Posts classified under: Computational and Systems Neuroscience

Dario Ringach, Ph.D.

Biography

visual neurophysiology and perception

Our research focuses on visual perception and neurophysiology. In particular, we are interested in cortical dynamics, circuitry, function, and mathematical modeling of the visual system. The main methods in the laboratory include multi-electrode recordings from single neurons, as well as intrisic and voltage senstive dye imaging of visual cortex.

We also have an interest in developing novel technologies to record and stimulate from large neuronal populations for use in prostheses.

Ladan Shams, Ph.D.

Publications

A selected list of publications:

Watkins, S, Shams, L, Tanaka, S, et al.   Sound alters activity in human V1 in association with illusory visual perception, NeuroImage , 2006; .
Shams, L, Iwaki, S, Chawla, A, et al.   Early modulation of visual cortex by sound: an MEG study, Neuroscience letters, 2005; 378(2): 76-81.
Shams, L, Ma, WJ, & Beierholm, U.   Sound-induced flash illusion as an optimal percept, Neuroreport, , 2005; 16(17): 1923-7.
Violentyev, A, Shimojo, S, & Shams, L.   Touch-induced visual illusion, Neuroreport, 2005; 16(10): 1107-10.
Shams, L., & von der Malsburg, C.   Acquisition of visual shape primitives, Vision Research, 2002; Vol. 42 (17): 2105-2122.
Shams, L.   Integration in the brain: The subconscious alteration of visual perception by cross-modal integration, Science & Consciousness Review, 2002; October(No. 1 ): .
Bhattacharya, J., Shams, L., S. & Shimojo, S.   Sound-induced illusory flash perception: Role of Gamma band responses, NeuroReport, 2002; Vol. 13: 1727-1730.
Shams, L. & von der Malsburg, C.   The role of complex cells in object recognition, Vision Research, 2002; Vol. 42 (22): 2547-2554.
Shams, L., Kamitani, Y., & Shimojo, S.   Visual illusion induced by sound, Cognitive Brain Research, 2002; Vol. 14: 147-152.
Shams, L., Brady, M. & Schaal, S.   Graph-matching vs. entropy-based methods for object detection, Neural Networks, 2001; 14: 345-354.
Shimojo, S., & Shams, L.   Sensory modalities are not separate modalities: plasticity and interactions, Current Opinion In Neurobiology, 2001; Vol. 11 (114): 505-509.
Shams, L., Kamitani, Y., Thompson, S. & Shimojo, S.   Sound alters visual evoked potentials in humans, NeuroReport, 2001; Vol. 12 (17): 3849-3852.
Shimojo, S., Scheier, C., Shams, L., & Watanabe, K.   Vision beyond visual modality: Auditory effects on visual perception, Journal of the Acoustical Society of Japan, Special Issue on Hearing and the Brain, 2001; Vol. 22 (2): .
Shams, L., Kamitani, Y., & Shimojo, S.   What you see is what you hear, Nature, 2000; Vol. 408: 788.
Shams, L., & von der Malsburg, C.   Are Object Shape Primitives Learnable? , NeuroComputing, 1999; Vol. 26-27: 855-863.

Stan Schein, M.D., Ph.D.

Publications

A selected list of publications:

G Brinkmann, P Goetschalckx, S Schein   Comparing the constructions of Goldberg, Fuller, Caspar, Klug and Coxeter, and a general approach to local symmetry-preserving operations, Proc Roy Soc Lond A , 2017; 2017.0267.
S Schein, AJ Yeh, K Coolsaet, JM Gayed   Decoration of the truncated tetrahedron—an Archimedean polyhedron—to produce a new class of convex equilateral polyhedra with tetrahedral symmetry, Symmetry, 2016; 8: 82-91.
X Zhang, P Ge, X Yu, JM Brannan, G Bi, Q Zhang, S Schein, ZH Zhou   Cryo-EM structure of the mature dengue virus at 3.5-Å resolution, Nature Structural and Molecular Biology, 2012; 20: 105-110.
Wang Zhi, Su Hai-Feng, Tan Yuan-Zhi, Schein Stan, Lin Shui-Chao, Liu Wei, Wang Shu-Ao, Wang Wen-Guang, Tung Chen-Ho, Sun Di, Zheng Lan-Sun   Assembly of silver Trigons into a buckyball-like Ag180 nanocage Proceedings of the National Academy of Sciences of the United States of America, 2017; 114(46): 12132-12137.
Schein Stan, Gayed James Maurice   Fourth class of convex equilateral polyhedron with polyhedral symmetry related to fullerenes and viruses Proceedings of the National Academy of Sciences of the United States of America, 2014; 111(8): 2920-5.
Zhang Xiaokang, Ge Peng, Yu Xuekui, Brannan Jennifer M, Bi Guoqiang, Zhang Qinfen, Schein Stan, Zhou Z Hong   Cryo-EM structure of the mature dengue virus at 3.5-Å resolution Nature structural & molecular biology, 2013; 20(1): 105-10.
Schein S, Ngo IT, Huang TM, Klug K, Sterling P, Herr S   Cone synapses in macaque fovea: I. Two types of non-S cones are distinguished by numbers of contacts with OFF midget bipolar cells Vis Neurosci, 2011; 28(1): 3-16.
Hongrong Liu, Lei Jin, Sok Boon S. Koh, Ivo Atanasov, Stan Schein, Lily Wu, Z. Hong Zhou   Atomic Structure of Human Adenovirus by Cryo-EM Reveals Interactions Among Protein Networks Science, 2010; 329(5995): 1038-1043.
Zhang X, Boyce M, Bhattacharya B, Zhang X, Schein S, Roy P, Zhou ZH   Bluetongue virus coat protein VP2 contains sialic acid-binding domains, and VP5 resembles enveloped virus fusion proteins Proc Natl Acad Sci U S A, 2010; 107(14): 6292-7.
Ge P, Tsao J, Schein S, Green TJ, Luo M, Zhou ZH   Cryo-EM model of the bullet-shaped vesicular stomatitis virus Science, 2010; 327(5966): 689-93.
Schein Stan, Friedrich Tara   A geometric constraint, the head-to-tail exclusion rule, may be the basis for the isolated-pentagon rule in fullerenes with more than 60 vertices Proceedings of the National Academy of Sciences of the United States of America, 2008; 105(49): 19142-7.
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Stan Schein, Michelle Sands-Kidner, Tara Friedrich   The physical basis for the head-to-tail rule that excludes most fullerene cages from self assembly Biophysical J, 2008; 94: 938-957.
Schein, S. Sands-Kidner, M.   A geometric principle may guide self-assembly of fullerene cages from clathrin triskelia and from carbon atoms Biophysical Journal, 2008; 94(3): 958-976.
S Schein, KM Ahmad   Efficiency of synaptic transmission of single-photoreceptor to rod bipolar dendrite, Biophysical J, 2006; 91: 3257-3267.
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S Schein, KM Ahmad   A clockwork hypothesis: Synaptic release by rod photoreceptors must be regular, Biophysical J, 2005; 89: 3931-3949.
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Schein, S. Sterling, P. Ngo, I. T. Huang, T. M. Herr, S.   Evidence that each S cone in macaque fovea drives one narrow-field and several wide-field blue-yellow ganglion cells Journal of Neuroscience, 2004; 24(38): 8366-8378.
Ahmad, K. M. Klug, K. Herr, S. Sterling, P. Schein, S.   Cell density ratios in a foveal patch in macaque retina Visual Neuroscience, 2003; 20(2): 189-209.
AA Sadun, V Carelli, SR Salomao, A Berezovsky, PA Quiros, F Sadun, AM DeNegri, R Andrade, M Moraes, A Passos, P Kjaer, J Pereira, ML Valentino, S Schein, R Belfort   Extensive investigation of a large Brazilian pedigree of 11778/Haplogroup J Leber American Journal of Ophthalmology, 2003; 136(2): 231-238.
S Herr, KJ Klug, P Sterling, S Schein   Inner S-cone bipolar cells provide all of the central elements for S cones in macaque retina, J Comp Neurol, 2003; 457: 185-201.
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K Klug, S Herr, IT Ngo, P Sterling, S Schein   Macaque retina contains an S-cone OFF midget pathway, J Neurosci, 2003; 23: 9881-9887.
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K Migdale, S Herr, K Klug, K Ahmad, K Linberg, P Sterling, S Schein   Two ribbon synaptic units in rod photoreceptors of macaque, human, and cat, J Comp Neurol, 2003; 455: 100-112.
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Herr, S. Klug, K. Sterling, P. Schein, S.   Inner S-cone bipolar cells provide all of the central elements for S cones in macaque retina Journal of Comparative Neurology, 2003; 457(2): 185-201.
Burris, C. Klug, K. Ngo, I. T. Sterling, P. Schein, S.   How Muller glial cells in macaque fovea coat and isolate the synaptic terminals of cone photoreceptors Journal of Comparative Neurology, 2002; 453(1): 100-111.
AA Sadun, V Carelli, SR Salomao, A Berezovsky, P Quiros, F Sadun, AM DeNegri, R Andrade, S Schein, R Belfort   A very large Brazilian pedigree with 11 778 Leber’s hereditary optic, Trans Ant Ophthalmol Soc, 2002; 100: 169-77.
C Burris, K Klug, IT Ngo, P Sterling, S Schein   How Müller glial cells in macaque fovea coat and isolate the synaptic terminals of cone photoreceptors, J Comp Neurol, 2002; 453: 100-11.
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Kate Wassum, Ph.D.

Publications

A selected list of publications:

Wassum KM, Greenfield, VY, Linker KE, Maidment NT, Ostlund SB.   Inflated Reward Value in Early Opiate Withdrawal Addiction Biology, 2014; .
Tolosa VM, Wassum KM, Maidment NT, Monbouquette HG.   Electrochemically-deposited iridium oxide reference electrode integrated with an electroenzymatic glutamate sensor on a multi-electrode array microprobe, Biosensors and Bioelectronics, 2013; .
Wassum KM, Ostlund SB, Loewinger GC, Maidment NT.   Phasic mesolimbic dopamine release tracks reward seeking during expression of Pavlovian-to-instrumental transfer, Biological Psychiatry, 2013; .
Wassum KM, Ostlund SB, Maidment NT.   Phasic mesolimbic dopamine signaling precedes and predicts performance of a self-initiated action sequence, Biological Psychiatry, 2012; .
Wassum KM, Tolosa VM, Tseng TC, Balleine BW, Monbouquette HG, Maidment NT.   Transient extracellular glutamate events in the basolateral amygdala track reward seeking actions, Journal of Neuroscience, 2012; .
Lichtenberg Nina T, Pennington Zachary T, Holley Sandra M, Greenfield Venuz Y, Cepeda Carlos, Levine Michael S, Wassum Kate M   Basolateral Amygdala to Orbitofrontal Cortex Projections Enable Cue-Triggered Reward Expectations The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017; 37(35): 8374-8384.
Hersman Sarah, Cushman Jesse, Lemelson Noah, Wassum Kate, Lotfipour Shahrdad, Fanselow Michael S   Optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations Scientific reports, 2017; 7(1): 2333.
Lichtenberg Nina T, Wassum Kate M   Amygdala mu-opioid receptors mediate the motivating influence of cue-triggered reward expectations The European journal of neuroscience, 2017; 45(3): 381-387.
Ostlund Sean B, Liu Angela T, Wassum Kate M, Maidment Nigel T   Modulation of cue-triggered reward seeking by cholinergic signaling in the dorsomedial striatum The European journal of neuroscience, 2017; 45(3): 358-364.
Collins Anne L, Aitken Tara J, Greenfield Venuz Y, Ostlund Sean B, Wassum Kate M   Nucleus Accumbens Acetylcholine Receptors Modulate Dopamine and Motivation Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016; 41(12): 2830-2838.
Wassum Kate M, Greenfield Venuz Y, Linker Kay E, Maidment Nigel T, Ostlund Sean B   Inflated reward value in early opiate withdrawal Addiction biology, 2016; 21(2): 221-33.
Aitken Tara J, Greenfield Venuz Y, Wassum Kate M   Nucleus accumbens core dopamine signaling tracks the need-based motivational value of food-paired cues Journal of neurochemistry, 2016; 136(5): 1026-36.
Malvaez Melissa, Greenfield Venuz Y, Wang Alice S, Yorita Allison M, Feng Lili, Linker Kay E, Monbouquette Harold G, Wassum Kate M   Corrigendum: Basolateral amygdala rapid glutamate release encodes an outcome-specific representation vital for reward-predictive cues to selectively invigorate reward-seeking actions Scientific reports, 2016; 6(5): 20891.
Collins Anne L, Greenfield Venuz Y, Bye Jeffrey K, Linker Kay E, Wang Alice S, Wassum Kate M   Dynamic mesolimbic dopamine signaling during action sequence learning and expectation violation Scientific reports, 2016; 6(5): 20231.
Fanselow Michael S, Wassum Kate M   The Origins and Organization of Vertebrate Pavlovian Conditioning Cold Spring Harbor perspectives in biology, 2015; 8(1): a021717.
Malvaez Melissa, Greenfield Venuz Y, Wang Alice S, Yorita Allison M, Feng Lili, Linker Kay E, Monbouquette Harold G, Wassum Kate M   Basolateral amygdala rapid glutamate release encodes an outcome-specific representation vital for reward-predictive cues to selectively invigorate reward-seeking actions Scientific reports, 2015; 5: 12511.
Wassum Kate M, Izquierdo Alicia   The basolateral amygdala in reward learning and addiction Neuroscience and biobehavioral reviews, 2015; .
Wassum Kate M, Phillips Paul E M   Probing the neurochemical correlates of motivation and decision making ACS chemical neuroscience, 2015; 6(1): 11-3.
Ostlund Sean B, LeBlanc Kimberly H, Kosheleff Alisa R, Wassum Kate M, Maidment Nigel T   Phasic mesolimbic dopamine signaling encodes the facilitation of incentive motivation produced by repeated cocaine exposure Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014; 39(10): 2441-9.
Tolosa Vanessa M, Wassum Kate M, Maidment Nigel T, Monbouquette Harold G   Electrochemically deposited iridium oxide reference electrode integrated with an electroenzymatic glutamate sensor on a multi-electrode array microprobe Biosensors & bioelectronics, 2013; 42(8): 256-60.
Wassum Kate M, Ostlund Sean B, Loewinger Gabriel C, Maidment Nigel T   Phasic mesolimbic dopamine release tracks reward seeking during expression of Pavlovian-to-instrumental transfer Biological psychiatry, 2013; 73(8): 747-55.
Wassum Kate M, Ostlund Sean B, Maidment Nigel T   Phasic mesolimbic dopamine signaling precedes and predicts performance of a self-initiated action sequence task Biological psychiatry, 2012; 71(10): 846-54.
Wassum Kate M, Tolosa Vanessa M, Tseng Tina C, Balleine Bernard W, Monbouquette Harold G, Maidment Nigel T   Transient extracellular glutamate events in the basolateral amygdala track reward-seeking actions The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012; 32(8): 2734-46.
Wassum Kate M, Ostlund Sean B, Balleine Bernard W, Maidment Nigel T   Differential dependence of Pavlovian incentive motivation and instrumental incentive learning processes on dopamine signaling Learning & memory (Cold Spring Harbor, N.Y.), 2011; 18(7): 475-83.
Wassum Kate M, Cely Ingrid C, Balleine Bernard W, Maidment Nigel T   Micro-opioid receptor activation in the basolateral amygdala mediates the learning of increases but not decreases in the incentive value of a food reward The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011; 31(5): 1591-9.
Ostlund Sean B, Wassum Kate M, Murphy Niall P, Balleine Bernard W, Maidment Nigel T   Extracellular dopamine levels in striatal subregions track shifts in motivation and response cost during instrumental conditioning The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011; 31(1): 200-7.
Wassum KM, Cely IC, Ostlund SB, Maidment NT, Balleine BW.   Disruption of endogenous opioid activity during instrumental learning enhances habit acquisition, Neuroscience, 2009; 163(3): 770-80.
Wassum KM, Ostlund SB, Maidment NT, Balleine BW.   Distinct opioid circuits determine the palatability and the desirability of rewarding events, Proc Natl Acad Sci USA, 2009; 106(30): 12512-7.
Wassum Kate M, Evans Christopher J   International Narcotics Research Conference – 39th Annual Meeting IDrugs : the investigational drugs journal, 2008; 11(9): 646-9.
Wassum Kate M, Tolosa Vanessa M, Wang Jianjun, Walker Eric, Monbouquette Harold G, Maidment Nigel T   Silicon Wafer-Based Platinum Microelectrode Array Biosensor for Near Real-Time Measurement of Glutamate in Vivo Sensors (Basel, Switzerland), 2008; 8(8): 5023-5036.
Wightman R Mark, Heien Michael L A V, Wassum Kate M, Sombers Leslie A, Aragona Brandon J, Khan Amina S, Ariansen Jennifer L, Cheer Joseph F, Phillips Paul E M, Carelli Regina M   Dopamine release is heterogeneous within microenvironments of the rat nucleus accumbens The European journal of neuroscience, 2007; 26(7): 2046-54.
Cheer Joseph F, Wassum Kate M, Sombers Leslie A, Heien Michael L A V, Ariansen Jennifer L, Aragona Brandon J, Phillips Paul E M, Wightman R Mark   Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007; 27(4): 791-5.
Cheer Joseph F, Wassum Kate M, Wightman R Mark   Cannabinoid modulation of electrically evoked pH and oxygen transients in the nucleus accumbens of awake rats Journal of neurochemistry, 2006; 97(4): 1145-54.
Heien Michael L A V, Khan Amina S, Ariansen Jennifer L, Cheer Joseph F, Phillips Paul E M, Wassum Kate M, Wightman R Mark   Real-time measurement of dopamine fluctuations after cocaine in the brain of behaving rats Proceedings of the National Academy of Sciences of the United States of America, 2005; 102(29): 10023-8.
Cheer Joseph F, Wassum Kate M, Heien Michael L A V, Phillips Paul E M, Wightman R Mark   Cannabinoids enhance subsecond dopamine release in the nucleus accumbens of awake rats The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004; 24(18): 4393-400.