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HomeUCLA Brain Research Institute (BRI)  > People  > Departments  > Psychiatry & Biobehavioral Sciences
Peter C. Whybrow, M.D.

Peter Whybrow, M.D., D.P.M., M.B., F.R.C.P.

Biography

Peter C. Whybrow, M.D. is the Judson Braun Distinguished Professor of the Department of Psychiatry and Biobehavioral Sciences at the David Geffen School of Medicine. Recruited to UCLA in 1997 from the University of Pennsylvania, Dr. Whybrow received his training in endocrinology and psychiatry in London and North Carolina. Born in England he was a member of the scientific staff of the British Medical Research Council before joining the faculty of Dartmouth Medical School in the 1970s, where he served as Chairman of Psychiatry and later as Executive Dean. He was recruited to the University of Pennsylvania in 1984 where he was the Ruth Meltzer Professor and Chairman of Psychiatry until 1996.

Dr. Whybrow is an international authority on depression and manic-depressive disease and the effects of thyroid hormone on brain and human behavior. A founding member and Fellow of the Royal College of Psychiatrists, Fellow of the American Association for the Advancement of Science, the American College of Psychiatrists, and the American Psychiatric Association, Dr. Whybrow has lectured widely across the United States and Europe, and is the recipient of many awards.

He is a frequent advisor to universities, foundations, and government agencies and is the author of numerous scientific papers and five books, including, A Mood Apart; The Thinker’s Guide to Emotion and its Disorder. Now published in paperback by Harper Perennial A Mood Apart has been translated into several languages and is widely acclaimed as the definitive guide to the experience and science of mood disorder written expressly for the general public. Dr. Whybrow’s most recent book, American Mania: When More Is Not Enough (W.W. Norton), was a Los Angeles Times best seller, has won several awards, and was cited by the New York Times Magazine as one of 78 notable ideas for 2005.

Joseph B. Watson, Ph.D.

Joseph Watson, Ph.D.

Biography

Dr. Watson received his Ph.D from the Department of Chemistry and Biochemistry at UCLA in 1985 in Jay Gralla’s Laboratory in which he combined virology and protein biochemistry to identify early SV40 virus replication and transcription complexes associated with the nuclear matrix of eukaryotic cells. He then went on to do a postdoctoral fellowship in molecular biology of the nervous system in Dr. J. Gregor Sutcliffe’s lab at The Scripps Research Institute in La Jolla, CA, where he began his initial studies of neurodegenerative diseases focusing on identifying novel genes relevant to Huntington’s Disease (HD). He returned to UCLA in 1989 as a member of the Mental Retardation Research Center and the Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at UCLA, studying synaptic targets of neurodegenerative diseases that include Parkinson’s Disease (PD), HD, and Alzheimer’s Disease. He has also served as the Vice Chair of the Neuroscience Undergraduate Interdepartmental Program for the UCLA campus and Outreach Program Director for the Brain Research Institute (BRI). He is also currently an Associate Dean in the Graduate Division.

Publications

A selected list of publications:

Sarafian Theodore A, Ryan Christopher M, Souda Puneet, Masliah Eliezer, Kar Upendra K, Vinters Harry V, Mathern Gary W, Faull Kym F, Whitelegge Julian P, Watson Joseph B   Impairment of mitochondria in adult mouse brain overexpressing predominantly full-length, N-terminally acetylated human α-synuclein PloS one, 2013; 8(5): e63557.
Chang Julia W, Arnold Monica M, Rozenbaum Anna, Caputo Anna, Schweizer Felix E, Huynh My, Mathern Gary W, Sarafian Theodore A, Watson Joseph B   Synaptoneurosome micromethod for fractionation of mouse and human brain, and primary neuronal cultures Journal of neuroscience methods, 2012; 211(2): 289-95.
Romero-Calderón Rafael, O’Hare Elizabeth D, Suthana Nanthia A, Scott-Van Zeeland Ashley A, Rizk-Jackson Angela, Attar Aida, Madsen Sarah K, Ghiani Cristina A, Evans Christopher J, Watson Joseph B   Project brainstorm: using neuroscience to connect college students with local schools PLoS biology, 2012; 10(4): e1001310.
Cummings Damian M, Alaghband Yasaman, Hickey Miriam A, Joshi Prasad R, Hong S Candice, Zhu Chunni, Ando Timothy K, André Véronique M, Cepeda Carlos, Watson Joseph B, Levine Michael S   A critical window of CAG repeat-length correlates with phenotype severity in the R6/2 mouse model of Huntington’s disease Journal of neurophysiology, 2012; 107(2): 677-91.
Cepeda Carlos, Cummings Damian M, Hickey Miriam A, Kleiman-Weiner Max, Chen Jane Y, Watson Joseph B, Levine Michael S   Rescuing the Corticostriatal Synaptic Disconnection in the R6/2 Mouse Model of Huntington’s Disease: Exercise, Adenosine Receptors and Ampakines PLoS currents, 2010; 2(2): .
Watson J B, Hatami A, David H, Masliah E, Roberts K, Evans C E, Levine M S   Alterations in corticostriatal synaptic plasticity in mice overexpressing human alpha-synuclein Neuroscience, 2009; 159(2): 501-13.
Watson J B, Arnold M M, Ho Y-S, O’Dell T J   Age-dependent modulation of hippocampal long-term potentiation by antioxidant enzymes Journal of neuroscience research, 2006; 84(7): 1564-74.
Chotiner J K, Khorasani H, Nairn A C, O’Dell T J, Watson J B   Adenylyl cyclase-dependent form of chemical long-term potentiation triggers translational regulation at the elongation step Neuroscience, 2003; 116(3): 743-52.
Watson J B, Khorasani H, Persson A, Huang K-P, Huang F L, O’Dell T J   Age-related deficits in long-term potentiation are insensitive to hydrogen peroxide: coincidence with enhanced autophosphorylation of Ca2+/calmodulin-dependent protein kinase II Journal of neuroscience research, 2002; 70(3): 298-308.
Cepeda Carlos, Crawford Cynthia A, Margulies Jody E, Watson Joseph B, Levine Michael S, Cohen Randy W   Enhanced epileptogenic susceptibility in a genetic model of reactive synaptogenesis: the spastic Han-Wistar rat Developmental neuroscience, 2002; 24(4): 262-71.
Watson, J.B.   Subtractive cDNA Hybridization and Brain: Then, Now, and Tomorrow, Handbook of Molecular-Genetic Techniques for Brain and Behavior Research (Techniques in the Behavior, 1999; Vol. 13: 189-199.
Makhinson M, Chotiner J K, Watson J B, O’Dell T J   Adenylyl cyclase activation modulates activity-dependent changes in synaptic strength and Ca2+/calmodulin-dependent kinase II autophosphorylation The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999; 19(7): 2500-10.
Johnson M W, Chotiner J K, Watson J B   Isolation and characterization of synaptoneurosomes from single rat hippocampal slices Journal of neuroscience methods, 1997; 77(2): 151-6.
Chang, JW Schumacher, E Coulter, PM Vinters, HV Watson, JB   Dendritic translocation of RC3/neurogranin mRNA in normal aging, Alzheimer disease and fronto-temporal dementia Journal of neuropathology and experimental neurology. , 1997; 56(10): 1105-18.
Julian Whitelegge, Ph.D.

Julian Whitelegge, Ph.D.

Biography

Julian Whitelegge received his Ph.D. from Imperial College of Science and Technology, University of London in 1989 and became heavily involved in mass spectrometry research in the mid nineties publishing his most cited paper on “electrospray-ionization mass spectrometry of intact intrinsic membrane proteins” in 1998. Dr. Whitelegge developed a keen interest in Fourier-transform mass spectrometry (FT-MS) while a Visiting Scientist in the Department of Chemistry and Chemical Biology, Cornell University working with Professor Fred McLafferty in 1999 and has nurtured this expertise since returning to UCLA. Currently, Dr. Whitelegge directs the proteomics activities of the Pasarow Mass Spectrometry Laboratory at UCLA, appointed as Adjunct Professor III in the NPI-Semel Institute in the David Geffen School of Medicine. He oversees both top-down and bottom-up mass spectrometry projects and trains post-graduate and post-doctoral associates in protein and peptide mass spectrometry and data interpretation. Dr. Whitelegge has authored and co-authored over one hundred and fifty original research papers. He edited the recently published, five-hundred page, book Protein Mass Spectrometry in Elsevier’s analytical chemistry series and is a member of the editorial board of Molecular and Cellular Proteomics.

William Yang

Xiangdong William Yang, M.D., Ph.D.

Biography

Dr. X. William Yang is a professor in the Department of Psychiatry & Biobehavioral Sciences at David Geffen School of Medicine at UCLA. He is also a member of the Center for Neurobehavioral Genetics at Semel Institute for Neuroscience & Human Behaviors, and a member of the Brain Research Institute at UCLA. He has served as a regular member at the NIH’s Cell Death in Neurodegeneration (CDIN) Study Section, a Scientific Advisory Board member of the Hereditary Disease Foundation, and a faculty member for Faculty 1000 Medicine?s Neurogenetics Section. William grew up in Tianjin, China. He obtained a combined M.S. and B.S. degrees with summa cum laude from Molecular Biophysics & Biochemistry Department at Yale University in 1991. He received Ph.D. in Molecular Genetics and Neuroscience from Rockefeller University in 1998. During his PhD thesis research with Dr. Nathaniel Heintz, William co-invented (together with Nat Heintz and Peter Model) the first recombineering technology to modify large pieces of DNA called Bacterial Artificial Chromosomes (BACs) and to generate BAC transgenic mice. The BAC transgenic technology is now a widely-used tool to generate transgenic animals for analyses of gene expression and gene function, and for modeling human diseases. After obtaining his Ph.D. degree, William went on to complete his M.D. training from Weill Medical College of Cornell University in 2000, and his Medicine Internship at New York-Presbyterian Hospital in 2001. After a brief postdoctoral training with Nat Heintz at Rockefeller University, William joined UCLA as an Assistant Professor in Dept. of Psychiatry in 2002.

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