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Benjamin Wu, D.D.S., Ph.D.

Biography

Prof. Ben Wu received his D.D.S. from the University of Pacific, his advanced prosthodontics specialty certificate at the Harvard School of Dental Medicine, and his Ph.D. in Materials Science and Engineering from the Massachusetts Institute of Technology. He is currently Professor and Chair of the UCLA Department of Bioengineering, and Chair of the Division of Advanced Prosthodontics in the School of Dentistry. He holds joint appointment in the Department of Materials Science and Engineering, and in the Department of Orthopedic Surgery in the School of Medicine. Prof. Wu is Director of the Weintraub Center for Reconstructive Biotechnology, and a member of the UCLA Brain Research Institute, the California NanoSystems Institute, and Fellow of the the Academy of Prosthodontics.

Publications

A selected list of publications:

Lee M, Siu RK, Ting K, Wu BM   Effect of nell-1 delivery on chondrocyte proliferation and cartilaginous extracellular matrix deposition Tissue Eng Part A, 2010; 16(5): 1791-800.
Yuki I, Uchiyama N, Murayama Y, Nien YL, Lee D, Ebara M, Ishii A, Chiang A, Vinters HV, Nishimura I, Wu BM, Vinuela F   Intravascular tissue reactions induced by various types of bioabsorbable polymeric materials: correlation between the degradation profiles and corresponding tissue reactions Neuroradiology, 2010; 52(11): 1017-24.
Pham EA, Ho WJ, Kamei DT, Wu BM   Modification of the diphenylamine assay for cell quantification in three-dimensional biodegradable polymeric scaffolds J Biomed Mater Res B Appl Biomater, 2010; 92(2): 499-507.
Aghaloo T, Cowan CM, Zhang X, Freymiller E, Soo C, Wu B, Ting K, Zhang Z   The effect of NELL1 and bone morphogenetic protein-2 on calvarial bone regeneration J Oral Maxillofac Surg, 2010; 68(2): 300-8.
Lee M, Li W, Siu RK, Whang J, Zhang X, Soo C, Ting K, Wu BM.   Biomimetic apatite-coated alginate/chitosan microparticles as osteogenic protein carriers Biomaterials, 2009; 30(30): 6094-101.
Choi CH, Heydarkhan-Hagvall S, Wu BM, Dunn JC, Beygui RE, Kim CJ.   Cell growth as a sheet on three-dimensional sharp-tip nanostructures J Biomed Mater Res A, 2009; 89(3): 804-17.
Kramerova I, Kudryashova E, Wu B, Germain S, Vandenborne K, Romain N, Haller RG, Verity MA, Spencer MJ.   Mitochondrial abnormalities, energy deficit and oxidative stress are features of calpain 3 deficiency in skeletal muscle Hum Mol Genet, 2009; 18(17): 3194-205.
Lee, M. Wu, B. M. Dunn, J. C. Y.   Effect of scaffold architecture and pore size on smooth muscle cell growth Journal of Biomedical Materials Research Part A, 2008; 87A(4): 1010-1016.
Brown, D. A. MacLellan, W. R. Dunn, J. C. Y. Wu, B. M. Beygui, R. E.   Hypoxic cell death is reduced by pH buffering in a model of engineered heart tissue Artificial Cells Blood Substitutes and Biotechnology, 2008; 36(2): 94-113.
Lee, M. Wu, B. M. Stelzner, M. Reichardt, H. M. Dunn, J. C. Y.   Intestinal smooth muscle cell maintenance by basic fibroblast growth factor Tissue Engineering Part A, 2008; 14(8): 1395-1402.
Lee M, Wu BM, Stelzner M, Reichardt HM, Dunn JC.   Intestinal smooth muscle cell maintenance by basic fibroblast growth factor Tissue Eng Part A, 2008; 14(8): 1395-402.
Chow, M. Duong, H. Wu, B. Tawil, B.   Mesenchymal stem cells differentiation into osteoblasts on 2D and in 3D fibrin scaffolds Wound Repair and Regeneration, 2008; 16(2): 175.
Kramerova, I. Kudryashova, E. Wu, B. Ottenheijm, C. Granzier, H. Spencer, M. J.   Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle Human Molecular Genetics, 2008; 17(21): 3271-3280.
Dave, D. S. Gunther-Lopez, V. Zhang, R. Leung, J. Kun, S. Gollapudi, K. Wu, B. Rodriguez, L. V.   Periurethral injection of autologous adipose-derived stem cells with hepatocyte growth factor-impregnated PLGA microspheres for treatment of stress urinary incontinence in an animal model Journal of Urology, 2008; 179(4): 109-109.
Heydarkhan-Hagvall, S. Schenke-Layland, K. Dhanasopon, A. P. Rofail, F. Smith, H. Wu, B. M. Shemin, R. Beygui, R. E. MacLellan, W. R.   Three-dimensional electrospun ECM-based hybrid scaffolds for cardiovascular tissue engineering Biomaterials, 2008; 29(19): 2907-2914.
Brown DA, MacLellan WR, Laks H, Dunn JC, Wu BM, Beygui RE   Analysis of oxygen transport in a diffusion-limited model of engineered heart tissue Biotechnol Bioeng, 2007; 97(4): 962-75.
Brown DA, MacLellan WR, Wu BM, Beygui RE   Analysis of pH gradients resulting from mass transport limitations in engineered heart tissue Annals of Biomed Eng, 2007; 35(11): 1885-1897.
Choi CH. Hagwall SH. Wu BM. Dunn JCY. Kim CJ   Cell interactions with 3D sharp tip nanotopography Biomaterials, 2007; 28(9): 1672-9.
Lee M. Wu BM. Dunn JYC   Effect of scaffold architecture and pore size on smooth muscle cell growth J. Biomed. Mat Res. Part A, 2007; 87(4): 1010-6.
Hagerman E. Shim J. Gupta V. Wu BM   Evaluation of laser spallation as a technique for measurement of cell adhesion strength J. Biomed. Mat. Res. Part A 82A, 2007; 82(4): 852-860.
Mack JJ, Cox BN, Lee M, Dunn JYC, Wu BM   Magnetically Actuable Polymer Nanocomposites for Bioengineering Applications J. Mater. Sci, 2007; 42(15): 6139-6147.
Cowan CM, Aghaloo T, Chou YF, Walder B, Zhang X, Soo C, Ting K, Wu BM.   MicroCT Evaluation of Three-Dimensional Mineralization in Response to BMP-2 Doses In Vitro and in Critical Sized Rat Calvarial Defects, Tissue Engineering, 2007; 13(3): 501-512.
Lee M. Iruela Arispe ML. Wu BM. Dunn JCY   Modulation of protein delivery from modular polymer scaffolds Biomaterials, 2007; 28(10): 1862-70.
Lee, M. Chen, T. T. Iruela-Arispe, M. L. Wu, B. M. Dunn, J. C. Y.   Modulation of protein delivery from modular polymer scaffolds Biomaterials, 2007; 28(10): 1862-1870.
Wan DC, Pomerantz JH, Brunet LJ, Kim JB, Chou YF, Wu, BM, Harland R, Blau HM, Longaker MT   Noggin suppression enhances in vitro osteogenesis and accelerates in vivo bone formation J. Biol Chem, 2007; 282(36): 26450-26459.
Aghaloo T, Amantea CM. Cowan KM, Richardson JA, Wu B, Parhami F, Tetradis S   Oxysterols enhance osteoblast differentiation in vitro and bone healing in vivo J. Orthop Res, 2007; 25(11): 1488-1497.
Wan DC, Siedhoff MT, Kwan MD, Nacamuli RP, Wu BM, Longaker MT   Refining Retinoic Acid Stimulation for Osteogenic Differentiation of Murine Adipose-Derived Adult Stromal Cells Tissue Engineering, 2007; 13(7): 1623-1631.
Cowan, C. M. Jiang, X. Q. Hsu, T. Soo, C. Zhang, B. J. Wang, J. Z. Kuroda, S. Wu, B. Zhang, Z. Y. Zhang, X. L. Ting, K.   Synergistic effects of Nell-1 and BMP-2 on the osteogenic differentiation of myoblasts Journal of Bone and Mineral Research, 2007; 22(6): 918-930.
Cowan CM, Jiang X, Hsu T, Soo C, Zhang J, Wang J, Kuroda S, Wu B, Zhang Z, Zhang X, Ting K   Synergistic effects of Nell-1 and BMP-2 on the osteogenic differentiation of myoblasts J Bone Mineral Res, 2007; 22(6): 918-30.
Petrigliano FA, English C. Barba D. Esmende S. Wu BM. McAllister MD   The Effects of Local bFGF Release and Uniaxial Strain on Cellular Adaptation and Gene Expression in a 3D Environment: Implications for Ligament Tissue Engineering Tissue Engineering, 2007; 13(11): 1-11.
Lu SS, Zhang X, Soo C, Hsu T, Napoli A, Aghaloo T, Wu BM, Tsou P, Ting K, Wang JC   The osteoinductive properties of Nell-1 in rat spinal fusion model The Spine Journal, 2007; 7(1): 50-60.
Yuki I, Lee D, Murayama Y, Chiang A, Vinters HV, Nishimura I, Wang CJ, Ishii A, Wu BM, Vinuela V   Thrombus organization and healing in an experimental aneurysm model. Part II. The effect of various types of bioabsorbable polymeric coils J. Neurosurgery, 2007; 107(1): 109-120.
Lee D, Yuki I, Murayama Y, Chiang A, Nishimura I, Vinters HV, Wang CJ, Nien YL, Ishii A, Wu BM, Vinuela F   Thrombus organization and healing in the swine experimental aneurysm model. Part I. A histological and molecular analysis J. Neurosurgery, 2007; 107(1): 94-108.
Dunn JCY. Chan WY, Cristini V. Kim JS. Lowengrub J. Singha S. Wu BM   Analysis of Cell Growth in Three-Dimensional Scaffolds Tissue Engineering, 2006; 12: 705-716.
Rodriguez LV. Alfonso Z. Zhang R. Leung J. Wu BM. Ignarro LJ.   Clonogenic multipotent stem cells in human adipose tissue differentiate into functional smooth muscle cells PNAS, 2006; 103(32): 12167-12172.
Mendoza J., Chang C., Blalock CL., Atkinson JB., WU BM., Dunn JYC.   Contractile Function of the Mechanically Lengthened Intestine J. Surgical Research, 2006; 136(1): 8-12.
Puapong DP., Wu BM., Lam MM., Atkinson JB., Dunn JCY.   Distension enterogenesis: Increasing the Size and Function of Small Intestine J. Pediatric Surgery , 2006; 41(4): 763-7.
Catelas I. Sese N. Dunn JCY. Helgerson S. Tawil B. Wu BM   Human Mesenchymal Stem Cells Proliferation and Osteogenic Differentiation in Fibrin Gels in vitro Tissue Engineering, 2006; 12(8): 1-12.
Hagerman EM. Chao SHH. Dunn JCY. Wu BM   Initial Adhesion Events for IEC-6: signal transduction, cell spreading, and cell adhesion strength Journal of Biomedical Materials Research , 2006; 76(2): 272-278.
Aghaloo T, Cowan K, Chou YF, Zhang X, Lee HF, Miao S, Hong N, Kuroda S, Wu B, Ting K, Soo C   Nell-1 Induced Bone Regeneration in Calvarial Defects Am J Pathol, 2006; 169(3): 903-15.
Cowan, C. M. Cheng, S. Ting, K. Soo, C. Walder, B. Wu, B. Kuroda, S. Zhang, X. L.   Nell-1 induced bone formation within the distracted intermaxillary suture Bone, 2006; 38(1): 48-58.
Cowan, C. M. Cheng, S. Ting, K. Soo, C. Walder, B. Wu, B. Kuroda, S. Zhang, X.   Nell-1 induced bone formation within the distracted intermaxillary suture Bone, 2006; 38(1): 48-58.
Zhang X, Cowan K, Jiang X, Soo C, Miao S, Carpenter D, Wu, B, Kuroda K, and Ting K.   Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development Lab Invest, 2006; 86(7): 633-44.
Kramerova, I. Kudryashova, E. Wu, B. Spencer, M. J.   Regulation of the M-cadherin-beta-catenin complex by calpain 3 during terminal stages of myogenic differentiation Molecular and Cellular Biology, 2006; 26(22): 8437-8447.
Chu Y. Wu BM. McCabe ER. Dunn JCY   Serum Free cultures of murine adrenal cortical cells. J. Pediatric Surgery, 2006; 41(12): 2008-2012.
Chang P.C.Y. Mendoza J. Park J. Lam MM. Wu BM. Atkinson JB. Dunn JCY.   Sustainability of mechanically lengthened bowel in rats J. Pediactric Surgery, 2006; 41(12): 2019-2022.
Ho, W. Tawil, B. Dunn, J. C. Y. Wu, B. M.   The behavior of human mesenchymal stem cells in 3D fibrin clots: Dependence on fibrinogen concentration and clot structure Tissue Engineering, 2006; 12(6): 1587-1595.
Dunn, JCY. Wu, BM   Tissue Engineering of Intestine, Encyclopedia of Biomaterials and Biomedical Engineering, 2006; 1-7.
Petrigliano FA., McAllister MD., Wu BM.   Tissue Engineering of the ACL: A Review of Current Strategies Arthroscopy, 2006; 22(4): 441-451.
Wu, B. Kitagawa, K. Liu, B. Zhang, N. Y. Xiong, Z. M. Inagaki, C.   Attenuation of amyloid beta (Abeta)-induced inhibition of phosphatidylinositol 4-kinase activity by Abeta fragments, Abeta20-29 and Abeta31-35 Neurosci Lett, 2006; 396(2): 148-52.
Wu, B. K. Li, C. C. Chen, H. J. Chang, J. L. Jeng, K. S. Chou, C. K. Hsu, M. T. Tsai, T. F.   Blocking of G1/S transition and cell death in the regenerating liver of Hepatitis B virus X protein transgenic mice Biochem Biophys Res Commun, 2006; 340(3): 916-28.
Wu, B. Liu, J.   Commutability between the semiclassical and adiabatic limits Phys Rev Lett, 2006; 96(2): 020405.
Chang, T. H. Wu, B. R. Chiang, M. Y. Liao, S. C. Ong, C. W. Hsu, H. F. Lin, S. Y.   Synthesis and mesomorphic behavior of a donor-acceptor-type hexaazatriphenylene Org Lett, 2005; 7(19): 4075-8.
Brown, D. A. Beygui, R. E. MacLellan, W. R. Laks, H. Dunn, J. C. Wu, B. M.   Modulation of gene expression in neonatal rat cardiomyocytes by surface modification of polylactide-co-glycolide substrates J Biomed Mater Res A, 2005; 74(3): 419-29.
Wu, B. T. Hung, P. F. Chen, H. C. Huang, R. N. Chang, H. H. Kao, Y. H.   The apoptotic effect of green tea (-)-epigallocatechin gallate on 3T3-L1 preadipocytes depends on the Cdk2 pathway J Agric Food Chem, 2005; 53(14): 5695-701.
Lee, M Dunn, JC Wu, BM   Scaffold fabrication by indirect three-dimensional printing Biomaterials. , 2005; 26(20): 4281-9.
Chou, Y.F., Wulur, I., Dunn, JCY., Wu, BM.   Biomimetic Nano-Ordered Apatites , Handbook of Nanostructured Biomaterials and Their Applications. edited by H. S. Nalwa,, 2005; 2(6): 198-222.
Cowan, C. M. Aalami, O. O. Shi, Y. Y. Chou, Y. F. Mari, C. Thomas, R. Quarto, N. Nacamuli, R. P. Contag, C. H. Wu, B. Longaker, M. T.   Bone morphogenetic protein 2 and retinoic acid accelerate in vivo bone formation, osteoclast recruitment, and bone turnover Tissue Eng, 2005; 11(3-4): 645-58.
Wu, B. Sun, Y. H. Wang, Y. W. Wang, Y. P. Zhu, Z. Y.   Characterization of transgene integration pattern in F4 hGH-transgenic common carp (Cyprinus carpio L.) Cell Res, 2005; 15(6): 447-54.
Yang CY. Brooks E. Li Y. Wong DTW. Denny P. Ho CM. Qi F. Shi W. Wolinsky L. Wu BM. Montemagno CD.   Detection of Picomolar levels of interleukin-8 in human saliva by SPR Lab on a Chip, 2005; 5(10): 1017-1023.
Wu, B. Gao, J. Wang, M. W.   Development of a complex scintillation proximity assay for high-throughput screening of PPARgamma modulators Acta Pharmacol Sin, 2005; 26(3): 339-44.
Cowan, CM Soo, C Ting, K Wu, B   Evolving concepts in bone tissue engineering Current topics in developmental biology, 2005; 66(86): 239-85.
Brown DA. Chou YF. Lam M. Beygui RE. Dunn JYC. Wu BM   Gelatin embedding cell-polymer constructs for frozen sections, J. Biomedical Materials Research, 2005; 72B: 79-85.
Chou YF. Dunn JCY. Wu BM   In vitro response of MC3T3-E1 preosteoblasts within three-dimensional apatite-coated PLGA scaffolds Journal of Biomedical Materials Research , 2005; 75(1): 81-90.
Wu, B. N. Tu, H. F. Welsh, D. G. Chen, I. J.   KMUP-1 activates BKCa channels in basilar artery myocytes via cyclic nucleotide-dependent protein kinases Br J Pharmacol, 2005; 146(6): 862-71.
Brown DA. Beygui RE. Antrobus S. Ross RS. MacLellan WR. Laks H. Dunn JYC. Wu BM.   Modulation of hypertrophy in neonatal rat cardiomyocytes by surface modification of synthetic substrates, J. Biomedical Materials Research, 2005; 74A(3): 419-429.
Wu, B. Wong, D. Lu, S. Dickstein, S. Silva, M. Gelety, T. J.   Optimal use of fresh and frozen-thawed testicular sperm for intracytoplasmic sperm injection in azoospermic patients J Assist Reprod Genet, 2005; 22(11-12): 389-94.
Jarrahy R., Huang W., Rudkin GH., Lee JM., Ishida K., Berry MD., Sukkarieh M., Wu BM., Yamaguchi DT., Miller TA.   Osteogenic differentiation is inhibited and angiogenic expression is enhanced in MC3T3-E1 cells cultured on three-dimensional scaffolds Am J Physiology – Cell Physiology, 2005; 289: 408-414.
Wu, B. Elmariah, S. Kaplan, F. S. Cheng, G. Mohler, E. R., 3rd   Paradoxical effects of statins on aortic valve myofibroblasts and osteoblasts: implications for end-stage valvular heart disease Arterioscler Thromb Vasc Biol, 2005; 25(3): 592-7.
Wu, B. Klatzky, R. L. Shelton, D. Stetten, G. D.   Psychophysical evaluation of in-situ ultrasound visualization IEEE Trans Vis Comput Graph, 2005; 11(6): 684-93.
Lee M. Dunn JCY. Wu BM.   Scaffold Fabrication by Indirect 3D Printing, Biomaterials, 2005; 26(20): 4281-4289.
Puk CK., Gamradt S., Wu B.M., McAllister D   The Effects of Short-Term Stimulation on Fibroblast Spreading in an Invitro 3D Syste J. Biomedical Materials Research , 2005; 76(4): 665-673.
Li Y, Denny P, Ho CM, Montemagno C, Shi W, Qi F, Wu B, Wolinsky L, Wong DT.   The Oral Fluid MEMS/ NEMS Chip (OFMNC): diagnostic and translational applications Advanced Dental Resesarch, 2005; 18(1): 3-5.
Chou, Y. F. Huang, W. Dunn, J. C. Miller, T. A. Wu, B. M.   The effect of biomimetic apatite structure on osteoblast viability, proliferation, and gene expression Biomaterials, 2005; 26(3): 285-95.
Wu, B. Muller, J. D.   Time-integrated fluorescence cumulant analysis in fluorescence fluctuation spectroscopy Biophys J, 2005; 89(4): 2721-35.
Wu, B. Zhang, G. Zhang, Y. Shuang, S. Choi, M. M.   Measurement of glucose concentrations in human plasma using a glucose biosensor Anal Biochem, 2005; 340(1): 181-3.
Brown, D. A. Chou, Y. F. Beygui, R. E. Dunn, J. C. Wu, B. M.   Gelatin-embedded cell-polymer constructs for histological cryosectioning J Biomed Mater Res B Appl Biomater, 2005; 72(1): 79-85.
Wu, B. Liu, Q. Sulikowski, G. A.   Total synthesis of apoptolidinone Angew Chem Int Ed Engl, 2004; 43(48): 6673-5.
Deng, Y. M. Wu, B. J. Witting, P. K. Stocker, R.   Probucol protects against smooth muscle cell proliferation by upregulating heme oxygenase-1 Circulation, 2004; 110(13): 1855-60.
Wu, B. T. Su, Y. H. Tsai, M. T. Wasserman, S. M. Topper, J. N. Yang, R. B.   A novel secreted, cell-surface glycoprotein containing multiple epidermal growth factor-like repeats and one CUB domain is highly expressed in primary osteoblasts and bones J Biol Chem, 2004; 279(36): 37485-90.
St. John M. Li Y. Zhou XF. DennyD. Ho CM. Montemagno C. Shi WY. Qi FX. Wu BM. Sinha U. Jordan R. Wolinsky L. Park NH. Abemayor E. Wong DTW   IL-6 and IL-8: Potential Biomarkers for Oral Cavity and Oropharyngeal SSC, Arch of Otolaryngology/Head & Neck Surgery , 2004; 130(8): 929-35.
Cowan, CM., Shi S., Alami, OO., Chou, YF., Thomas R. Marie C., Quarto N., Wu BM. Longaker MT.   Adipose-derived Mesenchymal Stromal Cells Tissue Engineer Bone in Critical Sized Mouse Calvarial Defects Nature Biotechnology, 2004; 22(5): 560-567.
Dunn, J. C. Chu, Y. Lam, M. M. Wu, B. M. Atkinson, J. B. McCabe, E. R.   Adrenal cortical cell transplantation J Pediatr Surg, 2004; 39(12): 1856-8.
Park J. Puapong DP. Wu BM. Atkinson JB. Dunn JCY   Enterogenesis by Mechanical Lengthening: Morphology and Function of the Lengthened Small Intestine J. Pediatric Surg, 2004; 39(12): 1823-1827.
Wu, B. N. Lin, R. J. Lo, Y. C. Shen, K. P. Wang, C. C. Lin, Y. T. Chen, I. J.   KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels Br J Pharmacol, 2004; 142(7): 1105-14.
Kreth, J., Hagerman, E., Tam, K., Merritt, J., Wu, B.M., Myung, M., Shi, W., and Qi, F   Quantitative Analyses of Streptococcus mutans Biofilms with Quartz Crystal Microbalance, Microjet Impingement, and Confocal Microscopy Biofilms, 2004; 1(4): 277-284.
Chen, X. Grzegorczyk, T. M. Wu, B. I. Pacheco, J., Jr. Kong, J. A.   Robust method to retrieve the constitutive effective parameters of metamaterials Phys Rev E Stat Nonlin Soft Matter Phys, 2004; 70(1 Pt 2): 016608.
Yang, W. Wu, B. Asakura, S. Kohno, I. Matsuda, M.   Soluble fibrin augments spreading of fibroblasts by providing RGD sequences of fibrinogen in soluble fibrin Thromb Res, 2004; 114(4): 293-300.
Wu, B. M. Nakamura, M. Rezaee, M.   Stent implantation for coronary aneurysm with edge stenosis: angiographic and intravascular analysis J Invasive Cardiol, 2004; 16(3): 149-51.
Wu, B.   Testing three competing hypotheses for explaining lethal violence Violence Vict, 2004; 19(4): 399-411.
Chou YF. Chiou WA. Xu Y. Dunn JCY. Wu BM   The Effect of pH on Structural Evolution of Accelerated Biomimetic Apatite Formation Biomaterials, 2004; 25(22): 5323-5331.
Wu, B. Li, P. Liu, Y. Lou, Z. Ding, Y. Shu, C. Ye, S. Bartlam, M. Shen, B. Rao, Z.   3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex Proc Natl Acad Sci U S A, 2004; 101(22): 8348-53.
Liu, B. Hattori, N. Jiang, B. Nakayama, Y. Zhang, N. Y. Wu, B. Kitagawa, K. Taketo, M. Matsuda, H. Inagaki, C.   Single cell RT-PCR demonstrates differential expression of GABAC receptor rho subunits in rat hippocampal pyramidal and granule cells Brain Res Mol Brain Res, 2004; 123(1-2): 1-6.
He, Y. Yang, J. Wu, B. Robinson, D. Sprankle, K. Kung, P. P. Lowery, K. Mohan, V. Hofstadler, S. Swayze, E. E. Griffey, R.   Synthesis and evaluation of novel bacterial rRNA-binding benzimidazoles by mass spectrometry Bioorg Med Chem Lett, 2004; 14(3): 695-9.
De Ugarte DA. Choi E. Weitzbuch H. Wulur I. Caulkins C. Wu BM. Fonkalsrud EW. Atkinson JB. Dunn JCY   Mucosal regeneration of a duodenal defect using small intestine submucosa The American Surgeon, 2004; 70(1): 49-51.
Wu, B. Yang, J. Robinson, D. Hofstadler, S. Griffey, R. Swayze, E. E. He, Y.   Synthesis of linked carbohydrates and evaluation of their binding for 16S RNA by mass spectrometry Bioorg Med Chem Lett, 2003; 13(22): 3915-8.
Wu, B. Abbott, T. Fishman, D. McMurray, W. Mor, G. Stone, K. Ward, D. Williams, K. Zhao, H.   Comparison of statistical methods for classification of ovarian cancer using mass spectrometry data Bioinformatics, 2003; 19(13): 1636-43.
Qin, W. Tyshenko, M. G. Wu, B. S. Walker, V. K. Robertson, R. M.   Cloning and characterization of a member of the Hsp70 gene family from Locusta migratoria, a highly thermotolerant insect Cell Stress Chaperones, 2003; 8(2): 144-52.
Sukotjo C. Lin A. Song KK. Ogawa I. Wu BM. Nishimura I   Oral fibroblast expression of wound inducible transcript-3.0 (wit-3.0) accelerates collagen gel contraction in vitro J. Biological Chemistry, 2003; 278(51): 51527-51534.
Zhang X. Carpenter D. Bokui N. Soo C. MiaoS. Truong T. Wu BM. Chen I. Vastardis H. Tanizawa K. Kuroda S. Ting K.   Overexpression of Nell-1, a craniosynostosis associated gene, induces apoptosis in osteoblasts during craniofacial development Journal of Bone and Mineral Research , 2003; 18(12): 2126-2134.
Nishimura I. Garrell R. Hedrick M. Iida K. Osher S. Wu BM   Precursor tissue analogs as a tissue-engineering strategy Tissue Engineering, 2003; 9(1): 77-89.
Hong, B. Wu, B. Li, Y.   Production of C-terminal amidated recombinant salmon calcitonin in Streptomyces lividans Appl Biochem Biotechnol, 2003; 110(2): 113-23.
Wu, B. Yee, A. Pineda-Lucena, A. Semesi, A. Ramelot, T. A. Cort, J. R. Jung, J. W. Edwards, A. Lee, W. Kennedy, M. Arrowsmith, C. H.   Solution structure of ribosomal protein S28E from Methanobacterium thermoautotrophicum Protein Sci, 2003; 12(12): 2831-7.
Drachman, D. B. Wu, J. M. Miagkov, A. Williams, M. A. Adams, R. N. Wu, B.   Specific immunotherapy of experimental myasthenia by genetically engineered APCs: the “guided missile” strategy Ann N Y Acad Sci, 2003; 998: 520-32.
Chen, J. Guo, J. Sun, J. Jiang, W. Wu, B.   TCM treatment of Parkinson’s syndrome–a report of 40 cases J Tradit Chin Med, 2003; 23(3): 168-9.

Xiangdong William Yang, M.D., Ph.D.

Biography

Dr. X. William Yang is a professor in the Department of Psychiatry & Biobehavioral Sciences at David Geffen School of Medicine at UCLA. He is also a member of the Center for Neurobehavioral Genetics at Semel Institute for Neuroscience & Human Behaviors, and a member of the Brain Research Institute at UCLA. He has served as a regular member at the NIH’s Cell Death in Neurodegeneration (CDIN) Study Section, a Scientific Advisory Board member of the Hereditary Disease Foundation, and a faculty member for Faculty 1000 Medicine?s Neurogenetics Section. William grew up in Tianjin, China. He obtained a combined M.S. and B.S. degrees with summa cum laude from Molecular Biophysics & Biochemistry Department at Yale University in 1991. He received Ph.D. in Molecular Genetics and Neuroscience from Rockefeller University in 1998. During his PhD thesis research with Dr. Nathaniel Heintz, William co-invented (together with Nat Heintz and Peter Model) the first recombineering technology to modify large pieces of DNA called Bacterial Artificial Chromosomes (BACs) and to generate BAC transgenic mice. The BAC transgenic technology is now a widely-used tool to generate transgenic animals for analyses of gene expression and gene function, and for modeling human diseases. After obtaining his Ph.D. degree, William went on to complete his M.D. training from Weill Medical College of Cornell University in 2000, and his Medicine Internship at New York-Presbyterian Hospital in 2001. After a brief postdoctoral training with Nat Heintz at Rockefeller University, William joined UCLA as an Assistant Professor in Dept. of Psychiatry in 2002.