Biography
The Portera-Cailliau laboratory investigates how developmental defects in network connectivity at the level of the cerebral cortex directly lead to symptoms of autism, learning disability and intellectual dysfunction. In particular they are studying sensory hypersensitivity in a model of fragile X syndrome, by combining in vivo two-photon calcium imaging, patch-clamp electrophysiology, and head-fixed behavior. Dr. Portera-Cailliau was born and raised in Madrid, Spain. He obtained a B.A. in Biochemistry & Cell Biology from U.C. San Diego in 1990. He then attended the Johns Hopkins School of Medicine and obtained an MD-PhD degree in 1997. His mentors were Drs. Donald Price and Lee Martin. After finishing a residency in Neurology at The Massachusetts General Hospital and Brigham & Women’s Hospital in Boston in 2001, Dr. Portera-Cailliau moved to Columbia University for a post-doctoral fellowship in Dr. Rafael Yuste’s laboratory. His second post-doc was with Dr. Karel Svoboda in Cold Spring Harbor Laboratory. He joined the UCLA faculty in November 2004 and has joint appointments in the Departments of Neurology and Neurobiology. He is a member of UCLA’s Brain Research Institute, the Integrated Center for Learning & Memory, and the Neuroscience Theme. Since 2013 he has served as co-director of the UCLA-Caltech Medical Scientist Training Program.
Publications
A selected list of publications:
Shen Yi, Lindemeyer A Kerstin, Spigelman Igor, Sieghart Werner, Olsen Richard W, Liang Jing Plasticity of GABAA receptors after ethanol pre-exposure in cultured hippocampal neurons Molecular pharmacology, 2011; 79(3): 432-42.
Ruangsri Supanigar, Lin Audrey, Mulpuri Yatendra, Lee Kyung, Spigelman Igor, Nishimura Ichiro RELATIONSHIP OF AXONAL VOLTAGE-GATED SODIUM CHANNEL 1.8 (NaV1.8) mRNA ACCUMULATION TO SCIATIC NERVE INJURY-INDUCED PAINFUL NEUROPATHY IN RATS The Journal of biological chemistry, 2011; .
Suryanarayanan Asha, Liang Jing, Meyer Edward M, Lindemeyer A Kerstin, Chandra Dev, Homanics Gregg E, Sieghart Werner, Olsen Richard W, Spigelman Igor Subunit Compensation and Plasticity of Synaptic GABA(A) Receptors Induced by Ethanol in ?4 Subunit Knockout Mice Frontiers in neuroscience, 2011; 5(3): 110.
Díaz-Cintra Sofia, Xue Baogang, Spigelman Igor, Van K, Wong Alan M, Obenaus Andre, Ribak Charles E Dentate granule cells form hilar basal dendrites in a rat model of hypoxia-ischemia Brain research, 2009; 1285: 182-7.
Thakor Devang Kashyap, Lin Audrey, Matsuka Yoshizo, Meyer Edward M, Ruangsri Supanigar, Nishimura Ichiro, Spigelman Igor Increased peripheral nerve excitability and local NaV1.8 mRNA up-regulation in painful neuropathy Molecular pain, 2009; 5(1): 14.
Ribak Charles E, Shapiro Lee A, Perez Zachary D, Spigelman Igor Microglia-associated granule cell death in the normal adult dentate gyrus Brain structure & function, 2009; .
Liang Jing, Spigelman Igor, Olsen Richard W Tolerance to sedative/hypnotic actions of GABAergic drugs correlates with tolerance to potentiation of extrasynaptic tonic currents of alcohol-dependent rats Journal of neurophysiology, 2009; 102(1): 224-33.
Matsuka Yoshizo, Ono Takeshi, Iwase Hirotate, Mitrirattanakul Somsak, Omoto Kevin S, Cho Ting, Lam Yan Yan N, Snyder Bradley, Spigelman Igor Altered ATP release and metabolism in dorsal root ganglia of neuropathic rats Molecular pain, 2008; 4(1): 66.
Jain Naveen K, Ishikawa Tomo-o, Spigelman Igor, Herschman Harvey R COX-2 expression and function in the hyperalgesic response to paw inflammation in mice Prostaglandins, leukotrienes, and essential fatty acids, 2008; 79(6): 183-90.
Liang Jing, Suryanarayanan Asha, Chandra Dev, Homanics Gregg E, Olsen Richard W, Spigelman Igor Functional consequences of GABAA receptor alpha 4 subunit deletion on synaptic and extrasynaptic currents in mouse dentate granule cells Alcoholism, clinical and experimental research, 2008; 32(1): 19-26.
Chandra Dev, Werner David F, Liang Jing, Suryanarayanan Asha, Harrison Neil L, Spigelman Igor, Olsen Richard W, Homanics Gregg E Normal acute behavioral responses to moderate/high dose ethanol in GABAA receptor alpha 4 subunit knockout mice Alcoholism, clinical and experimental research, 2008; 32(1): 10-8.
Mitrirattanakul Somsak, López-Valdés Héctor E, Liang Jing, Matsuka Yoshizo, Mackie Ken, Faull Kym F, Spigelman Igor Bidirectional alterations of hippocampal cannabinoid 1 receptors and their endogenous ligands in a rat model of alcohol withdrawal and dependence Alcoholism, clinical and experimental research, 2007; 31(5): 855-67.
Liang Jing, Suryanarayanan Asha, Abriam Alana, Snyder Bradley, Olsen Richard W, Spigelman Igor Mechanisms of reversible GABAA receptor plasticity after ethanol intoxication The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007; 27(45): 12367-77.
Thakor Devang, Spigelman Igor, Tabata Yasuhiko, Nishimura Ichiro Subcutaneous peripheral injection of cationized gelatin/DNA polyplexes as a platform for non-viral gene transfer to sensory neurons Molecular therapy : the journal of the American Society of Gene Therapy, 2007; 15(12): 2124-31.
Liang, J., Zhang, N., Cagetti, E. Houser, C.R., Olsen, R.W. and Spigelman, I. Chronic intermittent ethanol treatment-induced switch of ethanol actions from extrasynaptic to synaptic hippocampal GABAA receptors, Journal of Neuroscience, 2006; 26: 1749-1758.
Liang Jing, Zhang Nianhui, Cagetti Elisabetta, Houser Carolyn R, Olsen Richard W, Spigelman Igor Chronic intermittent ethanol-induced switch of ethanol actions from extrasynaptic to synaptic hippocampal GABAA receptors The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006; 26(6): 1749-58.
Chandra, D., Jia, F., Liang, J., Peng, Z., Suryanarayanan, A., Werner, D.F., Spigelman, I., Houser, C.R., Olsen, R.W., Harrison, N.L. and Homanics, G.E. GABA(A) receptor alpha4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol, Proceedings of the National Academy of Sciences USA, 2006; 103: 15230-15235.
Spigelman, I. Physiologic mechanisms of inhibition and status epilepticus, In: Status Epilepticus, Mechanisms and Management, C.G. Wasterlain and D.M. Treiman editors, MIT Press, Cambridge,, 2006; Chapter 21: 281-293.
Mitrirattanakul Somsak, Ramakul Navapoln, Guerrero Andre V, Matsuka Yoshizo, Ono Takeshi, Iwase Hirotate, Mackie Ken, Faull Kym F, Spigelman Igor Site-specific increases in peripheral cannabinoid receptors and their endogenous ligands in a model of neuropathic pain Pain, 2006; 126(1-3): 102-14.
Olsen, R.W., Liang, J., Cagetti, E., and Spigelman, I. Plasticity of GABAA receptors in brains of rats treated with chronic intermittent ethanol , Neurochemical Research, 2005; 30: 1579-1588.
Matsuka Y. and Spigelman, I. Hyperosmolar solutions selectively block action potentials in rat myelinated sensory fibers: implications for diabetic neuropathy, Journal of Neurophysiology, 2004; 91: 48-56.
Matsuka, Y Neubert, JK Maidment, NT Spigelman, I Concurrent release of ATP and substance P within guinea pig trigeminal ganglia in vivo Brain research. , 2001; 915(2): 248-55.
Spigelman, I., Gold, M.S., Light A.R. Electrophysiological Methods in Pain Research, Methods in Pain Research, 2001; Chapter 8: 147-168.
Spigelman, I., Neubert, J.K., Matsuka, Y., Maidment, N.T. Extracellular Sampling, Methods in Pain Research, 2001; Chapter 7: 133-146.
Neubert, JK Maidment, NT Matsuka, Y Adelson, DW Kruger, L Spigelman, I Inflammation-induced changes in primary afferent-evoked release of substance P within trigeminal ganglia in vivo Brain research. , 2000; 871(2): 181-91.
Spigelman, I Yan, XX Obenaus, A Lee, EY Wasterlain, CG Ribak, CE Dentate granule cells form novel basal dendrites in a rat model of temporal lobe epilepsy Neuroscience. , 1998; 86(1): 109-20.
Spigelman, I Obenaus, A Mazarati, A Wasterlain, CG Intravenously administered cell-permeant calcium buffer decreases evoked synaptic potentials in rat dentate gyrus in vivo Brain research. , 1998; 810(1-2): 269-73.
Spigelman, I Tymianski, M Wallace, CM Carlen, PL Velumian, AA Modulation of hippocampal synaptic transmission by low concentrations of cell-permeant Ca2+ chelators: effects of Ca2+ affinity, chelator structure and binding kinetics Neuroscience. , 1996; 75(2): 559-72.
Publications
A selected list of publications:
Meera Pratap, Olsen Richard W, Otis Thomas S, Wallner Martin Etomidate, propofol and the neurosteroid THDOC increase the GABA efficacy of recombinant alpha4beta3delta and alpha4beta3 GABA A receptors expressed in HEK cells Neuropharmacology, 2009; 56(1): 155-60.
Wallner M, Olsen R W Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABAA receptors as an opportunity for drug development? Br. J. Pharmacol, 2008; 154(2): 288-98.
Santhakumar Vijayalakshmi, Wallner Martin, Otis Thomas S Ethanol acts directly on extrasynaptic subtypes of GABAA receptors to increase tonic inhibition Alcohol, 2007; 41(3): 211-21.
Wallner Martin, Hanchar H Jacob, Olsen Richard W Low dose acute alcohol effects on GABA A receptor subtypes Pharmacol. Ther, 2006; 112(2): 513-28.
Hanchar H Jacob, Chutsrinopkun Panida, Meera Pratap, Supavilai Porntip, Sieghart Werner, Wallner Martin, Olsen Richard W Ethanol potently and competitively inhibits binding of the alcohol antagonist Ro15-4513 to alpha4/6beta3delta GABAA receptors Proc. Natl. Acad. Sci. U.S.A, 2006; 103(22): 8546-51.
Wallner M, Hanchar H J, Olsen R W Low-dose alcohol actions on alpha4beta3delta GABAA receptors are reversed by the behavioral alcohol antagonist Ro15-4513 Proc. Natl. Acad. Sci. U.S.A, 2006; 103(22): 8540-5.
Hanchar H Jacob, Dodson Paul D, Olsen Richard W, Otis Thomas S, Wallner Martin Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity Nat. Neurosci, 2005; 8(3): 339-45.
Wallner M, Hanchar H J, Olsen R W Ethanol enhances alpha 4 beta 3 delta and alpha 6 beta 3 delta gamma-aminobutyric acid type A receptors at low concentrations known to affect humans Proc. Natl. Acad. Sci. U.S.A, 2003; 100(25): 15218-23.
Meera P, Wallner M, Toro L A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin Proc. Natl. Acad. Sci. U.S.A, 2000; 97(10): 5562-7.
Wallner M, Meera P, Toro L Molecular basis of fast inactivation in voltage and Ca2+-activated K+ channels: a transmembrane beta-subunit homolog Proc. Natl. Acad. Sci. U.S.A, 1999; 96(7): 4137-42.
Meera P, Wallner M, Song M, Toro L Large conductance voltage- and calcium-dependent K+ channel, a distinct member of voltage-dependent ion channels with seven N-terminal transmembrane segments (S0-S6), an extracellular N terminus, and an intracellular (S9-S10) C terminus Proc. Natl. Acad. Sci. U.S.A, 1997; 94(25): 14066-71.
Wallner M, Meera P, Toro L Determinant for beta-subunit regulation in high-conductance voltage-activated and Ca(2+)-sensitive K+ channels: an additional transmembrane region at the N terminus Proc. Natl. Acad. Sci. U.S.A, 1996; 93(25): 14922-7.
Wallner M, Weigl L, Meera P, Lotan I Modulation of the skeletal muscle sodium channel alpha-subunit by the beta 1-subunit FEBS Lett, 1993; 336(3): 535-9.