Our lab studies how neural representations support behaviors like decision making. We approach this question by recording the electrical activity of neurons as rats perform behavioral tasks. Electrophysiological techniques are augmented with optogenetics and computational analyses. Current projects are exploring how interactions between the hippocampus and the orbitofrontal cortex support decision making, the encoding of spatial goals, and the formation of neural representations for abstract stimulus spaces.
A selected list of publications:
Wikenheiser Andrew M, Marrero-Garcia Yasmin, Schoenbaum Geoffrey Suppression of Ventral Hippocampal Output Impairs Integrated Orbitofrontal Encoding of Task Structure Neuron, 2017; 95(5): 1197-1207.e3.
Langdon Angela J, Wikenheiser Andrew M, Schoenbaum Geoffrey Rat mPFC and M2 Play a Waiting Game (at Different Timescales) Neuron, 2017; 94(4): 700-702.
Sadacca Brian F, Wikenheiser Andrew M, Schoenbaum Geoffrey Toward a theoretical role for tonic norepinephrine in the orbitofrontal cortex in facilitating flexible learning Neuroscience, 2017; 345(4): 124-129.
Wikenheiser Andrew M, Schoenbaum Geoffrey Over the river, through the woods: cognitive maps in the hippocampus and orbitofrontal cortex Nature reviews. Neuroscience, 2016; 17(8): 513-23.
Sharpe Melissa J, Wikenheiser Andrew M, Niv Yael, Schoenbaum Geoffrey The State of the Orbitofrontal Cortex Neuron, 2015; 88(6): 1075-1077.
Wikenheiser Andrew M, Redish A David Decoding the cognitive map: ensemble hippocampal sequences and decision making Current opinion in neurobiology, 2015; 32(6): 8-15.
Wikenheiser Andrew M, Redish A David Hippocampal theta sequences reflect current goals Nature neuroscience, 2015; 18(2): 289-94.
Wikenheiser Andrew M, Stephens David W, Redish A David Subjective costs drive overly patient foraging strategies in rats on an intertemporal foraging task Proceedings of the National Academy of Sciences of the United States of America, 2013; 110(20): 8308-13.
Wikenheiser Andrew M, Redish A David The balance of forward and backward hippocampal sequences shifts across behavioral states Hippocampus, 2013; 23(1): 22-9.
Wikenheiser Andrew M, Redish A David Hippocampal sequences link past, present, and future Trends in cognitive sciences, 2012; 16(7): 361-2.
Wikenheiser Andrew M, Redish A David Changes in reward contingency modulate the trial-to-trial variability of hippocampal place cells Journal of neurophysiology, 2011; 106(2): 589-98.