Posts classified under: Synapses, Cells, and Circuits

Steve Cannon, M.D., Ph.D.

Biography

The primary research interests of our laboratory are how ion channels regulate the electrical excitability of cells and how defects in these channels lead to human disease. In the past two decades, mutations of ion channel genes have been found to be the primary cause for over 100 human diseases. Our research program is focused on the mechanistic basis for a group of inherited conditions that alter the electrical excitability of skeletal muscle, including periodic paralysis and myotonia. We have characterized the gating defects of mutant channels, generated computational models of muscle excitability, and produced genetically-engineered mice to gain insights on the pathomechanisms of these disorders and to explore therapeutic interventions.

Laura DeNardo, Ph.D.

Publications

A selected list of publications:

Laura A DeNardo, Cindy D Liu, William E Allen, Eliza L Adams, Drew Friedmann, Ehsan Dadgar-Kiani, Lisa Fu, Casey J Guenthner, Jin Hyung Lee, Marc Tessier-Lavigne, Liqun Luo   Temporal Evolution of Cortical Ensembles Promoting Remote Memory Retrieval , 2018; .
Berns Dominic S, DeNardo Laura A, Pederick Daniel T, Luo Liqun   Teneurin-3 controls topographic circuit assembly in the hippocampus Nature, 2018; 554(7692): 328-333.
Savas Jeffrey N, Wang Yi-Zhi, DeNardo Laura A, Martinez-Bartolome Salvador, McClatchy Daniel B, Hark Timothy J, Shanks Natalie F, Cozzolino Kira A, Lavallée-Adam Mathieu, Smukowski Samuel N, Park Sung Kyu, Kelly Jeffery W, Koo Edward H, Nakagawa Terunaga, Masliah Eliezer, Ghosh Anirvan, Yates John R   Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer’s Disease-like Pathology Cell reports, 2017; 21(9): 2614-2627.
Allen William E, DeNardo Laura A, Chen Michael Z, Liu Cindy D, Loh Kyle M, Fenno Lief E, Ramakrishnan Charu, Deisseroth Karl, Luo Liqun   Thirst-associated preoptic neurons encode an aversive motivational drive Science (New York, N.Y.), 2017; 357(6356): 1149-1155.
DeNardo Laura, Luo Liqun   Genetic strategies to access activated neurons Current opinion in neurobiology, 2017; 45(6356): 121-129.
Savas JN, Ribeiro LF, Wierda KD, Wright R, DeNardo-Wilke LA, Chamma I, Wang Yi-Zhi, Zemla R, Lavallee- Adam M, Vennekens KM, O’Sullivan ML, Antonios JK, Hall EA, Thoumine O, Attie AD, Yates JR, Ghosh A, De Wit J   The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA receptors, Neuron, 2015; 87: 764-80.
DeNardo Laura A, Berns Dominic S, DeLoach Katherine, Luo Liqun   Connectivity of mouse somatosensory and prefrontal cortex examined with trans-synaptic tracing Nature neuroscience, 2015; 18(11): 1687-1697.
DeNardo Laura A, de Wit Joris, Otto-Hitt Stefanie, Ghosh Anirvan   NGL-2 regulates input-specific synapse development in CA1 pyramidal neurons Neuron, 2012; 76(4): 762-75.
Wilke Scott A, Hall Benjamin J, Antonios Joseph K, Denardo Laura A, Otto Stefanie, Yuan Bo, Chen Fading, Robbins Elissa M, Tiglio Katie, Williams Megan E, Qiu Zilong, Biederer Thomas, Ghosh Anirvan   NeuroD2 regulates the development of hippocampal mossy fiber synapses Neural development, 2012; 7(4): 9.

Scott Chandler, Ph.D.

Publications

A selected list of publications:

Hsiao, CF Wu, N Chandler, SH   Voltage-dependent calcium currents in trigeminal motoneurons of early postnatal rats: modulation by 5-HT receptors Journal of neurophysiology. , 2005; 94(3): 2063-72.
Wu, N Enomoto, A Tanaka, S Hsiao, CF Nykamp, DQ Izhikevich, E Chandler, SH   Persistent sodium currents in mesencephalic v neurons participate in burst generation and control of membrane excitability Journal of neurophysiology. , 2005; 93(5): 2710-22.
Tanaka, S Wu, N Hsaio, CF Turman, J Chandler, SH   Development of inward rectification and control of membrane excitability in mesencephalic v neurons Journal of neurophysiology. , 2003; 89(3): 1288-98.
Wu, N Hsiao, CF Chandler, SH   Membrane resonance and subthreshold membrane oscillations in mesencephalic V neurons: participants in burst generation The Journal of neuroscience : the official journal of the Society for Neuroscience. , 2001; 21(11): 3729-39.
Del Negro, C.A., Hsiao, C.F., and Chandler, S.H.   Outward currents controlling bursting dynamics in guinea pig trigeminal motoneurons, J. Neurophysiology, 1999; 81: 1478-1485.
Del Negro, CA Hsiao, CF Chandler, SH Garfinkel, A   Evidence for a novel bursting mechanism in rodent trigeminal neurons Biophysical journal. , 1998; 75(1): 174-82.
Hsiao, CF Del Negro, CA Trueblood, PR Chandler, SH   Ionic basis for serotonin-induced bistable membrane properties in guinea pig trigeminal motoneurons Journal of neurophysiology. , 1998; 79(6): 2847-56.
Del Negro, CA Chandler, SH   Physiological and theoretical analysis of K+ currents controlling discharge in neonatal rat mesencephalic trigeminal neurons Journal of neurophysiology. , 1997; 77(2): 537-53.