Posts classified under: S

Kalyanam Shivkumar, Ph.D.

Dr. Shivkumar is a physician scientist who serves as the director of the UCLA Cardiac Arrhythmia Center & EP Programs (since its establishment in 2002). His is a graduate of the UCLA STAR Program (class of 2000) and his field of specialization is interventional cardiac electrophysiology. He leads a large group at UCLA (comprising a diverse group of fifteen faculty members, several trainees and sixty staff + allied health professionals) involved in clinical care, teaching, research and biomedical innovation. The team provides state of the art clinical care, has developed several innovative therapies (e.g. epicardial ablation, neuromodulation) for the non-pharmacological management of cardiac arrhythmias and other cardiac interventions. The team has a major focus on mechanistic research on the neural control of the mammalian heart. Dr. Shivkumar also serves as the director and chief of the UCLA Cardiovascular Interventional Programs. Dr. Shivkumar’s research work relates to mechanisms of cardiac arrhythmias in humans especially the role of the autonomic nervous system and his research work transcends the perspective of a single organ and has implications for neurovisceral sciences in general. The UCLA Neurocardiology Research Program of Excellence was established by him as the specialized research arm of the Arrhythmia Center in 2014. Dr. Shivkumar and his colleagues are actively involved in human mechanistic studies, development of new intellectual property and medical technology for cardiovascular therapeutics. His IP has been incorporated into medical devices that are now FDA approved and in clinical use. He serves as an editor for several journals in cardiology and cardiac electrophysiology, and is a peer reviewer for several basic science and clinical journals. He also serves as a peer reviewer for the NIH in evaluating cardiac arrhythmia & neuroscience research. His research has been supported by grants from the American Heart Association, the Doris Duke Foundation, private donors and from the NIH (continuously since 2006). Currently Dr. Shivkumar oversees a 15-university NIH consortium on neural control of the heart. Dr. Shivkumar has mentored several STAR awardees and has received several teaching awards. He has been appointed to serve on the board of examiners for Clinical Cardiac Electrophysiology Section of the ABIM (American Board of Internal Medicine). He has been elected to the membership of the American Society of Clinical Investigation (ASCI) and serves as the institutional representative of UCLA for the ASCI. He was elected as an honorary Fellow of the Royal College of Physicians (London) in 2016 & President of the ISAN (International Society of Autonomic Neuroscience) in 2019.

https://www.mcip.ucla.edu/indiv-faculty-page/?id=3385
http://www.neuroscience.ucla.edu/profile/shivkumar-kalyanam
https://www.youtube.com/watch?v=u6NKp2Rc7c8
http://arrhythmia.ucla.edu/
https://www.the-asci.org/controllers/asci/AsciProfileController.php?pid=…
http://www.ncbi.nlm.nih.gov/pubmed/?term=Shivkumar+K[Author]

Melissa Sharpe, Ph.D.

Publications

A selected list of publications:

Maes Etienne J P, Sharpe Melissa J, Usypchuk Alexandra A, Lozzi Megan, Chang Chun Yun, Gardner Matthew P H, Schoenbaum Geoffrey, Iordanova Mihaela D   Causal evidence supporting the proposal that dopamine transients function as temporal difference prediction errors Nature neuroscience, 2020; .
Sharpe Melissa J, Batchelor Hannah M, Mueller Lauren E, Yun Chang Chun, Maes Etienne J P, Niv Yael, Schoenbaum Geoffrey   Dopamine transients do not act as model-free prediction errors during associative learning Nature communications, 2020; 11(1): 106.
Sharpe Melissa J, Stalnaker Thomas, Schuck Nicolas W, Killcross Simon, Schoenbaum Geoffrey, Niv Yael   An Integrated Model of Action Selection: Distinct Modes of Cortical Control of Striatal Decision Making Annual review of psychology, 2019; 70(1): 53-76.
Sharpe Melissa J, Killcross Simon   Modulation of attention and action in the medial prefrontal cortex of rats Psychological review, 2018; 125(5): 822-843.
Sharpe Melissa J   What a relief! A role for dopamine in positive (but not negative) valence Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018; 43(8): 1-2.
Langdon Angela J, Sharpe Melissa J, Schoenbaum Geoffrey, Niv Yael   Model-based predictions for dopamine Current opinion in neurobiology, 2018; 49(8): 1-7.
Sharpe Melissa J, Schoenbaum Geoffrey   Evaluation of the hypothesis that phasic dopamine constitutes a cached-value signal Neurobiology of learning and memory, 2017; 49(8): 1-7.
Sharpe Melissa J, Batchelor Hannah M, Schoenbaum Geoffrey   Preconditioned cues have no value eLife, 2017; 6(8): 1-7.
Sharpe Melissa J, Marchant Nathan J, Whitaker Leslie R, Richie Christopher T, Zhang Yajun J, Campbell Erin J, Koivula Pyry P, Necarsulmer Julie C, Mejias-Aponte Carlos, Morales Marisela, Pickel James, Smith Jeffrey C, Niv Yael, Shaham Yavin, Harvey Brandon K, Schoenbaum Geoffrey   Lateral Hypothalamic GABAergic Neurons Encode Reward Predictions that Are Relayed to the Ventral Tegmental Area to Regulate Learning Current biology : CB, 2017; 27(14): 2089-2100.e5.
Sharpe Melissa J, Chang Chun Yun, Liu Melissa A, Batchelor Hannah M, Mueller Lauren E, Jones Joshua L, Niv Yael, Schoenbaum Geoffrey   Dopamine transients are sufficient and necessary for acquisition of model-based associations Nature neuroscience, 2017; 20(5): 735-742.
Nasser Helen M, Calu Donna J, Schoenbaum Geoffrey, Sharpe Melissa J   The Dopamine Prediction Error: Contributions to Associative Models of Reward Learning Frontiers in psychology, 2017; 8(5): 244.
Sharpe Melissa J, Schoenbaum Geoffrey   Back to basics: Making predictions in the orbitofrontal-amygdala circuit Neurobiology of learning and memory, 2016; 131(5): 201-6.
Sharpe M J, Clemens K J, Morris M J, Westbrook R F   Daily Exposure to Sucrose Impairs Subsequent Learning About Food Cues: A Role for Alterations in Ghrelin Signaling and Dopamine D2 Receptors Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016; 41(5): 1357-65.
Sharpe Melissa J, Wikenheiser Andrew M, Niv Yael, Schoenbaum Geoffrey   The State of the Orbitofrontal Cortex Neuron, 2015; 88(6): 1075-1077.
Sharpe Melissa J, Killcross Simon   The prelimbic cortex directs attention toward predictive cues during fear learning Learning & memory (Cold Spring Harbor, N.Y.), 2015; 22(6): 289-93.
Sharpe Melissa, Killcross Simon   The prelimbic cortex uses contextual cues to modulate responding towards predictive stimuli during fear renewal Neurobiology of learning and memory, 2015; 118(6): 20-9.
Sharpe Melissa J, Killcross Simon   The prelimbic cortex contributes to the down-regulation of attention toward redundant cues Cerebral cortex (New York, N.Y. : 1991), 2014; 24(4): 1066-74.
Sharpe Melissa J, Killcross Simon   The prelimbic cortex uses higher-order cues to modulate both the acquisition and expression of conditioned fear Frontiers in systems neuroscience, 2014; 8(6): 235.
Sharpe Melissa J, Fardell Joanna E, Vardy Janette, Johnston Ian N   The chemotherapy agent oxaliplatin impairs the renewal of fear to an extinguished conditioned stimulus in rats Behavioural brain research, 2012; 227(1): 295-9.

Stan Schein, M.D., Ph.D.

Publications

A selected list of publications:

G Brinkmann, P Goetschalckx, S Schein   Comparing the constructions of Goldberg, Fuller, Caspar, Klug and Coxeter, and a general approach to local symmetry-preserving operations, Proc Roy Soc Lond A , 2017; 2017.0267.
S Schein, AJ Yeh, K Coolsaet, JM Gayed   Decoration of the truncated tetrahedron—an Archimedean polyhedron—to produce a new class of convex equilateral polyhedra with tetrahedral symmetry, Symmetry, 2016; 8: 82-91.
X Zhang, P Ge, X Yu, JM Brannan, G Bi, Q Zhang, S Schein, ZH Zhou   Cryo-EM structure of the mature dengue virus at 3.5-Å resolution, Nature Structural and Molecular Biology, 2012; 20: 105-110.
Wang Zhi, Su Hai-Feng, Tan Yuan-Zhi, Schein Stan, Lin Shui-Chao, Liu Wei, Wang Shu-Ao, Wang Wen-Guang, Tung Chen-Ho, Sun Di, Zheng Lan-Sun   Assembly of silver Trigons into a buckyball-like Ag180 nanocage Proceedings of the National Academy of Sciences of the United States of America, 2017; 114(46): 12132-12137.
Schein Stan, Gayed James Maurice   Fourth class of convex equilateral polyhedron with polyhedral symmetry related to fullerenes and viruses Proceedings of the National Academy of Sciences of the United States of America, 2014; 111(8): 2920-5.
Zhang Xiaokang, Ge Peng, Yu Xuekui, Brannan Jennifer M, Bi Guoqiang, Zhang Qinfen, Schein Stan, Zhou Z Hong   Cryo-EM structure of the mature dengue virus at 3.5-Å resolution Nature structural & molecular biology, 2013; 20(1): 105-10.
Schein S, Ngo IT, Huang TM, Klug K, Sterling P, Herr S   Cone synapses in macaque fovea: I. Two types of non-S cones are distinguished by numbers of contacts with OFF midget bipolar cells Vis Neurosci, 2011; 28(1): 3-16.
Hongrong Liu, Lei Jin, Sok Boon S. Koh, Ivo Atanasov, Stan Schein, Lily Wu, Z. Hong Zhou   Atomic Structure of Human Adenovirus by Cryo-EM Reveals Interactions Among Protein Networks Science, 2010; 329(5995): 1038-1043.
Zhang X, Boyce M, Bhattacharya B, Zhang X, Schein S, Roy P, Zhou ZH   Bluetongue virus coat protein VP2 contains sialic acid-binding domains, and VP5 resembles enveloped virus fusion proteins Proc Natl Acad Sci U S A, 2010; 107(14): 6292-7.
Ge P, Tsao J, Schein S, Green TJ, Luo M, Zhou ZH   Cryo-EM model of the bullet-shaped vesicular stomatitis virus Science, 2010; 327(5966): 689-93.
Schein Stan, Friedrich Tara   A geometric constraint, the head-to-tail exclusion rule, may be the basis for the isolated-pentagon rule in fullerenes with more than 60 vertices Proceedings of the National Academy of Sciences of the United States of America, 2008; 105(49): 19142-7.
Download
Stan Schein, Michelle Sands-Kidner, Tara Friedrich   The physical basis for the head-to-tail rule that excludes most fullerene cages from self assembly Biophysical J, 2008; 94: 938-957.
Schein, S. Sands-Kidner, M.   A geometric principle may guide self-assembly of fullerene cages from clathrin triskelia and from carbon atoms Biophysical Journal, 2008; 94(3): 958-976.
S Schein, KM Ahmad   Efficiency of synaptic transmission of single-photoreceptor to rod bipolar dendrite, Biophysical J, 2006; 91: 3257-3267.
Download
S Schein, KM Ahmad   A clockwork hypothesis: Synaptic release by rod photoreceptors must be regular, Biophysical J, 2005; 89: 3931-3949.
Download
Schein, S. Sterling, P. Ngo, I. T. Huang, T. M. Herr, S.   Evidence that each S cone in macaque fovea drives one narrow-field and several wide-field blue-yellow ganglion cells Journal of Neuroscience, 2004; 24(38): 8366-8378.
Ahmad, K. M. Klug, K. Herr, S. Sterling, P. Schein, S.   Cell density ratios in a foveal patch in macaque retina Visual Neuroscience, 2003; 20(2): 189-209.
AA Sadun, V Carelli, SR Salomao, A Berezovsky, PA Quiros, F Sadun, AM DeNegri, R Andrade, M Moraes, A Passos, P Kjaer, J Pereira, ML Valentino, S Schein, R Belfort   Extensive investigation of a large Brazilian pedigree of 11778/Haplogroup J Leber American Journal of Ophthalmology, 2003; 136(2): 231-238.
S Herr, KJ Klug, P Sterling, S Schein   Inner S-cone bipolar cells provide all of the central elements for S cones in macaque retina, J Comp Neurol, 2003; 457: 185-201.
Download
K Klug, S Herr, IT Ngo, P Sterling, S Schein   Macaque retina contains an S-cone OFF midget pathway, J Neurosci, 2003; 23: 9881-9887.
Download
K Migdale, S Herr, K Klug, K Ahmad, K Linberg, P Sterling, S Schein   Two ribbon synaptic units in rod photoreceptors of macaque, human, and cat, J Comp Neurol, 2003; 455: 100-112.
Download
Herr, S. Klug, K. Sterling, P. Schein, S.   Inner S-cone bipolar cells provide all of the central elements for S cones in macaque retina Journal of Comparative Neurology, 2003; 457(2): 185-201.
Burris, C. Klug, K. Ngo, I. T. Sterling, P. Schein, S.   How Muller glial cells in macaque fovea coat and isolate the synaptic terminals of cone photoreceptors Journal of Comparative Neurology, 2002; 453(1): 100-111.
AA Sadun, V Carelli, SR Salomao, A Berezovsky, P Quiros, F Sadun, AM DeNegri, R Andrade, S Schein, R Belfort   A very large Brazilian pedigree with 11 778 Leber’s hereditary optic, Trans Ant Ophthalmol Soc, 2002; 100: 169-77.
C Burris, K Klug, IT Ngo, P Sterling, S Schein   How Müller glial cells in macaque fovea coat and isolate the synaptic terminals of cone photoreceptors, J Comp Neurol, 2002; 453: 100-11.
Download
1 2 3 8