Posts classified under: Physiology

Laura DeNardo, Ph.D.

Publications

A selected list of publications:

Laura A DeNardo, Cindy D Liu, William E Allen, Eliza L Adams, Drew Friedmann, Ehsan Dadgar-Kiani, Lisa Fu, Casey J Guenthner, Jin Hyung Lee, Marc Tessier-Lavigne, Liqun Luo   Temporal Evolution of Cortical Ensembles Promoting Remote Memory Retrieval , 2018; .
Berns Dominic S, DeNardo Laura A, Pederick Daniel T, Luo Liqun   Teneurin-3 controls topographic circuit assembly in the hippocampus Nature, 2018; 554(7692): 328-333.
Savas Jeffrey N, Wang Yi-Zhi, DeNardo Laura A, Martinez-Bartolome Salvador, McClatchy Daniel B, Hark Timothy J, Shanks Natalie F, Cozzolino Kira A, Lavallée-Adam Mathieu, Smukowski Samuel N, Park Sung Kyu, Kelly Jeffery W, Koo Edward H, Nakagawa Terunaga, Masliah Eliezer, Ghosh Anirvan, Yates John R   Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer’s Disease-like Pathology Cell reports, 2017; 21(9): 2614-2627.
Allen William E, DeNardo Laura A, Chen Michael Z, Liu Cindy D, Loh Kyle M, Fenno Lief E, Ramakrishnan Charu, Deisseroth Karl, Luo Liqun   Thirst-associated preoptic neurons encode an aversive motivational drive Science (New York, N.Y.), 2017; 357(6356): 1149-1155.
DeNardo Laura, Luo Liqun   Genetic strategies to access activated neurons Current opinion in neurobiology, 2017; 45(6356): 121-129.
Savas JN, Ribeiro LF, Wierda KD, Wright R, DeNardo-Wilke LA, Chamma I, Wang Yi-Zhi, Zemla R, Lavallee- Adam M, Vennekens KM, O’Sullivan ML, Antonios JK, Hall EA, Thoumine O, Attie AD, Yates JR, Ghosh A, De Wit J   The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA receptors, Neuron, 2015; 87: 764-80.
DeNardo Laura A, Berns Dominic S, DeLoach Katherine, Luo Liqun   Connectivity of mouse somatosensory and prefrontal cortex examined with trans-synaptic tracing Nature neuroscience, 2015; 18(11): 1687-1697.
DeNardo Laura A, de Wit Joris, Otto-Hitt Stefanie, Ghosh Anirvan   NGL-2 regulates input-specific synapse development in CA1 pyramidal neurons Neuron, 2012; 76(4): 762-75.
Wilke Scott A, Hall Benjamin J, Antonios Joseph K, Denardo Laura A, Otto Stefanie, Yuan Bo, Chen Fading, Robbins Elissa M, Tiglio Katie, Williams Megan E, Qiu Zilong, Biederer Thomas, Ghosh Anirvan   NeuroD2 regulates the development of hippocampal mossy fiber synapses Neural development, 2012; 7(4): 9.

Steve Cannon, M.D., Ph.D.

Biography

The primary research interests of our laboratory are how ion channels regulate the electrical excitability of cells and how defects in these channels lead to human disease. In the past two decades, mutations of ion channel genes have been found to be the primary cause for over 100 human diseases. Our research program is focused on the mechanistic basis for a group of inherited conditions that alter the electrical excitability of skeletal muscle, including periodic paralysis and myotonia. We have characterized the gating defects of mutant channels, generated computational models of muscle excitability, and produced genetically-engineered mice to gain insights on the pathomechanisms of these disorders and to explore therapeutic interventions.

Baljit Khakh, Ph.D.

Biography

Baljit S. Khakh received a Ph.D. degree from the University of Cambridge in 1995. During his graduate studies, he also spent some time at the Geneva Biomedical Research Institute. Dr. Khakh completed a postdoctoral fellowship in the laboratory of Dr. Graeme Henderson at the University of Bristol, followed by a fellowship at the California Institute of Technology, working in the laboratories of Drs. Henry A. Lester and Norman Davidson as a Wellcome Trust International Prize Traveling Research Fellow, and Senior Research Fellow in the Division of Biology. In 2001, Dr. Khakh returned to Cambridge in the Division of Neurobiology at the MRC Laboratory of Molecular Biology. Dr. Khakh joined UCLA in April 2006.

H. Ronald Kaback, M.D.

Biography

H. Ronald Kaback has been a member of the faculty at UCLA since he joined the Depts. of Physiology and Microbiology, Immunology & Molecular Genetics, as well as the Molecular Biology Institute, in 1989 as a full professor. Dr. Kaback earned his B.S. at Haverford College and his M.D. at The Albert Einstein College of Medicine, where he also did an internship in Pediatrics. After a year as a graduate student, he became a Commissioned Officer in the USPHS at the NIH and subsequently became at Staff Associate. He then moved to the Roche Institute of Molecular Biology in Nutley, NJ where he later became Head of Biochemistry before coming to UCLA. He is a member of the National Academy of Science and is the recipient of many awards for his work.

Publications

A selected list of publications:

Zhou, Y. Guan, L. Kaback, H. R.   Opening and closing of the periplasmic gate in lactose permease, Proc Natl Acad Sci U S A, 2008; in press.
Nie, Y. Ermolova, N. Kaback, H. R.   Site-directed Alkylation of LacY: Effect of the Proton Electrochemical Gradient J Mol Biol, 2007; 374(2): 356-64.
Smirnova, I. Kasho, V. Choe, J. Y. Altenbach, C. Hubbell, W. L. Kaback, H. R.   Sugar binding induces an outward facing conformation of LacY Proc Natl Acad Sci U S A, 2007; 104: 16504-16509.
Guan, L. Mirza, O. Verner, G. Iwata, S. Kaback, H. R.   Structural determination of wild-type lactose permease Proc Natl Acad Sci U S A, 2007; 104(39): 15294-8.
Majumdar, D. S. Smirnova, I. Kasho, V. Nir, E. Kong, X. Weiss, S. Kaback, H. R.   Single-molecule FRET reveals sugar-induced conformational dynamics in LacY Proc Natl Acad Sci U S A, 2007; 104(31): 12640-12645.
Guan, L. Kaback, H. R.   Site-directed alkylation of cysteine to test solvent accessibility of membrane proteins Nat Protoc, 2007; 2(8): 2012-7.
Shimohata, N. Nagamori, S. Akiyama, Y. Kaback, H. R. Ito, K.   SecY alterations that impair membrane protein folding and generate a membrane stress J Cell Biol, 2007; 176(3): 307-17.
Smirnova, I. N. Kasho, V. N. Kaback, H. R.   Direct Sugar Binding to LacY Measured by Resonance Energy Transfer Biochemistry, 2006; 45(51): 15279-87.
Kaback, H. R. Dunten, R. Frillingos, S. Venkatesan, P. Kwaw, I. Zhang, W. Ermolova, N.   Site-directed alkylation and the alternating access model for LacY Proc Natl Acad Sci U S A, 2006; .
Guan, L. Kaback, H. R.   Lessons from Lactose Permease Annu Rev Biophys Biomol Struct, 2006; 35: 67-91.
Nie, Y. Smirnova, I. Kasho, V. Kaback, H. R.   Energetics of Ligand-induced Conformational Flexibility in the Lactose Permease of Escherichia coli J Biol Chem, 2006; 281(47): 35779-84.
Vadyvaloo, V. Smirnova, I. N. Kasho, V. N. Kaback, H. Ronald   Conservation of residues involved in sugar/H(+) symport by the sucrose permease of Escherichia coli relative to lactose permease J Mol Biol, 2006; 358(4): 1051-9.
Kasho, V. N. Smirnova, I. N. Kaback, H. R.   Sequence alignment and homology threading reveals prokaryotic and eukaryotic proteins similar to lactose permease J Mol Biol, 2006; 358(4): 1060-70.
Ermolova, N. Madhvani, R. V. Kaback, H. R.   Site-directed alkylation of cysteine replacements in the lactose permease of Escherichia coli: helices I, III, VI, and XI Biochemistry, 2006; 45(13): 4182-9.
Mirza, O. 2006)200251183Guan, L. Verner, G. Iwata, S. Kaback, H. R.   Structural evidence for induced fit and a mechanism for sugar/H(+) symport in LacY Embo J, 2006; 25: 1177-1183.
Guan, L. Smirnova, I. N. Verner, G. Nagamoni, S. Kaback, H. R.   Manipulating phospholipids for crystallization of a membrane transport protein Proc Natl Acad Sci U S A, 2006; 103(6): 1723-6.
Kaback, H. R.   Structure and mechanism of the lactose permease C R Biol, 2005; 328(6): 557-67.
Kaback, H. R   The Passion of the Permease, Biophysical and Structural Aspects of Bioenergetics, 2005; 359-373.
Ermolova, N. V. Smirnova, I. N. Kasho, V. N. Kaback, H. R.   Interhelical packing modulates conformational flexibility in the lactose permease of Escherichia coli Biochemistry, 2005; 44(21): 7669-77.
van Bloois, E. Nagamori, S. Koningstein, G. Ullers, R. S. Preuss, M. Oudega, B. Harms, N. Kaback, H. R. Herrmann, J. M. Luirink, J.   The Sec-independent function of Escherichia coli YidC is evolutionary-conserved and essential J Biol Chem, 2005; 280(13): 12996-3003.
Weinglass, A. B. Soskine, M. Vazquez-Ibar, J. L. Whitelegge, J. P. Faull, K. F. Kaback, H. R. Schuldiner, S.   Exploring the role of a unique carboxyl residue in EmrE by mass spectrometry J Biol Chem, 2005; 280(9): 7487-92.
Sun, J. Savva, C. G. Deaton, J. Kaback, H. R. Svrakic, M. Young, R. Holzenburg, A.   Asymmetric binding of membrane proteins to GroEL Arch Biochem Biophys, 2005; 434(2): 352-7.