Posts classified under: Computational and Systems Neuroscience

Neil Harris, Ph.D.


Professor Harris directs NEIL lab with over 25 years of experience with rodent CNS injury models and in particular using MRI and PET to assess structure and function. He received his B.Sc. in Biology/Neuroscience from University of Portsmouth in 1988, and his Ph.D. in Physiology from King’s College London in 1991. Dr. Harris’s early focus of research addressed the question of optimal timing for intervention after the diagnosis of infantile hydrocephalus. Prior to joining University of California Los Angeles (UCLA), Dr. Harris received training in multimodality imaging techniques, including PET, structural MRI, fMRI, DTI, and Glucose/blood-flow autoradiography at Kings college University of London, University of Florida McKnight Brain Institute, the Royal College of Surgeons unit of Biophysics in the Institute of Child Health, and University of Cambridge Department of Neurosurgery. Subsequently, Dr. Harris conducted studies to address forebrain ischemic stroke looking at the potential use of non-invasive biomarkers to determine salvageable areas of brain. The studies were cited amongst primary reported findings on biophysical mechanism of the change in water diffusion after stroke. Dr. Harris currently resides as Professor in Residence of UCLA Department of Neurosurgery where he primarily conducts investigations on Traumatic Brain Injury and is the scientific director of UCLA 7T animal imaging core.

Keith Holyoak, Ph.D.


Combining behavioral studies of normal cognition, computational modeling, and neuropsychological and neuroimaging studies, to understand the role of the prefrontal cortex in human thinking Keith J. Holyoak conducts research in human reasoning and problem solving. Much of his work is concerned with the role of analogy in thinking. One of the major themes of this work is the way in which analogy serves as a psychological mechanism for learning and transfer of knowledge. In his book Mental Leaps with Paul Thagard, he presents a general theory of analogical thinking that includes analysis of how the capacity to use analogy evolved in primates, how it develops in children, and how it is used to reason in domains ranging from law and politics to science. Other related reserach, in collaboration with Dan Simon, deals with complex decision-making in fields such as the law. Holyoaks research combines studies of thinking in normal adults with neuropsychological studies of how thinking in brain-damaged individuals. This work, in collaboration with Barbara Knowlton and others, is investigating the role of prefrontal cortex in complex human reasoning. In addition to experimental work, Holyoak works with John Hummel to develop computational models of human thinking based on neural-network models. These models use neural synchrony to preform dynamic variable binding, and thereby represent and maniputlate symbolic knowledge. The overall goal is to understand the neural basis for human thought.

Alicia Izquierdo, Ph.D.


A selected list of publications:

Hart Evan E, Blair Garrett J, O’Dell Thomas J, Blair Hugh T, Izquierdo Alicia   Chemogenetic Modulation and Single-Photon Calcium Imaging in Anterior Cingulate Cortex Reveal a Mechanism for Effort-Based Decisions The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020; 40(29): 5628-5643.
Aguirre Claudia G, Stolyarova Alexandra, Das Kanak, Kolli Saisriya, Marty Vincent, Ray Lara, Spigelman Igor, Izquierdo Alicia   Sex-dependent effects of chronic intermittent voluntary alcohol consumption on attentional, not motivational, measures during probabilistic learning and reversal PloS one, 2020; 15(6): e0234729.
Stolyarova A, Rakhshan M, Hart E E, O’Dell T J, Peters M A K, Lau H, Soltani A, Izquierdo A   Contributions of anterior cingulate cortex and basolateral amygdala to decision confidence and learning under uncertainty Nature communications, 2019; 10(1): 4704.
Soltani Alireza, Izquierdo Alicia   Adaptive learning under expected and unexpected uncertainty Nature reviews. Neuroscience, 2019; .
Izquierdo Alicia, Aguirre Claudia, Hart Evan E, Stolyarova Alexandra   Rodent Models of Adaptive Value Learning and Decision-Making Methods in molecular biology (Clifton, N.J.), 2019; 2011: 105-119.
Hart Evan E, Izquierdo Alicia   Quantity versus quality: Convergent findings in effort-based choice tasks Behavioural processes, 2019; 164: 178-185.
Izquierdo Alicia   Functional Heterogeneity within Rat Orbitofrontal Cortex in Reward Learning and Decision Making The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017; 37(44): 10529-10540.
Hart Evan E, Gerson Julian O, Zoken Yael, Garcia Marisella, Izquierdo Alicia   Anterior cingulate cortex supports effort allocation toward a qualitatively preferred option The European journal of neuroscience, 2017; .
Thompson Andrew B, Gerson Julian, Stolyarova Alexandra, Bugarin Amador, Hart Evan E, Jentsch J David, Izquierdo Alicia   Steep effort discounting of a preferred reward over a freely-available option in prolonged methamphetamine withdrawal in male rats Psychopharmacology, 2017; .
Hart Evan E, Izquierdo Alicia   Basolateral amygdala supports the maintenance of value and effortful choice of a preferred option The European journal of neuroscience, 2016; .
Izquierdo Alicia, Silva Alcino J   Hijacking translation in addiction eLife, 2016; 5: .
Hart Evan E, Stolyarova Alexandra, Conoscenti Michael A, Minor Thomas R, Izquierdo Alicia   Rigid patterns of effortful choice behavior after acute stress in rats Stress (Amsterdam, Netherlands), 2016; 1-10.
Izquierdo Alicia, Pozos Hilda, Torre Adrianna De La, DeShields Simone, Cevallos James, Rodriguez Jonathan, Stolyarova Alexandra   Sex differences, learning flexibility, and striatal dopamine D1 and D2 following adolescent drug exposure in rats Behavioural brain research, 2016; .
Izquierdo A, Brigman J L, Radke A K, Rudebeck P H, Holmes A   The neural basis of reversal learning: An updated perspective Neuroscience, 2016; .
Stolyarova Alexandra, Izquierdo Alicia   Distinct patterns of outcome valuation and amygdala-prefrontal cortex synaptic remodeling in adolescence and adulthood Frontiers in behavioral neuroscience, 2015; 9: 115.
Thompson Andrew B, Stolyarova Alexandra, Ying Zhe, Zhuang Yumei, Gomez-Pinilla Fernando, Izquierdo Alicia   Methamphetamine blocks exercise effects on Bdnf and Drd2 gene expression in frontal cortex and striatum Neuropharmacology, 2015; .
Ochoa Jesus G, Stolyarova Alexandra, Kaur Amandeep, Hart Evan E, Bugarin Amador, Izquierdo Alicia   Post-training depletions of basolateral amygdala serotonin fail to disrupt discrimination, retention, or reversal learning Frontiers in neuroscience, 2015; 9: 155.
Wassum Kate M, Izquierdo Alicia   The basolateral amygdala in reward learning and addiction Neuroscience and biobehavioral reviews, 2015; .
Ye Tony, Pozos Hilda, Phillips Tamara J, Izquierdo Alicia   Long-term effects of exposure to methamphetamine in adolescent rats Drug and alcohol dependence, 2014; .
Stolyarova Alexandra, O’Dell Steve J, Marshall John F, Izquierdo Alicia   Positive and negative feedback learning and associated dopamine and serotonin transporter binding after methamphetamine Behavioural brain research, 2014; .
Stolyarova Alexandra, Thompson Andrew B, Barrientos Ruth M, Izquierdo Alicia   Reductions in Frontocortical Cytokine Levels are Associated with Long-Lasting Alterations in Reward Valuation after Methamphetamine Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014; .
Izquierdo Alicia, Darling Chelsi, Manos Nic, Pozos Hilda, Kim Charissa, Ostrander Serena, Cazares Victor, Stepp Haley, Rudebeck Peter H   Basolateral amygdala lesions facilitate reward choices after negative feedback in rats The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013; 33(9): 4105-9.
Kosheleff Alisa R, Rodriguez Danilo, O’Dell Steve J, Marshall John F, Izquierdo Alicia   Comparison of single-dose and extended methamphetamine administration on reversal learning in rats Psychopharmacology, 2012; 224(3): 459-67.
Barkus Chris, Feyder Michael, Graybeal Carolyn, Wright Tara, Wiedholz Lisa, Izquierdo Alicia, Kiselycznyk Carly, Schmitt Wolfram, Sanderson David J, Rawlins J Nicholas P, Saksida Lisa M, Bussey Timothy J, Sprengel Rolf, Bannerman David, Holmes Andrew   Do GluA1 knockout mice exhibit behavioral abnormalities relevant to the negative or cognitive symptoms of schizophrenia and schizoaffective disorder? Neuropharmacology, 2012; 62(3): 1263-72.
Izquierdo Alicia, Carlos Kathleen, Ostrander Serena, Rodriguez Danilo, McCall-Craddolph Aaron, Yagnik Gargey, Zhou Feimeng   Impaired reward learning and intact motivation after serotonin depletion in rats Behavioural brain research, 2012; 233(2): 494-9.
Izquierdo Alicia, Jentsch J David   Reversal learning as a measure of impulsive and compulsive behavior in addictions Psychopharmacology, 2012; 219(2): 607-20.
Izquierdo Alicia, Belcher Annabelle M   Rodent models of adaptive decision making Methods in molecular biology (Clifton, N.J.), 2012; 829(3): 85-101.
Kosheleff Alisa R, Grimes Millie, O’Dell Steve J, Marshall John F, Izquierdo Alicia   Work aversion and associated changes in dopamine and serotonin transporter after methamphetamine exposure in rats Psychopharmacology, 2012; 219(2): 411-20.
Ostrander Serena, Cazares Victor A, Kim Charissa, Cheung Shauna, Gonzalez Isabel, Izquierdo Alicia   Orbitofrontal cortex and basolateral amygdala lesions result in suboptimal and dissociable reward choices on cue-guided effort in rats Behavioral neuroscience, 2011; 125(3): 350-9.
Izquierdo Alicia, Murray Elisabeth A   Functional interaction of medial mediodorsal thalamic nucleus but not nucleus accumbens with amygdala and orbital prefrontal cortex is essential for adaptive response selection after reinforcer devaluation The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010; 30(2): 661-9.
Brigman Jonathan L, Mathur Poonam, Harvey-White Judith, Izquierdo Alicia, Saksida Lisa M, Bussey Timothy J, Fox Stephanie, Deneris Evan, Murphy Dennis L, Holmes Andrew   Pharmacological or genetic inactivation of the serotonin transporter improves reversal learning in mice Cerebral cortex (New York, N.Y. : 1991), 2010; 20(8): 1955-63.
Izquierdo Alicia, Belcher Annabelle M, Scott Lori, Cazares Victor A, Chen Jack, O’Dell Steven J, Malvaez Melissa, Wu Tiffany, Marshall John F   Reversal-specific learning impairments after a binge regimen of methamphetamine in rats: possible involvement of striatal dopamine Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010; 35(2): 505-14.
Chudasama Yogita, Izquierdo Alicia, Murray Elisabeth A   Distinct contributions of the amygdala and hippocampus to fear expression The European journal of neuroscience, 2009; 30(12): 2327-37.
Izquierdo Alicia, Newman Timothy K, Higley J Dee, Murray Elisabeth A   Genetic modulation of cognitive flexibility and socioemotional behavior in rhesus monkeys Proceedings of the National Academy of Sciences of the United States of America, 2007; 104(35): 14128-33.
Wellman C L, Izquierdo A, Garrett J E, Martin K P, Carroll J, Millstein R, Lesch K-P, Murphy D L, Holmes A   Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007; 27(3): 684-91.
Murray Elisabeth A, Izquierdo Alicia   Orbitofrontal cortex and amygdala contributions to affect and action in primates Annals of the New York Academy of Sciences, 2007; 1121(8): 273-96.
Izquierdo Alicia, Murray Elisabeth A   Selective bilateral amygdala lesions in rhesus monkeys fail to disrupt object reversal learning The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007; 27(5): 1054-62.
Izquierdo Alicia, Wellman Cara L, Holmes Andrew   Brief uncontrollable stress causes dendritic retraction in infralimbic cortex and resistance to fear extinction in mice The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006; 26(21): 5733-8.
Izquierdo Alicia, Wiedholz Lisa M, Millstein Rachel A, Yang Rebecca J, Bussey Timothy J, Saksida Lisa M, Holmes Andrew   Genetic and dopaminergic modulation of reversal learning in a touchscreen-based operant procedure for mice Behavioural brain research, 2006; 171(2): 181-8.
Izquierdo Alicia, Suda Robin K, Murray Elisabeth A   Comparison of the effects of bilateral orbital prefrontal cortex lesions and amygdala lesions on emotional responses in rhesus monkeys The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005; 25(37): 8534-42.
Izquierdo Alicia, Murray Elisabeth A   Opposing effects of amygdala and orbital prefrontal cortex lesions on the extinction of instrumental responding in macaque monkeys The European journal of neuroscience, 2005; 22(9): 2341-6.
Izquierdo Alicia, Suda Robin K, Murray Elisabeth A   Bilateral orbital prefrontal cortex lesions in rhesus monkeys disrupt choices guided by both reward value and reward contingency The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004; 24(34): 7540-8.
Izquierdo Alicia, Murray Elisabeth A   Combined unilateral lesions of the amygdala and orbital prefrontal cortex impair affective processing in rhesus monkeys Journal of neurophysiology, 2004; 91(5): 2023-39.
Baxter M G, Parker A, Lindner C C, Izquierdo A D, Murray E A   Control of response selection by reinforcer value requires interaction of amygdala and orbital prefrontal cortex The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000; 20(11): 4311-9.
Boothe R G, Louden T, Aiyer A, Izquierdo A, Drews C, Lambert S R   Visual outcome after contact lens and intraocular lens correction of neonatal monocular aphakia in monkeys Investigative ophthalmology & visual science, 2000; 41(1): 110-9.