Director, Fuster Laboratory for Cognitive Neuroscience
Biography
Dr. Michele A. Basso is a Professor in the Departments of Psychiatry and Biobehavioral Sciences and Neurobiology. She studied Neuroscience at Stony Brook University in NY and was a post-doctoral fellow at the National Eye Institute, NIH. After serving as a faculty member at the University of Wisconsin Madison, she moved to UCLA to join the faculty and direct the Fuster Laboratory of Cognitive Neuroscience. The work performed in her laboratory is aimed at unravelling the neuronal circuits of decision-making in health and disease. Her work spans multiple species and employs multiple technologies designed to understand how memory and sensory information are combined to give rise to our decisions.
Publications
A selected list of publications:
Perugini Alessandra, Basso Michele A Perceptual decisions based on previously learned information are independent of dopaminergic tone Journal of neurophysiology, 2018; 119(3): 849-861.
Odegaard Brian, Grimaldi Piercesare, Cho Seong Hah, Peters Megan A K, Lau Hakwan, Basso Michele A Superior colliculus neuronal ensemble activity signals optimal rather than subjective confidence Proceedings of the National Academy of Sciences of the United States of America, 2018; 115(7): E1588-E1597.
Crapse Trinity B, Lau Hakwan, Basso Michele A A Role for the Superior Colliculus in Decision Criteria Neuron, 2018; 97(1): 181-194.e6.
May Paul J, Basso Michele A Connections between the zona incerta and superior colliculus in the monkey and squirrel Brain structure & function, 2018; 223(1): 371-390.
Basso Michele A, May Paul J Circuits for Action and Cognition: A View from the Superior Colliculus Annual review of vision science, 2017; 3(1): 197-226.
Ghitani Nima, Bayguinov Peter O, Basso Michele A, Jackson Meyer B A sodium afterdepolarization in rat superior colliculus neurons and its contribution to population activity Journal of neurophysiology, 2016; 116(1): 191-200.
Perugini Alessandra, Ditterich Jochen, Basso Michele A Patients with Parkinson’s Disease Show Impaired Use of Priors in Conditions of Sensory Uncertainty Current biology : CB, 2016; 26(14): 1902-10.
Basso Michele A Monkey neurophysiology to clinical neuroscience and back again Proceedings of the National Academy of Sciences of the United States of America, 2016; 113(24): 6591-3.
Crapse Trinity B, Basso Michele A Insights into decision making using choice probability Journal of neurophysiology, 2015; 114(6): 3039-49.
Grimaldi Piercesare, Lau Hakwan, Basso Michele A There are things that we know that we know, and there are things that we do not know we do not know: Confidence in decision-making Neuroscience and biobehavioral reviews, 2015; 55: 88-97.
Bayguinov Peter O, Ghitani Nima, Jackson Meyer B, Basso Michele A A hard-wired priority map in the superior colliculus shaped by asymmetric inhibitory circuitry Journal of neurophysiology, 2015; 114(1): 662-76.
Vokoun Corinne R, Huang Xin, Jackson Meyer B, Basso Michele A Response normalization in the superficial layers of the superior colliculus as a possible mechanism for saccadic averaging The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014; 34(23): 7976-87.
Ghitani Nima, Bayguinov Peter O, Vokoun Corinne R, McMahon Shane, Jackson Meyer B, Basso Michele A Excitatory synaptic feedback from the motor layer to the sensory layers of the superior colliculus The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014; 34(20): 6822-33.
Mahamed Safraaz, Garrison Tiffany J, Shires Joel, Basso Michele A Stimulation of the Substantia Nigra Influences the Specification of Memory-Guided Saccades Journal of neurophysiology, 2013; 39(1): .
Powers Alice S, Basso Michele A, Evinger Craig Blinks slow memory-guided saccades Journal of neurophysiology, 2013; 109(3): 734-41.
Vokoun Corinne R, Jackson Meyer B, Basso Michele A Circuit dynamics of the superior colliculus revealed by in vitro voltage imaging Annals of the New York Academy of Sciences, 2011; 1233(2): 41-7.
Li Xiaobing, Basso Michele A Cues to move increased information in superior colliculus tuning curves Journal of neurophysiology, 2011; 106(2): 690-703.
Shires Joel, Joshi Siddhartha, Basso Michele A Shedding new light on the role of the basal ganglia-superior colliculus pathway in eye movements Current opinion in neurobiology, 2010; 20(6): 717-25.
Vokoun Corinne R, Jackson Meyer B, Basso Michele A Intralaminar and interlaminar activity within the rodent superior colliculus visualized with voltage imaging The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010; 30(32): 10667-82.
Kim Byounghoon, Basso Michele A A probabilistic strategy for understanding action selection The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010; 30(6): 2340-55.
Gooding Diane C, Basso Michele A The tell-tale tasks: a review of saccadic research in psychiatric patient populations Brain and cognition, 2008; 68(3): 371-90.
Liu Ping, Basso Michele A Substantia nigra stimulation influences monkey superior colliculus neuronal activity bilaterally Journal of neurophysiology, 2008; 100(2): 1098-112.
Basso Michele A Electrical stimulation of nervous system tissue. Introduction Neuroscience and biobehavioral reviews, 2008; 32(3): 331.
Li Xiaobing, Basso Michele A Preparing to move increases the sensitivity of superior colliculus neurons The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008; 28(17): 4561-77.
Kim Byounghoon, Basso Michele A Saccade target selection in the superior colliculus: a signal detection theory approach The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008; 28(12): 2991-3007.
Utter Amy A, Basso Michele A The basal ganglia: an overview of circuits and function Neuroscience and biobehavioral reviews, 2008; 32(3): 333-42.
Basso Michele A, Liu Ping Context-dependent effects of substantia nigra stimulation on eye movements Journal of neurophysiology, 2007; 97(6): 4129-42.
Smith Joshua J, Hadzic Vezira, Li Xiaobing, Liu Ping, Day Tiffany, Utter Amy, Kim Byounghoon, Washington Ida M, Basso Michele A Objective measures of health and well-being in laboratory rhesus monkeys (Macaca mulatta) Journal of medical primatology, 2006; 35(6): 388-96.
Li Xiaobing, Kim Byounghoon, Basso Michele A Transient pauses in delay-period activity of superior colliculus neurons Journal of neurophysiology, 2006; 95(4): 2252-64.
Li Xiaobing, Basso Michele A Competitive stimulus interactions within single response fields of superior colliculus neurons The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005; 25(49): 11357-73.
Basso Michele A, Pokorny Jennifer J, Liu Ping Activity of substantia nigra pars reticulata neurons during smooth pursuit eye movements in monkeys The European journal of neuroscience, 2005; 22(2): 448-64.
Basso Michele A, Uhlrich Daniel, Bickford Martha E Cortical function: a view from the thalamus Neuron, 2005; 45(4): 485-8.
Williamson Shawn S, Zivotofsky Ari Z, Basso Michele A Modulation of gaze-evoked blinks depends primarily on extraretinal factors Journal of neurophysiology, 2005; 93(1): 627-32.
Basso Michele A, Wurtz Robert H Neuronal activity in substantia nigra pars reticulata during target selection The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002; 22(5): 1883-94.
Biography
Dr Bisley received his Ph.D. from the University of Melbourne in Australia where he studied the peripheral somatosensory system. He did his first post-doc at the University of Rochester working with Dr Tatiana Pasternak, where he studied the neural mechanisms underlying memory for motion. In 1999, he went to Washington, DC where he worked with Dr Michael E. Goldberg at Georgetown University and the National Eye Institute, studying the neural mechanisms underlying visuo-spatial attention. Dr Bisley moved to Columbia University with Dr Goldberg in 2002 and joined UCLA in 2006.
Biography
A vertebrate photoreceptor uses a G-protein receptor (rhodopsin) and a G-protein cascade to produce the electrical response that signals a change in light intensity. Powerful new techniques have made it possible to understand the working of this cascade in extraordinary detail. The reason for this is that practically every protein involved in the cascade in a photoreceptor, from the pigment molecule rhodopsin to the G-protein and channels, but including also a large number of control proteins, are expressed only in the photoreceptors and nowhere else in the body. This makes it possible with genetic techniques to create mice in which these proteins have been knocked out, over or under expressed, or replaced with proteins of modified structure. We use electrical recording to study the effects of such genetic alterations on the light responses of mouse rods and cones, in order to understand the role of these proteins in the visual cascade. We are especially interested in modulatory enzymes and their function in light and dark adaptation. We also have a long-standing interest in mechanisms of photoreceptor degeneration in genetically inherited disease.
Publications
A selected list of publications:
Fain Gordon, Sampath Alapakkam P Rod and cone interactions in the retina F1000Research, 2018; 7: .
Morshedian Ala, Woodruff Michael L, Fain Gordon L Role of recoverin in rod photoreceptor light adaptation The Journal of physiology, 2018; 596(8): 1513-1526.
Morshedian Ala, Toomey Matthew B, Pollock Gabriel E, Frederiksen Rikard, Enright Jennifer M, McCormick Stephen D, Cornwall M Carter, Fain Gordon L, Corbo Joseph C Cambrian origin of the CYP27C1-mediated vitamin A Royal Society open science, 2017; 4(7): 170362.
Morshedian Ala, Fain Gordon L Light adaptation and the evolution of vertebrate photoreceptors The Journal of physiology, 2017; 595(14): 4947-4960.
Kaylor Joanna J, Xu Tongzhou, Ingram Norianne T, Tsan Avian, Hakobyan Hayk, Fain Gordon L, Travis Gabriel H Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate Nature communications, 2017; 8(1): 16.
Morshedian Ala, Fain Gordon L The evolution of rod photoreceptors Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2017; 372(1717): 16.
Ingram Norianne T, Sampath Alapakkam P, Fain Gordon L Why are rods more sensitive than cones? The Journal of physiology, 2016; 594(19): 5415-26.
Reingruber Jürgen, Holcman David, Fain Gordon L How rods respond to single photons: Key adaptations of a G-protein cascade that enable vision at the physical limit of perception BioEssays : news and reviews in molecular, cellular and developmental biology, 2015; 37(11): 1243-52.
Morshedian Ala, Fain Gordon L Single-photon sensitivity of lamprey rods with cone-like outer segments Current biology : CB, 2015; 25(4): 484-7.
Reingruber Jürgen, Pahlberg Johan, Woodruff Michael L, Sampath Alapakkam P, Fain Gordon L, Holcman David Detection of single photons by toad and mouse rods Proceedings of the National Academy of Sciences of the United States of America, 2013; 110(48): 19378-83.
Chen Ching-Kang, Woodruff Michael L, Chen Frank S, Chen Yenlin, Cilluffo Marianne C, Tranchina Daniel, Fain Gordon L Modulation of mouse rod response decay by rhodopsin kinase and recoverin The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012; 32(45): 15998-6006.
Chen Jeannie, Woodruff Michael L, Wang Tian, Concepcion Francis A, Tranchina Daniel, Fain Gordon L Channel modulation and the mechanism of light adaptation in mouse rods The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010; 30(48): 16232-40.
Fain Gordon L, Hardie Roger, Laughlin Simon B Phototransduction and the evolution of photoreceptors Current biology : CB, 2010; 20(3): R114-24.
Okawa Haruhisa, Sampath Alapakkam P, Laughlin Simon B, Fain Gordon L ATP consumption by mammalian rod photoreceptors in darkness and in light Current biology : CB, 2008; 18(24): 1917-21.
Dizhoor Alexander M, Woodruff Michael L, Olshevskaya Elena V, Cilluffo Marianne C, Cornwall M Carter, Sieving Paul A, Fain Gordon L Night blindness and the mechanism of constitutive signaling of mutant G90D rhodopsin The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008; 28(45): 11662-72.
Fain GL Why photoreceptors die (and why they don’t), BioEssays, 2006; 28: 344-354.