Publications
Structure of the human K2P13.1(THIK-1) channel reveals a novel hydrophilic pore restriction and lipid cofactor site Roy-Chowdhury S, Jang S, Abderemane-Ali F, Naughton F, Grabe M, Minor DL Jr. BioRxiv (pre-print). 2024.
EMC chaperone-CaV structure reveals an ion channel assembly intermediate Chen Z, Mondal A, Abderemane-Ali F, Jang S, Niranjan S, Montaño JL, Zaro BW, Minor DL Jr. Nature. 2023.
Definition of a saxitoxin (STX) binding code enables discovery and characterization of the Anuran saxiphilin family. Chen Z*, Zakrzewska S*, Hajare HS, Alvarez-Buylla A, Abderemane-Ali F, Bogan M, Ramirez D, O’Connell LA, Du Bois J, Minor DL Jr. Proceedings of the National Academy of Sciences of the United States of America. 2022. (*equal contribution)
Differential effects of modified batrachotoxins on voltage-gated sodium channel fast and slow inactivation. MacKenzie TMG*, Abderemane-Ali F*, Garrison CE*, Minor DL Jr, Du Bois J. Cell Chemical Biology. 2021. (*equal contribution)
Evidence that toxin resistance in poison birds and frogs is not rooted in sodium channel mutations and may rely on “toxin sponge” proteins. Abderemane-Ali F, Rossen ND, Kobiela ME, Craig RA, Garrison CE, Chen Z, Colleran CM, O’Connell LA, Du Bois J, Dumbacher JP, Minor DL Jr. Journal of General Physiology. 2021.
K2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions. Lolicato M*, Natale AM*, Abderemane-Ali F, Crottès D, Capponi S, Duman R, Wagner A, Rosenberg JM, Grabe M, Minor DL Jr. Science advances. 2020. (*equal contribution)
Up-regulation of voltage-gated sodium channels by peptides mimicking S4-S5 linkers reveals a variation of the ligand-receptor mechanism. Malak AO*, Abderemane-Ali F*, Wei Y, Coyan FC, Pontus G, Shaya D, Marionneau C, Loussouarn G. Scientific Reports. 2020. (*equal contribution)
A selectivity filter gate controls voltage-gated calcium channel calcium-dependent inactivation. Abderemane-Ali F, Findeisen F, Rossen ND, Minor DL Jr. Neuron. 2019.
A calmodulin C-lobe Ca2+-dependent switch governs KV7 channel function. Chang A*, Abderemane-Ali F*, Hura GL, Rossen ND, Gate RE, Minor DL Jr. Neuron. 2018. (*equal contribution)
Stapled voltage-gated calcium channel (CaV) α-interaction domain (AID) peptides pct as selective protein-protein interaction inhibitors of CaV Function. Findeisen F, Campiglio M, Jo H, Abderemane-Ali F, Rumpf CH, Pope L, Rossen ND, Flucher BE, DeGrado WF, Minor DL Jr. ACS Chemical Neuroscience. 2017.
A long QT mutation substitutes cholesterol for phosphatidylinositol-4,5-bisphosphate in KCNQ1 channel regulation. Coyan FC, Abderemane-Ali F*, Amarouch MY*, Piron J, Mordel J, Nicolas CS, Steenman M, Mérot J, Marionneau C, Thomas A, Brasseur R, Baró I, Loussouarn G. PLoS One. 2014. (*equal contribution)
Structure of a prokaryotic sodium channel pore reveals essential gating elements and an outer ion binding site common to eukaryotic channels. Shaya D*, Findeisen F*, Abderemane-Ali F, Arrigoni C, Wong S, Nurva SR, Loussouarn G, Minor DL Jr. Journal of Molecular Biology. 2013. (*equal contribution)
Dual effect of phosphatidylinositol (4,5)-bisphosphate PIP2 on Shaker K+ channels. Abderemane-Ali F, Es-Salah-Lamoureux Z, Delemotte L, Kasimova MA, Labro AJ, Snyders DJ, Fedida D, Tarek M, Baró I, Loussouarn G. Journal of Biological Chemistry. 2012.
Opposite effects of the S4-S5 linker and PIP2 on voltage-gated channel function: KCNQ1/KCNE1 and other channels. Choveau FS, Abderemane-Ali F, Coyan FC, Es-Salah-Lamoureux Z, Baró I, Loussouarn G. Frontiers in Pharmacology. 2012.
KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain. Choveau FS, Rodriguez N, Abderemane-Ali F, Labro AJ, Rose T, Dahimène S, Boudin H, Le Hénaff C, Escande D, Snyders DJ, Charpentier F, Mérot J, Baró I, Loussouarn G. Journal of Biological Chemistry. 2011.
Biography
The primary research interests of our laboratory are how ion channels regulate the electrical excitability of cells and how defects in these channels lead to human disease. In the past two decades, mutations of ion channel genes have been found to be the primary cause for over 100 human diseases. Our research program is focused on the mechanistic basis for a group of inherited conditions that alter the electrical excitability of skeletal muscle, including periodic paralysis and myotonia. We have characterized the gating defects of mutant channels, generated computational models of muscle excitability, and produced genetically-engineered mice to gain insights on the pathomechanisms of these disorders and to explore therapeutic interventions.
Publications
A selected list of publications:
Laura A DeNardo, Cindy D Liu, William E Allen, Eliza L Adams, Drew Friedmann, Ehsan Dadgar-Kiani, Lisa Fu, Casey J Guenthner, Jin Hyung Lee, Marc Tessier-Lavigne, Liqun Luo Temporal Evolution of Cortical Ensembles Promoting Remote Memory Retrieval , 2018; .
Berns Dominic S, DeNardo Laura A, Pederick Daniel T, Luo Liqun Teneurin-3 controls topographic circuit assembly in the hippocampus Nature, 2018; 554(7692): 328-333.
Savas Jeffrey N, Wang Yi-Zhi, DeNardo Laura A, Martinez-Bartolome Salvador, McClatchy Daniel B, Hark Timothy J, Shanks Natalie F, Cozzolino Kira A, Lavallée-Adam Mathieu, Smukowski Samuel N, Park Sung Kyu, Kelly Jeffery W, Koo Edward H, Nakagawa Terunaga, Masliah Eliezer, Ghosh Anirvan, Yates John R Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer’s Disease-like Pathology Cell reports, 2017; 21(9): 2614-2627.
Allen William E, DeNardo Laura A, Chen Michael Z, Liu Cindy D, Loh Kyle M, Fenno Lief E, Ramakrishnan Charu, Deisseroth Karl, Luo Liqun Thirst-associated preoptic neurons encode an aversive motivational drive Science (New York, N.Y.), 2017; 357(6356): 1149-1155.
DeNardo Laura, Luo Liqun Genetic strategies to access activated neurons Current opinion in neurobiology, 2017; 45(6356): 121-129.
Savas JN, Ribeiro LF, Wierda KD, Wright R, DeNardo-Wilke LA, Chamma I, Wang Yi-Zhi, Zemla R, Lavallee- Adam M, Vennekens KM, O’Sullivan ML, Antonios JK, Hall EA, Thoumine O, Attie AD, Yates JR, Ghosh A, De Wit J The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA receptors, Neuron, 2015; 87: 764-80.
DeNardo Laura A, Berns Dominic S, DeLoach Katherine, Luo Liqun Connectivity of mouse somatosensory and prefrontal cortex examined with trans-synaptic tracing Nature neuroscience, 2015; 18(11): 1687-1697.
DeNardo Laura A, de Wit Joris, Otto-Hitt Stefanie, Ghosh Anirvan NGL-2 regulates input-specific synapse development in CA1 pyramidal neurons Neuron, 2012; 76(4): 762-75.
Wilke Scott A, Hall Benjamin J, Antonios Joseph K, Denardo Laura A, Otto Stefanie, Yuan Bo, Chen Fading, Robbins Elissa M, Tiglio Katie, Williams Megan E, Qiu Zilong, Biederer Thomas, Ghosh Anirvan NeuroD2 regulates the development of hippocampal mossy fiber synapses Neural development, 2012; 7(4): 9.