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Posts classified under: Clinical and Preclinical Magnetic Resonance Spectroscopy

HomeUCLA Brain Research Institute (BRI)  > People  > Affinity Groups  > Clinical and Preclinical Magnetic Resonance Spectroscopy
Ronald M. Harper, Ph.D.

Ronald Harper, Ph.D.

Biography

The laboratory examines neural mechanisms underlying sleep state: control of breathing, somatomotor activity, and cardiovascular action in developing and adult small animal preparations. Neural mechanisms are examined through neurophysiologic techniques which include assessment of intrinsic optical changes in neural tissue, functional magnetic resonance imaging, and chronic single neuron recording; the optical imaging and cell recording studies are often combined with microdialysis techniques to determine neurochemical mechanisms underlying cell action. We found that a substantial portion of sleep effects on normal and disordered breathing result from rostral brain influences on pontine and medullary structures, that activity over wide areas of these structures can be visualized during ventilatory and pressor challenges in freely behaving animals, and that immature development of mechanisms controlling descending rostral brain influences on breathing can place the organism at risk.

Katherine Karlsgodt, Ph.D.

Katherine Karlsgodt, Ph.D.

Publications

A selected list of publications:

Barber Anita D, Lindquist Martin A, DeRosse Pamela, Karlsgodt Katherine H   Dynamic Functional Connectivity States Reflecting Psychotic-like Experiences Biological psychiatry. Cognitive neuroscience and neuroimaging, 2018; 3(5): 443-453.
Uddin Lucina Q, Karlsgodt Katherine H   Future Directions for Examination of Brain Networks in Neurodevelopmental Disorders Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53, 2018; 47(3): 483-497.
Blair Melanie A, Nitzburg George, DeRosse Pamela, Karlsgodt Katherine H   Relationship between executive function, attachment style, and psychotic like experiences in typically developing youth Schizophrenia research, 2018; 47(3): 483-497.
Karlsgodt Katherine H, Bato Angelica A, Ikuta Toshikazu, Peters Bart D, DeRosse Pamela, Szeszko Philip R, Malhotra Anil K   Functional Activation During a Cognitive Control Task in Healthy Youth Specific to Externalizing or Internalizing Behaviors Biological psychiatry. Cognitive neuroscience and neuroimaging, 2018; 3(2): 133-140.
Ikuta Toshikazu, Del Arco Alberto, Karlsgodt Katherine H   White matter integrity in the fronto-striatal accumbofrontal tract predicts impulsivity Brain imaging and behavior, 2018; 3(2): 133-140.
Eckfeld Ariel, Karlsgodt Katherine H, Haut Kristen M, Bachman Peter, Jalbrzikowski Maria, Zinberg Jamie, van Erp Theo G M, Cannon Tyrone D, Bearden Carrie E   Disrupted Working Memory Circuitry in Adolescent Psychosis Frontiers in human neuroscience, 2017; 11(11): 394.
Sarpal Deepak K, Robinson Delbert G, Fales Christina, Lencz Todd, Argyelan Miklos, Karlsgodt Katherine H, Gallego Juan A, John Majnu, Kane John M, Szeszko Philip R, Malhotra Anil K   Relationship between Duration of Untreated Psychosis and Intrinsic Corticostriatal Connectivity in Patients with Early Phase Schizophrenia Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017; 42(11): 2214-2221.
Ibrahim Amira F A, Montojo Caroline A, Haut Kristen M, Karlsgodt Katherine H, Hansen Laura, Congdon Eliza, Rosser Tena, Bilder Robert M, Silva Alcino J, Bearden Carrie E   Spatial working memory in neurofibromatosis 1: Altered neural activity and functional connectivity NeuroImage. Clinical, 2017; 15(11): 801-811.
Schreiner Matthew, Forsyth Jennifer K, Karlsgodt Katherine H, Anderson Ariana E, Hirsh Nurit, Kushan Leila, Uddin Lucina Q, Mattiacio Leah, Coman Ioana L, Kates Wendy R, Bearden Carrie E   Intrinsic Connectivity Network-Based Classification and Detection of Psychotic Symptoms in Youth With 22q11.2 Deletions Cerebral cortex (New York, N.Y. : 1991), 2017; 27(6): 3294-3306.
Chang Eric H, Argyelan Miklos, Aggarwal Manisha, Chandon Toni-Shay S, Karlsgodt Katherine H, Mori Susumu, Malhotra Anil K   Diffusion tensor imaging measures of white matter compared to myelin basic protein immunofluorescence in tissue cleared intact brains Data in brief, 2017; 10(1): 438-443.
Chang Eric H, Argyelan Miklos, Aggarwal Manisha, Chandon Toni-Shay S, Karlsgodt Katherine H, Mori Susumu, Malhotra Anil K   The role of myelination in measures of white matter integrity: Combination of diffusion tensor imaging and two-photon microscopy of CLARITY intact brains NeuroImage, 2017; 147(6): 253-261.
DeRosse Pamela, Ikuta Toshikazu, Karlsgodt Katherine H, Peters Bart D, Gopin Chaya B, Szeszko Philip R, Malhotra Anil K   White Matter Abnormalities Associated With Subsyndromal Psychotic-Like Symptoms Predict Later Social Competence in Children and Adolescents Schizophrenia bulletin, 2017; 43(1): 152-159.
Schwehm Andrew, Robinson Delbert G, Gallego Juan A, Karlsgodt Katherine H, Ikuta Toshikazu, Peters Bart D, Malhotra Anil K, Szeszko Philip R   Age and Sex Effects on White Matter Tracts in Psychosis from Adolescence through Middle Adulthood Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016; 41(10): 2473-80.
Karlsgodt Katherine H   Diffusion Imaging of White Matter In Schizophrenia: Progress and Future Directions Biological psychiatry. Cognitive neuroscience and neuroimaging, 2016; 1(3): 209-217.
Sarpal Deepak K, Argyelan Miklos, Robinson Delbert G, Szeszko Philip R, Karlsgodt Katherine H, John Majnu, Weissman Noah, Gallego Juan A, Kane John M, Lencz Todd, Malhotra Anil K   Baseline Striatal Functional Connectivity as a Predictor of Response to Antipsychotic Drug Treatment The American journal of psychiatry, 2016; 173(1): 69-77.
Ikuta Toshikazu, DeRosse Pamela, Argyelan Miklos, Karlsgodt Katherine H, Kingsley Peter B, Szeszko Philip R, Malhotra Anil K   Subcortical modulation in auditory processing and auditory hallucinations Behavioural brain research, 2015; 295(1): 78-81.
Karlsgodt Katherine H, John Majnu, Ikuta Toshikazu, Rigoard Philippe, Peters Bart D, Derosse Pamela, Malhotra Anil K, Szeszko Philip R   The accumbofrontal tract: Diffusion tensor imaging characterization and developmental change from childhood to adulthood Human brain mapping, 2015; 36(12): 4954-63.
Haut Kristen M, Karlsgodt Katherine H, Bilder Robert M, Congdon Eliza, Freimer Nelson B, London Edythe D, Sabb Fred W, Ventura Joseph, Cannon Tyrone D   Memory systems in schizophrenia: Modularity is preserved but deficits are generalized Schizophrenia research, 2015; 168(1-2): 223-30.
Karlsgodt Katherine H, Bato Angelica A, Blair Melanie A, DeRosse Pamela, Szeszko Philip R, Malhotra Anil K   White matter microstructure in the executive network associated with aggression in healthy adolescents and young adults Social cognitive and affective neuroscience, 2015; 10(9): 1251-6.
DeRosse Pamela, Karlsgodt Katherine H   Examining the Psychosis Continuum Current behavioral neuroscience reports, 2015; 2(2): 80-89.
Sarpal Deepak K, Robinson Delbert G, Lencz Todd, Argyelan Miklos, Ikuta Toshikazu, Karlsgodt Katherine, Gallego Juan A, Kane John M, Szeszko Philip R, Malhotra Anil K   Antipsychotic treatment and functional connectivity of the striatum in first-episode schizophrenia JAMA psychiatry, 2015; 72(1): 5-13.
Peters Bart D, Karlsgodt Katherine H   White matter development in the early stages of psychosis Schizophrenia research, 2015; 161(1): 61-9.
DeRosse Pamela, Ikuta Toshikazu, Peters Bart D, Karlsgodt Katherine H, Szeszko Philip R, Malhotra Anil K   Adding insult to injury: childhood and adolescent risk factors for psychosis predict lower fractional anisotropy in the superior longitudinal fasciculus in healthy adults Psychiatry research, 2014; 224(3): 296-302.
Jalbrzikowski Maria, Villalon-Reina Julio E, Karlsgodt Katherine H, Senturk Damla, Chow Carolyn, Thompson Paul M, Bearden Carrie E   Altered white matter microstructure is associated with social cognition and psychotic symptoms in 22q11.2 microdeletion syndrome Frontiers in behavioral neuroscience, 2014; 8(3): 393.
Schreiner Matthew J, Karlsgodt Katherine H, Uddin Lucina Q, Chow Carolyn, Congdon Eliza, Jalbrzikowski Maria, Bearden Carrie E   Default mode network connectivity and reciprocal social behavior in 22q11.2 deletion syndrome Social cognitive and affective neuroscience, 2014; 9(9): 1261-7.
White Corey N, Congdon Eliza, Mumford Jeanette A, Karlsgodt Katherine H, Sabb Fred W, Freimer Nelson B, London Edythe D, Cannon Tyrone D, Bilder Robert M, Poldrack Russell A   Decomposing decision components in the stop-signal task: a model-based approach to individual differences in inhibitory control Journal of cognitive neuroscience, 2014; 26(8): 1601-14.
Peters Bart D, Voineskos Aristotle N, Szeszko Philip R, Lett Tristram A, DeRosse Pamela, Guha Saurav, Karlsgodt Katherine H, Ikuta Toshikazu, Felsky Daniel, John Majnu, Rotenberg David J, Kennedy James L, Lencz Todd, Malhotra Anil K   Brain white matter development is associated with a human-specific haplotype increasing the synthesis of long chain fatty acids The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014; 34(18): 6367-76.
Congdon Eliza, Altshuler Lori L, Mumford Jeanette A, Karlsgodt Katherine H, Sabb Fred W, Ventura Joseph, McGough James J, London Edythe D, Cannon Tyrone D, Bilder Robert M, Poldrack Russell A   Neural activation during response inhibition in adult attention-deficit/hyperactivity disorder: preliminary findings on the effects of medication and symptom severity Psychiatry research, 2014; 222(1-2): 17-28.
Helfinstein Sarah M, Schonberg Tom, Congdon Eliza, Karlsgodt Katherine H, Mumford Jeanette A, Sabb Fred W, Cannon Tyrone D, London Edythe D, Bilder Robert M, Poldrack Russell A   Predicting risky choices from brain activity patterns Proceedings of the National Academy of Sciences of the United States of America, 2014; 111(7): 2470-5.
Karlsgodt Katherine H, van Erp Theo G M, Bearden Carrie E, Cannon Tyrone D   Altered relationships between age and functional brain activation in adolescents at clinical high risk for psychosis Psychiatry research, 2014; 221(1): 21-9.
Congdon Eliza, Bato Angelica A, Schonberg Tom, Mumford Jeanette A, Karlsgodt Katherine H, Sabb Fred W, London Edythe D, Cannon Tyrone D, Bilder Robert M, Poldrack Russell A   Differences in neural activation as a function of risk-taking task parameters Frontiers in neuroscience, 2013; 7(1): 173.
Bearden Carrie E, Karlsgodt Katherine H, Bachman Peter, van Erp Theo G M, Winkler Anderson M, Glahn David C   Genetic architecture of declarative memory: implications for complex illnesses The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2012; 18(5): 516-32.
Karlsgodt Katherine H, Rosser Tena, Lutkenhoff Evan S, Cannon Tyrone D, Silva Alcino, Bearden Carrie E   Alterations in white matter microstructure in neurofibromatosis-1 PloS one, 2012; 7(10): e47854.
Lutkenhoff Evan, Karlsgodt Katherine H, Gutman Boris, Stein Jason L, Thompson Paul M, Cannon Tyrone D, Jentsch J David   Structural and functional neuroimaging phenotypes in dysbindin mutant mice NeuroImage, 2012; 62(1): 120-9.
Karlsgodt Katherine H, Jacobson Sarah C, Seal Marc, Fusar-Poli Paolo   The relationship of developmental changes in white matter to the onset of psychosis Current pharmaceutical design, 2012; 18(4): 422-33.
Gee Dylan G, Karlsgodt Katherine H, van Erp Theo G M, Bearden Carrie E, Lieberman Matthew D, Belger Aysenil, Perkins Diana O, Olvet Doreen M, Cornblatt Barbara A, Constable Todd, Woods Scott W, Addington Jean, Cadenhead Kristin S, McGlashan Thomas H, Seidman Larry J, Tsuang Ming T, Walker Elaine F, Cannon Tyrone D, Cannon Tyrone D   Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: a preliminary study Schizophrenia research, 2012; 134(1): 1-9.
Karlsgodt Katherine H, Bachman Peter, Winkler Anderson M, Bearden Carrie E, Glahn David C   Genetic influence on the working memory circuitry: behavior, structure, function and extensions to illness Behavioural brain research, 2011; 225(2): 610-22.
Karlsgodt Katherine H, Robleto Karla, Trantham-Davidson Heather, Jairl Corey, Cannon Tyrone D, Lavin Antonieta, Jentsch J David   Reduced dysbindin expression mediates N-methyl-D-aspartate receptor hypofunction and impaired working memory performance Biological psychiatry, 2011; 69(1): 28-34.
Mittal Vijay A, Karlsgodt Katherine, Zinberg Jamie, Cannon Tyrone D, Bearden Carrie E   Identification and treatment of a pineal region tumor in an adolescent with prodromal psychotic symptoms The American journal of psychiatry, 2010; 167(9): 1033-7.
Karlsgodt Katherine H, Sun Daqiang, Cannon Tyrone D   Structural and Functional Brain Abnormalities in Schizophrenia Current directions in psychological science, 2010; 19(4): 226-231.
Shilyansky Carrie, Karlsgodt Katherine H, Cummings Damian M, Sidiropoulou Kyriaki, Hardt Molly, James Alex S, Ehninger Dan, Bearden Carrie E, Poirazi Panayiota, Jentsch J David, Cannon Tyrone D, Levine Michael S, Silva Alcino J   Neurofibromin regulates corticostriatal inhibitory networks during working memory performance Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(29): 13141-6.
Karlsgodt Katherine H, Kochunov Peter, Winkler Anderson M, Laird Angela R, Almasy Laura, Duggirala Ravindranath, Olvera Rene L, Fox Peter T, Blangero John, Glahn David C   A multimodal assessment of the genetic control over working memory The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010; 30(24): 8197-202.
Sanz Jacqueline H, Karlsgodt Katherine H, Bearden Carrie E, van Erp Theo G M, Nandy Rajesh R, Ventura Joseph, Nuechterlein Keith, Cannon Tyrone D   Symptomatic and functional correlates of regional brain physiology during working memory processing in patients with recent onset schizophrenia Psychiatry research, 2009; 173(3): 177-82.
Karlsgodt Katherine H, Niendam Tara A, Bearden Carrie E, Cannon Tyrone D   White matter integrity and prediction of social and role functioning in subjects at ultra-high risk for psychosis Biological psychiatry, 2009; 66(6): 562-9.
Karlsgodt Katherine H, Sanz Jacqueline, van Erp Theo G M, Bearden Carrie E, Nuechterlein Keith H, Cannon Tyrone D   Re-evaluating dorsolateral prefrontal cortex activation during working memory in schizophrenia Schizophrenia research, 2009; 108(1-3): 143-50.
Karlsgodt Katherine H, Sun Daqiang, Jimenez Amy M, Lutkenhoff Evan S, Willhite Rachael, van Erp Theo G M, Cannon Tyrone D   Developmental disruptions in neural connectivity in the pathophysiology of schizophrenia Development and psychopathology, 2008; 20(4): 1297-327.
Karlsgodt Katherine H, van Erp Theo G M, Poldrack Russell A, Bearden Carrie E, Nuechterlein Keith H, Cannon Tyrone D   Diffusion tensor imaging of the superior longitudinal fasciculus and working memory in recent-onset schizophrenia Biological psychiatry, 2008; 63(5): 512-8.
van Erp Theo G M, Lesh Tyler A, Knowlton Barbara J, Bearden Carrie E, Hardt Molly, Karlsgodt Katherine H, Shirinyan David, Rao Vikas, Green Michael F, Subotnik Kenneth L, Nuechterlein Keith, Cannon Tyrone D   Remember and know judgments during recognition in chronic schizophrenia Schizophrenia research, 2008; 100(1-3): 181-90.
Yamamoto Rinah T, Karlsgodt Katherine H, Rott David, Lukas Scott E, Elman Igor   Effects of perceived cocaine availability on subjective and objective responses to the drug Substance abuse treatment, prevention, and policy, 2007; 2(1-3): 30.
Karlsgodt Katherine H, Glahn David C, van Erp Theo G M, Therman Sebastian, Huttunen Matti, Manninen Marko, Kaprio Jaakko, Cohen Mark S, Lönnqvist Jouko, Cannon Tyrone D   The relationship between performance and fMRI signal during working memory in patients with schizophrenia, unaffected co-twins, and control subjects Schizophrenia research, 2007; 89(1-3): 191-7.
Cannon Tyrone D, Glahn David C, Kim Junghoon, Van Erp Theo G M, Karlsgodt Katherine, Cohen Mark S, Nuechterlein Keith H, Bava Sunita, Shirinyan David   Dorsolateral prefrontal cortex activity during maintenance and manipulation of information in working memory in patients with schizophrenia Archives of general psychiatry, 2005; 62(10): 1071-80.
Karlsgodt Katherine H, Shirinyan David, van Erp Theo G M, Cohen Mark S, Cannon Tyrone D   Hippocampal activations during encoding and retrieval in a verbal working memory paradigm NeuroImage, 2005; 25(4): 1224-31.
Elman Igor, Lukas Scott E, Karlsgodt Katherine H, Gasic Gregory P, Breiter Hans C   Acute cortisol administration triggers craving in individuals with cocaine dependence Psychopharmacology bulletin, 2003; 37(3): 84-9.
Karlsgodt Katherine H, Lukas Scott E, Elman Igor   Psychosocial stress and the duration of cocaine use in non-treatment seeking individuals with cocaine dependence The American journal of drug and alcohol abuse, 2003; 29(3): 539-51.
Elman Igor, Karlsgodt Katherine H, Gastfriend David R, Chabris Christopher F, Breiter Hans C   Cocaine-primed craving and its relationship to depressive symptomatology in individuals with cocaine dependence Journal of psychopharmacology (Oxford, England), 2002; 16(2): 163-7.
Rajesh Kumar, Ph.D.

Rajesh Kumar, Ph.D.

Biography

Dr. Kumar has a doctoral degree in Radiology from Sanjay Gandhi Postgraduate Institute of Medical Sciences, UP, India in 2002. He received Postdoctoral training in Neurobiology at the Department of Neurobiology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, California from December 2002 to June 2006. Dr. Kumar has been an Assistant Researcher from July 2006 to September 14, 2013 the Department of Neurobiology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, California. Dr. Kumar joined in the Department of Anesthesiology with secondary appointment in the Department of Radiological Sciences, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, California in September 15, 2013. He has expertise in various magnetic resonance imaging (MRI) and spectroscopy procedures. Dr. Kumar’s research is based on the evaluation of the neural tissue integrity, resulting from breathing or cardiovascular effects, in brain areas of patients with obstructive sleep apnea (OSA) and heart failure (HF) using MR procedures. It helps understand the brain processes that affect autonomic, memory and mood regulations in patients with these conditions.Dr. Kumar is funded by National Institutes of Health (NIH) since August 2012. His current NIH R01 studies involve determination of the pathological stage and nature of white matter damage, using diffusion tensor imaging, including fiber tractography, diffusional kurtosis imaging, and magnetization transfer imaging procedures, in recently-diagnosed, treatment naïve OSA subjects, and examination of how damaged brain autonomic regulatory areas (hypothalamus, insula cortex, and cerebellum) respond to an autonomic challenge, using diffusion tensor imaging and functional MRI procedures, and the laterality of functional responses to that challenge in HF subjects. Dr. Kumar has published over 80 peer-reviewed research manuscripts, 5 book chapters, and over 140 abstracts presented in national and international scientific meetings.

Paul M. Macey, Ph.D.

Paul Macey, Ph.D.

Biography

Paul M. Macey is a neuroscientist who has worked at UCLA since 1999. He is an Associate Professor of Nursing, and serves in the School of Nursing Administration as Director of Information Technology and Innovation, and Chief Innovation Officer. Dr. Macey completed a degree in Electrical Engineering at the University of Canterbury, New Zealand, where he focused on bringing engineering approaches to the analysis of breathing signals recorded from infants during sleep. He started at UCLA in a post-doctoral position in the Department of Neurobiology, and continued as and Assistant then Associate Researcher. Dr. Macey then joined the School of Nursing and Brain Research Institute as a faculty member. Dr. Macey teaches in the undergraduate Nursing program, and serves on various faculty committees.

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