Posts classified under: Physiology

Biography

Synaptic and molecular mechanisms in learning and memory formation My lab is currently investigating the synaptic and molecular mechanisms involved in learning and memory formation in the mammalian central nervous system. Electrophysiological techniques are used to study synaptic transmission in a variety of in vitro preparations but most work concerns the mechanisms responsible for long-lasting changes in synaptic transmission that occur in the hippocampus, a region of the brain known to have an important role in learning and memory. In our experiments we use electrophysiological, pharmacological, and molecular genetic (transgenic mice) approaches to decipher the molecular components of the biochemical pathways responsible for memory formation in the mammalian brain and eventually hope to understand how alterations in these pathways may contribute to the memory impairment that occurs in pathological conditions such as Alzheimer’s disease or even as a result of normal aging.

 

Ryan Tomás J, Kopanitsa Maksym V, Indersmitten Tim, Nithianantharajah Jess, Afinowi Nurudeen O, Pettit Charles, Stanford Lianne E, Sprengel Rolf, Saksida Lisa M, Bussey Timothy J, O’Dell Thomas J, Grant Seth G N, Komiyama Noboru H   Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior Nature neuroscience, 2013; 16(1): 25-32.

Shigetomi Eiji, Jackson-Weaver Olan, Huckstepp Robert T, O’Dell Thomas J, Khakh Baljit S   TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive D-serine release The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013; 33(24): 10143-53.

Ch’ng Toh Hean, Uzgil Besim, Lin Peter, Avliyakulov Nuraly K, O’Dell Thomas J, Martin Kelsey C   Activity-dependent transport of the transcriptional coactivator CRTC1 from synapse to nucleus Cell, 2012; 150(1): 207-21.

Ziehn Marina O, Avedisian Andrea A, Dervin Shannon M, O’Dell Thomas J, Voskuhl Rhonda R   Estriol preserves synaptic transmission in the hippocampus during autoimmune demyelinating disease Laboratory investigation; a journal of technical methods and pathology, 2012; 92(8): 1234-45.

Zheng Sika, Gray Erin E, Chawla Geetanjali, Porse Bo Torben, O’Dell Thomas J, Black Douglas L   PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2 Nature neuroscience, 2012; 15(3): 381-8, S1.

Coba Marcelo P, Komiyama Noboru H, Nithianantharajah Jess, Kopanitsa Maksym V, Indersmitten Tim, Skene Nathan G, Tuck Ellie J, Fricker David G, Elsegood Kathryn A, Stanford Lianne E, Afinowi Nurudeen O, Saksida Lisa M, Bussey Timothy J, O’Dell Thomas J, Grant Seth G N   TNiK is required for postsynaptic and nuclear signaling pathways and cognitive function The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012; 32(40): 13987-99.

Ziehn Marina O, Avedisian Andrea A, Dervin Shannon M, Umeda Elizabeth A, O’Dell Thomas J, Voskuhl Rhonda R   Therapeutic testosterone administration preserves excitatory synaptic transmission in the hippocampus during autoimmune demyelinating disease The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012; 32(36): 12312-24.

Moody Teena D, Watabe Ayako M, Indersmitten Tim, Komiyama Noboru H, Grant Seth G N, O’Dell Thomas J   Beta-adrenergic receptor activation rescues theta frequency stimulation-induced LTP deficits in mice expressing C-terminally truncated NMDA receptor GluN2A subunits Learning & memory (Cold Spring Harbor, N.Y.), 2011; 18(2): 118-27.

Carlisle Holly J, Luong Tinh N, Medina-Marino Andrew, Schenker Leslie, Khorosheva Eugenia, Indersmitten Tim, Gunapala Keith M, Steele Andrew D, O’Dell Thomas J, Patterson Paul H, Kennedy Mary B   Deletion of densin-180 results in abnormal behaviors associated with mental illness and reduces mGluR5 and DISC1 in the postsynaptic density fraction The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011; 31(45): 16194-207.

Tenorio Gustavo, Connor Steven A, Guévremont Diane, Abraham Wickliffe C, Williams Joanna, O’Dell Thomas J, Nguyen Peter V   ‘Silent’ priming of translation-dependent LTP by ß-adrenergic receptors involves phosphorylation and recruitment of AMPA receptors Learning & memory (Cold Spring Harbor, N.Y.), 2010; 17(12): 627-38.

Wiltgen Brian J, Royle Gordon A, Gray Erin E, Abdipranoto Andrea, Thangthaeng Nopporn, Jacobs Nate, Saab Faysal, Tonegawa Susumu, Heinemann Stephen F, O’Dell Thomas J, Fanselow Michael S, Vissel Bryce   A role for calcium-permeable AMPA receptors in synaptic plasticity and learning PloS one, 2010; 5(9): .

Bliss Joanne M, Gray Erin E, Dhaka Ajay, O’Dell Thomas J, Colicelli John   Fear learning and extinction are linked to neuronal plasticity through Rin1 signaling Journal of neuroscience research, 2010; 88(4): 917-26.

Arbuckle Margaret I, Komiyama Noboru H, Delaney Ada, Coba Marcelo, Garry Emer M, Rosie Roberta, Allchorne Andrew J, Forsyth Lynsey H, Bence Matthew, Carlisle Holly J, O’Dell Thomas J, Mitchell Rory, Fleetwood-Walker Susan M, Grant Seth G N   The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment EMBO reports, 2010; 11(6): 473-8.

O’Dell Thomas J, Connor Steven A, Gelinas Jennifer N, Nguyen Peter V   Viagra for your synapses: Enhancement of hippocampal long-term potentiation by activation of beta-adrenergic receptors Cellular signalling, 2010; 22(5): 728-36.

Jeffrey Rachel A, Ch’ng Toh Hean, O’Dell Thomas J, Martin Kelsey C   Activity-dependent anchoring of importin alpha at the synapse involves regulated binding to the cytoplasmic tail of the NR1-1a subunit of the NMDA receptor The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009; 29(50): 15613-20.

Wang Louisa M-C, Dragich Joanna M, Kudo Takashi, Odom Irene H, Welsh David K, O’Dell Thomas J, Colwell Christopher S   Expression of the circadian clock gene Period2 in the hippocampus: possible implications for synaptic plasticity and learned behaviour ASN neuro, 2009; 1(3): .

Fink Ann E, O’Dell Thomas J   Short trains of theta frequency stimulation enhance CA1 pyramidal neuron excitability in the absence of synaptic potentiation The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009; 29(36): 11203-14.

Chaudhary V Bala, Bowker Matthew A, O’Dell Thomas E, Grace James B, Redman Andrea E, Rillig Matthias C, Johnson Nancy C   Untangling the biological contributions to soil stability in semiarid shrublands Ecological applications : a publication of the Ecological Society of America, 2009; 19(1): 110-22.

Carlisle Holly J, Fink Ann E, Grant Seth G N, O’Dell Thomas J   Opposing effects of PSD-93 and PSD-95 on long-term potentiation and spike timing-dependent plasticity The Journal of physiology, 2008; 586(Pt 24): 5885-900.

Fink Ann E, Sariñana Joshua, Gray Erin E, O’dell Thomas J   Activity-dependent depression of local excitatory connections in the CA1 region of mouse hippocampus Journal of neurophysiology, 2007; 97(6): 3926-36.

Gray Erin E, Fink Ann E, Sariñana Joshua, Vissel Bryce, O’Dell Thomas J   Long-term potentiation in the hippocampal CA1 region does not require insertion and activation of GluR2-lacking AMPA receptors Journal of neurophysiology, 2007; 98(4): 2488-92.

Delgado Jary Y, Coba Marcelo, Anderson Christopher N G, Thompson Kimberly R, Gray Erin E, Heusner Carrie L, Martin Kelsey C, Grant Seth G N, O’Dell Thomas J   NMDA receptor activation dephosphorylates AMPA receptor glutamate receptor 1 subunits at threonine 840 The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007; 27(48): 13210-21.

Cuthbert Peter C, Stanford Lianne E, Coba Marcelo P, Ainge James A, Fink Ann E, Opazo Patricio, Delgado Jary Y, Komiyama Noboru H, O’Dell Thomas J, Grant Seth G N   Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007; 27(10): 2673-82.

Dunham Susie M, O’Dell Thomas E, Molina Randy   Forest stand age and the occurrence of chanterelle (Cantharellus) species in Oregon’s central Cascade Mountains Mycological research, 2006; 110(Pt 12): 1433-40.

Dunham Susie M, O’Dell Thomas E, Molina Randy   Spatial analysis of within-population microsatellite variability reveals restricted gene flow in the Pacific golden chanterelle (Cantharellus formosus) Mycologia, 2006; 98(2): 250-9.

Delgado Jary Y, O’dell Thomas J   Long-term potentiation persists in an occult state following mGluR-dependent depotentiation Neuropharmacology, 2005; 48(7): 936-48.

Ho Oanh H, Delgado Jary Y, O’Dell Thomas J   Phosphorylation of proteins involved in activity-dependent forms of synaptic plasticity is altered in hippocampal slices maintained in vitro Journal of neurochemistry, 2004; 91(6): 1344-57.

Thompson Kimberly R, Otis Klara Olofsdotter, Chen Dillon Y, Zhao Yali, O’Dell Thomas J, Martin Kelsey C   Synapse to nucleus signaling during long-term synaptic plasticity; a role for the classical active nuclear import pathway Neuron, 2004; 44(6): 997-1009.

Watabe Ayako M, O’Dell Thomas J   Age-related changes in theta frequency stimulation-induced long-term potentiation Neurobiology of aging, 2003; 24(2): 267-72.

Dunham Susie M, O’Dell Thomas E, Molina Randy   Analysis of nrDNA sequences and microsatellite allele frequencies reveals a cryptic chanterelle species Cantharellus cascadensis sp. nov. from the American Pacific Northwest Mycological research, 2003; 107(Pt 10): 1163-77.

Opazo Patricio, Watabe Ayako M, Grant Seth G N, O’Dell Thomas J   Phosphatidylinositol 3-kinase regulates the induction of long-term potentiation through extracellular signal-related kinase-independent mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003; 23(9): 3679-88.

Dhaka Ajay, Costa Rui M, Hu Hailiang, Irvin Dwain K, Patel Apoor, Kornblum Harley I, Silva Alcino J, O’Dell Thomas J, Colicelli John   The RAS effector RIN1 modulates the formation of aversive memories The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003; 23(3): 748-57.

Watabe Ayako M, Carlisle Holly J, O’Dell Thomas J   Postsynaptic induction and presynaptic expression of group 1 mGluR-dependent LTD in the hippocampal CA1 region Journal of neurophysiology, 2002; 87(3): 1395-403.

Komiyama Noboru H, Watabe Ayako M, Carlisle Holly J, Porter Karen, Charlesworth Paul, Monti Jennifer, Strathdee Douglas J C, O’Carroll Colin M, Martin Stephen J, Morris Richard G M, O’Dell Thomas J, Grant Seth G N   SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002; 22(22): 9721-32.

Grant, SG O’Dell, TJ   Multiprotein complex signaling and the plasticity problem Current opinion in neurobiology. , 2001; 11(3): 363-8.

Watabe, AM Zaki, PA O’Dell, TJ   Coactivation of beta-adrenergic and cholinergic receptors enhances the induction of long-term potentiation and synergistically activates mitogen-activated protein kinase in the hippocampal CA1 region The Journal of neuroscience : the official journal of the Society for Neuroscience. , 2000; 20(16): 5924-31.

Makhinson, M Chotiner, JK Watson, JB O’Dell, TJ   Adenylyl cyclase activation modulates activity-dependent changes in synaptic strength and Ca2+/calmodulin-dependent kinase II autophosphorylation The Journal of neuroscience : the official journal of the Society for Neuroscience. , 1999; 19(7): 2500-10.

Migaud M, Charlesworth P, Dempster M, Webster LC, Watabe AM, Makhinson M, He Y, Ramsay MF, Morris RGM, O’Dell TJ, and Grant, SGN   Enhanced long term potentiation and impaired learning in mice with mutant postsynatpic density-95 protein, Nature, 1998; 396: 433-439.

Thomas MJ, Watabe AM, Moody TD, Makhinson M, and O’Dell TJ   Postsynaptic complex spike bursting enables the inductio of LTP by theta frequency synaptic stimulation, J. Neuroscience, 1998; 18: 7118-7126.

Thomas, MJ Moody, TD Makhinson, M O’Dell, TJ   Activity-dependent beta-adrenergic modulation of low frequency stimulation induced LTP in the hippocampal CA1 region Neuron. , 1996; 17(3): 475-82.