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Scott Chandler, Ph.D.

Selected Publications:

Hsiao, CF Wu, N Chandler, SH   Voltage-dependent calcium currents in trigeminal motoneurons of early postnatal rats: modulation by 5-HT receptors Journal of neurophysiology. , 2005; 94(3): 2063-72.
Wu, N Enomoto, A Tanaka, S Hsiao, CF Nykamp, DQ Izhikevich, E Chandler, SH   Persistent sodium currents in mesencephalic v neurons participate in burst generation and control of membrane excitability Journal of neurophysiology. , 2005; 93(5): 2710-22.
Tanaka, S Wu, N Hsaio, CF Turman, J Chandler, SH   Development of inward rectification and control of membrane excitability in mesencephalic v neurons Journal of neurophysiology. , 2003; 89(3): 1288-98.
Wu, N Hsiao, CF Chandler, SH   Membrane resonance and subthreshold membrane oscillations in mesencephalic V neurons: participants in burst generation The Journal of neuroscience : the official journal of the Society for Neuroscience. , 2001; 21(11): 3729-39.
Del Negro, C.A., Hsiao, C.F., and Chandler, S.H.   Outward currents controlling bursting dynamics in guinea pig trigeminal motoneurons, J. Neurophysiology, 1999; 81: 1478-1485.
Del Negro, CA Hsiao, CF Chandler, SH Garfinkel, A   Evidence for a novel bursting mechanism in rodent trigeminal neurons Biophysical journal. , 1998; 75(1): 174-82.
Hsiao, CF Del Negro, CA Trueblood, PR Chandler, SH   Ionic basis for serotonin-induced bistable membrane properties in guinea pig trigeminal motoneurons Journal of neurophysiology. , 1998; 79(6): 2847-56.
Del Negro, CA Chandler, SH   Physiological and theoretical analysis of K+ currents controlling discharge in neonatal rat mesencephalic trigeminal neurons Journal of neurophysiology. , 1997; 77(2): 537-53.
Stephen Caldwell Cannon, M.D., Ph.D.

Steve Cannon, M.D., Ph.D.

Biography

The primary research interests of our laboratory are how ion channels regulate the electrical excitability of cells and how defects in these channels lead to human disease. In the past two decades, mutations of ion channel genes have been found to be the primary cause for over 100 human diseases. Our research program is focused on the mechanistic basis for a group of inherited conditions that alter the electrical excitability of skeletal muscle, including periodic paralysis and myotonia. We have characterized the gating defects of mutant channels, generated computational models of muscle excitability, and produced genetically-engineered mice to gain insights on the pathomechanisms of these disorders and to explore therapeutic interventions.

Timothy Cloughesy, M.D.

Selected Publications

Bryant JA, Finn RS, Slamon DJ, Cloughesy TF, Charles AC   EGF activates intracellular and intercellular calcium signaling by distinct pathways in tumor cells Cancer biology & therapy. , 2004; 3(12): 1243-9.
Graham CA, Cloughesy TF   Brain tumor treatment: chemotherapy and other new developments Seminars in oncology nursing. , 2004; 20(4): 260-72.
Chang SM, Kuhn J, Wen P, Greenberg H, Schiff D, Conrad C, Fink K, Robins HI, Cloughesy T, De Angelis L, Razier J, Hess K, Dancey J, Prados MD   Phase I/pharmacokinetic study of CCI-779 in patients with recurrent malignant glioma on enzyme-inducing antiepileptic drugs Investigational new drugs. , 2004; 22(4): 427-35.
Puduvalli VK, Yung WK, Hess KR, Kuhn JG, Groves MD, Levin VA, Zwiebel J, Chang SM, Cloughesy TF, Junck L, Wen P, Lieberman F, Conrad CA, Gilbert MR, Meyers CA, Liu V, Mehta MP, Nicholas MK, Prados M   Phase II study of fenretinide (NSC 374551) in adults with recurrent malignant gliomas: A North American Brain Tumor Consortium study Journal of clinical oncology : official journal of the American Society of Clinical Oncology. , 2004; 22(21): 4282-9.
Mischel PS, Cloughesy TF, Nelson SF   DNA-microarray analysis of brain cancer: molecular classification for therapy Nature reviews. Neuroscience. , 2004; 5(10): 782-92.
Freije WA, Castro-Vargas FE, Fang Z, Horvath S, Cloughesy T, Liau LM, Mischel PS, Nelson SF   Gene expression profiling of gliomas strongly predicts survival Cancer research. , 2004; 64(18): 6503-10.
Kaleita TA, Wellisch DK, Cloughesy TF, Ford JM, Freeman D, Belin TR, Goldman J   Prediction of neurocognitive outcome in adult brain tumor patients Journal of neuro-oncology. , 2004; 67(1-2): 245-53.
Wang Y, Zhu S, Cloughesy TF, Liau LM, Mischel PS   p53 disruption profoundly alters the response of human glioblastoma cells to DNA topoisomerase I inhibition Oncogene. , 2004; 23(6): 1283-90.
Parker RJ, Fruehauf JP, Mehta R, Filka E, Cloughesy T   A prospective blinded study of the predictive value of an extreme drug resistance assay in patients receiving CPT-11 for recurrent glioma Journal of neuro-oncology. , 2004; 66(3): 365-75.
Prados MD, Yung WK, Jaeckle KA, Robins HI, Mehta MP, Fine HA, Wen PY, Cloughesy TF, Chang SM, Nicholas MK, Schiff D, Greenberg HS, Junck L, Fink KL, Hess KR, Kuhn J   Phase 1 trial of irinotecan (CPT-11) in patients with recurrent malignant glioma: a North American Brain Tumor Consortium study Neuro-oncology. , 2004; 6(1): 44-54.
Lu KV, Jong KA, Rajasekaran AK, Cloughesy TF, Mischel PS   Upregulation of tissue inhibitor of metalloproteinases (TIMP)-2 promotes matrix metalloproteinase (MMP)-2 activation and cell invasion in a human glioblastoma cell line Laboratory investigation; a journal of technical methods and pathology. , 2004; 84(1): 8-20.
Shai R, Shi T, Kremen TJ, Horvath S, Liau LM, Cloughesy TF, Mischel PS, Nelson SF   Gene expression profiling identifies molecular subtypes of gliomas Oncogene. , 2003; 22(31): 4918-23.
Mischel PS, Nelson SF, Cloughesy TF   Molecular analysis of glioblastoma: pathway profiling and its implications for patient therapy Cancer biology & therapy. , 2003; 2(3): 242-7.
Brown PD, Wald JT, McDermott MW, Baumann GS, Cloughesy TF   Oncodiagnosis panel: 2002. Metastatic NSCLC Radiographics : a review publication of the Radiological Society of North America, Inc. , 2003; 23(6): 1591-611.
Brown PD, Wald JT, McDermott MW, Baumann GS, Cloughesy TF   Oncodiagnosis panel: 2002. Optic nerve glioma or optic nerve meningioma Radiographics, 2003; 23(6): 1591-611.
Brown PD, Wald JT, McDermott MW, Baumann GS, Cloughesy TF   Oncodiagnosis panel: 2002. Patient’s symptoms not related to the lesion seen in the MR images Radiographics, 2003; 23(6): 1591-611.
Brown PD, Wald JT, McDermott MW, Baumann GS, Cloughesy TF   Oncodiagnosis panel: 2002. Primary glial neoplasm or less likely an intracranial abscess Radiographics : a review publication of the Radiological Society of North America, Inc. , 2003; 23(6): 1591-611.
Jaeckle KA, Hess KR, Yung WK, Greenberg H, Fine H, Schiff D, Pollack IF, Kuhn J, Fink K, Mehta M, Cloughesy T, Nicholas MK, Chang S, Prados M   Phase II evaluation of temozolomide and 13-cis-retinoic acid for the treatment of recurrent and progressive malignant glioma: a North American Brain Tumor Consortium study Journal of clinical oncology : official journal of the American Society of Clinical Oncology. , 2003; 21(12): 2305-11.
Mischel PS, Cloughesy TF   Targeted molecular therapy of GBM Brain Pathol, 2003; 13(1): 52-61.
Choe G, Horvath S, Cloughesy TF, Crosby K, Seligson D, Palotie A, Inge L, Smith BL, Sawyers CL, Mischel PS   Analysis of the phosphatidylinositol 3′-kinase signaling pathway in glioblastoma patients in vivo Cancer research. , 2003; 63(11): 2742-6.
Cloughesy TF, Filka E, Kuhn J, Nelson G, Kabbinavar F, Friedman H, Miller LL, Elfring GL   Two studies evaluating irinotecan treatment for recurrent malignant glioma using an every-3-week regimen Cancer. , 2003; 97(9 Suppl): 2381-6.
Mischel PS, Shai R, Shi T, Horvath S, Lu KV, Choe G, Seligson D, Kremen TJ, Palotie A, Liau LM, Cloughesy TF, Nelson SF   Identification of molecular subtypes of glioblastoma by gene expression profiling Oncogene. , 2003; 22(15): 2361-73.
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