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David S. Williams, Ph.D.

David Williams, Ph.D.

Publications

A selected list of publications:

Esteve-Rudd Julian, Hazim Roni A, Diemer Tanja, Paniagua Antonio E, Volland Stefanie, Umapathy Ankita, Williams David S   Defective phagosome motility and degradation in cell nonautonomous RPE pathogenesis of a dominant macular degeneration Proceedings of the National Academy of Sciences of the United States of America, 2018; 115(21): 5468-5473.
Hazim Roni A, Williams David S   Cell Culture Analysis of the Phagocytosis of Photoreceptor Outer Segments by Primary Mouse RPE Cells Methods in molecular biology (Clifton, N.J.), 2018; 1753(3): 63-71.
Volland Stefanie, Williams David S   Preservation of Photoreceptor Nanostructure for Electron Tomography Using Transcardiac Perfusion Followed by High-Pressure Freezing and Freeze-Substitution Advances in experimental medicine and biology, 2018; 1074(3): 603-607.
Hazim Roni A, Karumbayaram Saravanan, Jiang Mei, Dimashkie Anupama, Lopes Vanda S, Li Douran, Burgess Barry L, Vijayaraj Preethi, Alva-Ornelas Jackelyn A, Zack Jerome A, Kohn Donald B, Gomperts Brigitte N, Pyle April D, Lowry William E, Williams David S   Differentiation of RPE cells from integration-free iPS cells and their cell biological characterization Stem cell research & therapy, 2017; 8(1): 217.
Galloway Chad A, Dalvi Sonal, Hung Sandy S C, MacDonald Leslie A, Latchney Lisa R, Wong Raymond C B, Guymer Robyn H, Mackey David A, Williams David S, Chung Mina M, Gamm David M, Pébay Alice, Hewitt Alex W, Singh Ruchira   Drusen in patient-derived hiPSC-RPE models of macular dystrophies Proceedings of the National Academy of Sciences of the United States of America, 2017; 114(39): E8214-E8223.
Goldberg Andrew F X, Moritz Orson L, Williams David S   Molecular basis for photoreceptor outer segment architecture Progress in retinal and eye research, 2016; 55(1): 52-81.
Hazim Roni, Jiang Mei, Esteve-Rudd Julian, Diemer Tanja, Lopes Vanda S, Williams David S   Live-Cell Imaging of Phagosome Motility in Primary Mouse RPE Cells Advances in experimental medicine and biology, 2016; 854(30): 751-5.
Volland Stefanie, Hughes Louise C, Kong Christina, Burgess Barry L, Linberg Kenneth A, Luna Gabriel, Zhou Z Hong, Fisher Steven K, Williams David S   Three-dimensional organization of nascent rod outer segment disk membranes Proceedings of the National Academy of Sciences of the United States of America, 2015; 112(48): 14870-5.
Jiang Mei, Esteve-Rudd Julian, Lopes Vanda S, Diemer Tanja, Lillo Concepción, Rump Agrani, Williams David S   Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis The Journal of cell biology, 2015; 210(4): 595-611.
Volland Stefanie, Esteve-Rudd Julian, Hoo Juyea, Yee Claudine, Williams David S   A comparison of some organizational characteristics of the mouse central retina and the human macula PloS one, 2015; 10(4): e0125631.
Eblimit Aiden, Nguyen Thanh-Minh T, Chen Yiyun, Esteve-Rudd Julian, Zhong Hua, Letteboer Stef, Van Reeuwijk Jeroen, Simons David L, Ding Qian, Wu Ka Man, Li Yumei, Van Beersum Sylvia, Moayedi Yalda, Xu Huidan, Pickard Patrick, Wang Keqing, Gan Lin, Wu Samuel M, Williams David S, Mardon Graeme, Roepman Ronald, Chen Rui   Spata7 is a retinal ciliopathy gene critical for correct RPGRIP1 localization and protein trafficking in the retina Human molecular genetics, 2015; 24(6): 1584-601.
Lopes Vanda S, Williams David S   Gene Therapy for the Retinal Degeneration of Usher Syndrome Caused by Mutations in MYO7A Cold Spring Harbor perspectives in medicine, 2015; 5(6): 1584-601.
Frost Laura S, Lopes Vanda S, Bragin Alvina, Reyes-Reveles Juan, Brancato Jennifer, Cohen Art, Mitchell Claire H, Williams David S, Boesze-Battaglia Kathleen   The Contribution of Melanoregulin to Microtubule-Associated Protein 1 Light Chain 3 (LC3) Associated Phagocytosis in Retinal Pigment Epithelium Molecular neurobiology, 2014; .
Crouse Jacquelin A, Lopes Vanda S, Sanagustin Jovenal T, Keady Brian T, Williams David S, Pazour Gregory J   Distinct functions for IFT140 and IFT20 in opsin transport Cytoskeleton (Hoboken, N.J.), 2014; 71(5): 302-10.
Almenar-Queralt Angels, Falzone Tomas L, Shen Zhouxin, Lillo Concepcion, Killian Rhiannon L, Arreola Angela S, Niederst Emily D, Ng Kheng S, Kim Sonia N, Briggs Steven P, Williams David S, Goldstein Lawrence S B   UV irradiation accelerates amyloid precursor protein (APP) processing and disrupts APP axonal transport The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014; 34(9): 3320-39.
Lopes VS, Boye SE, Louie CM, Boye S, Dyka F, Chiodo V, Fofo H, Hauswirth WW, Williams DS   Retinal gene therapy with a large MYO7A cDNA using Adeno-associated virus Gene Therapy, 2013; .
Harkewicz R, Du H, Tong Z, Alkuraya H, Bedell M, Sun W, Wang X, Hsu YH, Esteve-Rudd J, Hughes G, Su Z, Zhang M, Lopes VS, Molday RS, Williams DS, Dennis EA, Zhang K   Essential role of ELOVL4 in very long chain fatty acid synthesis and retinal function Journal of Biological Chemistry , 2012; 287: 11469-11480.
Engelhardt M, Tosha C, Lopes VS, Chen B, Nguyen L, Nusinowitz S, Williams DS   Functional and morphological analysis of the subretinal injection of RPE cells Visual Neuroscience, 2012; 29: 83-93.
Trivedi D, Colin E, Louie CM, Williams DS   Live-cell imaging evidence for the ciliary transport of rod photoreceptor opsin by heterotrimeric kinesin-2 Journal of Neuroscience, 2012; 32: 10587-10593.
Da Cruz Sandrine, Parone Philippe A, Lopes Vanda S, Lillo Concepción, McAlonis-Downes Melissa, Lee Sandra K, Vetto Anne P, Petrosyan Susanna, Marsala Martin, Murphy Anne N, Williams David S, Spiegelman Bruce M, Cleveland Don W   Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS Cell metabolism, 2012; 15(5): 778-86.
Phillips JB, Blanco-Sanchez B, Lentz JJ, Tallafuss A, Khanobdee K, Sampath S, Jacobs ZG, Han PF, Mishra M, Williams DS, Keats BJ, Washbourne P, Westerfield M   Harmonin (Ush1c) is required in zebrafish Muller glial cells for photoreceptor synaptic development and function Disease Models & Mechanisms , 2011; 4: 786-800.
Jacobson SG, Cideciyan AV, Gibbs D, Sumaroka A, Roman AJ, Aleman TS, Schwartz SB, Olivares MB, Russell RC, Steinberg JD, Kenna MA, Kimberling WJ, Rehm HL, Williams DS   Retinal Disease Course in Usher Syndrome 1B due to MYO7A Mutations Investigative Ophthalmology & Visual Science, 2011; 52: 7924-7936.
Lopes VS, Gibbs D, Libby RT, Aleman TS, Welch DL, Lillo C, Jacobson SG, Radu RA, Steel KP, Williams DS   The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65 Human Molecular Genetics, 2011; 20: 2560-2570.
Williams DS, Lopes VS   The many different cellular functions of MYO7A in the retina Biochemical Society transactions, 2011; 39: 1207-10.
Louie CM, Caridi G, Lopes VS, Brancati F, Kispert A, Lancaster MA, Schlossman AM, Otto EA, Leitges M, Grone HJ, Lopez I, Gudiseva HV, O’Toole JF, Vallespin E, Ayyagari R, Ayuso C, Cremers FP, den Hollander Al, Koenekoop RK, Dallapiccola B, Ghiggeri GM, Hildebrandt F, Valente EM, Williams DS, Gleeson JG   AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis Nature Genetics , 2010; 42: 175-180.
Lopes VS, Jimeno D, Khanobdee K, Song X, Chen B, Nusinowitz S, Williams DS   Dysfunction of Heterotrimeric Kinesin-2 in Rod Photoreceptor Cells and the Role of Opsin Mislocalization in Rapid Cell Death Molecular Biology of the Cell, 2010; 21: 4076-4088.
Gibbs D, Diemer T, Khanobdee K, Hu J, Bok D, Williams DS   Function of MYO7A in the human RPE and the validity of shaker1 mice as a model for Usher syndrome 1B Investigative Ophthalmology and Visual Science, 2010; 51: 1130-1135.
Liao JL,Yu J, Huang K, Hu J, Diemer T, Ma Z, Dvash T, Yang XJ, Travis GH, Williams DS, Bok D, Fan G   Molecular signature of primary retinal pigment epithelium and stem-cell-derived RPE cells Human Molecular Genetics , 2010; 19: 4229-4238.
Louie Carrie M, Caridi Gianluca, Lopes Vanda S, Brancati Francesco, Kispert Andreas, Lancaster Madeline A, Schlossman Andrew M, Otto Edgar A, Leitges Michael, Gröne Hermann-Josef, Lopez Irma, Gudiseva Harini V, O’Toole John F, Vallespin Elena, Ayyagari Radha, Ayuso Carmen, Cremers Frans P M, den Hollander Anneke I, Koenekoop Robert K, Dallapiccola Bruno, Ghiggeri Gian Marco, Hildebrandt Friedhelm, Valente Enza Maria, Williams David S, Gleeson Joseph G   AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis Nature genetics, 2010; 42(2): 175-80.
Williams David S, Cash Alan, Hamadani Lara, Diemer Tanja   Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway Aging cell, 2009; 8(6): 765-8.
Gibbs Daniel, Cideciyan Artur V, Jacobson Samuel G, Williams David S   Retinal pigment epithelium defects in humans and mice with mutations in MYO7A: imaging melanosome-specific autofluorescence Investigative ophthalmology & visual science, 2009; 50(9): 4386-93.
Schwander M, Lopes V, Sczaniecka A, Gibbs D, Lillo C, Delano D, Tarantino LM, Wiltshire T, Williams DS, Müller U   A novel allele of myosin VIIa reveals a critical function for the C-terminal FERM domain for melanosome transport in retinal pigment epithelial cells Journal of Neuroscience, 2009; 29: 15810-15818.
Falzone Tomás L, Stokin Gorazd B, Lillo Concepción, Rodrigues Elizabeth M, Westerman Eileen L, Williams David S, Goldstein Lawrence S B   Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009; 29(18): 5758-67.
Damek-Poprawa Monika, Diemer Tanja, Lopes Vanda S, Lillo Concepción, Harper Dawn C, Marks Michael S, Wu Yalin, Sparrow Janet R, Rachel Rivka A, Williams David S, Boesze-Battaglia Kathleen   Melanoregulin (MREG) modulates lysosome function in pigment epithelial cells The Journal of biological chemistry, 2009; 284(16): 10877-89.
Niranjala J.K. Tillakaratne, Ph.D

Niranjala Tillakaratne, Ph.D

Publications

A selected list of publications:

Duru Paul, Tillakaratne Niranjala, Kim Jung, Zhong Hui, Stauber Stacey, Pham Tran, Xiao Mei Si, Edgerton V. Reggie, Roy Roland.   Spinal neuronal activation during locomotor-like activity enabled by epidural stimulation and 5-hydroxytryptamine agonists in spinal rats, J Neurosci Res, 2015; 93(8): 1229-1239.
Tillakaratne Niranjala J K, Duru Paul, Fujino Hidemi, Zhong Hui, Xiao Mei Si, Edgerton V Reggie, Roy Roland R   Identification of interneurons activated at different inclines during treadmill locomotion in adult rats Journal of neuroscience research, 2014; 92(12): 1714-22.
Shah Prithvi K, Garcia-Alias Guillermo, Choe Jaehoon, Gad Parag, Gerasimenko Yury, Tillakaratne Niranjala, Zhong Hui, Roy Roland R, Edgerton V Reggie   Use of quadrupedal step training to re-engage spinal interneuronal networks and improve locomotor function after spinal cord injury Brain : a journal of neurology, 2013; 136(Pt 11): 3362-77.
Joseph M Selvan, Ying Zhe, Zhuang Yumei, Zhong Hui, Wu Aiguo, Bhatia Harsharan S, Cruz Rusvelda, Tillakaratne Niranjala J K, Roy Roland R, Edgerton V Reggie, Gomez-Pinilla Fernando   Effects of diet and/or exercise in enhancing spinal cord sensorimotor learning PloS one, 2012; 7(7): e41288.
Joseph M Selvan, Bilousova Tina, Zdunowski Sharon, Wu Zhongqi-Phyllis, Middleton Blake, Boudzinskaia Maia, Wong Bonnie, Ali Noore, Zhong Hui, Yong Jing, Washburn Lorraine, Escande-Beillard Nathalie, Dang Hoa, Edgerton V Reggie, Tillakaratne Niranjala J K, Kaufman Daniel L   Transgenic mice with enhanced neuronal major histocompatibility complex class I expression recover locomotor function better after spinal cord injury Journal of neuroscience research, 2011; 89(3): 365-72.
Tillakaratne NJ, Guu JJ, de Leon RD, Bigbee AJ, London NJ, Zhong H, Ziegler M,Joynes R, Roy RR, Edgerton VR.   Functional recovery of stepping in rats after a complete neonatal spinal cord transection is not due to regrowth across the lesion site , Neuroscience, 2010; 166: 23-33.
Khristy W, Ali NJ, Bravo AB, de Leon R, Roy RR, Zhong H, London NJ, Edgerton VR, Tillakaratne NJ   Changes in GABA(A) receptor subunit gamma 2 in extensor and flexor motoneurons and astrocytes after spinal cord transection and motor training, Brain Res, 2009; 1273: 9-17.
Otoshi CK, Walwyn WM, Tillakaratne NJ, Zhong H, Roy RR, Edgerton VR   Distribution and localization of 5-HT(1A) receptors in the rat lumbar spinal cord after transection and deafferentation, J Neurotrauma, 2009; 26: 575-84.
Jindrich DL, Joseph MS, Otoshi CK, Wei RY, Zhong H, Roy RR, Tillakaratne NJ,Edgerton VR   Spinal learning in the adult mouse using the Horridge paradigm, J Neurosci Methods, , 2009; 182(2): 250-4.
Edgerton VR, Courtine G, Gerasimenko YP, Lavrov I, Ichiyama RM, Fong AJ, Cai LL, Otoshi CK, Tillakaratne NJ, Burdick JW, Roy RR   Training locomotor networks, Brain Res Rev, 2008; 57: 241-54 (Review).
Bigbee AJ, Crown ED, Ferguson AR, Roy RR, Tillakaratne NJ, Grau JW, Edgerton VR   Two chronic motor training paradigms differentially influence acute, Behav Brain Res, 2007; 180: 95-101.
Ahn, SN Guu, JJ Tobin, AJ Edgerton, VR Tillakaratne, NJ   Use of c-fos to identify activity-dependent spinal neurons after stepping in intact adult rats Spinal Cord, 2006; 44: 547-59.
Zanjani H, Lemaigre-Dubreuil Y, Tillakaratne NJK, Blokhin A, McMahon RP, Tobin AJ and Vogel MW.   Cerebellar Purkinje cell loss in aging Hu-Bcl2 transgenic mice, J Comp Neurol, 2004; 475: 481-92.
Edgerton VR, Tillakaratne NJK, Bigbee AJ, de Leon RD, and Roy RR   Locomotor recovery potential after spinal cord injury, Neuro-behavioral determinants of interlimb coordination, edited by Swinnen S. & P Duysens J, 2004; .
Edgerton, VR Tillakaratne, NJ Bigbee, AJ de Leon, RD Roy, RR   Plasticity of the spinal neural circuitry after injury Annual review of neuroscience. , 2004; 27: 145-67.
Hoang, TX Nieto, JH Tillakaratne, NJ Havton, LA   Autonomic and motor neuron death is progressive and parallel in a lumbosacral ventral root avulsion model of cauda equina injury The Journal of comparative neurology. , 2003; 467(4): 477-86.
Mackie, M Hughes, DI Maxwell, DJ Tillakaratne, NJ Todd, AJ   Distribution and colocalisation of glutamate decarboxylase isoforms in the rat spinal cord Neuroscience. , 2003; 119(2): 461-72.
Tillakaratne, NJ de Leon, RD Hoang, TX Roy, RR Edgerton, VR Tobin, AJ   Use-dependent modulation of inhibitory capacity in the feline lumbar spinal cord The Journal of neuroscience, 2002; 22(8): 3130-43.
Edgerton, VR Leon, RD Harkema, SJ Hodgson, JA London, N Reinkensmeyer, DJ Roy, RR Talmadge, RJ Tillakaratne, NJ Timoszyk, W Tobin, A   Retraining the injured spinal cord The Journal of physiology. , 2001; 533(Pt 1): 15-22.
Tillakaratne, NJ Mouria, M Ziv, NB Roy, RR Edgerton, VR Tobin, AJ   Increased expression of glutamate decarboxylase (GAD(67)) in feline lumbar spinal cord after complete thoracic spinal cord transection Journal of neuroscience research. , 2000; 60(2): 219-30.
Banerjee, PK Tillakaratne, NJ Brailowsky, S Olsen, RW Tobin, AJ Snead, OC   Alterations in GABAA receptor alpha 1 and alpha 4 subunit mRNA levels in thalamic relay nuclei following absence-like seizures in rats Experimental neurology. , 1998; 154(1): 213-23.
Banerjee PK, Olsen RW, Tillakaratne NJK, Brailowsky S, Tobin AJ, and Snead OC, 3rd.   Absence seizures decrease steroid modulation of t-[35S]butylbicyclophosphorothionate binding in thalamic relay nuclei, J Pharmacol Exp Ther, 1998; 287: 766-772.
Edgerton VR, Roy RR, de Leon RD, Tillakaratne NJK, and Hodgson JA.   Does motor learning occur in spinal cord?, The neuroscientist, 1997; 3: 287-294.
Edgerton, VR de Leon, RD Tillakaratne, N Recktenwald, MR Hodgson, JA Roy, RR   Use-dependent plasticity in spinal stepping and standing Advances in neurology. , 1997; 72: 233-47.
Mahmoudi M, Kang M H, Tillakaratne N, Tobin A J, Olsen R W   Chronic intermittent ethanol treatment in rats increases GABA(A) receptor alpha4-subunit expression: possible relevance to alcohol dependence Journal of neurochemistry, 1997; 68(6): 2485-92.
Tillakaratne N J, Medina-Kauwe L, Gibson K M   gamma-Aminobutyric acid (GABA) metabolism in mammalian neural and nonneural tissues Comparative biochemistry and physiology. Part A, Physiology, 1995; 112(2): 247-63.
Segovia J, Lawless G M, Tillakaratne N J, Brenner M, Tobin A J   Cyclic AMP decreases the expression of a neuronal marker (GAD67) and increases the expression of an astroglial marker (GFAP) in C6 cells Journal of neurochemistry, 1994; 63(4): 1218-25.
Hendrickson A E, Tillakaratne N J, Mehra R D, Esclapez M, Erickson A, Vician L, Tobin A J   Differential localization of two glutamic acid decarboxylases (GAD65 and GAD67) in adult monkey visual cortex The Journal of comparative neurology, 1994; 343(4): 566-81.
Medina-Kauwe L K, Tillakaratne N J, Wu J Y, Tobin A J   A rat brain cDNA encodes enzymatically active GABA transaminase and provides a molecular probe for GABA-catabolizing cells Journal of neurochemistry, 1994; 62(4): 1267-75.
Esclapez M, Tillakaratne N J, Kaufman D L, Tobin A J, Houser C R   Comparative localization of two forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the forms The Journal of neuroscience : the official journal of the Society for Neuroscience, 1994; 14(3 Pt 2): 1834-55.
Esclapez M, Tillakaratne N J, Tobin A J, Houser C R   Comparative localization of mRNAs encoding two forms of glutamic acid decarboxylase with nonradioactive in situ hybridization methods The Journal of comparative neurology, 1993; 331(3): 339-62.
Greif K F, Tillakaratne N J, Erlander M G, Feldblum S, Tobin A J   Transient increase in expression of a glutamate decarboxylase (GAD) mRNA during the postnatal development of the rat striatum Developmental biology, 1992; 153(1): 158-64.
Kasckow J W, Tillakaratne N J, Kim H, Strecker G J, Tobin A J, Olsen R W   Expression of GABAA receptor polypeptides in clonal rat cell lines Brain research, 1992; 581(1): 143-7.
Bu D F, Erlander M G, Hitz B C, Tillakaratne N J, Kaufman D L, Wagner-McPherson C B, Evans G A, Tobin A J   Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene Proceedings of the National Academy of Sciences of the United States of America, 1992; 89(6): 2115-9.
Tillakaratne N J, Erlander M G, Collard M W, Greif K F, Tobin A J   Glutamate decarboxylases in nonneural cells of rat testis and oviduct: differential expression of GAD65 and GAD67 Journal of neurochemistry, 1992; 58(2): 618-27.
Erlander M G, Tillakaratne N J, Feldblum S, Patel N, Tobin A J   Two genes encode distinct glutamate decarboxylases Neuron, 1991; 7(1): 91-100.
Khrestchatisky M, MacLennan A J, Tillakaratne N J, Chiang M Y, Tobin A J   Sequence and regional distribution of the mRNA encoding the alpha 2 polypeptide of rat gamma-aminobutyric acidA receptors Journal of neurochemistry, 1991; 56(5): 1717-22.
MacLennan A J, Brecha N, Khrestchatisky M, Sternini C, Tillakaratne N J, Chiang M Y, Anderson K, Lai M, Tobin A J   Independent cellular and ontogenetic expression of mRNAs encoding three alpha polypeptides of the rat GABAA receptor Neuroscience, 1991; 43(2-3): 369-80.
Greif K F, Erlander M G, Tillakaratne N J, Tobin A J   Postnatal expression of glutamate decarboxylases in developing rat cerebellum Neurochemical research, 1991; 16(3): 235-42.
Tobin A J, Khrestchatisky M, MacLennan A J, Chiang M Y, Tillakaratne N J, Xu W T, Jackson M B, Brecha N, Sternini C, Olsen R W   Structural, developmental and functional heterogeneity of rat GABAA receptors Advances in experimental medicine and biology, 1991; 287(3): 365-74.
John Maclennan A, Frantz G D, Weatherwax R C, Tillakaratne N J, Tobin A J   Expression of mRNAs that encode D2 dopamine receptor subtypes: Anatomical, developmental, and pharmacological studies Molecular and cellular neurosciences, 1990; 1(2): 151-60.
Segovia J, Tillakaratne N J, Whelan K, Tobin A J, Gale K   Parallel increases in striatal glutamic acid decarboxylase activity and mRNA levels in rats with lesions of the nigrostriatal pathway Brain research, 1990; 529(1-2): 345-8.
Kim Y S, Thomas J W, Tillakaratne N J, Montpied P, Suzdak P D, Banner C, Ginns E, Tobin A J, Paul S M   Glutamic acid decarboxylase mRNA in rat brain: regional distribution and effects of intrastriatal kainic acid Brain research, 1987; 427(1): 77-82.
Xian-Jie Yang

Xian-Jie Yang, Ph.D.

Biography

Xian-Jie Yang is a developmental biologist, who has served on the UCLA School of Medicine faculty since she joined the Department of Ophthalmology in 1996. She is a member of the Molecular Biology Institute, Brain Research Institute, and has become an associate professor in 2003. Dr, Yang obtained her B.S in biology from Beijing Normal University and her Ph.D. from Cornell University in Biochemistry, Cell and Molecular Biology after studying transcription regulation. She pursued her postdoctoral training at Harvard University and Harvard Medical School working on vertebrate neural development. Her research centers on development and diseases of the vertebrate retina, in particular growth factor signaling mechanisms during normal neural differentiation and neuronal survival in retinal degeneration. Her laboratory is also developing cellular and molecular therapies for inherited retinal diseases.

William H. Yong, M.D.

William Yong, M.D.

Biography

 

Dr. Yong obtained a bachelors degree in molecular biology at UC Berkeley and a masters degree in biology (cellular and molecular) at San Francisco State University. For the masters degree, he studied the AIDS retrovirus while in the laboratory of Professor Jay Levy at UCSF. He attended medical school at UCLA where he completed his Honors thesis research with Professor Harry Vinters and graduated as a Deans Scholar. He trained in Pathology and Laboratory Medicine at Massachusetts General Hospital, Harvard Medical School, where he worked in the molecular neuro-oncology laboratory of Dr. David Louis. For his work there, Dr. Yong was awarded the American Association of Neuropathologists Lucien J. Rubinstein Award in Neuro-oncology. He completed his neuropathology fellowship at UCLA.

Subsequently, he was the Director of Neuropathology at Cedars-Sinai Medical Center for eight years before returning to the UCLA Medical Center. He is currently Chief of Neuropathology, Director of the UCLA Brain Tumor Translational Resource and Director of the UCLA Neuropathology Fellowship Program. He is a recipient of a Golden Apple Award for teaching and the Johnny Mercer Foundation Research Award for Brain Cancer among others. Dr. Yong is Professor of Pathology and Laboratory Medicine and serves on editorial boards and grant review panels. He teaches UCLA medical and dental students as well as residents and fellows in pathology, neuropathology, neurosurgery, and neurology. He is an adviser and mentor for junior faculty. As an attending neuropathologist at the UCLA Medical Center, his clinical expertise includes brain and pituitary tumors as well as neuromuscular pathology. He provide international telepathology consultations for complex brain cases. He works closely with UCLA Neurosurgery and Neuro-oncology physicians in determining diagnoses and molecular testing of brain tumor samples.

Current main research interests include biobanking methods and end-stage immunopathology and neuropathology in brain cancer patients.  He consults for the National Neurologic AIDS Brain Bank. His team has also conducted or collaboarated on studies in bioinformatics, nanotechnology, non-invasive imaging, neuroradiology, and targeted therapies. Collaborations have spanned AIDS, stroke, dementia, and epilepsy.

Publications

A selected list of publications:

Antonios Joseph P, Soto Horacio, Everson Richard G, Moughon Diana, Orpilla Joey R, Shin Namjo P, Sedighim Shaina, Treger Janet, Odesa Sylvia, Tucker Alexander, Yong William H, Li Gang, Cloughesy Timothy F, Liau Linda M, Prins Robert M   Immunosuppressive tumor-infiltrating myeloid cells mediate adaptive immune resistance via a PD-1/PD-L1 mechanism in glioblastoma Neuro-oncology, 2017; .
Abdaljaleel Maram, Mazumder Rajarshi, Patel Chirag B, Im Kyuseok, Pope Whitney, Liau Linda M, Vinters Harry V, Yong William H   Multiple calcifying pseudoneoplasms of the neuraxis (MCAPNON): Distinct entity, CAPNON variant, or old neurocysticercosis? Neuropathology : official journal of the Japanese Society of Neuropathology, 2016; .
Lee Seung J, Bui Timothy T, Chen Cheng Hao Jacky, Lagman Carlito, Chung Lawrance K, Sidhu Sabrin, Seo David J, Yong William H, Siegal Todd L, Kim Minsu, Yang Isaac   Central Neurocytoma: A Review of Clinical Management and Histopathologic Features Brain tumor research and treatment, 2016; 4(2): 49-57.
Lamers Susanna L, Rose Rebecca, Maidji Ekaterina, Agsalda-Garcia Melissa, Nolan David J, Fogel Gary B, Salemi Marco, Garcia Debra L, Bracci Paige, Yong William, Commins Deborah, Said Jonathan, Khanlou Negar, Hinkin Charles H, Sueiras Miguel Valdes, Mathisen Glenn, Donovan Suzanne, Shiramizu Bruce, Stoddart Cheryl A, McGrath Michael S, Singer Elyse J   HIV DNA Is Frequently Present within Pathologic Tissues Evaluated at Autopsy from Combined Antiretroviral Therapy-Treated Patients with Undetectable Viral Loads Journal of virology, 2016; 90(20): 8968-83.
Nguyen HuyTram N, Lie Amy, Li Tie, Chowdhury Reshmi, Liu Fei, Ozer Byram, Wei Bowen, Green Richard M, Ellingson Benjamin M, Wang He-Jing, Elashoff Robert, Liau Linda M, Yong William H, Nghiemphu Phioanh L, Cloughesy Timothy, Lai Albert   Human TERT promoter mutation enables survival advantage from MGMT promoter methylation in IDH1 wild-type primary glioblastoma treated by standard chemoradiotherapy Neuro-oncology, 2016; 90(20): 8968-83.
Antonios Joseph P, Soto Horacio, Everson Richard G, Orpilla Joey, Moughon Diana, Shin Namjo, Sedighim Shaina, Yong William H, Li Gang, Cloughesy Timothy F, Liau Linda M, Prins Robert M   PD-1 blockade enhances the vaccination-induced immune response in glioma JCI insight, 2016; 1(10): 2468-77.
Ellingson Benjamin M, Nguyen Huytram N, Lai Albert, Nechifor Ruben E, Zaw Okkar, Pope Whitney B, Yong William H, Nghiemphu Phioanh L, Liau Linda M, Cloughesy Timothy F   Contrast-enhancing tumor growth dynamics of preoperative, treatment-naive human glioblastoma Cancer, 2016; 122(11): 1718-27.
Hsu Melody S, Sedighim Shaina, Wang Tina, Antonios Joseph P, Everson Richard G, Tucker Alexander M, Du Lin, Emerson Ryan, Yusko Erik, Sanders Catherine, Robins Harlan S, Yong William H, Davidson Tom B, Li Gang, Liau Linda M, Prins Robert M   TCR Sequencing Can Identify and Track Glioma-Infiltrating T Cells after DC Vaccination Cancer immunology research, 2016; 4(5): 412-8.
Heaney Anthony P, Sumerel Brittany, Rajalingam Raja, Bergsneider Marvin, Yong William H, Liau Linda M   HLA Markers DQ8 and DR53 Are Associated With Lymphocytic Hypophysitis and May Aid in Differential Diagnosis The Journal of clinical endocrinology and metabolism, 2015; 100(11): 4092-7.
Choy Winward, Terterov Sergei, Kaprealian Tania B, Trang Andy, Ung Nolan, DeSalles Antonio, Chung Lawrance K, Martin Neil, Selch Michael, Bergsneider Marvin, Vinters Harry V, Yong William H, Yang Isaac   Predictors of recurrence following resection of intracranial chordomas Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2015; 22(11): 1792-6.
Yong William H, Shabihkhani Maryam, Telesca Donatello, Yang Shuai, Tso Jonathan L, Menjivar Jimmy C, Wei Bowen, Lucey Gregory M, Mareninov Sergey, Chen Zugen, Liau Linda M, Lai Albert, Nelson Stanley F, Cloughesy Timothy F, Tso Cho-Lea   Ribosomal Proteins RPS11 and RPS20, Two Stress-Response Markers of Glioblastoma Stem Cells, Are Novel Predictors of Poor Prognosis in Glioblastoma Patients PloS one, 2015; 10(10): e0141334.
Harris Robert J, Cloughesy Timothy F, Liau Linda M, Prins Robert M, Antonios Joseph P, Li Debiao, Yong William H, Pope Whitney B, Lai Albert, Nghiemphu Phioanh L, Ellingson Benjamin M   pH-weighted molecular imaging of gliomas using amine chemical exchange saturation transfer MRI Neuro-oncology, 2015; 17(11): 1514-24.
Liu Feng, Hon Gary C, Villa Genaro R, Turner Kristen M, Ikegami Shiro, Yang Huijun, Ye Zhen, Li Bin, Kuan Samantha, Lee Ah Young, Zanca Ciro, Wei Bowen, Lucey Greg, Jenkins David, Zhang Wei, Barr Cathy L, Furnari Frank B, Cloughesy Timothy F, Yong William H, Gahman Timothy C, Shiau Andrew K, Cavenee Webster K, Ren Bing, Mischel Paul S   EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling Molecular cell, 2015; 60(2): 307-18.
Masui Kenta, Tanaka Kazuhiro, Ikegami Shiro, Villa Genaro R, Yang Huijun, Yong William H, Cloughesy Timothy F, Yamagata Kanato, Arai Nobutaka, Cavenee Webster K, Mischel Paul S   Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance Proceedings of the National Academy of Sciences of the United States of America, 2015; 112(30): 9406-11.
Karavaeva Elena, Harris Robert J, Leu Kevin, Shabihkhani Maryam, Yong William H, Pope Whitney B, Lai Albert, Nghiemphu Phioanh L, Liau Linda M, Chen Wei, Czernin Johannes, Cloughesy Timothy F, Ellingson Benjamin M   Relationship Between [18F]FDOPA PET Uptake, Apparent Diffusion Coefficient (ADC), and Proliferation Rate in Recurrent Malignant Gliomas Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 2015; 17(3): 434-42.
Li Sichen, Chowdhury Reshmi, Liu Fei, Chou Arthur P, Li Tie, Mody Reema R, Lou Jerry J, Chen Weidong, Reiss Jean, Soto Horacio, Prins Robert, Liau Linda M, Mischel Paul S, Nghiemphu Phioanh L, Yong William H, Cloughesy Timothy F, Lai Albert   Tumor-suppressive miR148a is silenced by CpG island hypermethylation in IDH1-mutant gliomas Clinical cancer research : an official journal of the American Association for Cancer Research, 2014; 20(22): 5808-22.
Piccioni David E, Selfridge Julia, Mody Reema R, Chowdhury Reshmi, Li Sichen, Lalezari Shadi, Wawrzynski James, Quan Jennifer, Zurayk Mira, Chou Arthur P, Sanchez Desiree E, Liau Linda M, Ellingson Benjamin M, Pope Whitney B, Nghiemphu Phioanh L, Green Richard M, Wang He-Jing, Yong William H, Elashoff Robert, Cloughesy Timothy F, Lai Albert   Deferred use of bevacizumab for recurrent glioblastoma is not associated with diminished efficacy Neuro-oncology, 2014; 16(6): 815-22.
Bergsneider Marvin, Mirsadraei Leili, Yong William H, Salamon Noriko, Linetsky Michael, Wang Marilene B, McArthur David L, Heaney Anthony P   The pituitary stalk effect: is it a passing phenomenon? Journal of neuro-oncology, 2014; 117(3): 477-84.
Lou Jerry J, Mirsadraei Leili, Sanchez Desiree E, Wilson Ryan W, Shabihkhani Maryam, Lucey Gregory M, Wei Bowen, Singer Elyse J, Mareninov Sergey, Yong William H   A review of room temperature storage of biospecimen tissue and nucleic acids for anatomic pathology laboratories and biorepositories Clinical biochemistry, 2014; 47(4-5): 267-73.
Shabihkhani Maryam, Lucey Gregory M, Wei Bowen, Mareninov Sergey, Lou Jerry J, Vinters Harry V, Singer Elyse J, Cloughesy Timothy F, Yong William H   The procurement, storage, and quality assurance of frozen blood and tissue biospecimens in pathology, biorepository, and biobank settings Clinical biochemistry, 2014; 47(4-5): 258-66.
Yong William H, Dry Sarah M, Shabihkhani Maryam   A practical approach to clinical and research biobanking Methods in molecular biology (Clifton, N.J.), 2014; 1180(1): 137-62.
Masui Kenta, Tanaka Kazuhiro, Akhavan David, Babic Ivan, Gini Beatrice, Matsutani Tomoo, Iwanami Akio, Liu Feng, Villa Genaro R, Gu Yuchao, Campos Carl, Zhu Shaojun, Yang Huijun, Yong William H, Cloughesy Timothy F, Mellinghoff Ingo K, Cavenee Webster K, Shaw Reuben J, Mischel Paul S   mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc Cell metabolism, 2013; 18(5): 726-39.
Mareninov Sergey, De Jesus Jason, Sanchez Desiree E, Kay Andrew B, Wilson Ryan W, Babic Ivan, Chen Weidong, Telesca Donatello, Lou Jerry J, Mirsadraei Leili, Gardner Tracie P, Khanlou Negar, Vinters Harry V, Shafa Bob B, Lai Albert, Liau Linda M, Mischel Paul S, Cloughesy Timothy F, Yong William H   Lyophilized brain tumor specimens can be used for histologic, nucleic acid, and protein analyses after 1 year of room temperature storage Journal of neuro-oncology, 2013; 113(3): 365-73.
Babic Ivan, Anderson Erik S, Tanaka Kazuhiro, Guo Deliang, Masui Kenta, Li Bing, Zhu Shaojun, Gu Yuchao, Villa Genaro R, Akhavan David, Nathanson David, Gini Beatrice, Mareninov Sergey, Li Rui, Camacho Carolina Espindola, Kurdistani Siavash K, Eskin Ascia, Nelson Stanley F, Yong William H, Cavenee Webster K, Cloughesy Timothy F, Christofk Heather R, Black Douglas L, Mischel Paul S   EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer Cell metabolism, 2013; 17(6): 1000-8.
Papour Asael, Taylor Zach, Sherman Adria, Sanchez Desiree, Lucey Gregory, Liau Linda, Stafsudd Oscar, Yong William, Grundfest Warren   Optical imaging for brain tissue characterization using relative fluorescence lifetime imaging Journal of biomedical optics, 2013; 18(6): 60504.
Lalezari Shadi, Chou Arthur P, Tran Anh, Solis Orestes E, Khanlou Negar, Chen Weidong, Li Sichen, Carrillo Jose A, Chowdhury Reshmi, Selfridge Julia, Sanchez Desiree E, Wilson Ryan W, Zurayk Mira, Lalezari Jonathan, Lou Jerry J, Ormiston Laurel, Ancheta Karen, Hanna Robert, Miller Paul, Piccioni David, Ellingson Benjamin M, Buchanan Colin, Mischel Paul S, Nghiemphu Phioanh L, Green Richard, Wang He-Jing, Pope Whitney B, Liau Linda M, Elashoff Robert M, Cloughesy Timothy F, Yong William H, Lai Albert   Combined analysis of O6-methylguanine-DNA methyltransferase protein expression and promoter methylation provides optimized prognostication of glioblastoma outcome Neuro-oncology, 2013; 15(3): 370-81.
Singer Elyse J, Valdes-Sueiras Miguel, Commins Deborah L, Yong William, Carlson Margrit   HIV stroke risk: evidence and implications Therapeutic advances in chronic disease, 2013; 4(2): 61-70.
Yadav Nitin, Bhatia Sanjiv, Ragheb John, Mehta Rupal, Jayakar Prasanna, Yong William, Lin Wei-Chiang   In vivo detection of epileptic brain tissue using static fluorescence and diffuse reflectance spectroscopy Journal of biomedical optics, 2013; 18(2): 27006.
Lazovic Jelena, Soto Horacio, Piccioni David, Lou Jerry R, Li Sichen, Mirsadraei Leili, Yong William, Prins Robert, Liau Linda M, Ellingson Benjamin M, Cloughesy Timothy F, Lai Albert, Pope Whitney B   Detection of 2-hydroxyglutaric acid in vivo by proton magnetic resonance spectroscopy in U87 glioma cells overexpressing isocitrate dehydrogenase-1 mutation Neuro-oncology, 2012; 14(12): 1465-72.
Chou Arthur P, Chowdhury Reshmi, Li Sichen, Chen Weidong, Kim Andrew J, Piccioni David E, Selfridge Julia M, Mody Reema R, Chang Stephen, Lalezari Shadi, Lin Jeffrey, Sanchez Desiree E, Wilson Ryan W, Garrett Matthew C, Harry Bret, Mottahedeh Jack, Nghiemphu Phioanh L, Kornblum Harley I, Mischel Paul S, Prins Robert M, Yong William H, Cloughesy Timothy, Nelson Stanley F, Liau Linda M, Lai Albert   Identification of retinol binding protein 1 promoter hypermethylation in isocitrate dehydrogenase 1 and 2 mutant gliomas Journal of the National Cancer Institute, 2012; 104(19): 1458-69.
Lai Albert, Kharbanda Samir, Pope Whitney B, Tran Anh, Solis Orestes E, Peale Franklin, Forrest William F, Pujara Kanan, Carrillo Jose A, Pandita Ajay, Ellingson Benjamin M, Bowers Chauncey W, Soriano Robert H, Schmidt Nils O, Mohan Sankar, Yong William H, Seshagiri Somasekar, Modrusan Zora, Jiang Zhaoshi, Aldape Kenneth D, Mischel Paul S, Liau Linda M, Escovedo Cameron J, Chen Weidong, Nghiemphu Phioanh Leia, James C David, Prados Michael D, Westphal Manfred, Lamszus Katrin, Cloughesy Timothy, Phillips Heidi S   Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011; 29(34): 4482-90.
Solis Orestes E, Mehta Rupal I, Lai Albert, Mehta Rashi I, Farchoukh Lama O, Green Richard M, Cheng Jerry C, Natarajan Sathima, Vinters Harry V, Cloughesy Timothy, Yong William H   Rosette-forming glioneuronal tumor: a pineal region case with IDH1 and IDH2 mutation analyses and literature review of 43 cases Journal of neuro-oncology, 2011; 102(3): 477-84.
Ellison David W, Dalton James, Kocak Mehmet, Nicholson Sarah Leigh, Fraga Charles, Neale Geoff, Kenney Anna M, Brat Dan J, Perry Arie, Yong William H, Taylor Roger E, Bailey Simon, Clifford Steven C, Gilbertson Richard J   Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups Acta neuropathologica, 2011; 121(3): 381-96.
Lou Jerry J, Andrechak Gary, Riben Michael, Yong William H   A review of radio frequency identification technology for the anatomic pathology or biorepository laboratory: Much promise, some progress, and more work needed Journal of pathology informatics, 2011; 2(2): 34.
Leung Alina A, Lou Jerry J, Mareninov Sergey, Silver Steven S, Routbort Mark J, Riben Michael, Andrechak Gary, Yong William H   Tolerance testing of passive radio frequency identification tags for solvent, temperature, and pressure conditions encountered in an anatomic pathology or biorepository setting Journal of pathology informatics, 2010; 1(9): 21.
Sun Jing, Masterman-Smith Michael D, Graham Nicholas A, Jiao Jing, Mottahedeh Jack, Laks Dan R, Ohashi Minori, DeJesus Jason, Kamei Ken-ichiro, Lee Ki-Bum, Wang Hao, Yu Zeta T F, Lu Yi-Tsung, Hou Shuang, Li Keyu, Liu Max, Zhang Nangang, Wang Shutao, Angenieux Brigitte, Panosyan Eduard, Samuels Eric R, Park Jun, Williams Dirk, Konkankit Vera, Nathanson David, van Dam R Michael, Phelps Michael E, Wu Hong, Liau Linda M, Mischel Paul S, Lazareff Jorge A, Kornblum Harley I, Yong William H, Graeber Thomas G, Tseng Hsian-Rong   A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimens Cancer research, 2010; 70(15): 6128-38.
Mehta Rupal I, Mehta Rashi I, Solis Orestes E, Jahan Reza, Salamon Noriko, Tobis Jonathan M, Yong William H, Vinters Harry V, Fishbein Michael C   Hydrophilic polymer emboli: an under-recognized iatrogenic cause of ischemia and infarct Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2010; 23(7): 921-30.
Guo Deliang, Prins Robert M, Dang Julie, Kuga Daisuke, Iwanami Akio, Soto Horacio, Lin Kelly Y, Huang Tiffany T, Akhavan David, Hock M Benjamin, Zhu Shaojun, Kofman Ava A, Bensinger Steve J, Yong William H, Vinters Harry V, Horvath Steve, Watson Andrew D, Kuhn John G, Robins H Ian, Mehta Minesh P, Wen Patrick Y, DeAngelis Lisa M, Prados Michael D, Mellinghoff Ingo K, Cloughesy Timothy F, Mischel Paul S   EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy Science signaling, 2009; 2(101): ra82.
Mehta Rupal I, Mehta Rashi I, Fishbein Michael C, Solis Orestes E, Jahan Reza, Salamon Noriko, Vinters Harry V, Yong William H   Intravascular polymer material after coil embolization of a giant cerebral aneurysm Human pathology, 2009; 40(12): 1803-7.
Yong William H, Butte Pramod V, Pikul Brian K, Jo Javier A, Fang Qiyin, Papaioannou Thanassis, Black Keith, Marcu Laura   Distinction of brain tissue, low grade and high grade glioma with time-resolved fluorescence spectroscopy Frontiers in bioscience : a journal and virtual library, 2006; 11(6): 1255-63.
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