

Publications

View a up-to-date publication list: https://pubmed.ncbi.nlm.nih.gov/collections/48826753/?sort=date

A selected list of publications:

Pradhan Amynah, Smith Monique, McGuire Brenna, Evans Christopher, Walwyn Wendy   Chronic inflammatory injury results in increased coupling of delta opioid receptors to voltage-gated Ca2+ channels Molecular pain, 2013; 9(4): 8.
Williams John T, Ingram Susan L, Henderson Graeme, Chavkin Charles, von Zastrow Mark, Schulz Stefan, Koch Thomas, Evans Christopher J, Christie Macdonald J   Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance Pharmacological reviews, 2013; 65(1): 223-54.
Mittal Nitish, Tan Miao, Egbuta Onyemachi, Desai Nina, Crawford Cynthia, Xie Cui-Wei, Evans Christopher, Walwyn Wendy   Evidence that Behavioral Phenotypes of Morphine in β-arr2-/- Mice Are Due to the Unmasking of JNK Signaling Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012; 10(2): .
Matynia Anna, Parikh Sachin, Chen Bryan, Kim Paul, McNeill David S, Nusinowitz Steven, Evans Christopher, Gorin Michael B   Intrinsically photosensitive retinal ganglion cells are the primary but not exclusive circuit for light aversion Experimental eye research, 2012; 105(23): 60-9.
Pradhan Amynah A, Smith Monique L, Kieffer Brigitte L, Evans Christopher J   Ligand-directed signalling within the opioid receptor family British journal of pharmacology, 2012; 167(5): 960-9.
Piault Elisabeth, Doshi Sameepa, Brandt Barbara A, Angün Colpan, Evans Christopher J, Bergqvist Agneta, Trocio Jeffrey   Linguistic validation of translation of the self-assessment goal achievement (saga) questionnaire from English Health and quality of life outcomes, 2012; 10: 40.
Romero-Calderón Rafael, O’Hare Elizabeth D, Suthana Nanthia A, Scott-Van Zeeland Ashley A, Rizk-Jackson Angela, Attar Aida, Madsen Sarah K, Ghiani Cristina A, Evans Christopher J, Watson Joseph B   Project brainstorm: using neuroscience to connect college students with local schools PLoS biology, 2012; 10(4): e1001310.
Ma Yao-Ying, Cepeda Carlos, Chatta Payush, Franklin Lana, Evans Christopher J, Levine Michael S   Regional and cell-type-specific effects of DAMGO on striatal D1 and D2 dopamine receptor-expressing medium-sized spiny neurons ASN neuro, 2012; 4(2): .
Washburn Lorraine R, Zekzer Dan, Eitan Shoshana, Lu Yuxin, Dang Hoa, Middleton Blake, Evans Christopher J, Tian Jide, Kaufman Daniel L   A potential role for shed soluble major histocompatibility class I molecules as modulators of neurite outgrowth PloS one, 2011; 6(3): e18439.
Lasch Kathryn F, Evans Christopher J, Schatell Dori   A qualitative analysis of patient-reported symptoms of anemia Nephrology nursing journal : journal of the American Nephrology Nurses’ Association, 2011; 36(6): 621-4, 631-2; quiz 633.
Lam Hoa, Maga Matthew, Pradhan Amynah, Evans Christopher J, Maidment Nigel T, Hales Tim G, Walwyn Wendy   Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking β-arrestin 2 Molecular pain, 2011; 7(8): 24.
Evans Christopher J, Chiou Chiun-Fang, Fitzgerald Kristina A, Evans William J, Ferrell Betty R, Dale William, Fried Linda P, Gandra Shravanthi R, Dennee-Sommers Brooke, Patrick Donald L   Development of a new patient-reported outcome measure in sarcopenia Journal of the American Medical Directors Association, 2011; 12(3): 226-33.
Brubaker Linda, Khullar Vik, Piault Elisabeth, Evans Christopher J, Bavendam Tamara, Beach James, Yeh Yating, Kopp Zoe S, Kelleher Con J, Trocio Jeffrey   Goal attainment scaling in patients with lower urinary tract symptoms: development and pilot testing of the Self-Assessment Goal Achievement (SAGA) questionnaire International urogynecology journal, 2011; 22(8): 937-46.
Ng-Mak Daisy S, Fitzgerald Kristina A, Norquist Josephine M, Banderas Benjamin F, Nelsen Linda M, Evans Christopher J, Healy Cynthia G, Ho Tony W, Bigal Marcelo   Key concepts of migraine postdrome: a qualitative study to develop a post-migraine questionnaire Headache, 2011; 51(1): 105-17.
Poole Daniel P, Pelayo Juan-Carlos, Scherrer Gregory, Evans Christopher J, Kieffer Brigitte L, Bunnett Nigel W   Localization and regulation of fluorescently labeled delta opioid receptor, expressed in enteric neurons of mice Gastroenterology, 2011; 141(3): 982-991.e1-8.
Pradhan Amynah A A, Walwyn Wendy, Nozaki Chihiro, Filliol Dominique, Erbs Eric, Matifas Audrey, Evans Christopher, Kieffer Brigitte L   Ligand-directed trafficking of the δ-opioid receptor in vivo: two paths toward analgesic tolerance The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010; 30(49): 16459-68.
Escande-Beillard Nathalie, Washburn Lorraine, Zekzer Dan, Wu Zhongqi-Phyllis, Eitan Shoshy, Ivkovic Sonja, Lu Yuxin, Dang Hoa, Middleton Blake, Bilousova Tina V, Yoshimura Yoshitaka, Evans Christopher J, Joyce Sebastian, Tian Jide, Kaufman Daniel L   Neurons preferentially respond to self-MHC class I allele products regardless of peptide presented Journal of immunology (Baltimore, Md. : 1950), 2010; 184(2): 816-23.
Walwyn Wendy M, Miotto Karen A, Evans Christopher J   Opioid pharmaceuticals and addiction: the issues, and research directions seeking solutions Drug and alcohol dependence, 2010; 108(3): 156-65.
Iguchi Martin Y, Evans Christopher J   What neurobiology tells us about addiction Addiction (Abingdon, England), 2010; 105(5): 793-5; discussion 795-6.
Walwyn Wendy, John Scott, Maga Matthew, Evans Christopher J, Hales Tim G   Delta receptors are required for full inhibitory coupling of mu-receptors to voltage-dependent Ca(2+) channels in dorsal root ganglion neurons Molecular pharmacology, 2009; 76(1): 134-43.
Hofford Rebecca S, Hodgson Stephen R, Roberts Kris W, Bryant Camron D, Evans Christopher J, Eitan Shoshana   Extracellular signal-regulated kinase activation in the amygdala mediates elevated plus maze behavior during opioid withdrawal Behavioural pharmacology, 2009; 20(7): 576-83.
Yu Y Joy, Arttamangkul Seksiri, Evans Christopher J, Williams John T, von Zastrow Mark   Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of mu-opioid receptors in CNS neurons The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009; 29(1): 222-33.
Kieffer Brigitte L, Evans Christopher J   Opioid receptors: from binding sites to visible molecules in vivo Neuropharmacology, 2009; 56 Suppl 1(1): 205-12.
Bryant Camron D, Roberts Kristofer W, Culbertson Christopher S, Le Alan, Evans Christopher J, Fanselow Michael S   Pavlovian conditioning of multiple opioid-like responses in mice Drug and alcohol dependence, 2009; 103(1-2): 74-83.
Marquez Paul, Bebawy David, Lelièvre Vincent, Coûté Anne-Claire, Evans Christopher J, Waschek James A, Lutfy Kabirullah   The role of endogenous PACAP in motor stimulation and conditioned place preference induced by morphine in mice Psychopharmacology, 2009; 204(3): 457-63.
Tan Miao, Walwyn Wendy M, Evans Christopher J, Xie Cui-Wei   p38 MAPK and beta-arrestin 2 mediate functional interactions between endogenous micro-opioid and alpha2A-adrenergic receptors in neurons The Journal of biological chemistry, 2009; 284(10): 6270-81.
Piault Elisabeth, Evans Christopher J, Espindle Derek, Kopp Zoe, Brubaker Linda, Abrams Paul   Development and validation of the Overactive Bladder Satisfaction (OAB-S) Questionnaire Neurourology and urodynamics, 2008; 27(3): 179-90.
Wassum Kate M, Evans Christopher J   International Narcotics Research Conference – 39th Annual Meeting IDrugs : the investigational drugs journal, 2008; 11(9): 646-9.
Gioiosa, L.Chen, X.Watkins, R.Klanfer, N.Bryant, C. D.Evans, C. J.Arnold, A. P.   Sex chromosome complement affects nociception in tests of acute and chronic exposure to morphine in mice Horm Behav, 2008; 53(1): 124-30.
Parthan Anju, Evans Christopher J, Le Kim   Chronic low back pain: epidemiology, economic burden and patient-reported outcomes in the USA Expert review of pharmacoeconomics & outcomes research, 2006; 6(3): 359-69.
Evans Christopher J, Parthan Anju, Le Kim   Economic and humanistic burden of fibromyalgia in the USA Expert review of pharmacoeconomics & outcomes research, 2006; 6(3): 303-14.
Kho, S. T. Lopez, I. A. Evans, C. Ishiyama, A. Ishiyama, G.   Immunolocalization of orphanin FQ in rat cochlea Brain Res, 2006; 1113(1): 146-52.
Bryant Camron D, Roberts Kristofer W, Byun Janet S, Fanselow Michael S, Evans Christopher J   Morphine analgesic tolerance in 129P3/J and 129S6/SvEv mice Pharmacology, biochemistry, and behavior, 2006; 85(4): 769-79.
Walwyn, W. M. Wei, W. Xie, C. W. Chiu, K. Kieffer, B. L. Evans, C. J. Maidment, N. T.   Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neurons Neuroscience, 2006; 142(2): 493-503.
Bryant Camron D, Eitan Shoshana, Sinchak Kevin, Fanselow Michael S, Evans Christopher J   NMDA receptor antagonism disrupts the development of morphine analgesic tolerance in male, but not female C57BL/6J mice American journal of physiology. Regulatory, integrative and comparative physiology, 2006; 291(2): R315-26.
Walwyn Wendy, Maidment Nigel T, Sanders Matthew, Evans Christopher J, Kieffer Brigitte L, Hales Tim G   Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons Molecular pharmacology, 2005; 68(6): 1688-98.
Evans Christopher J, Trudeau Elyse, Mertzanis Polyxane, Marquis Patrick, Peña Beatriz M, Wong Josephine, Mayne Tracy   Development and validation of the Pain Treatment Satisfaction Scale (PTSS): a patient satisfaction questionnaire for use in patients with chronic or acute pain Pain, 2004; 112(3): 254-66.
Walwyn, W. M. Keith, D. E., Jr. Wei, W. Tan, A. M. Xie, C. W. Evans, C. J. Kieffer, B. L. Maidment, N. T.   Functional coupling, desensitization and internalization of virally expressed mu opioid receptors in cultured dorsal root ganglion neurons from mu opioid receptor knockout mice Neuroscience, 2004; 123(1): 111-21.
Evans Christopher J   Health and work productivity assessment: state of the art or state of flux? Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine, 2004; 46(6 Suppl): S3-11.
Evans Christopher J   Secrets of the opium poppy revealed Neuropharmacology, 2004; 47 Suppl 1(6 Suppl): 293-9.
Eitan, S. Bryant, C. D. Saliminejad, N. Yang, Y. C. Vojdani, E. Keith, D., Jr. Polakiewicz, R. Evans, C. J.   Brain region-specific mechanisms for acute morphine-induced mitogen-activated protein kinase modulation and distinct patterns of activation during analgesic tolerance and locomotor sensitization J Neurosci, 2003; 23(23): 8360-9.
Lutfy, K. Eitan, S. Bryant, C. D. Yang, Y. C. Saliminejad, N. Walwyn, W. Kieffer, B. L. Takeshima, H. Carroll, F. I. Maidment, N. T. Evans, C. J.   Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors J Neurosci, 2003; 23(32): 10331-7.
Charles, A. C. Mostovskaya, N. Asas, K. Evans, C. J. Dankovich, M. L. Hales, T. G.   Coexpression of delta-opioid receptors with micro receptors in GH3 cells changes the functional response to micro agonists from inhibitory to excitatory Mol Pharmacol, 2003; 63(1): 89-95.
Li, Y. Eitan, S. Wu, J. Evans, C. J. Kieffer, B. Sun, X. Polakiewicz, R. D.   Morphine induces desensitization of insulin receptor signaling Mol Cell Biol, 2003; 23(17): 6255-66.
Reeve, J. R., Jr. Keire, D. A. Coskun, T. Green, G. M. Evans, C. Ho, F. J. Lee, T. D. Davis, M. T. Shively, J. E. Solomon, T. E.   Synthesis of biologically active canine CCK-58 Regul Pept, 2003; 113(1-3): 71-7.
Arjomand, J. Cole, S. Evans, C. J.   Novel orphanin FQ/nociceptin transcripts are expressed in human immune cells J Neuroimmunol, 2002; 130(1-2): 100-8.
Kieffer Brigitte L, Evans Christopher J   Opioid tolerance-in search of the holy grail Cell, 2002; 108(5): 587-90.
Zaki, P. A. Keith, D. E., Jr. Thomas, J. B. Carroll, F. I. Evans, C. J.   Agonist-, antagonist-, and inverse agonist-regulated trafficking of the delta-opioid receptor correlates with, but does not require, G protein activation J Pharmacol Exp Ther, 2001; 298(3): 1015-20.
Arjomand, J. Evans, C. J.   Differential splicing of transcripts encoding the orphanin FQ/nociceptin precursor J Neurochem, 2001; 77(3): 720-9.
Ishiyama, A. Ishiyama, G. Baloh, R. W. Evans, C. J.   Heroin-induced reversible profound deafness and vestibular dysfunction Addiction, 2001; 96(9): 1363-4.
Piros, E. T. Charles, R. C. Song, L. Evans, C. J. Hales, T. G.   Cloned delta-opioid receptors in GH(3) cells inhibit spontaneous Ca(2+) oscillations and prolactin release through K(IR) channel activation J Neurophysiol, 2000; 83(5): 2691-8.
Melone, M. Brecha, N. C. Sternini, C. Evans, C. Conti, F.   Etorphine increases the number of mu-opioid receptor-positive cells in the cerebral cortex Neuroscience, 2000; 100(3): 439-43.
Zaki, P. A. Keith, D. E., Jr. Brine, G. A. Carroll, F. I. Evans, C. J.   Ligand-induced changes in surface mu-opioid receptor number: relationship to G protein activation? J Pharmacol Exp Ther, 2000; 292(3): 1127-34.
Rabizadeh, S. Ye, X. Sperandio, S. Wang, J. J. Ellerby, H. M. Ellerby, L. M. Giza, C. Andrusiak, R. L. Frankowski, H. Yaron, Y. Moayeri, N. N. Rovelli, G. Evans, C. J. Butcher, L. L. Nolan, G. P. Assa-Munt, N. Bredesen, D. E.   Neurotrophin dependence domain: a domain required for the mediation of apoptosis by the p75 neurotrophin receptor J Mol Neurosci, 2000; 15(3): 215-29.
Lo, E. H. Pierce, A. R. Matsumoto, K. Kano, T. Evans, C. J. Newcomb, R.   Alterations in K+ evoked profiles of neurotransmitter and neuromodulator amino acids after focal ischemia-reperfusion Neuroscience, 1998; 83(2): 449-58.
Monteillet-Agius, G. Fein, J. Anton, B. Evans, C. J.   ORL-1 and mu opioid receptor antisera label different fibers in areas involved in pain processing J Comp Neurol, 1998; 399(3): 373-83.
Murray, S. R. Evans, C. J. von Zastrow, M.   Phosphorylation is not required for dynamin-dependent endocytosis of a truncated mutant opioid receptor J Biol Chem, 1998; 273(39): 24987-91.
Unterwald, E. M. Anton, B. To, T. Lam, H. Evans, C. J.   Quantitative immunolocalization of mu opioid receptors: regulation by naltrexone Neuroscience, 1998; 85(3): 897-905.
Keith, D. E. Anton, B. Murray, S. R. Zaki, P. A. Chu, P. C. Lissin, D. V. Monteillet-Agius, G. Stewart, P. L. Evans, C. J. von Zastrow, M.   mu-Opioid receptor internalization: opiate drugs have differential effects on a conserved endocytic mechanism in vitro and in the mammalian brain Mol Pharmacol, 1998; 53(3): 377-84.
Rocha, L. L. Evans, C. J. Maidment, N. T.   Amygdala kindling modifies extracellular opioid peptide content in rat hippocampus measured by microdialysis J Neurochem, 1997; 68(2): 616-24.
Yu, T. P. Fein, J. Phan, T. Evans, C. J. Xie, C. W.   Orphanin FQ inhibits synaptic transmission and long-term potentiation in rat hippocampus Hippocampus, 1997; 7(1): 88-94.
Olive, M. F. Anton, B. Micevych, P. Evans, C. J. Maidment, N. T.   Presynaptic versus postsynaptic localization of mu and delta opioid receptors in dorsal and ventral striatopallidal pathways J Neurosci, 1997; 17(19): 7471-9.
Gylys, K. H. Tran, N. Magendzo, K. Zaki, P. Evans, C. J.   cAMP decreases steady-state levels of delta-opioid receptor mRNA in NG108-15 cells Neuroreport, 1997; 8(9-10): 2369-72.
Sternini, C. Spann, M. Anton, B. Keith, D. E., Jr. Bunnett, N. W. von Zastrow, M. Evans, C. Brecha, N. C.   Agonist-selective endocytosis of mu opioid receptor by neurons in vivo Proc Natl Acad Sci U S A, 1996; 93(17): 9241-6.
Anton, B. Fein, J. To, T. Li, X. Silberstein, L. Evans, C. J.   Immunohistochemical localization of ORL-1 in the central nervous system of the rat J Comp Neurol, 1996; 368(2): 229-51.
Zhu, J. Yin, J. Law, P. Y. Claude, P. A. Rice, K. C. Evans, C. J. Chen, C. Yu, L. Liu-Chen, L. Y.   Irreversible binding of cis-(+)-3-methylfentanyl isothiocyanate to the delta opioid receptor and determination of its binding domain J Biol Chem, 1996; 271(3): 1430-4.
Tian, J. Clare-Salzler, M. Herschenfeld, A. Middleton, B. Newman, D. Mueller, R. Arita, S. Evans, C. Atkinson, M. A. Mullen, Y. Sarvetnick, N. Tobin, A. J. Lehmann, P. V. Kaufman, D. L.   Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice Nat Med, 1996; 2(12): 1348-53.
Keith, D. E. Murray, S. R. Zaki, P. A. Chu, P. C. Lissin, D. V. Kang, L. Evans, C. J. von Zastrow, M.   Morphine activates opioid receptors without causing their rapid internalization J Biol Chem, 1996; 271(32): 19021-4.
Keith, D. E., Jr. Evans, C. J.   Mu opioid receptor-like sequences are present throughout vertebrate evolution J Mol Evol, 1996; 43(3): 179-84.
Johnson, J. Chen, T. K. Rickman, D. W. Evans, C. Brecha, N. C.   Multiple gamma-Aminobutyric acid plasma membrane transporters (GAT-1, GAT-2, GAT-3) in the rat retina J Comp Neurol, 1996; 375(2): 212-24.
Li, X. Keith, D. E., Jr. Evans, C. J.   Multiple opioid receptor-like genes are identified in diverse vertebrate phyla FEBS Lett, 1996; 397(1): 25-9.
Rocha, L. Maidment, N. T. Evans, C. J. Ackermann, R. F. Engel, J., Jr.   Opioid peptide release and mu-receptor binding during amygdala kindling in rats: regional discordances Epilepsy Res Suppl, 1996; 12(number): 215-28.
Rocha, L. Briones, M. Ackermann, R. F. Anton, B. Maidment, N. T. Evans, C. J. Engel, J., Jr.   Pentylenetetrazol-induced kindling: early involvement of excitatory and inhibitory systems Epilepsy Res, 1996; 26(1): 105-13.
Trapaidze, N. Keith, D. E. Cvejic, S. Evans, C. J. Devi, L. A.   Sequestration of the delta opioid receptor. Role of the C terminus in agonist-mediated internalization J Biol Chem, 1996; 271(46): 29279-85.
Piros, E. T. Prather, P. L. Law, P. Y. Evans, C. J. Hales, T. G.   Voltage-dependent inhibition of Ca2+ channels in GH3 cells by cloned mu- and delta-opioid receptors Mol Pharmacol, 1996; 50(4): 947-56.
Piros, E. T. Prather, P. L. Loh, H. H. Law, P. Y. Evans, C. J. Hales, T. G.   Ca2+ channel and adenylyl cyclase modulation by cloned mu-opioid receptors in GH3 cells Mol Pharmacol, 1995; 47(5): 1041-9.
Milligan, C. E. Webster, L. Piros, E. T. Evans, C. J. Cunningham, T. J. Levitt, P.   Induction of opioid receptor-mediated macrophage chemotactic activity after neonatal brain injury J Immunol, 1995; 154(12): 6571-81.
Olive, M. F. Bertolucci, M. Evans, C. J. Maidment, N. T.   Microdialysis reveals a morphine-induced increase in pallidal opioid peptide release Neuroreport, 1995; 6(8): 1093-6.
Prather, P. L. McGinn, T. M. Erickson, L. J. Evans, C. J. Loh, H. H. Law, P. Y.   Ability of delta-opioid receptors to interact with multiple G-proteins is independent of receptor density J Biol Chem, 1994; 269(33): 21293-302.
Law, P. Y. McGinn, T. M. Wick, M. J. Erikson, L. J. Evans, C. Loh, H. H.   Analysis of delta-opioid receptor activities stably expressed in CHO cell lines: function of receptor density? J Pharmacol Exp Ther, 1994; 271(3): 1686-94.
Mastrogiacomo, A. Evans, C. J. Gundersen, C. B.   Antipeptide antibodies against a Torpedo cysteine-string protein J Neurochem, 1994; 62(3): 873-80.
Kaufman, D. L. Xia, Y. R. Keith, D. E., Jr. Newman, D. Evans, C. J. Lusis, A. J.   Localization of the delta-opioid receptor gene to mouse chromosome 4 by linkage analysis Genomics, 1994; 19(2): 405-6.
Rocha, L. Maidment, N. T. Evans, C. J. Ackermann, R. F. Engel, J., Jr.   Microdialysis reveals changes in extracellular opioid peptide levels in the amygdala induced by amygdaloid kindling stimulation Exp Neurol, 1994; 126(2): 277-83.
Reeve, J. R., Jr. Eysselein, V. E. Ho, F. J. Chew, P. Vigna, S. R. Liddle, R. A. Evans, C.   Natural and synthetic CCK-58. Novel reagents for studying cholecystokinin physiology Ann N Y Acad Sci, 1994; 713(number): 11-21.
Liu, Y. Schweitzer, E. S. Nirenberg, M. J. Pickel, V. M. Evans, C. J. Edwards, R. H.   Preferential localization of a vesicular monoamine transporter to dense core vesicles in PC12 cells J Cell Biol, 1994; 127(5): 1419-33.
Von Zastrow, M. Keith, D. E., Jr. Evans, C. J.   Agonist-induced state of the delta-opioid receptor that discriminates between opioid peptides and opiate alkaloids Mol Pharmacol, 1993; 44(1): 166-72.
Keith, D. E., Jr. Anton, B. Evans, C. J.   Characterization and mapping of a delta opioid receptor clone from NG108-15 cells Proc West Pharmacol Soc, 1993; 36(number): 299-306.
Ruppert, C. Sandrasagra, A. Anton, B. Evans, C. Schweitzer, E. S. Tobin, A. J.   Rat-1 fibroblasts engineered with GAD65 and GAD67 cDNAs in retroviral vectors produce and release GABA J Neurochem, 1993; 61(2): 768-71.
Evans, C. J. Keith, D. E., Jr. Morrison, H. Magendzo, K. Edwards, R. H.   Cloning of a delta opioid receptor by functional expression Science, 1992; 258(5090): 1952-5.
Madden, J. th Evans, C. J. Tyler, A. N. Esch, F. S. Bohlen, P. Makk, G. Weber, E.   Isolation and characterization of opioid peptides from rabbit cerebellum J Neurochem, 1991; 56(6): 1914-20.
Maidment, N. T. Siddall, B. Rudolph, V. D. Evans, C. J.   Postmortem changes in rat brain extracellular opioid peptides revealed by microdialysis J Neurochem, 1991; 56(6): 1980-4.
Abood, M. E. Eberwine, J. H. Erdelyi, E. Evans, C. J.   Regulation of both preproenkephalin mRNA and its derived opioids by haloperidol–a method for measurement of peptides and mRNA in the same tissue extract Brain Res Mol Brain Res, 1990; 8(3): 243-8.
Tecott, L. H. Rubenstein, J. L. Paxinos, G. Evans, C. J. Eberwine, J. H. Valentino, K. L.   Developmental expression of proenkephalin mRNA and peptides in rat striatum Brain Res Dev Brain Res, 1989; 49(1): 75-86.
Feistner, G. J. Hojrup, P. Evans, C. J. Barofsky, D. F. Faull, K. F. Roepstorff, P.   Mass spectrometric charting of bovine posterior/intermediate pituitary peptides Proc Natl Acad Sci U S A, 1989; 86(16): 6013-7.
Maidment, N. T. Brumbaugh, D. R. Rudolph, V. D. Erdelyi, E. Evans, C. J.   Microdialysis of extracellular endogenous opioid peptides from rat brain in vivo Neuroscience, 1989; 33(3): 549-57.
Stevens, K. E. Leslie, F. M. Evans, C. J. Belluzzi, J. D. Stein, L.   BAM-18: analgesia, hyperalgesia and locomotor effects Neuropeptides, 1988; 12(1): 21-7.
Eberwine, J. H. Barchas, J. D. Hewlett, W. A. Evans, C. J.   Isolation of enzyme cDNA clones by enzyme immunodetection assay: isolation of a peptide acetyltransferase Proc Natl Acad Sci U S A, 1987; 84(5): 1449-53.
Boarder, M. R. Evans, C. Adams, M. Erdelyi, E. Barchas, J. D.   Peptide E and its products, BAM 18 and Leu-enkephalin, in bovine adrenal medulla and cultured chromaffin cells: release in response to stimulation J Neurochem, 1987; 49(6): 1824-32.
Hurlbut, D. E. Evans, C. J. Barchas, J. D. Leslie, F. M.   Pharmacological properties of a proenkephalin A-derived opioid peptide: BAM 18 Eur J Pharmacol, 1987; 138(3): 359-66.
Lorenz, R. G. Tyler, A. N. Faull, K. F. Makk, G. Barchas, J. D. Evans, C. J.   Characterization of endorphins from the pituitary of the spiny dogfish Squalus acanthias Peptides, 1986; 7(1): 119-26.
Bartolome, J. V. Bartolome, M. B. Daltner, L. A. Evans, C. J. Barchas, J. D. Kuhn, C. M. Schanberg, S. M.   Effects of beta-endorphin on ornithine decarboxylase in tissues of developing rats: a potential role for this endogenous neuropeptide in the modulation of tissue growth Life Sci, 1986; 38(25): 2355-62.
Stevens, K. E. Leslie, F. M. Evans, C. J. Barchas, J. D. Belluzzi, J. D. Stein, L.   Intraventricular administration of BAM-18: antinociceptive and locomotor activity in the rat NIDA Res Monogr, 1986; 75(number): 446-9.
Kaldany, R. R. Campanelli, J. T. Makk, G. Evans, C. J. Scheller, R. H.   Proteolytic processing of a peptide precursor in Aplysia neuron R14 J Biol Chem, 1986; 261(13): 5751-7.
Hurlbut, D. E. Evans, C. J. Barchas, J. D. Leslie, F. M.   The pharmacological profile of BAM 18 NIDA Res Monogr, 1986; 75(number): 81-4.
Evans, C. J. Erdelyi, E. Hunter, J. Barchas, J. D.   Co-localization and characterization of immunoreactive peptides derived from two opioid precursors in guinea pig adrenal glands J Neurosci, 1985; 5(12): 3423-7.
Lorenz, R. G. Evans, C. J. Barchas, J. D.   Effects of dehydration on pro-dynorphin derived peptides in the neuro-intermediate lobe of the rat pituitary Life Sci, 1985; 37(16): 1523-8.
Evans, C. J. Barchas, J. D. Esch, F. S. Bohlen, P. Weber, E   Isolation and characterization of an endogenous C-terminal fragment of the alpha-neo-endorphin/dynorphin precursor from bovine caudate nucleus J Neurosci, 1985; 5(7): 1803-7.
Roth, K. A. Makk, G. Beck, O. Faull, K. Tatemoto, K. Evans, C. J. Barchas, J. D.   Isolation and characterization of substance P, substance P 5-11, and substance K from two metastatic ileal carcinoids Regul Pept, 1985; 12(3): 185-99.
Wallace, E. F. Weber, E. Barchas, J. D. Evans, C. J.   A putative processing enzyme from Aplysia that cleaves dynorphin A at the single arginine residue Biochem Biophys Res Commun, 1984; 119(1): 415-22.
Bostwick, D. G. Roth, K. A. Evans, C. J. Barchas, J. D. Bensch, K. G.   Gastrin-releasing peptide, a mammalian analog of bombesin, is present in human neuroendocrine lung tumors Am J Pathol, 1984; 117(2): 195-200.
Roth, K. A. Evans, C. J. Weber, E. Barchas, J. D. Bostwick, D. G. Bensch, K. G.   Gastrin-releasing peptide-related peptides in a human malignant lung carcinoid tumor Cancer Res, 1983; 43(11): 5411-5.
Roth, K. A. Evans, C. J. Lorenz, R. G. Weber, E. Barchas, J. D. Chang, J. K.   Identification of gastrin releasing peptide-related substances in guinea pig and rat brain Biochem Biophys Res Commun, 1983; 112(2): 528-36.
Evans, C. J. Erdelyi, E. Weber, E. Barchas, J. D.   Identification of pro-opiomelanocortin-derived peptides in the human adrenal medulla Science, 1983; 221(4614): 957-60.
Boarder, M. R. Weber, E. Evans, C. J. Erdelyi, E. Barchas, J.   Measurement of total opioid peptides in rat brain and pituitary by radioimmunoassay directed at the alpha-N-acetyl derivative J Neurochem, 1983; 40(16): 1517-22.
Weber, E. Esch, F. S. Bohlen, P. Paterson, S. Corbett, A. D. McKnight, A. T. Kosterlitz, H. W. Barchas, J. D. Evans, C. J.   Metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain Proc Natl Acad Sci U S A, 1983; 80(23): 7362-6.
Mues, G. Fuchs, I. Wei, E. T. Weber, E. Evans, C. J. Barchas, J. D. Chang, J. K.   Blood pressure elevation in rats by peripheral administration of Tyr-Gly-Gly-Phe-Met-Arg-Phe and the invertebrate neuropeptide, Phe-Met-Arg-Phe-NH2 Life Sci, 1982; 31(23): 2555-61.
Weber, E. Evans, C. J. Chang, J. K. Barchas, J. D.   Brain distributions of alpha-neo-endorphin and beta-neo-endorphin: evidence for regional processing differences Biochem Biophys Res Commun, 1982; 108(1): 81-8.
Weber, E. Evans, C. J. Barchas, J. D.   Mapping of hypothalamic opioid peptide neurons by a novel immunohistochemical technique: relation to alpha-Neo-endorphin and vasopressin systems Adv Biochem Psychopharmacol, 1982; 33(number): 519-26.
Weber, E. Evans, C. J. Barchas, J. D.   Predominance of the amino-terminal octapeptide fragment of dynorphin in rat brain regions Nature, 1982; 299(5878): 77-9.
Weber, E. Evans, C. J. Barchas, J. D.   Acetylated and nonacetylated forms of beta-endorphin in rat brain and pituitary Biochem Biophys Res Commun, 1981; 103(3): 982-9.
Weber, E.Truscott, R. J.Evans, C.Sullivan, S.Angwin, P.Barchas, J. D.   Alpha-N-acetyl beta-endorphins in the pituitary: immunohistochemical localization using antibodies raised against dynorphin(1-13) J Neurochem, 1981; 36(6): 1977-85.
Evans, C. J. Weber, E. Barchas, J. D.   Isolation and characterization of alpha-N-acetyl beta-endorphin(1-26) from the rat posterior/intermediate pituitary lobe Biochem Biophys Res Commun, 1981; 102(3): 897-904.
Weber, E. Evans, C. J. Samuelsson, S. J. Barchas, J. D.   Novel peptide neuronal system in rat brain and pituitary Science, 1981; 214(4526): 1248-51.
Austen, B. M.Evans, C. J.Smyth, D. G.   Susceptibility of neuroactive peptides to aminopeptidase digestion is related to molecular size Biochem Biophys Res Commun, 1979; 91(4): 1211-7.
Ronald M. Harper, Ph.D.

Ronald Harper, Ph.D.

Biography

The laboratory examines neural mechanisms underlying sleep state: control of breathing, somatomotor activity, and cardiovascular action in developing and adult small animal preparations. Neural mechanisms are examined through neurophysiologic techniques which include assessment of intrinsic optical changes in neural tissue, functional magnetic resonance imaging, and chronic single neuron recording; the optical imaging and cell recording studies are often combined with microdialysis techniques to determine neurochemical mechanisms underlying cell action. We found that a substantial portion of sleep effects on normal and disordered breathing result from rostral brain influences on pontine and medullary structures, that activity over wide areas of these structures can be visualized during ventilatory and pressor challenges in freely behaving animals, and that immature development of mechanisms controlling descending rostral brain influences on breathing can place the organism at risk.

Katherine Karlsgodt, Ph.D.

Katherine Karlsgodt, Ph.D.

Publications

A selected list of publications:

Barber Anita D, Lindquist Martin A, DeRosse Pamela, Karlsgodt Katherine H   Dynamic Functional Connectivity States Reflecting Psychotic-like Experiences Biological psychiatry. Cognitive neuroscience and neuroimaging, 2018; 3(5): 443-453.
Uddin Lucina Q, Karlsgodt Katherine H   Future Directions for Examination of Brain Networks in Neurodevelopmental Disorders Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53, 2018; 47(3): 483-497.
Blair Melanie A, Nitzburg George, DeRosse Pamela, Karlsgodt Katherine H   Relationship between executive function, attachment style, and psychotic like experiences in typically developing youth Schizophrenia research, 2018; 47(3): 483-497.
Karlsgodt Katherine H, Bato Angelica A, Ikuta Toshikazu, Peters Bart D, DeRosse Pamela, Szeszko Philip R, Malhotra Anil K   Functional Activation During a Cognitive Control Task in Healthy Youth Specific to Externalizing or Internalizing Behaviors Biological psychiatry. Cognitive neuroscience and neuroimaging, 2018; 3(2): 133-140.
Ikuta Toshikazu, Del Arco Alberto, Karlsgodt Katherine H   White matter integrity in the fronto-striatal accumbofrontal tract predicts impulsivity Brain imaging and behavior, 2018; 3(2): 133-140.
Eckfeld Ariel, Karlsgodt Katherine H, Haut Kristen M, Bachman Peter, Jalbrzikowski Maria, Zinberg Jamie, van Erp Theo G M, Cannon Tyrone D, Bearden Carrie E   Disrupted Working Memory Circuitry in Adolescent Psychosis Frontiers in human neuroscience, 2017; 11(11): 394.
Sarpal Deepak K, Robinson Delbert G, Fales Christina, Lencz Todd, Argyelan Miklos, Karlsgodt Katherine H, Gallego Juan A, John Majnu, Kane John M, Szeszko Philip R, Malhotra Anil K   Relationship between Duration of Untreated Psychosis and Intrinsic Corticostriatal Connectivity in Patients with Early Phase Schizophrenia Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017; 42(11): 2214-2221.
Ibrahim Amira F A, Montojo Caroline A, Haut Kristen M, Karlsgodt Katherine H, Hansen Laura, Congdon Eliza, Rosser Tena, Bilder Robert M, Silva Alcino J, Bearden Carrie E   Spatial working memory in neurofibromatosis 1: Altered neural activity and functional connectivity NeuroImage. Clinical, 2017; 15(11): 801-811.
Schreiner Matthew, Forsyth Jennifer K, Karlsgodt Katherine H, Anderson Ariana E, Hirsh Nurit, Kushan Leila, Uddin Lucina Q, Mattiacio Leah, Coman Ioana L, Kates Wendy R, Bearden Carrie E   Intrinsic Connectivity Network-Based Classification and Detection of Psychotic Symptoms in Youth With 22q11.2 Deletions Cerebral cortex (New York, N.Y. : 1991), 2017; 27(6): 3294-3306.
Chang Eric H, Argyelan Miklos, Aggarwal Manisha, Chandon Toni-Shay S, Karlsgodt Katherine H, Mori Susumu, Malhotra Anil K   Diffusion tensor imaging measures of white matter compared to myelin basic protein immunofluorescence in tissue cleared intact brains Data in brief, 2017; 10(1): 438-443.
Chang Eric H, Argyelan Miklos, Aggarwal Manisha, Chandon Toni-Shay S, Karlsgodt Katherine H, Mori Susumu, Malhotra Anil K   The role of myelination in measures of white matter integrity: Combination of diffusion tensor imaging and two-photon microscopy of CLARITY intact brains NeuroImage, 2017; 147(6): 253-261.
DeRosse Pamela, Ikuta Toshikazu, Karlsgodt Katherine H, Peters Bart D, Gopin Chaya B, Szeszko Philip R, Malhotra Anil K   White Matter Abnormalities Associated With Subsyndromal Psychotic-Like Symptoms Predict Later Social Competence in Children and Adolescents Schizophrenia bulletin, 2017; 43(1): 152-159.
Schwehm Andrew, Robinson Delbert G, Gallego Juan A, Karlsgodt Katherine H, Ikuta Toshikazu, Peters Bart D, Malhotra Anil K, Szeszko Philip R   Age and Sex Effects on White Matter Tracts in Psychosis from Adolescence through Middle Adulthood Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016; 41(10): 2473-80.
Karlsgodt Katherine H   Diffusion Imaging of White Matter In Schizophrenia: Progress and Future Directions Biological psychiatry. Cognitive neuroscience and neuroimaging, 2016; 1(3): 209-217.
Sarpal Deepak K, Argyelan Miklos, Robinson Delbert G, Szeszko Philip R, Karlsgodt Katherine H, John Majnu, Weissman Noah, Gallego Juan A, Kane John M, Lencz Todd, Malhotra Anil K   Baseline Striatal Functional Connectivity as a Predictor of Response to Antipsychotic Drug Treatment The American journal of psychiatry, 2016; 173(1): 69-77.
Ikuta Toshikazu, DeRosse Pamela, Argyelan Miklos, Karlsgodt Katherine H, Kingsley Peter B, Szeszko Philip R, Malhotra Anil K   Subcortical modulation in auditory processing and auditory hallucinations Behavioural brain research, 2015; 295(1): 78-81.
Karlsgodt Katherine H, John Majnu, Ikuta Toshikazu, Rigoard Philippe, Peters Bart D, Derosse Pamela, Malhotra Anil K, Szeszko Philip R   The accumbofrontal tract: Diffusion tensor imaging characterization and developmental change from childhood to adulthood Human brain mapping, 2015; 36(12): 4954-63.
Haut Kristen M, Karlsgodt Katherine H, Bilder Robert M, Congdon Eliza, Freimer Nelson B, London Edythe D, Sabb Fred W, Ventura Joseph, Cannon Tyrone D   Memory systems in schizophrenia: Modularity is preserved but deficits are generalized Schizophrenia research, 2015; 168(1-2): 223-30.
Karlsgodt Katherine H, Bato Angelica A, Blair Melanie A, DeRosse Pamela, Szeszko Philip R, Malhotra Anil K   White matter microstructure in the executive network associated with aggression in healthy adolescents and young adults Social cognitive and affective neuroscience, 2015; 10(9): 1251-6.
DeRosse Pamela, Karlsgodt Katherine H   Examining the Psychosis Continuum Current behavioral neuroscience reports, 2015; 2(2): 80-89.
Sarpal Deepak K, Robinson Delbert G, Lencz Todd, Argyelan Miklos, Ikuta Toshikazu, Karlsgodt Katherine, Gallego Juan A, Kane John M, Szeszko Philip R, Malhotra Anil K   Antipsychotic treatment and functional connectivity of the striatum in first-episode schizophrenia JAMA psychiatry, 2015; 72(1): 5-13.
Peters Bart D, Karlsgodt Katherine H   White matter development in the early stages of psychosis Schizophrenia research, 2015; 161(1): 61-9.
DeRosse Pamela, Ikuta Toshikazu, Peters Bart D, Karlsgodt Katherine H, Szeszko Philip R, Malhotra Anil K   Adding insult to injury: childhood and adolescent risk factors for psychosis predict lower fractional anisotropy in the superior longitudinal fasciculus in healthy adults Psychiatry research, 2014; 224(3): 296-302.
Jalbrzikowski Maria, Villalon-Reina Julio E, Karlsgodt Katherine H, Senturk Damla, Chow Carolyn, Thompson Paul M, Bearden Carrie E   Altered white matter microstructure is associated with social cognition and psychotic symptoms in 22q11.2 microdeletion syndrome Frontiers in behavioral neuroscience, 2014; 8(3): 393.
Schreiner Matthew J, Karlsgodt Katherine H, Uddin Lucina Q, Chow Carolyn, Congdon Eliza, Jalbrzikowski Maria, Bearden Carrie E   Default mode network connectivity and reciprocal social behavior in 22q11.2 deletion syndrome Social cognitive and affective neuroscience, 2014; 9(9): 1261-7.
White Corey N, Congdon Eliza, Mumford Jeanette A, Karlsgodt Katherine H, Sabb Fred W, Freimer Nelson B, London Edythe D, Cannon Tyrone D, Bilder Robert M, Poldrack Russell A   Decomposing decision components in the stop-signal task: a model-based approach to individual differences in inhibitory control Journal of cognitive neuroscience, 2014; 26(8): 1601-14.
Peters Bart D, Voineskos Aristotle N, Szeszko Philip R, Lett Tristram A, DeRosse Pamela, Guha Saurav, Karlsgodt Katherine H, Ikuta Toshikazu, Felsky Daniel, John Majnu, Rotenberg David J, Kennedy James L, Lencz Todd, Malhotra Anil K   Brain white matter development is associated with a human-specific haplotype increasing the synthesis of long chain fatty acids The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014; 34(18): 6367-76.
Congdon Eliza, Altshuler Lori L, Mumford Jeanette A, Karlsgodt Katherine H, Sabb Fred W, Ventura Joseph, McGough James J, London Edythe D, Cannon Tyrone D, Bilder Robert M, Poldrack Russell A   Neural activation during response inhibition in adult attention-deficit/hyperactivity disorder: preliminary findings on the effects of medication and symptom severity Psychiatry research, 2014; 222(1-2): 17-28.
Helfinstein Sarah M, Schonberg Tom, Congdon Eliza, Karlsgodt Katherine H, Mumford Jeanette A, Sabb Fred W, Cannon Tyrone D, London Edythe D, Bilder Robert M, Poldrack Russell A   Predicting risky choices from brain activity patterns Proceedings of the National Academy of Sciences of the United States of America, 2014; 111(7): 2470-5.
Karlsgodt Katherine H, van Erp Theo G M, Bearden Carrie E, Cannon Tyrone D   Altered relationships between age and functional brain activation in adolescents at clinical high risk for psychosis Psychiatry research, 2014; 221(1): 21-9.
Congdon Eliza, Bato Angelica A, Schonberg Tom, Mumford Jeanette A, Karlsgodt Katherine H, Sabb Fred W, London Edythe D, Cannon Tyrone D, Bilder Robert M, Poldrack Russell A   Differences in neural activation as a function of risk-taking task parameters Frontiers in neuroscience, 2013; 7(1): 173.
Bearden Carrie E, Karlsgodt Katherine H, Bachman Peter, van Erp Theo G M, Winkler Anderson M, Glahn David C   Genetic architecture of declarative memory: implications for complex illnesses The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2012; 18(5): 516-32.
Karlsgodt Katherine H, Rosser Tena, Lutkenhoff Evan S, Cannon Tyrone D, Silva Alcino, Bearden Carrie E   Alterations in white matter microstructure in neurofibromatosis-1 PloS one, 2012; 7(10): e47854.
Lutkenhoff Evan, Karlsgodt Katherine H, Gutman Boris, Stein Jason L, Thompson Paul M, Cannon Tyrone D, Jentsch J David   Structural and functional neuroimaging phenotypes in dysbindin mutant mice NeuroImage, 2012; 62(1): 120-9.
Karlsgodt Katherine H, Jacobson Sarah C, Seal Marc, Fusar-Poli Paolo   The relationship of developmental changes in white matter to the onset of psychosis Current pharmaceutical design, 2012; 18(4): 422-33.
Gee Dylan G, Karlsgodt Katherine H, van Erp Theo G M, Bearden Carrie E, Lieberman Matthew D, Belger Aysenil, Perkins Diana O, Olvet Doreen M, Cornblatt Barbara A, Constable Todd, Woods Scott W, Addington Jean, Cadenhead Kristin S, McGlashan Thomas H, Seidman Larry J, Tsuang Ming T, Walker Elaine F, Cannon Tyrone D, Cannon Tyrone D   Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: a preliminary study Schizophrenia research, 2012; 134(1): 1-9.
Karlsgodt Katherine H, Bachman Peter, Winkler Anderson M, Bearden Carrie E, Glahn David C   Genetic influence on the working memory circuitry: behavior, structure, function and extensions to illness Behavioural brain research, 2011; 225(2): 610-22.
Karlsgodt Katherine H, Robleto Karla, Trantham-Davidson Heather, Jairl Corey, Cannon Tyrone D, Lavin Antonieta, Jentsch J David   Reduced dysbindin expression mediates N-methyl-D-aspartate receptor hypofunction and impaired working memory performance Biological psychiatry, 2011; 69(1): 28-34.
Mittal Vijay A, Karlsgodt Katherine, Zinberg Jamie, Cannon Tyrone D, Bearden Carrie E   Identification and treatment of a pineal region tumor in an adolescent with prodromal psychotic symptoms The American journal of psychiatry, 2010; 167(9): 1033-7.
Karlsgodt Katherine H, Sun Daqiang, Cannon Tyrone D   Structural and Functional Brain Abnormalities in Schizophrenia Current directions in psychological science, 2010; 19(4): 226-231.
Shilyansky Carrie, Karlsgodt Katherine H, Cummings Damian M, Sidiropoulou Kyriaki, Hardt Molly, James Alex S, Ehninger Dan, Bearden Carrie E, Poirazi Panayiota, Jentsch J David, Cannon Tyrone D, Levine Michael S, Silva Alcino J   Neurofibromin regulates corticostriatal inhibitory networks during working memory performance Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(29): 13141-6.
Karlsgodt Katherine H, Kochunov Peter, Winkler Anderson M, Laird Angela R, Almasy Laura, Duggirala Ravindranath, Olvera Rene L, Fox Peter T, Blangero John, Glahn David C   A multimodal assessment of the genetic control over working memory The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010; 30(24): 8197-202.
Sanz Jacqueline H, Karlsgodt Katherine H, Bearden Carrie E, van Erp Theo G M, Nandy Rajesh R, Ventura Joseph, Nuechterlein Keith, Cannon Tyrone D   Symptomatic and functional correlates of regional brain physiology during working memory processing in patients with recent onset schizophrenia Psychiatry research, 2009; 173(3): 177-82.
Karlsgodt Katherine H, Niendam Tara A, Bearden Carrie E, Cannon Tyrone D   White matter integrity and prediction of social and role functioning in subjects at ultra-high risk for psychosis Biological psychiatry, 2009; 66(6): 562-9.
Karlsgodt Katherine H, Sanz Jacqueline, van Erp Theo G M, Bearden Carrie E, Nuechterlein Keith H, Cannon Tyrone D   Re-evaluating dorsolateral prefrontal cortex activation during working memory in schizophrenia Schizophrenia research, 2009; 108(1-3): 143-50.
Karlsgodt Katherine H, Sun Daqiang, Jimenez Amy M, Lutkenhoff Evan S, Willhite Rachael, van Erp Theo G M, Cannon Tyrone D   Developmental disruptions in neural connectivity in the pathophysiology of schizophrenia Development and psychopathology, 2008; 20(4): 1297-327.
Karlsgodt Katherine H, van Erp Theo G M, Poldrack Russell A, Bearden Carrie E, Nuechterlein Keith H, Cannon Tyrone D   Diffusion tensor imaging of the superior longitudinal fasciculus and working memory in recent-onset schizophrenia Biological psychiatry, 2008; 63(5): 512-8.
van Erp Theo G M, Lesh Tyler A, Knowlton Barbara J, Bearden Carrie E, Hardt Molly, Karlsgodt Katherine H, Shirinyan David, Rao Vikas, Green Michael F, Subotnik Kenneth L, Nuechterlein Keith, Cannon Tyrone D   Remember and know judgments during recognition in chronic schizophrenia Schizophrenia research, 2008; 100(1-3): 181-90.
Yamamoto Rinah T, Karlsgodt Katherine H, Rott David, Lukas Scott E, Elman Igor   Effects of perceived cocaine availability on subjective and objective responses to the drug Substance abuse treatment, prevention, and policy, 2007; 2(1-3): 30.
Karlsgodt Katherine H, Glahn David C, van Erp Theo G M, Therman Sebastian, Huttunen Matti, Manninen Marko, Kaprio Jaakko, Cohen Mark S, Lönnqvist Jouko, Cannon Tyrone D   The relationship between performance and fMRI signal during working memory in patients with schizophrenia, unaffected co-twins, and control subjects Schizophrenia research, 2007; 89(1-3): 191-7.
Cannon Tyrone D, Glahn David C, Kim Junghoon, Van Erp Theo G M, Karlsgodt Katherine, Cohen Mark S, Nuechterlein Keith H, Bava Sunita, Shirinyan David   Dorsolateral prefrontal cortex activity during maintenance and manipulation of information in working memory in patients with schizophrenia Archives of general psychiatry, 2005; 62(10): 1071-80.
Karlsgodt Katherine H, Shirinyan David, van Erp Theo G M, Cohen Mark S, Cannon Tyrone D   Hippocampal activations during encoding and retrieval in a verbal working memory paradigm NeuroImage, 2005; 25(4): 1224-31.
Elman Igor, Lukas Scott E, Karlsgodt Katherine H, Gasic Gregory P, Breiter Hans C   Acute cortisol administration triggers craving in individuals with cocaine dependence Psychopharmacology bulletin, 2003; 37(3): 84-9.
Karlsgodt Katherine H, Lukas Scott E, Elman Igor   Psychosocial stress and the duration of cocaine use in non-treatment seeking individuals with cocaine dependence The American journal of drug and alcohol abuse, 2003; 29(3): 539-51.
Elman Igor, Karlsgodt Katherine H, Gastfriend David R, Chabris Christopher F, Breiter Hans C   Cocaine-primed craving and its relationship to depressive symptomatology in individuals with cocaine dependence Journal of psychopharmacology (Oxford, England), 2002; 16(2): 163-7.
Edythe D. London, Ph.D.

Edythe London, Ph.D.

Biography

Dr. London received her Ph.D. in Pharmacology from the University of Maryland and her postdoctoral training at Johns Hopkins School of Medicine. Before coming to UCLA in 2001, she was the Director of the Brain Imaging Center for the National Institute on Drug Abuse, and held faculty appointments at the University of Maryland and Johns Hopkins Schools of Medicine. Dr. London is a Professor-in-Residence in the Departments of Psychiatry and Biobehavioral Sciences and Molecular and Medical Pharmacology. Her work focuses on the use of neuroimaging to study neural circuitry underlying self-control and behaviors related to addiction.

Publications

A selected list of publications:

Lee, B, Groman, S, London, E D, Jentsch, J D   Dopamine D2/D3 receptors play a specific role in the reversal of a learned visual discrimination in monkeys, Neuropsychopharmacology, 2007; 32(10): 2125-2134.
Wong, D F, Kuwabara, H, Schretlen, D J, Bonson, K R, Nandi, A, Brasic, J R, Kimes, A S, Maris, M A, Kumar, A, Contoreggi, C, Links, J, Ernst, M, Rousset, O, Zukin, S, Grace, A A, Lee, J S, Rohde, C, Jasinski, D R, Gjedde, A, London, E D   Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving, Neuropsychopharmacology, 2006; 31(12): 2716-2727.
London, E D, Berman, S M, Voytek, B, Simon, S L, Mandelkern, M A, Monterosso, J, Thompson, P M, Brody, A L, Geaga, J A, Hong, M S, Hayashi, K M, Rawson, R A, Ling, W   Cerebral metabolic dysfunction and impaired vigilance in recently abstinent methamphetamine abusers, Biological Psychiatry, 2005; 58(10): 770-778.
Rotheram-Fuller, E, Shoptaw, S, Berman, S M, London, E D   Impaired performance in a test of decision-making by opiate-dependent tobacco smokers, Drug and Alcohol Dependence, 2004; 73(1): 79-86.
London, E D, Simon, S L, Berman, S M, Mandelkern, M A, Lichtman, A M, Bramen, J, … Ling, W   Mood disturbances and regional cerebral metabolic abnormalities in recently abstinent methamphetamine abusers, Archives of General Psychiatry, 2004; 61(1): 73-84.
Thompson, P M, Hayashi, K M, Simon, S L, Geaga, J A, Hong, M S, Sui, Y, Lee, J Y, Toga, A W, Ling, W, London, E D   Structural abnormalities in the brains of human subjects who use methamphetamine, Journal of Neuroscience, 2004; 24(26): 6028-6036.
Ernst, M, Bolla, K, Mouratidis, M, Contoreggi, C, Matochik, J A, Kurian, V, … London, E D   Decision-making in a risk-taking task: a PET study, Neuropsychopharmacology, 2002; 26(5): 682-691.
Bonson, K R, Grant, S J, Contoreggi C S, Links, J M, Metcalfe J, Weyl, H L, … London, E D   Neural systems and cue-induced cocaine craving, Neuropsychopharmacology, 2002; 26(3): 376-386.
Ernst, M, Heishman, S J, Spurgeon, L, & London, E D   Smoking history and nicotine effects on cognitive performance, Neuropsychopharmacology, 2001; 25(3): 313-319.
Faulkner, P, Ghahremani, D G, Tyndale, R F, Cox, C M, Kazanjian, A S, Paterson, N, Lotfipour, S, Hellemann, G S, Petersen, N, Vigil, C, London, E D   Reduced-Nicotine Cigarettes in Young Smokers: Impact of Nicotine Metabolism on Nicotine Dose Effects Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017; 42(8): 1610-1618.
Okita, K, Mandelkern, M A, London, E D   Cigarette Use and Striatal Dopamine D2/3 Receptors: Possible Role in the Link between Smoking and Nicotine Dependence The international journal of neuropsychopharmacology, 2016; 19(11): 15-22.
Okita, K, Petersen, N, Robertson, C L, Dean, A C, Mandelkern, M A, London, E D   Sex Differences in Midbrain Dopamine D2-Type Receptor Availability and Association with Nicotine Dependence Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016; 41(12): 2913-2919.
Robertson, C L, Ishibashi, K, Chudzynski, J, Mooney, L J, Rawson, R A, Dolezal, B A, Cooper, C B, Brown, A K, Mandelkern, M A, London, E D   Effect of Exercise Training on Striatal Dopamine D2/D3 Receptors in Methamphetamine Users during Behavioral Treatment Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016; 41(6): 1629-36.
Morales, A M, Kohno, M, Robertson, C L, Dean, A C, Mandelkern, M A, London, E D   Gray-matter volume, midbrain dopamine D2/D3 receptors and drug craving in methamphetamine users Molecular psychiatry, 2015; 20(6): 764-71.
Robertson, C L, Ishibashi, K, Mandelkern, M A, Brown, A K, Ghahremani, D G, Sabb, F, Bilder, R, Cannon, T, Borg, J, London, E D   Striatal D1- and D2-type dopamine receptors are linked to motor response inhibition in human subjects The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015; 35(15): 5990-7.
Kohno, M, Ghahremani, D G, Morales, A M, Robertson, C L, Ishibashi, K, Morgan, A T, Mandelkern, M A, London, E D   Risk-taking behavior: dopamine D2/D3 receptors, feedback, and frontolimbic activity Cerebral cortex (New York, N.Y. : 1991), 2015; 25(1): 236-45.
O’Neill, J, Tobias, M C, Hudkins, M, London, E D   Glutamatergic neurometabolites during early abstinence from chronic methamphetamine abuse The international journal of neuropsychopharmacology, 2014; 18(3): 236-45.
Kohno, M, Morales, A M, Ghahremani, D G, Hellemann, G, London, E D   Risky decision making, prefrontal cortex, and mesocorticolimbic functional connectivity in methamphetamine dependence JAMA psychiatry, 2014; 71(7): 812-20.
O’Neill, J, Tobias, M C, Hudkins, M, Oh, E Y, Hellemann, G S, Nurmi, E L, London, E D   Thalamic glutamate decreases with cigarette smoking Psychopharmacology, 2014; 231(13): 2717-24.
Groman, S M, Morales, A M, Lee, B, London, E D, Jentsch, J D   Methamphetamine-induced increases in putamen gray matter associate with inhibitory control Psychopharmacology, 2013; 229(3): 527-38.
Brown, A K, Mandelkern, M A, Farahi, J, Robertson, C, Ghahremani, D G, Sumerel, B, Moallem, N, London, E D   Sex differences in striatal dopamine D2/D3 receptor availability in smokers and non-smokers The international journal of neuropsychopharmacology, 2012; 15(7): 989-94.
Zorick, T, Lee, B, Mandelkern, M A, Fong, T, Robertson, C, Ghahremani, D G, Brown, A K, Sumerel, B, London, E D   Low striatal dopamine receptor availability linked to caloric intake during abstinence from chronic methamphetamine abuse Molecular psychiatry, 2012; 17(6): 569-71.
Ghahremani, D G, Lee, B, Robertson, C L, Tabibnia, G, Morgan, A T, De Shetler, N, Brown, A K, Monterosso, J R, Aron, A R, Mandelkern, M A, Poldrack, R A, London, E D   Striatal dopamine D₂/D₃ receptors mediate response inhibition and related activity in frontostriatal neural circuitry in humans The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012; 32(21): 7316-24.
Ishibashi, K, Berman, S M, Paz-Filho, G, Lee, B, Robertson, C, Mandelkern, M A, Wong, M L, Licinio, J, London, E D   Dopamine D2/D3 receptor availability in genetically leptin-deficient patients after long-term leptin replacement Molecular psychiatry, 2012; 17(4): 352-3.
Groman, S M, Lee, B, Seu, E, James, A S, Feiler, K, Mandelkern, M A, London, E D, Jentsch, J D   Dysregulation of D₂-mediated dopamine transmission in monkeys after chronic escalating methamphetamine exposure The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012; 32(17): 5843-52.
Payer, D E, Nurmi, E L, Wilson, S A, McCracken, J T, London, E D   Effects of methamphetamine abuse and serotonin transporter gene variants on aggression and emotion-processing neurocircuitry Translational psychiatry, 2012; 2(4): e80.
Dean, A C, Sevak, R J, Monterosso, J R, Hellemann, G, Sugar, C A, London, E D   Acute modafinil effects on attention and inhibitory control in methamphetamine-dependent humans Journal of studies on alcohol and drugs, 2011; 72(6): 943-53.
Zorick, T, Sugar, C A, Hellemann, G, Shoptaw, S, London, E D   Poor response to sertraline in methamphetamine dependence is associated with sustained craving for methamphetamine Drug and alcohol dependence, 2011; 118(2-3): 500-3.
Ghahremani, D G, Tabibnia, G, Monterosso, J, Hellemann, G, Poldrack, R A, London, E D   Effect of modafinil on learning and task-related brain activity in methamphetamine-dependent and healthy individuals Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011; 36(5): 950-9.
Zorick, T, Mandelkern, M A, Lee, B, Wong, M-L, Miotto, K, Shabazian, J, London, E D   Elevated plasma prolactin in abstinent methamphetamine-dependent subjects The American journal of drug and alcohol abuse, 2011; 37(1): 62-7.
Zorick, T, Sevak, R J, Miotto, K, Shoptaw, S, Swanson, A-N, Clement, C, De La Garza, R, Newton, T F, London, E D   Pilot safety evaluation of varenicline for the treatment of methamphetamine dependence Journal of experimental pharmacology, 2010; 2(10): 13-8.
Zorick, T, Nestor, L, Miotto, K, Sugar, C, Hellemann, G, Scanlon, G, Rawson, R, London, E D   Withdrawal symptoms in abstinent methamphetamine-dependent subjects Addiction (Abingdon, England), 2010; 105(10): 1809-18.
Azizian, A, Nestor, L J, Payer, D, Monterosso, J R, Brody, A L, London, E D   Smoking reduces conflict-related anterior cingulate activity in abstinent cigarette smokers performing a Stroop task Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010; 35(3): 775-82.
London, E D, Berman, S M, Mohammadian, P, Ritchie, T, Mandelkern, M A, Susselman, M K W, Schlagenhauf, F, Noble, E P   Effect of the TaqIA polymorphism on ethanol response in the brain Psychiatry research, 2009; 174(3): 163-70.
Lee, B, London, E D, Poldrack, R A, Farahi, J, Nacca, A, Monterosso, J R, Mumford, J A, Bokarius, A V, Dahlbom, M, Mukherjee, J, Bilder, R M, Brody, A L, Mandelkern, M A   Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009; 29(47): 14734-40.
Brody, A L, Mandelkern, M A, Olmstead, R E, Allen-Martinez, Z, Scheibal, D, Abrams, A L, Costello, M R, Farahi, J, Saxena, S, Monterosso, J, London, E D   Ventral striatal dopamine release in response to smoking a regular vs a denicotinized cigarette Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009; 34(2): 282-9.
Xu, J, Azizian, A, Monterosso, J, Domier, C P, Brody, A L, Fong, T W, London, E D   Gender effects on mood and cigarette craving during early abstinence and resumption of smoking Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2008; 10(11): 1653-61.
Berman, S M, Voytek, B, Mandelkern, M A, Hassid, B D, Isaacson, A, Monterosso, J, Miotto, K, Ling, W, London, E D   Changes in cerebral glucose metabolism during early abstinence from chronic methamphetamine abuse Molecular psychiatry, 2008; 13(9): 897-908.
Baicy, K, London, E D, Monterosso, J, Wong, M-L, Delibasi, T, Sharma, A, Licinio, J   Leptin replacement alters brain response to food cues in genetically leptin-deficient adults Proceedings of the National Academy of Sciences of the United States of America, 2007; 104(46): 18276-9.
Galynker, I I, Eisenberg, D, Matochik, J A, Gertmenian-King, E, Cohen, L, Kimes, A S, Contoreggi, C, Kurian, V, Ernst, M, Rosenthal, R N, Prosser, J, London, E D   Cerebral metabolism and mood in remitted opiate dependence Drug and alcohol dependence, 2007; 90(2-3): 166-74.
Xu, J, Mendrek, A, Cohen, M S, Monterosso, J, Simon, S, Brody, A L, Jarvik, M, Rodriguez, P, Ernst, M, London, E D   Effects of acute smoking on brain activity vary with abstinence in smokers performing the N-Back task: a preliminary study Psychiatry research, 2006; 148(2-3): 103-9.
Ernst M, Matochik J A, Heishman S J, Van Horn J D, Jons P H, Henningfield J E, London E D   Effect of nicotine on brain activation during performance of a working memory task Proceedings of the National Academy of Sciences of the United States of America, 2001; 98(8): 4728-33.
Mukhin A G, Gündisch D, Horti A G, Koren A O, Tamagnan G, Kimes A S, Chambers J, Vaupel D B, King S L, Picciotto M R, Innis R B, London E D   5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors Molecular pharmacology, 2000; 57(3): 642-9.
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