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Elaine Hsiao, Ph.D.

Biography

Elaine is an Assistant Professor at UCLA, where she is interested in all things microbial, neural and immune. She completed her B.S. in Microbiology, Immunology and Molecular Genetics at UCLA, which sparked her love for molecular biology and bacteria. She went on to complete her Ph.D. in Neurobiology at Caltech, where she studied the neurobiological bases of autism and schizophrenia, with a focus on maternal effects on fetal development, and neuroimmune and microbial contributions to behavioral disorders. Inspired by the amazing and complex interactions between body systems, the Hsiao laboratory is investigating how “peripheral” changes in the immune system and resident microbiota impact the nervous system.

 

Publications

A selected list of publications:

Hsiao Elaine Y   Gastrointestinal issues in autism spectrum disorder Harvard review of psychiatry, 2015; 22(2): 104-11.
Yano Jessica M, Yu Kristie, Donaldson Gregory P, Shastri Gauri G, Ann Phoebe, Ma Liang, Nagler Cathryn R, Ismagilov Rustem F, Mazmanian Sarkis K, Hsiao Elaine Y   Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis Cell, 2015; 161(2): 264-76.
Hsiao Elaine Y, McBride Sara W, Hsien Sophia, Sharon Gil, Hyde Embriette R, McCue Tyler, Codelli Julian A, Chow Janet, Reisman Sarah E, Petrosino Joseph F, Patterson Paul H, Mazmanian Sarkis K   Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders Cell, 2013; 155(7): 1451-63.
Hsiao Elaine Y   Immune dysregulation in autism spectrum disorder International review of neurobiology, 2013; 113(7): 269-302.
Garay Paula A, Hsiao Elaine Y, Patterson Paul H, McAllister A K   Maternal immune activation causes age- and region-specific changes in brain cytokines in offspring throughout development Brain, behavior, and immunity, 2013; 31(7): 54-68.
Hsiao Elaine Y, Patterson Paul H   Placental regulation of maternal-fetal interactions and brain development Developmental neurobiology, 2012; 72(10): 1317-26.
Hsiao Elaine Y, McBride Sara W, Chow Janet, Mazmanian Sarkis K, Patterson Paul H   Modeling an autism risk factor in mice leads to permanent immune dysregulation Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(31): 12776-81.
Malkova Natalia V, Yu Collin Z, Hsiao Elaine Y, Moore Marlyn J, Patterson Paul H   Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism Brain, behavior, and immunity, 2012; 26(4): 607-16.
Hsiao Elaine Y, Patterson Paul H   Activation of the maternal immune system induces endocrine changes in the placenta via IL-6 Brain, behavior, and immunity, 2011; 25(4): 604-15.
Ito Hiroshi T, Smith Stephen E P, Hsiao Elaine, Patterson Paul H   Maternal immune activation alters nonspatial information processing in the hippocampus of the adult offspring Brain, behavior, and immunity, 2010; 24(6): 930-41.

Baljit Khakh, Ph.D.

Biography

Baljit S. Khakh received a Ph.D. degree from the University of Cambridge in 1995. During his graduate studies, he also spent some time at the Geneva Biomedical Research Institute. Dr. Khakh completed a postdoctoral fellowship in the laboratory of Dr. Graeme Henderson at the University of Bristol, followed by a fellowship at the California Institute of Technology, working in the laboratories of Drs. Henry A. Lester and Norman Davidson as a Wellcome Trust International Prize Traveling Research Fellow, and Senior Research Fellow in the Division of Biology. In 2001, Dr. Khakh returned to Cambridge in the Division of Neurobiology at the MRC Laboratory of Molecular Biology. Dr. Khakh joined UCLA in April 2006.

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